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O75084

- FZD7_HUMAN

UniProt

O75084 - FZD7_HUMAN

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Protein
Frizzled-7
Gene
FZD7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. PDZ domain binding Source: UniProtKB
  3. Wnt-activated receptor activity Source: RefGenome
  4. Wnt-protein binding Source: BHF-UCL
  5. frizzled binding Source: UniProtKB
  6. protein binding Source: IntAct

GO - Biological processi

  1. G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RefGenome
  2. T cell differentiation in thymus Source: Ensembl
  3. Wnt signaling pathway, calcium modulating pathway Source: RefGenome
  4. axonogenesis Source: RefGenome
  5. brain development Source: RefGenome
  6. canonical Wnt signaling pathway Source: UniProtKB
  7. cellular response to retinoic acid Source: UniProtKB
  8. gonad development Source: RefGenome
  9. mesenchymal to epithelial transition Source: BHF-UCL
  10. negative regulation of cell-substrate adhesion Source: BHF-UCL
  11. negative regulation of ectodermal cell fate specification Source: BHF-UCL
  12. neuron differentiation Source: UniProtKB
  13. non-canonical Wnt signaling pathway via JNK cascade Source: BHF-UCL
  14. positive regulation of JNK cascade Source: BHF-UCL
  15. positive regulation of epithelial cell proliferation involved in wound healing Source: BHF-UCL
  16. positive regulation of phosphorylation Source: BHF-UCL
  17. positive regulation of transcription, DNA-templated Source: BHF-UCL
  18. regulation of catenin import into nucleus Source: BHF-UCL
  19. regulation of transcription, DNA-templated Source: BHF-UCL
  20. satellite cell maintenance involved in skeletal muscle regeneration Source: Ensembl
  21. somatic stem cell division Source: Ensembl
  22. stem cell maintenance Source: BHF-UCL
  23. substrate adhesion-dependent cell spreading Source: Ensembl
  24. vasculature development Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_172581. PCP/CE pathway.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_207044. TCF dependent signaling in response to WNT.
SignaLinkiO75084.

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-7
Short name:
Fz-7
Short name:
hFz7
Alternative name(s):
FzE3
Gene namesi
Name:FZD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:4045. FZD7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 256224Extracellular Reviewed prediction
Add
BLAST
Transmembranei257 – 27721Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini278 – 28811Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei289 – 30921Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini310 – 33627Extracellular Reviewed prediction
Add
BLAST
Transmembranei337 – 35721Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini358 – 37922Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei380 – 40021Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini401 – 42323Extracellular Reviewed prediction
Add
BLAST
Transmembranei424 – 44421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini445 – 47026Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei471 – 49121Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini492 – 52837Extracellular Reviewed prediction
Add
BLAST
Transmembranei529 – 54921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini550 – 57425Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical part of cell Source: RefGenome
  2. cytoplasm Source: RefGenome
  3. integral component of membrane Source: BHF-UCL
  4. neuron projection membrane Source: RefGenome
  5. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28462.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 Reviewed prediction
Add
BLAST
Chaini33 – 574542Frizzled-7
PRO_0000012996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 110 By similarity
Disulfide bondi57 ↔ 103 By similarity
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi94 ↔ 131 By similarity
Disulfide bondi120 ↔ 160 By similarity
Disulfide bondi124 ↔ 148 By similarity
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiO75084.
PaxDbiO75084.
PRIDEiO75084.

PTM databases

PhosphoSiteiO75084.

Expressioni

Tissue specificityi

High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.

Gene expression databases

BgeeiO75084.
CleanExiHS_FZD7.
GenevestigatoriO75084.

Interactioni

Subunit structurei

Interacts with MAGI3 and DVL1 By similarity. Interacts with MYOC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SDCBPO005604EBI-746917,EBI-727004
WNT3P567033EBI-746917,EBI-3644922

Protein-protein interaction databases

BioGridi113920. 4 interactions.
IntActiO75084. 6 interactions.
MINTiMINT-1461434.
STRINGi9606.ENSP00000286201.

