O75081 (MTG16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein CBFA2T3

Alternative name(s):
MTG8-related protein 2
Myeloid translocation gene on chromosome 16 protein
Short name=hMTG16
Zinc finger MYND domain-containing protein 4

Gene names

Name:	CBFA2T3
Synonyms:	MTG16, MTGR2, ZMYND4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	653 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation. Ref.8 Ref.9 Ref.11 Ref.15 Isoform 2 functions as an A-kinase-anchoring protein. Ref.8 Ref.9 Ref.11 Ref.15
Subunit structure	Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 By similarity. Heterodimer with RUNX1T1 and CBFA2T2. Interacts with ERBB4, HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, NCOR1, NCOR2, and ZNF652. According to Ref.10, may not interact with HDAC6. Interacts with PLXNA1, PLXNA3 and PRKAR1A. Isoform 2 interacts with PRKAR2A, PDE7A and probably PDE4A. Ref.7 Ref.9 Ref.10 Ref.11 Ref.12 Ref.14 Ref.15 Ref.18
Subcellular location	Isoform 1: Nucleus › nucleolus. Note: The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm. Ref.9 Ref.10 Isoform 2: Nucleus › nucleoplasm. Golgi apparatus membrane Ref.9 Ref.10.
Tissue specificity	Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level). Ref.1 Ref.4 Ref.11
Induction	Down-regulated by all-trans retinoic acid (ATRA). Ref.13
Involvement in disease	A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.
Sequence similarities	Belongs to the CBFA2T family. Contains 1 MYND-type zinc finger. Contains 1 TAFH (NHR1) domain.
Sequence caution	The sequence AAH62624.1 differs from that shown. Reason: Aberrant splicing. The sequence BAA31276.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAA31277.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Differentiation Transcription Transcription regulation
Cellular component	Golgi apparatus Membrane Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Repressor
PTM	Isopeptide bond Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Traceable author statement PubMed 9447981. Source: ProtInc granulocyte differentiation Inferred from direct assay Ref.11. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell nucleoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	chromatin binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ZNF652	Q9Y2D9	2	EBI-1190217,EBI-1190229

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75081-1)

Also known as: CBFA2T3A; MTG16a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75081-2)

Also known as: CBFA2T3B; MTG16b;

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     102-126: Missing.

Isoform 3 (identifier: O75081-4)

Also known as: MTG16c;

The sequence of this isoform differs from the canonical sequence as follows:
     51-127: APVDRKAKAS...CLKWSMVCLL → V

Note: No experimental confirmation available.

Isoform 4 (identifier: O75081-5)

Also known as: MTG16HEL;

