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Protein

WD repeat-containing protein 1

Gene

WDR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000071127-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
SignaLinkiO75083.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 1
Alternative name(s):
Actin-interacting protein 1
Short name:
AIP1
NORI-1
Gene namesi
Name:WDR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:12754. WDR1.

Subcellular locationi

GO - Cellular componenti

  • actin filament Source: Ensembl
  • cell-cell junction Source: UniProtKB
  • cell projection Source: UniProtKB-KW
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • myelin sheath Source: Ensembl
  • podosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi9948.
OpenTargetsiENSG00000071127.
PharmGKBiPA37358.

Polymorphism and mutation databases

BioMutaiWDR1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513411 – 606WD repeat-containing protein 1Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28N6-acetyllysineCombined sources1
Modified residuei81N6-acetyllysineCombined sources1
Modified residuei95N6-acetyllysineCombined sources1
Modified residuei115N6-acetyllysineCombined sources1
Modified residuei238PhosphotyrosineCombined sources1
Modified residuei480N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO75083.
PaxDbiO75083.
PeptideAtlasiO75083.
PRIDEiO75083.
TopDownProteomicsiO75083-1. [O75083-1]

2D gel databases

OGPiO75083.
REPRODUCTION-2DPAGEIPI00746165.
O75083.
UCD-2DPAGEO75083.

PTM databases

iPTMnetiO75083.
PhosphoSitePlusiO75083.
SwissPalmiO75083.

Expressioni

Gene expression databases

BgeeiENSG00000071127.
CleanExiHS_WDR1.
ExpressionAtlasiO75083. baseline and differential.
GenevisibleiO75083. HS.

Organism-specific databases

HPAiCAB020804.
HPA036434.
HPA058132.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115273. 100 interactors.
IntActiO75083. 29 interactors.
STRINGi9606.ENSP00000427687.

Structurei

3D structure databases

ProteinModelPortaliO75083.
SMRiO75083.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati56 – 95WD 1Add BLAST40
Repeati100 – 143WD 2Add BLAST44
Repeati144 – 184WD 3Add BLAST41
Repeati187 – 226WD 4Add BLAST40
Repeati232 – 271WD 5Add BLAST40
Repeati318 – 359WD 6Add BLAST42
Repeati363 – 401WD 7Add BLAST39
Repeati443 – 482WD 8Add BLAST40
Repeati487 – 526WD 9Add BLAST40
Repeati530 – 569WD 10Add BLAST40
Repeati574 – 605WD 11Add BLAST32

Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated
Contains 11 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
GeneTreeiENSGT00390000009416.
HOVERGENiHBG000780.
InParanoidiO75083.
OMAiWDVGANS.
OrthoDBiEOG091G03SZ.
PhylomeDBiO75083.
TreeFamiTF300821.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75083-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPYEIKKVFA SLPQVERGVS KIIGGDPKGN NFLYTNGKCV ILRNIDNPAL
60 70 80 90 100
ADIYTEHAHQ VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP
110 120 130 140 150
FAGKIKDIAW TEDSKRIAVV GEGREKFGAV FLWDSGSSVG EITGHNKVIN
160 170 180 190 200
SVDIKQSRPY RLATGSDDNC AAFFEGPPFK FKFTIGDHSR FVNCVRFSPD
210 220 230 240 250
GNRFATASAD GQIYIYDGKT GEKVCALGGS KAHDGGIYAI SWSPDSTHLL
260 270 280 290 300
SASGDKTSKI WDVSVNSVVS TFPMGSTVLD QQLGCLWQKD HLLSVSLSGY
310 320 330 340 350
INYLDRNNPS KPLHVIKGHS KSIQCLTVHK NGGKSYIYSG SHDGHINYWD
360 370 380 390 400
SETGENDSFA GKGHTNQVSR MTVDESGQLI SCSMDDTVRY TSLMLRDYSG
410 420 430 440 450
QGVVKLDVQP KCVAVGPGGY AVVVCIGQIV LLKDQRKCFS IDNPGYEPEV
460 470 480 490 500
VAVHPGGDTV AIGGVDGNVR LYSILGTTLK DEGKLLEAKG PVTDVAYSHD
510 520 530 540 550
GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW SPDNEHFASG
560 570 580 590 600
GMDMMVYVWT LSDPETRVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK

EWTITY
Length:606
Mass (Da):66,194
Last modified:January 23, 2007 - v4
Checksum:i8C08C31D5CD097F1
GO
Isoform 2 (identifier: O75083-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-186: Missing.

Note: No experimental confirmation available.
Show »
Length:466
Mass (Da):50,694
Checksum:i4CC6C543EB6F365D
GO

Sequence cautioni

The sequence AAD05045 differs from that shown. Aberrant splicing.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013445185I → V.1 PublicationCorresponds to variant rs13441dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01292647 – 186Missing in isoform 2. 1 PublicationAdd BLAST140

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020056 mRNA. Translation: AAD05044.1.
AF020260 mRNA. Translation: AAD05045.1. Sequence problems.
AB010427 mRNA. Translation: BAA31855.2.
AK291614 mRNA. Translation: BAF84303.1.
AC005674 Genomic DNA. No translation available.
AC093664 Genomic DNA. No translation available.
BC000201 mRNA. Translation: AAH00201.1.
BC002489 mRNA. Translation: AAH02489.1.
BC030541 mRNA. Translation: AAH30541.1.
AL050108 mRNA. Translation: CAB43276.1.
AL110208 mRNA. Translation: CAB53674.2.
CCDSiCCDS54739.1. [O75083-3]
CCDS54740.1. [O75083-1]
PIRiT13152.
RefSeqiNP_005103.2. NM_005112.4. [O75083-3]
NP_059830.1. NM_017491.3. [O75083-1]
UniGeneiHs.128548.
Hs.713658.

Genome annotation databases

EnsembliENST00000382451; ENSP00000371889; ENSG00000071127. [O75083-3]
ENST00000382452; ENSP00000371890; ENSG00000071127. [O75083-1]
ENST00000499869; ENSP00000427687; ENSG00000071127. [O75083-1]
ENST00000502702; ENSP00000426725; ENSG00000071127. [O75083-3]
GeneIDi9948.
KEGGihsa:9948.
UCSCiuc032tcf.2. human. [O75083-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020056 mRNA. Translation: AAD05044.1.
AF020260 mRNA. Translation: AAD05045.1. Sequence problems.
AB010427 mRNA. Translation: BAA31855.2.
AK291614 mRNA. Translation: BAF84303.1.
AC005674 Genomic DNA. No translation available.
AC093664 Genomic DNA. No translation available.
BC000201 mRNA. Translation: AAH00201.1.
BC002489 mRNA. Translation: AAH02489.1.
BC030541 mRNA. Translation: AAH30541.1.
AL050108 mRNA. Translation: CAB43276.1.
AL110208 mRNA. Translation: CAB53674.2.
CCDSiCCDS54739.1. [O75083-3]
CCDS54740.1. [O75083-1]
PIRiT13152.
RefSeqiNP_005103.2. NM_005112.4. [O75083-3]
NP_059830.1. NM_017491.3. [O75083-1]
UniGeneiHs.128548.
Hs.713658.

3D structure databases

ProteinModelPortaliO75083.
SMRiO75083.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115273. 100 interactors.
IntActiO75083. 29 interactors.
STRINGi9606.ENSP00000427687.

PTM databases

iPTMnetiO75083.
PhosphoSitePlusiO75083.
SwissPalmiO75083.

Polymorphism and mutation databases

BioMutaiWDR1.

2D gel databases

OGPiO75083.
REPRODUCTION-2DPAGEIPI00746165.
O75083.
UCD-2DPAGEO75083.

Proteomic databases

EPDiO75083.
PaxDbiO75083.
PeptideAtlasiO75083.
PRIDEiO75083.
TopDownProteomicsiO75083-1. [O75083-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382451; ENSP00000371889; ENSG00000071127. [O75083-3]
ENST00000382452; ENSP00000371890; ENSG00000071127. [O75083-1]
ENST00000499869; ENSP00000427687; ENSG00000071127. [O75083-1]
ENST00000502702; ENSP00000426725; ENSG00000071127. [O75083-3]
GeneIDi9948.
KEGGihsa:9948.
UCSCiuc032tcf.2. human. [O75083-1]

Organism-specific databases

CTDi9948.
DisGeNETi9948.
GeneCardsiWDR1.
HGNCiHGNC:12754. WDR1.
HPAiCAB020804.
HPA036434.
HPA058132.
MIMi604734. gene.
neXtProtiNX_O75083.
OpenTargetsiENSG00000071127.
PharmGKBiPA37358.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
GeneTreeiENSGT00390000009416.
HOVERGENiHBG000780.
InParanoidiO75083.
OMAiWDVGANS.
OrthoDBiEOG091G03SZ.
PhylomeDBiO75083.
TreeFamiTF300821.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000071127-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.
SignaLinkiO75083.

Miscellaneous databases

ChiTaRSiWDR1. human.
GeneWikiiWDR1.
GenomeRNAii9948.
PROiO75083.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000071127.
CleanExiHS_WDR1.
ExpressionAtlasiO75083. baseline and differential.
GenevisibleiO75083. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR1_HUMAN
AccessioniPrimary (citable) accession number: O75083
Secondary accession number(s): A8K6E9
, A8MPU4, O75313, Q8N6E5, Q9UG05, Q9UG78, Q9UQE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 170 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.