Structurei

3D structure databases

ProteinModelPortaliO75084.
SMRiO75084. Positions 49-155, 204-565.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 163120FZ
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi552 – 5576Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members By similarity
Motifi572 – 5743PDZ-binding

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway By similarity.
The FZ domain is involved in binding with Wnt ligands By similarity.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257258.
HOGENOMiHOG000233237.
HOVERGENiHBG006977.
InParanoidiO75084.
KOiK02432.
OMAiCVERFSE.
OrthoDBiEOG7M3J01.
PhylomeDBiO75084.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026552. FZD7.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF31. PTHR11309:SF31. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75084-1 [UniParc]FASTAAdd to Basket

« Hide

MRDPGAAAPL SSLGLCALVL ALLGALSAGA GAQPYHGEKG ISVPDHGFCQ    50
PISIPLCTDI AYNQTILPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF 100
FLCSMYAPVC TVLDQAIPPC RSLCERARQG CEALMNKFGF QWPERLRCEN 150
FPVHGAGEIC VGQNTSDGSG GPGGGPTAYP TAPYLPDLPF TALPPGASDG 200
RGRPAFPFSC PRQLKVPPYL GYRFLGERDC GAPCEPGRAN GLMYFKEEER 250
RFARLWVGVW SVLCCASTLF TVLTYLVDMR RFSYPERPII FLSGCYFMVA 300
VAHVAGFLLE DRAVCVERFS DDGYRTVAQG TKKEGCTILF MVLYFFGMAS 350
SIWWVILSLT WFLAAGMKWG HEAIEANSQY FHLAAWAVPA VKTITILAMG 400
QVDGDLLSGV CYVGLSSVDA LRGFVLAPLF VYLFIGTSFL LAGFVSLFRI 450
RTIMKHDGTK TEKLEKLMVR IGVFSVLYTV PATIVLACYF YEQAFREHWE 500
RTWLLQTCKS YAVPCPPGHF PPMSPDFTVF MIKYLMTMIV GITTGFWIWS 550
GKTLQSWRRF YHRLSHSSKG ETAV 574
Length:574
Mass (Da):63,620
Last modified:September 27, 2004 - v2
Checksum:i801934246B426DF5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241G → D.
Corresponds to variant rs35111363 [ dbSNP | Ensembl ].
VAR_049292
Natural varianti24 – 241G → S.1 Publication
VAR_033024
Natural varianti196 – 1961G → E.
Corresponds to variant rs34908164 [ dbSNP | Ensembl ].
VAR_033941
Natural varianti487 – 4871A → V.
Corresponds to variant rs35600847 [ dbSNP | Ensembl ].
VAR_033942

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81A → V in BAA32424. 1 Publication
Sequence conflicti15 – 151L → F in BAA32424. 1 Publication
Sequence conflicti201 – 2011R → K in BAA32424. 1 Publication
Sequence conflicti308 – 3081L → F in BAA32424. 1 Publication
Sequence conflicti408 – 4081S → N in BAA32424. 1 Publication
Sequence conflicti415 – 4151L → F in BAA32424. 1 Publication
Sequence conflicti433 – 4331L → F in BAA32424. 1 Publication
Sequence conflicti447 – 4471L → F in BAA32424. 1 Publication
Sequence conflicti534 – 5341Y → C in BAA32424. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010881 mRNA. Translation: BAA32424.1.
AB017365 mRNA. Translation: BAA34668.1.
AC069148 Genomic DNA. Translation: AAX93250.1.
CH471063 Genomic DNA. Translation: EAW70298.1.
BC015915 mRNA. Translation: AAH15915.1.
CCDSiCCDS2351.1.
PIRiJE0339.
RefSeqiNP_003498.1. NM_003507.1.
UniGeneiHs.173859.