The sequence of this isoform differs from the canonical sequence as follows:
     51-51: A → GKPALAAAGAPALCTPGQADARPVLGPA
     52-653: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 653	653	Protein CBFA2T3		PRO_0000307173
Regions
	Domain	171 – 266	96	TAFH
	Zinc finger	556 – 592	37	MYND-type
	Region	1 – 435	435	Mediates localization to the nucleus By similarity
	Region	1 – 430	430	Mediates interaction with PDE7A (in isoform 2)
	Region	1 – 127	127	Required for nucleolar targeting (in isoform 1)
	Region	485 – 506	22	Mediates interaction with PRKAR2A
	Coiled coil	488 – 543	56	Potential
	Compositional bias	42 – 99	58	Pro-rich
Sites
	Site	51 – 52	2	Breakpoint for translocation to form type-1 RUNX1-CBFA2T3 fusion protein
	Site	127 – 128	2	Breakpoint for translocation to form type-2 RUNX1-CBFA2T3 fusion protein
Amino acid modifications
	Cross-link	535		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.16
Natural variations
	Alternative sequence	1 – 61	61	Missing in isoform 2.		VSP_028620
	Alternative sequence	51 – 127	77	APVDR…MVCLL → V in isoform 3.		VSP_028621
	Alternative sequence	51	1	A → GKPALAAAGAPALCTPGQAD ARPVLGPA in isoform 4.		VSP_028622
	Alternative sequence	52 – 653	602	Missing in isoform 4.		VSP_028623
	Alternative sequence	102 – 126	25	Missing in isoform 2.		VSP_028624
	Natural variant	306	1	R → H in a colorectal cancer sample; somatic mutation. Ref.19		VAR_035447
	Natural variant	429	1	E → G. Ref.1 Corresponds to variant rs1053526 [ dbSNP | Ensembl ].		VAR_035374
	Natural variant	518	1	E → K in a colorectal cancer sample; somatic mutation. Ref.19		VAR_035448
	Natural variant	534	1	A → V in a colorectal cancer sample; somatic mutation. Ref.19		VAR_035449
Experimental info
	Mutagenesis	494	1	V → P or A: Loss of interaction with PRKAR2A. Ref.9
	Sequence conflict	231	1	F → L in AAH47019. Ref.3
	Sequence conflict	295	1	T → S in AAC64702. Ref.4
	Sequence conflict	305	1	D → E in BAA29061. Ref.1
	Sequence conflict	370	1	R → P in AAC64698. Ref.4
	Sequence conflict	420	1	L → V in AAC64698. Ref.4
	Sequence conflict	542	1	A → D in AAC64701. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (CBFA2T3A) (MTG16a) [UniParc]. Last modified October 23, 2007. Version 2. Checksum: 0B72B602120FA5DE	FASTA	653	71,192
	10 20 30 40 50 60 MPASRLRDRA ASSASGSTCG SMSQTHPVLE SGLLASAGCS APRGPRKGGP APVDRKAKAS 70 80 90 100 110 120 AMPDSPAEVK TQPRSTPPSM PPPPPAASQG ATRPPSFTPH THREDGPATL PHGRFHGCLK 130 140 150 160 170 180 WSMVCLLMNG SSHSPTAING APCTPNGFSN GPATSSTASL STQHLPPACG ARQLSKLKRF 190 200 210 220 230 240 LTTLQQFGSD ISPEIGERVR TLVLGLVNST LTIEEFHSKL QEATNFPLRP FVIPFLKANL 250 260 270 280 290 300 PLLQRELLHC ARLAKQTPAQ YLAQHEQLLL DASASSPIDS SELLLEVNEN GKRRTPDRTK 310 320 330 340 350 360 ENGSDRDPLH PEHLSKRPCT LNPAQRYSPS NGPPQPTPPP HYRLEDIAMA HHFRDAYRHP 370 380 390 400 410 420 DPRELRERHR PLVVPGSRQE EVIDHKLTER EWAEEWKHLN NLLNCIMDMV EKTRRSLTVL 430 440 450 460 470 480 RRCQEADREE LNHWARRYSD AEDTKKGPAP AAARPRSSSA GPEGPQLDVP REFLPRTLTG 490 500 510 520 530 540 YVPEDIWRKA EEAVNEVKRQ AMSELQKAVS DAERKAHELI TTERAKMERA LAEAKRQASE 550 560 570 580 590 600 DALTVINQQE DSSESCWNCG RKASETCSGC NAARYCGSFC QHRDWEKHHH VCGQSLQGPT 610 620 630 640 650 AVVADPVPGP PEAAHSLGPS LPVGAASPSE AGSAGPSRPG SPSPPGPLDT VPR
	Isoform 2 (CBFA2T3B) (MTG16b) [UniParc]. Checksum: 6BF84FE5AA33B71B	FASTA	567	62,372
	10 20 30 40 50 60 MPDSPAEVKT QPRSTPPSMP PPPPAASQGA TRPPSFTPHT LMNGSSHSPT AINGAPCTPN 70 80 90 100 110 120 GFSNGPATSS TASLSTQHLP PACGARQLSK LKRFLTTLQQ FGSDISPEIG ERVRTLVLGL 130 140 150 160 170 180 VNSTLTIEEF HSKLQEATNF PLRPFVIPFL KANLPLLQRE LLHCARLAKQ TPAQYLAQHE 190 200 210 220 230 240 QLLLDASASS PIDSSELLLE VNENGKRRTP DRTKENGSDR DPLHPEHLSK RPCTLNPAQR 250 260 270 280 290 300 YSPSNGPPQP TPPPHYRLED IAMAHHFRDA YRHPDPRELR ERHRPLVVPG SRQEEVIDHK 310 320 330 340 350 360 LTEREWAEEW KHLNNLLNCI MDMVEKTRRS LTVLRRCQEA DREELNHWAR RYSDAEDTKK 370 380 390 400 410 420 GPAPAAARPR SSSAGPEGPQ LDVPREFLPR TLTGYVPEDI WRKAEEAVNE VKRQAMSELQ 430 440 450 460 470 480 KAVSDAERKA HELITTERAK MERALAEAKR QASEDALTVI NQQEDSSESC WNCGRKASET 490 500 510 520 530 540 CSGCNAARYC GSFCQHRDWE KHHHVCGQSL QGPTAVVADP VPGPPEAAHS LGPSLPVGAA 550 560 SPSEAGSAGP SRPGSPSPPG PLDTVPR
