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O75084

- FZD7_HUMAN

UniProt

O75084 - FZD7_HUMAN

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Protein

Frizzled-7

Gene

FZD7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

GO - Molecular functioni

  1. frizzled binding Source: UniProtKB
  2. G-protein coupled receptor activity Source: UniProtKB-KW
  3. PDZ domain binding Source: UniProtKB
  4. Wnt-activated receptor activity Source: RefGenome
  5. Wnt-protein binding Source: BHF-UCL

GO - Biological processi

  1. axonogenesis Source: RefGenome
  2. brain development Source: RefGenome
  3. canonical Wnt signaling pathway Source: UniProtKB
  4. cellular response to retinoic acid Source: UniProtKB
  5. gonad development Source: RefGenome
  6. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RefGenome
  7. mesenchymal to epithelial transition Source: BHF-UCL
  8. negative regulation of cell-substrate adhesion Source: BHF-UCL
  9. negative regulation of ectodermal cell fate specification Source: BHF-UCL
  10. neuron differentiation Source: UniProtKB
  11. non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
  12. positive regulation of epithelial cell proliferation involved in wound healing Source: BHF-UCL
  13. positive regulation of JNK cascade Source: BHF-UCL
  14. positive regulation of phosphorylation Source: BHF-UCL
  15. positive regulation of transcription, DNA-templated Source: BHF-UCL
  16. regulation of catenin import into nucleus Source: BHF-UCL
  17. regulation of transcription, DNA-templated Source: BHF-UCL
  18. skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Source: Ensembl
  19. somatic stem cell division Source: Ensembl
  20. stem cell maintenance Source: BHF-UCL
  21. substrate adhesion-dependent cell spreading Source: Ensembl
  22. T cell differentiation in thymus Source: Ensembl
  23. vasculature development Source: RefGenome
  24. Wnt signaling pathway, calcium modulating pathway Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_172581. PCP/CE pathway.
REACT_172638. Asymmetric localization of PCP proteins.
REACT_18372. Class B/2 (Secretin family receptors).
SignaLinkiO75084.

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-7
Short name:
Fz-7
Short name:
hFz7
Alternative name(s):
FzE3
Gene namesi
Name:FZD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:4045. FZD7.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 256224ExtracellularSequence AnalysisAdd
BLAST
Transmembranei257 – 27721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini278 – 28811CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei289 – 30921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini310 – 33627ExtracellularSequence AnalysisAdd
BLAST
Transmembranei337 – 35721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini358 – 37922CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei380 – 40021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini401 – 42323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei424 – 44421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini445 – 47026CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei471 – 49121Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini492 – 52837ExtracellularSequence AnalysisAdd
BLAST
Transmembranei529 – 54921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini550 – 57425CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. apical part of cell Source: RefGenome
  2. cytoplasm Source: RefGenome
  3. integral component of membrane Source: BHF-UCL
  4. neuron projection membrane Source: RefGenome
  5. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28462.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 574542Frizzled-7PRO_0000012996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 110PROSITE-ProRule annotation
Disulfide bondi57 ↔ 103PROSITE-ProRule annotation
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi94 ↔ 131PROSITE-ProRule annotation
Disulfide bondi120 ↔ 160PROSITE-ProRule annotation
Disulfide bondi124 ↔ 148PROSITE-ProRule annotation
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiO75084.
PaxDbiO75084.
PRIDEiO75084.

PTM databases

PhosphoSiteiO75084.

Expressioni

Tissue specificityi

High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.

Gene expression databases

BgeeiO75084.
CleanExiHS_FZD7.
GenevestigatoriO75084.

Interactioni

Subunit structurei

Interacts with MAGI3 and DVL1 (By similarity). Interacts with MYOC.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SDCBPO005604EBI-746917,EBI-727004
WNT3P567033EBI-746917,EBI-3644922

Protein-protein interaction databases

BioGridi113920. 4 interactions.
IntActiO75084. 6 interactions.
MINTiMINT-1461434.
STRINGi9606.ENSP00000286201.

Structurei

3D structure databases

ProteinModelPortaliO75084.
SMRiO75084. Positions 49-155, 230-565.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 163120FZPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi552 – 5576Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity
Motifi572 – 5743PDZ-binding