Genome annotation databases

EnsembliENST00000286201; ENSP00000286201; ENSG00000155760.
GeneIDi8324.
KEGGihsa:8324.
UCSCiuc002uyw.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010881 mRNA. Translation: BAA32424.1 .
AB017365 mRNA. Translation: BAA34668.1 .
AC069148 Genomic DNA. Translation: AAX93250.1 .
CH471063 Genomic DNA. Translation: EAW70298.1 .
BC015915 mRNA. Translation: AAH15915.1 .
CCDSi CCDS2351.1.
PIRi JE0339.
RefSeqi NP_003498.1. NM_003507.1.
UniGenei Hs.173859.

3D structure databases

ProteinModelPortali O75084.
SMRi O75084. Positions 49-155, 204-565.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113920. 4 interactions.
IntActi O75084. 6 interactions.
MINTi MINT-1461434.
STRINGi 9606.ENSP00000286201.

Protein family/group databases

MEROPSi I93.001.
GPCRDBi Search...

PTM databases

PhosphoSitei O75084.

Proteomic databases

MaxQBi O75084.
PaxDbi O75084.
PRIDEi O75084.

Protocols and materials databases

DNASUi 8324.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000286201 ; ENSP00000286201 ; ENSG00000155760 .
GeneIDi 8324.
KEGGi hsa:8324.
UCSCi uc002uyw.1. human.

Organism-specific databases

CTDi 8324.
GeneCardsi GC02P202863.
HGNCi HGNC:4045. FZD7.
MIMi 603410. gene.
neXtProti NX_O75084.
PharmGKBi PA28462.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG257258.
HOGENOMi HOG000233237.
HOVERGENi HBG006977.
InParanoidi O75084.
KOi K02432.
OMAi CVERFSE.
OrthoDBi EOG7M3J01.
PhylomeDBi O75084.
TreeFami TF317907.

Enzyme and pathway databases

Reactomei REACT_172581. PCP/CE pathway.
REACT_18372. Class B/2 (Secretin family receptors).
REACT_207044. TCF dependent signaling in response to WNT.
SignaLinki O75084.

Miscellaneous databases

ChiTaRSi FZD7. human.
GeneWikii FZD7.
GenomeRNAii 8324.
NextBioi 31171.
PROi O75084.
SOURCEi Search...

Gene expression databases

Bgeei O75084.
CleanExi HS_FZD7.
Genevestigatori O75084.

Family and domain databases

Gene3Di 1.10.2000.10. 1 hit.
InterProi IPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026552. FZD7.
IPR017981. GPCR_2-like.
[Graphical view ]
PANTHERi PTHR11309. PTHR11309. 1 hit.
PTHR11309:SF31. PTHR11309:SF31. 1 hit.
Pfami PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view ]
PRINTSi PR00489. FRIZZLED.
SMARTi SM00063. FRI. 1 hit.
[Graphical view ]
SUPFAMi SSF63501. SSF63501. 1 hit.
PROSITEi PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals."
    Tanaka S., Akiyoshi T., Mori M., Wands J.R., Sugimachi K.
    Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], COUPLING TO BETA-CATENIN PATHWAY.
    Tissue: Esophageal carcinoma.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7."
    Sagara N., Toda G., Hirai M., Terada M., Katoh M.
    Biochem. Biophys. Res. Commun. 252:117-122(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal lung.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. Cited for: INTERACTION WITH MYOC.
  7. "Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas."
    Chanock S.J., Burdett L., Yeager M., Llaca V., Langeroed A., Presswalla S., Kaaresen R., Strausberg R.L., Gerhard D.S., Kristensen V., Perou C.M., Boerresen-Dale A.-L.
    Breast Cancer Res. 9:R5-R5(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SER-24.

Entry informationi

Entry nameiFZD7_HUMAN
AccessioniPrimary (citable) accession number: O75084
Secondary accession number(s): O94816, Q53S59, Q96B74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: September 27, 2004
Last modified: September 3, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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