	Isoform 3 (MTG16c) [UniParc]. Checksum: D8F4F45B7DE9C0B7	FASTA	577	63,121
	10 20 30 40 50 60 MPASRLRDRA ASSASGSTCG SMSQTHPVLE SGLLASAGCS APRGPRKGGP VMNGSSHSPT 70 80 90 100 110 120 AINGAPCTPN GFSNGPATSS TASLSTQHLP PACGARQLSK LKRFLTTLQQ FGSDISPEIG 130 140 150 160 170 180 ERVRTLVLGL VNSTLTIEEF HSKLQEATNF PLRPFVIPFL KANLPLLQRE LLHCARLAKQ 190 200 210 220 230 240 TPAQYLAQHE QLLLDASASS PIDSSELLLE VNENGKRRTP DRTKENGSDR DPLHPEHLSK 250 260 270 280 290 300 RPCTLNPAQR YSPSNGPPQP TPPPHYRLED IAMAHHFRDA YRHPDPRELR ERHRPLVVPG 310 320 330 340 350 360 SRQEEVIDHK LTEREWAEEW KHLNNLLNCI MDMVEKTRRS LTVLRRCQEA DREELNHWAR 370 380 390 400 410 420 RYSDAEDTKK GPAPAAARPR SSSAGPEGPQ LDVPREFLPR TLTGYVPEDI WRKAEEAVNE 430 440 450 460 470 480 VKRQAMSELQ KAVSDAERKA HELITTERAK MERALAEAKR QASEDALTVI NQQEDSSESC 490 500 510 520 530 540 WNCGRKASET CSGCNAARYC GSFCQHRDWE KHHHVCGQSL QGPTAVVADP VPGPPEAAHS 550 560 570 LGPSLPVGAA SPSEAGSAGP SRPGSPSPPG PLDTVPR
	Isoform 4 (MTG16HEL) [UniParc]. Checksum: 03A1369FCDF569CA	FASTA	78	7,436
	10 20 30 40 50 60 MPASRLRDRA ASSASGSTCG SMSQTHPVLE SGLLASAGCS APRGPRKGGP GKPALAAAGA 70 PALCTPGQAD ARPVLGPA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family." Gamou T., Kitamura E., Hosoda F., Shimuzu K., Hayashi Y., Nagase T., Yokoyama Y., Ohki M. Blood 91:4028-4037(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), CHROMOSOMAL TRANSLOCATION WITH RUNX1, TISSUE SPECIFICITY, VARIANT GLY-429. Tissue: Brain.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung and Pancreas.
[4]	"CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family." Calabi F., Cilli V. Genomics 52:332-341(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-297 AND 492-604, NUCLEOTIDE SEQUENCE [MRNA] OF 341-431, TISSUE SPECIFICITY. Tissue: Brain.
[5]	"AML1-MTG16 fusion gene in therapy-related acute leukemia with t(16;21)(q24;q22): two new cases." Salomon-Nguyen F., Busson-Le Coniat M., Lafage Pochitaloff M., Mozziconacci J., Berger R., Bernard O.A. Leukemia 14:1704-1705(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH RUNX1.
[6]	"AML1/MTG16 fusion gene from a t(16;21)(q24;q22) translocation in treatment-induced leukemia after breast cancer." La Starza R., Sambani C., Crescenzi B., Matteucci C., Martelli M.F., Mecucci C. Haematologica 86:212-213(2001) [PubMed] [Europe PMC] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH RUNX1.
[7]	"ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain." Amann J.M., Nip J., Strom D.K., Lutterbach B., Harada H., Lenny N., Downing J.R., Meyers S., Hiebert S.W. Mol. Cell. Biol. 21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HDAC1; HDAC2; HDAC3; HDAC6; HDAC8; NCOR1 AND NCOR2.
[8]	"CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3." Kochetkova M., McKenzie O.L.D., Bais A.J., Martin J.M., Secker G.A., Seshadri R., Powell J.A., Hinze S.J., Gardner A.E., Spendlove H.E., O'Callaghan N.J., Cleton-Jansen A.-M., Cornelisse C., Whitmore S.A., Crawford J., Kremmidiotis G., Sutherland G.R., Callen D.F. Cancer Res. 62:4599-4604(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes." Schillace R.V., Andrews S.F., Liberty G.A., Davey M.P., Carr D.W. J. Immunol. 168:1590-1599(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION (ISOFORM 2), INTERACTION WITH PRKAR2A, MUTAGENESIS OF VAL-494, SUBCELLULAR LOCATION (ISOFORM 2).
[10]	"The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t(16; 21)-positive myeloid malignancies." Hoogeveen A.T., Rossetti S., Stoyanova V., Schonkeren J., Fenaroli A., Schiaffonati L., van Unen L., Sacchi N. Oncogene 21:6703-6712(2002) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS 3 AND 4), SUBCELLULAR LOCATION, INTERACTION WITH CBFA2T2; HDAC1; HDAC3 AND RUNX1T1.
[11]	"AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation." Ibanez V., Sharma A., Buonamici S., Verma A., Kalakonda S., Wang J., Kadkol S., Saunthararajah Y. Cancer Res. 64:4547-4554(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH NCOR1, TISSUE SPECIFICITY.