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257258.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000233237.
HOVERGENiHBG006977.
InParanoidiO75084.
KOiK02432.
OMAiCVERFSE.
OrthoDBiEOG7M3J01.
PhylomeDBiO75084.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026552. FZD7.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF31. PTHR11309:SF31. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75084-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRDPGAAAPL SSLGLCALVL ALLGALSAGA GAQPYHGEKG ISVPDHGFCQ
60 70 80 90 100
PISIPLCTDI AYNQTILPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF
110 120 130 140 150
FLCSMYAPVC TVLDQAIPPC RSLCERARQG CEALMNKFGF QWPERLRCEN
160 170 180 190 200
FPVHGAGEIC VGQNTSDGSG GPGGGPTAYP TAPYLPDLPF TALPPGASDG
210 220 230 240 250
RGRPAFPFSC PRQLKVPPYL GYRFLGERDC GAPCEPGRAN GLMYFKEEER
260 270 280 290 300
RFARLWVGVW SVLCCASTLF TVLTYLVDMR RFSYPERPII FLSGCYFMVA
310 320 330 340 350
VAHVAGFLLE DRAVCVERFS DDGYRTVAQG TKKEGCTILF MVLYFFGMAS
360 370 380 390 400
SIWWVILSLT WFLAAGMKWG HEAIEANSQY FHLAAWAVPA VKTITILAMG
410 420 430 440 450
QVDGDLLSGV CYVGLSSVDA LRGFVLAPLF VYLFIGTSFL LAGFVSLFRI
460 470 480 490 500
RTIMKHDGTK TEKLEKLMVR IGVFSVLYTV PATIVLACYF YEQAFREHWE
510 520 530 540 550
RTWLLQTCKS YAVPCPPGHF PPMSPDFTVF MIKYLMTMIV GITTGFWIWS
560 570
GKTLQSWRRF YHRLSHSSKG ETAV
Length:574
Mass (Da):63,620
Last modified:September 27, 2004 - v2
Checksum:i801934246B426DF5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81A → V in BAA32424. (PubMed:9707618)Curated
Sequence conflicti15 – 151L → F in BAA32424. (PubMed:9707618)Curated
Sequence conflicti201 – 2011R → K in BAA32424. (PubMed:9707618)Curated
Sequence conflicti308 – 3081L → F in BAA32424. (PubMed:9707618)Curated
Sequence conflicti408 – 4081S → N in BAA32424. (PubMed:9707618)Curated
Sequence conflicti415 – 4151L → F in BAA32424. (PubMed:9707618)Curated
Sequence conflicti433 – 4331L → F in BAA32424. (PubMed:9707618)Curated
Sequence conflicti447 – 4471L → F in BAA32424. (PubMed:9707618)Curated
Sequence conflicti534 – 5341Y → C in BAA32424. (PubMed:9707618)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241G → D.
Corresponds to variant rs35111363 [ dbSNP | Ensembl ].
VAR_049292
Natural varianti24 – 241G → S.1 Publication
VAR_033024
Natural varianti196 – 1961G → E.
Corresponds to variant rs34908164 [ dbSNP | Ensembl ].
VAR_033941
Natural varianti487 – 4871A → V.
Corresponds to variant rs35600847 [ dbSNP | Ensembl ].
VAR_033942

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010881 mRNA. Translation: BAA32424.1.
AB017365 mRNA. Translation: BAA34668.1.
AC069148 Genomic DNA. Translation: AAX93250.1.
CH471063 Genomic DNA. Translation: EAW70298.1.
BC015915 mRNA. Translation: AAH15915.1.
CCDSiCCDS2351.1.
PIRiJE0339.
RefSeqiNP_003498.1. NM_003507.1.
UniGeneiHs.173859.

Genome annotation databases

EnsembliENST00000286201; ENSP00000286201; ENSG00000155760.
GeneIDi8324.
KEGGihsa:8324.
UCSCiuc002uyw.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010881 mRNA. Translation: BAA32424.1 .
AB017365 mRNA. Translation: BAA34668.1 .
AC069148 Genomic DNA. Translation: AAX93250.1 .
CH471063 Genomic DNA. Translation: EAW70298.1 .
BC015915 mRNA. Translation: AAH15915.1 .
CCDSi CCDS2351.1.
PIRi JE0339.
RefSeqi NP_003498.1. NM_003507.1.
UniGenei Hs.173859.

3D structure databases

ProteinModelPortali O75084.
SMRi O75084. Positions 49-155, 230-565.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113920. 4 interactions.
IntActi O75084. 6 interactions.
MINTi MINT-1461434.
STRINGi 9606.ENSP00000286201.

Protein family/group databases

MEROPSi I93.001.
GPCRDBi Search...

PTM databases

PhosphoSitei O75084.

Proteomic databases

MaxQBi O75084.
PaxDbi O75084.
PRIDEi O75084.

Protocols and materials databases

DNASUi 8324.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000286201 ; ENSP00000286201 ; ENSG00000155760 .
GeneIDi 8324.
KEGGi hsa:8324.
UCSCi uc002uyw.1. human.

Organism-specific databases

CTDi 8324.
GeneCardsi GC02P202863.
HGNCi HGNC:4045. FZD7.
MIMi 603410. gene.
neXtProti NX_O75084.
PharmGKBi PA28462.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG257258.
GeneTreei ENSGT00760000118864.
HOGENOMi HOG000233237.
HOVERGENi HBG006977.
InParanoidi O75084.
KOi K02432.
OMAi CVERFSE.
OrthoDBi EOG7M3J01.
PhylomeDBi O75084.
TreeFami TF317907.

Enzyme and pathway databases

Reactomei REACT_172581. PCP/CE pathway.
REACT_172638. Asymmetric localization of PCP proteins.
REACT_18372. Class B/2 (Secretin family receptors).
SignaLinki O75084.

Miscellaneous databases

ChiTaRSi FZD7. human.
GeneWikii FZD7.
GenomeRNAii 8324.
NextBioi 31171.
PROi O75084.
SOURCEi Search...

Gene expression databases

Bgeei O75084.
CleanExi HS_FZD7.
Genevestigatori O75084.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026552. FZD7.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF31. PTHR11309:SF31. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals."
    Tanaka S., Akiyoshi T., Mori M., Wands J.R., Sugimachi K.
    Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], COUPLING TO BETA-CATENIN PATHWAY.
    Tissue: Esophageal carcinoma.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7."
    Sagara N., Toda G., Hirai M., Terada M., Katoh M.
    Biochem. Biophys. Res. Commun. 252:117-122(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal lung.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. Cited for: INTERACTION WITH MYOC.
  7. "Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."
    Chanock S.J., Burdett L., Yeager M., Llaca V., Langeroed A., Presswalla S., Kaaresen R., Strausberg R.L., Gerhard D.S., Kristensen V., Perou C.M., Boerresen-Dale A.-L.
    Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SER-24.

Entry informationi

Entry nameiFZD7_HUMAN
AccessioniPrimary (citable) accession number: O75084
Secondary accession number(s): O94816, Q53S59, Q96B74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: September 27, 2004
Last modified: November 26, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3