##gff-version 3 O75081 UniProtKB Chain 1 653 . . . ID=PRO_0000307173;Note=Protein CBFA2T3 O75081 UniProtKB Domain 171 266 . . . Note=TAFH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00440 O75081 UniProtKB Zinc finger 556 592 . . . Note=MYND-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00134 O75081 UniProtKB Region 1 435 . . . Note=Mediates localization to the nucleus;Ontology_term=ECO:0000250;evidence=ECO:0000250 O75081 UniProtKB Region 1 430 . . . Note=Mediates interaction with PDE7A (in isoform 2) O75081 UniProtKB Region 1 127 . . . Note=Required for nucleolar targeting (in isoform 1) O75081 UniProtKB Region 1 109 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75081 UniProtKB Region 145 242 . . . Note=Interaction with ZBTB33;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23251453;Dbxref=PMID:23251453 O75081 UniProtKB Region 176 268 . . . Note=Interaction with HIF1A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25974097;Dbxref=PMID:25974097 O75081 UniProtKB Region 284 342 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75081 UniProtKB Region 394 412 . . . Note=Nervy homology region 2 (NHR2)%3B essential for down-regulation of PFKFB3%2C PFKFB4 and PDK1 expression;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23840896;Dbxref=PMID:23840896 O75081 UniProtKB Region 434 472 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75081 UniProtKB Region 485 533 . . . Note=Nervy homology region 3 (NHR3)%3B essential for down-regulation of PFKFB3%2C PFKFB4 and PDK1 expression;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23840896;Dbxref=PMID:23840896 O75081 UniProtKB Region 485 506 . . . Note=Mediates interaction with PRKAR2A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11823486;Dbxref=PMID:11823486 O75081 UniProtKB Region 603 653 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75081 UniProtKB Coiled coil 488 543 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 O75081 UniProtKB Compositional bias 10 30 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75081 UniProtKB Compositional bias 75 90 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75081 UniProtKB Compositional bias 286 314 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75081 UniProtKB Compositional bias 434 449 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75081 UniProtKB Compositional bias 638 653 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite O75081 UniProtKB Binding site 556 556 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00134 O75081 UniProtKB Binding site 559 559 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00134 O75081 UniProtKB Binding site 567 567 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00134 O75081 UniProtKB Binding site 570 570 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00134 O75081 UniProtKB Binding site 576 576 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00134 O75081 UniProtKB Binding site 580 580 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00134 O75081 UniProtKB Binding site 588 588 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00134 O75081 UniProtKB Binding site 592 592 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00134 O75081 UniProtKB Site 51 52 . . . Note=Breakpoint for translocation to form type-1 RUNX1-CBFA2T3 fusion protein O75081 UniProtKB Site 127 128 . . . Note=Breakpoint for translocation to form type-2 RUNX1-CBFA2T3 fusion protein O75081 UniProtKB Modified residue 457 457 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O75081 UniProtKB Modified residue 459 459 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O75081 UniProtKB Modified residue 479 479 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 O75081 UniProtKB Modified residue 637 637 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 O75081 UniProtKB Modified residue 641 641 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 O75081 UniProtKB Modified residue 650 650 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 O75081 UniProtKB Alternative sequence 1 61 . . . ID=VSP_028620;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9596646;Dbxref=PMID:9596646 O75081 UniProtKB Alternative sequence 51 127 . . . ID=VSP_028621;Note=In isoform 3. APVDRKAKASAMPDSPAEVKTQPRSTPPSMPPPPPAASQGATRPPSFTPHTHREDGPATLPHGRFHGCLKWSMVCLL->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75081 UniProtKB Alternative sequence 51 51 . . . ID=VSP_028622;Note=In isoform 4. A->GKPALAAAGAPALCTPGQADARPVLGPA;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75081 UniProtKB Alternative sequence 52 653 . . . ID=VSP_028623;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75081 UniProtKB Alternative sequence 102 126 . . . ID=VSP_028624;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9596646;Dbxref=PMID:9596646 O75081 UniProtKB Natural variant 306 306 . . . ID=VAR_035447;Note=In a colorectal cancer sample%3B somatic mutation. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs745972870,PMID:16959974 O75081 UniProtKB Natural variant 429 429 . . . ID=VAR_035374;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9596646;Dbxref=dbSNP:rs1053526,PMID:9596646 O75081 UniProtKB Natural variant 518 518 . . . ID=VAR_035448;Note=In a colorectal cancer sample%3B somatic mutation. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs774310781,PMID:16959974 O75081 UniProtKB Natural variant 534 534 . . . ID=VAR_035449;Note=In a colorectal cancer sample%3B somatic mutation. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs553618592,PMID:16959974 O75081 UniProtKB Mutagenesis 494 494 . . . Note=Loss of interaction with PRKAR2A. V->P%2CA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11823486;Dbxref=PMID:11823486 O75081 UniProtKB Sequence conflict 231 231 . . . Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75081 UniProtKB Sequence conflict 295 295 . . . Note=T->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75081 UniProtKB Sequence conflict 305 305 . . . Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75081 UniProtKB Sequence conflict 370 370 . . . Note=R->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75081 UniProtKB Sequence conflict 420 420 . . . Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75081 UniProtKB Sequence conflict 542 542 . . . Note=A->D;Ontology_term=ECO:0000305;evidence=ECO:0000305