[12]	"A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines." Asirvatham A.L., Galligan S.G., Schillace R.V., Davey M.P., Vasta V., Beavo J.A., Carr D.W. J. Immunol. 173:4806-4814(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PDE4A AND PDE7A.
[13]	"The leukemia-associated ETO homologues are differently expressed during hematopoietic differentiation." Lindberg S.R., Olsson A., Persson A.-M., Olsson I. Exp. Hematol. 33:189-198(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[14]	"ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression." Linggi B., Carpenter G. J. Biol. Chem. 281:25373-25380(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ERBB4.
[15]	"ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription." Kumar R., Manning J., Spendlove H.E., Kremmidiotis G., McKirdy R., Lee J., Millband D.N., Cheney K.M., Stampfer M.R., Dwivedi P.P., Morris H.A., Callen D.F. Mol. Cancer Res. 4:655-665(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH ZNF652.
[16]	"The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells." Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D. J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-535, MASS SPECTROMETRY. Tissue: Lung adenocarcinoma.
[17]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[18]	"Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner." Fiedler S.E., Schillace R.V., Daniels C.J., Andrews S.F., Carr D.W. FEBS Lett. 584:873-877(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PLXNA1; PLXNA3 AND PRKAR1A.
[19]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-306; LYS-518 AND VAL-534.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB010419 mRNA. Translation: BAA29061.1. AB010420 mRNA. Translation: BAA29062.1. AB013286 Genomic DNA. Translation: BAA31276.1. Sequence problems. AB013286 Genomic DNA. Translation: BAA31277.1. Sequence problems. CH471184 Genomic DNA. Translation: EAW66748.1. CH471184 Genomic DNA. Translation: EAW66752.1. BC047019 mRNA. Translation: AAH47019.1. BC062624 mRNA. Translation: AAH62624.1. Sequence problems. AF052217, AF052216 Genomic DNA. Translation: AAC64701.1. AF052215, AF052213, AF052214 Genomic DNA. Translation: AAC64702.1. AF052220 mRNA. Translation: AAC64698.1.
IPI	IPI00218436. IPI00306845. IPI00640985. IPI00868925. IPI00869145.
RefSeq	NP_005178.4. NM_005187.5. NP_787127.1. NM_175931.2.
UniGene	Hs.513811.
3D structure databases
HSSP	HSSP built from PDB template 1WQ6 based on UniProtKB Q06455.
ProteinModelPortal	O75081.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-48898N.
IntAct	O75081. 8 interactions.
PTM databases
PhosphoSite	O75081.
Proteomic databases
PaxDb	O75081.
PRIDE	O75081.
Protocols and materials databases
DNASU	863.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000268679; ENSP00000268679; ENSG00000129993. ENST00000327483; ENSP00000332122; ENSG00000129993. ENST00000360302; ENSP00000353449; ENSG00000129993. ENST00000448839; ENSP00000401254; ENSG00000129993.
GeneID	863.
KEGG	hsa:863.
UCSC	uc002fml.2. human. uc002fmm.2. human.
Organism-specific databases
CTD	863.
GeneCards	GC16M088941.
H-InvDB	HIX0013342.
HGNC	HGNC:1537. CBFA2T3.
MIM	603870. gene.
neXtProt	NX_O75081.
PharmGKB	PA26113.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG79810.
HOVERGEN	HBG000169.
InParanoid	O75081.
OMA	DMAMAHH.
OrthoDB	EOG4548Z9.
PhylomeDB	O75081.
Gene expression databases
ArrayExpress	O75081.
Bgee	O75081.
Genevestigator	O75081.
Family and domain databases
InterPro	IPR013289. ETO. IPR013292. MTG16. IPR014896. NHR2. IPR003894. TAFH_NHR1. IPR002893. Znf_MYND. [Graphical view]
Pfam	PF08788. NHR2. 1 hit. PF07531. TAFH. 1 hit. PF01753. zf-MYND. 1 hit. [Graphical view]
PRINTS	PR01875. ETOFAMILY. PR01878. MTG16PROTEIN.
SMART	SM00549. TAFH. 1 hit. [Graphical view]
PROSITE	PS51119. TAFH. 1 hit. PS01360. ZF_MYND_1. 1 hit. PS50865. ZF_MYND_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CBFA2T3. human.
GenomeRNAi	863.
NextBio	3596.
SOURCE	Search...

Entry information

Entry name

MTG16_HUMAN

Accession

Primary (citable) accession number: O75081
Secondary accession number(s): D3DX78 , O60615, O60616, O60617, O75082, O75107, O75108, Q0P5Z6, Q6P5W6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.