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Protein

WD repeat-containing protein 1

Gene

WDR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.
SignaLinkiO75083.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 1
Alternative name(s):
Actin-interacting protein 1
Short name:
AIP1
NORI-1
Gene namesi
Name:WDR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000071127.16.
HGNCiHGNC:12754. WDR1.
MIMi604734. gene.
neXtProtiNX_O75083.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi9948.
OpenTargetsiENSG00000071127.
PharmGKBiPA37358.

Polymorphism and mutation databases

BioMutaiWDR1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513411 – 606WD repeat-containing protein 1Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28N6-acetyllysineCombined sources1
Modified residuei81N6-acetyllysineCombined sources1
Modified residuei95N6-acetyllysineCombined sources1
Modified residuei115N6-acetyllysineCombined sources1
Modified residuei238PhosphotyrosineCombined sources1
Modified residuei480N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO75083.
PaxDbiO75083.
PeptideAtlasiO75083.
PRIDEiO75083.
TopDownProteomicsiO75083-1. [O75083-1]

2D gel databases

OGPiO75083.
REPRODUCTION-2DPAGEiIPI00746165.
O75083.
UCD-2DPAGEiO75083.

PTM databases

iPTMnetiO75083.
PhosphoSitePlusiO75083.
SwissPalmiO75083.

Expressioni

Gene expression databases

BgeeiENSG00000071127.
CleanExiHS_WDR1.
ExpressionAtlasiO75083. baseline and differential.
GenevisibleiO75083. HS.

Organism-specific databases

HPAiCAB020804.
HPA036434.
HPA058132.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115273. 102 interactors.
IntActiO75083. 32 interactors.
MINTiO75083.
STRINGi9606.ENSP00000427687.

Structurei

3D structure databases

ProteinModelPortaliO75083.
SMRiO75083.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati4 – 45WD 1Add BLAST42
Repeati48 – 87WD 2Add BLAST40
Repeati93 – 135WD 3Add BLAST43
Repeati138 – 176WD 4Add BLAST39
Repeati180 – 218WD 5Add BLAST39
Repeati224 – 263WD 6Add BLAST40
Repeati270 – 306WD 7Add BLAST37
Repeati311 – 351WD 8Add BLAST41
Repeati358 – 408WD 9Add BLAST51
Repeati432 – 474WD 10Add BLAST43
Repeati480 – 518WD 11Add BLAST39
Repeati523 – 561WD 12Add BLAST39
Repeati566 – 604WD 13Add BLAST39

Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
GeneTreeiENSGT00390000009416.
HOVERGENiHBG000780.
InParanoidiO75083.
OMAiDGHINYW.
OrthoDBiEOG091G03SZ.
PhylomeDBiO75083.
TreeFamiTF300821.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
PfamiView protein in Pfam
PF00400. WD40. 4 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 11 hits.
SUPFAMiSSF50974. SSF50974. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75083-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPYEIKKVFA SLPQVERGVS KIIGGDPKGN NFLYTNGKCV ILRNIDNPAL
60 70 80 90 100
ADIYTEHAHQ VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP
110 120 130 140 150
FAGKIKDIAW TEDSKRIAVV GEGREKFGAV FLWDSGSSVG EITGHNKVIN
160 170 180 190 200
SVDIKQSRPY RLATGSDDNC AAFFEGPPFK FKFTIGDHSR FVNCVRFSPD
210 220 230 240 250
GNRFATASAD GQIYIYDGKT GEKVCALGGS KAHDGGIYAI SWSPDSTHLL
260 270 280 290 300
SASGDKTSKI WDVSVNSVVS TFPMGSTVLD QQLGCLWQKD HLLSVSLSGY
310 320 330 340 350
INYLDRNNPS KPLHVIKGHS KSIQCLTVHK NGGKSYIYSG SHDGHINYWD
360 370 380 390 400
SETGENDSFA GKGHTNQVSR MTVDESGQLI SCSMDDTVRY TSLMLRDYSG
410 420 430 440 450
QGVVKLDVQP KCVAVGPGGY AVVVCIGQIV LLKDQRKCFS IDNPGYEPEV
460 470 480 490 500
VAVHPGGDTV AIGGVDGNVR LYSILGTTLK DEGKLLEAKG PVTDVAYSHD
510 520 530 540 550
GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW SPDNEHFASG
560 570 580 590 600
GMDMMVYVWT LSDPETRVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK

EWTITY
Length:606
Mass (Da):66,194
Last modified:January 23, 2007 - v4
Checksum:i8C08C31D5CD097F1
GO
Isoform 2 (identifier: O75083-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-186: Missing.

Note: No experimental confirmation available.
Show »
Length:466
Mass (Da):50,694
Checksum:i4CC6C543EB6F365D
GO

Sequence cautioni

The sequence AAD05045 differs from that shown. Aberrant splicing.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013445185I → V1 PublicationCorresponds to variant dbSNP:rs13441Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01292647 – 186Missing in isoform 2. 1 PublicationAdd BLAST140

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020056 mRNA. Translation: AAD05044.1.
AF020260 mRNA. Translation: AAD05045.1. Sequence problems.
AB010427 mRNA. Translation: BAA31855.2.
AK291614 mRNA. Translation: BAF84303.1.
AC005674 Genomic DNA. No translation available.
AC093664 Genomic DNA. No translation available.
BC000201 mRNA. Translation: AAH00201.1.
BC002489 mRNA. Translation: AAH02489.1.
BC030541 mRNA. Translation: AAH30541.1.
AL050108 mRNA. Translation: CAB43276.1.
AL110208 mRNA. Translation: CAB53674.2.
CCDSiCCDS54739.1. [O75083-3]
CCDS54740.1. [O75083-1]
PIRiT13152.
RefSeqiNP_005103.2. NM_005112.4. [O75083-3]
NP_059830.1. NM_017491.3. [O75083-1]
UniGeneiHs.128548.
Hs.713658.

Genome annotation databases

EnsembliENST00000382451; ENSP00000371889; ENSG00000071127. [O75083-3]
ENST00000382452; ENSP00000371890; ENSG00000071127. [O75083-1]
ENST00000499869; ENSP00000427687; ENSG00000071127. [O75083-1]
ENST00000502702; ENSP00000426725; ENSG00000071127. [O75083-3]
GeneIDi9948.
KEGGihsa:9948.
UCSCiuc032tcf.2. human. [O75083-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiWDR1_HUMAN
AccessioniPrimary (citable) accession number: O75083
Secondary accession number(s): A8K6E9
, A8MPU4, O75313, Q8N6E5, Q9UG05, Q9UG78, Q9UQE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 180 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome