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Protein

WD repeat-containing protein 1

Gene

WDR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).By similarity3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.
SignaLinkiO75083.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 1
Alternative name(s):
Actin-interacting protein 1
Short name:
AIP1
NORI-1
Gene namesi
Name:WDR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:12754. WDR1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37358.

Polymorphism and mutation databases

BioMutaiWDR1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved
Chaini2 – 606605WD repeat-containing protein 1PRO_0000051341Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei28 – 281N6-acetyllysineCombined sources
Modified residuei81 – 811N6-acetyllysineCombined sources
Modified residuei95 – 951N6-acetyllysineCombined sources
Modified residuei115 – 1151N6-acetyllysineCombined sources
Modified residuei238 – 2381PhosphotyrosineCombined sources
Modified residuei480 – 4801N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO75083.
PaxDbiO75083.
PeptideAtlasiO75083.
PRIDEiO75083.
TopDownProteomicsiO75083-1. [O75083-1]

2D gel databases

OGPiO75083.
REPRODUCTION-2DPAGEIPI00746165.
O75083.
UCD-2DPAGEO75083.

PTM databases

iPTMnetiO75083.
PhosphoSiteiO75083.
SwissPalmiO75083.

Expressioni

Gene expression databases

BgeeiO75083.
CleanExiHS_WDR1.
ExpressionAtlasiO75083. baseline and differential.
GenevisibleiO75083. HS.

Organism-specific databases

HPAiCAB020804.
HPA036434.

Interactioni

Protein-protein interaction databases

BioGridi115273. 100 interactions.
IntActiO75083. 29 interactions.
STRINGi9606.ENSP00000427687.

Structurei

3D structure databases

ProteinModelPortaliO75083.
SMRiO75083. Positions 8-606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati56 – 9540WD 1Add
BLAST
Repeati100 – 14344WD 2Add
BLAST
Repeati144 – 18441WD 3Add
BLAST
Repeati187 – 22640WD 4Add
BLAST
Repeati232 – 27140WD 5Add
BLAST
Repeati318 – 35942WD 6Add
BLAST
Repeati363 – 40139WD 7Add
BLAST
Repeati443 – 48240WD 8Add
BLAST
Repeati487 – 52640WD 9Add
BLAST
Repeati530 – 56940WD 10Add
BLAST
Repeati574 – 60532WD 11Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated
Contains 11 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
GeneTreeiENSGT00390000009416.
HOVERGENiHBG000780.
InParanoidiO75083.
OMAiWDVGANS.
OrthoDBiEOG7TXKG1.
PhylomeDBiO75083.
TreeFamiTF300821.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75083-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPYEIKKVFA SLPQVERGVS KIIGGDPKGN NFLYTNGKCV ILRNIDNPAL
60 70 80 90 100
ADIYTEHAHQ VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP
110 120 130 140 150
FAGKIKDIAW TEDSKRIAVV GEGREKFGAV FLWDSGSSVG EITGHNKVIN
160 170 180 190 200
SVDIKQSRPY RLATGSDDNC AAFFEGPPFK FKFTIGDHSR FVNCVRFSPD
210 220 230 240 250
GNRFATASAD GQIYIYDGKT GEKVCALGGS KAHDGGIYAI SWSPDSTHLL
260 270 280 290 300
SASGDKTSKI WDVSVNSVVS TFPMGSTVLD QQLGCLWQKD HLLSVSLSGY
310 320 330 340 350
INYLDRNNPS KPLHVIKGHS KSIQCLTVHK NGGKSYIYSG SHDGHINYWD
360 370 380 390 400
SETGENDSFA GKGHTNQVSR MTVDESGQLI SCSMDDTVRY TSLMLRDYSG
410 420 430 440 450
QGVVKLDVQP KCVAVGPGGY AVVVCIGQIV LLKDQRKCFS IDNPGYEPEV
460 470 480 490 500
VAVHPGGDTV AIGGVDGNVR LYSILGTTLK DEGKLLEAKG PVTDVAYSHD
510 520 530 540 550
GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW SPDNEHFASG
560 570 580 590 600
GMDMMVYVWT LSDPETRVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK

EWTITY
Length:606
Mass (Da):66,194
Last modified:January 23, 2007 - v4
Checksum:i8C08C31D5CD097F1
GO
Isoform 2 (identifier: O75083-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-186: Missing.

Note: No experimental confirmation available.
Show »
Length:466
Mass (Da):50,694
Checksum:i4CC6C543EB6F365D
GO

Sequence cautioni

The sequence AAD05045.1 differs from that shown.Aberrant splicing.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti185 – 1851I → V.1 Publication
Corresponds to variant rs13441 [ dbSNP | Ensembl ].
VAR_013445

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei47 – 186140Missing in isoform 2. 1 PublicationVSP_012926Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020056 mRNA. Translation: AAD05044.1.
AF020260 mRNA. Translation: AAD05045.1. Sequence problems.
AB010427 mRNA. Translation: BAA31855.2.
AK291614 mRNA. Translation: BAF84303.1.
AC005674 Genomic DNA. No translation available.
AC093664 Genomic DNA. No translation available.
BC000201 mRNA. Translation: AAH00201.1.
BC002489 mRNA. Translation: AAH02489.1.
BC030541 mRNA. Translation: AAH30541.1.
AL050108 mRNA. Translation: CAB43276.1.
AL110208 mRNA. Translation: CAB53674.2.
CCDSiCCDS54739.1. [O75083-3]
CCDS54740.1. [O75083-1]
PIRiT13152.
RefSeqiNP_005103.2. NM_005112.4. [O75083-3]
NP_059830.1. NM_017491.3. [O75083-1]
UniGeneiHs.128548.
Hs.713658.

Genome annotation databases

EnsembliENST00000382451; ENSP00000371889; ENSG00000071127. [O75083-3]
ENST00000382452; ENSP00000371890; ENSG00000071127. [O75083-1]
ENST00000499869; ENSP00000427687; ENSG00000071127. [O75083-1]
ENST00000502702; ENSP00000426725; ENSG00000071127. [O75083-3]
GeneIDi9948.
KEGGihsa:9948.
UCSCiuc032tcf.2. human. [O75083-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020056 mRNA. Translation: AAD05044.1.
AF020260 mRNA. Translation: AAD05045.1. Sequence problems.
AB010427 mRNA. Translation: BAA31855.2.
AK291614 mRNA. Translation: BAF84303.1.
AC005674 Genomic DNA. No translation available.
AC093664 Genomic DNA. No translation available.
BC000201 mRNA. Translation: AAH00201.1.
BC002489 mRNA. Translation: AAH02489.1.
BC030541 mRNA. Translation: AAH30541.1.
AL050108 mRNA. Translation: CAB43276.1.
AL110208 mRNA. Translation: CAB53674.2.
CCDSiCCDS54739.1. [O75083-3]
CCDS54740.1. [O75083-1]
PIRiT13152.
RefSeqiNP_005103.2. NM_005112.4. [O75083-3]
NP_059830.1. NM_017491.3. [O75083-1]
UniGeneiHs.128548.
Hs.713658.

3D structure databases

ProteinModelPortaliO75083.
SMRiO75083. Positions 8-606.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115273. 100 interactions.
IntActiO75083. 29 interactions.
STRINGi9606.ENSP00000427687.

PTM databases

iPTMnetiO75083.
PhosphoSiteiO75083.
SwissPalmiO75083.

Polymorphism and mutation databases

BioMutaiWDR1.

2D gel databases

OGPiO75083.
REPRODUCTION-2DPAGEIPI00746165.
O75083.
UCD-2DPAGEO75083.

Proteomic databases

EPDiO75083.
PaxDbiO75083.
PeptideAtlasiO75083.
PRIDEiO75083.
TopDownProteomicsiO75083-1. [O75083-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382451; ENSP00000371889; ENSG00000071127. [O75083-3]
ENST00000382452; ENSP00000371890; ENSG00000071127. [O75083-1]
ENST00000499869; ENSP00000427687; ENSG00000071127. [O75083-1]
ENST00000502702; ENSP00000426725; ENSG00000071127. [O75083-3]
GeneIDi9948.
KEGGihsa:9948.
UCSCiuc032tcf.2. human. [O75083-1]

Organism-specific databases

CTDi9948.
GeneCardsiWDR1.
HGNCiHGNC:12754. WDR1.
HPAiCAB020804.
HPA036434.
MIMi604734. gene.
neXtProtiNX_O75083.
PharmGKBiPA37358.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0318. Eukaryota.
ENOG410XQN1. LUCA.
GeneTreeiENSGT00390000009416.
HOVERGENiHBG000780.
InParanoidiO75083.
OMAiWDVGANS.
OrthoDBiEOG7TXKG1.
PhylomeDBiO75083.
TreeFamiTF300821.

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.
SignaLinkiO75083.

Miscellaneous databases

ChiTaRSiWDR1. human.
GeneWikiiWDR1.
GenomeRNAii9948.
PROiO75083.
SOURCEiSearch...

Gene expression databases

BgeeiO75083.
CleanExiHS_WDR1.
ExpressionAtlasiO75083. baseline and differential.
GenevisibleiO75083. HS.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 4 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50974. SSF50974. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein."
    Adler H.J., Winnicki R.S., Gong T.-W.L., Lomax M.I.
    Genomics 56:59-69(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Abe Y., Nezu K., Ueda N.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lymphoid tissue.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-185.
    Tissue: Colon, Eye and Mammary gland.
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-17 (ISOFORMS 1/2).
    Tissue: Platelet.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 58-606 (ISOFORM 1).
    Tissue: Uterus.
  8. Lubec G., Afjehi-Sadat L.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 290-306 (ISOFORMS 1/2), IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain and Cajal-Retzius cell.
  9. Cited for: FUNCTION.
  10. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Critical roles of actin-interacting protein 1 in cytokinesis and chemotactic migration of mammalian cells."
    Kato A., Kurita S., Hayashi A., Kaji N., Ohashi K., Mizuno K.
    Biochem. J. 414:261-270(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-28; LYS-81; LYS-95; LYS-115 AND LYS-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Proteomic analysis of podosome fractions from macrophages reveals similarities to spreading initiation centres."
    Cervero P., Himmel M., Kruger M., Linder S.
    Eur. J. Cell Biol. 91:908-922(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  18. "Actin-interacting protein 1 controls assembly and permeability of intestinal epithelial apical junctions."
    Lechuga S., Baranwal S., Ivanov A.I.
    Am. J. Physiol. 308:G745-G756(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiWDR1_HUMAN
AccessioniPrimary (citable) accession number: O75083
Secondary accession number(s): A8K6E9
, A8MPU4, O75313, Q8N6E5, Q9UG05, Q9UG78, Q9UQE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 166 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.