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O75081

- MTG16_HUMAN

UniProt

O75081 - MTG16_HUMAN

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Protein

Protein CBFA2T3

Gene
CBFA2T3, MTG16, MTGR2, ZMYND4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation.4 Publications
Isoform 2 functions as an A-kinase-anchoring protein.4 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei51 – 522Breakpoint for translocation to form type-1 RUNX1-CBFA2T3 fusion protein
Sitei127 – 1282Breakpoint for translocation to form type-2 RUNX1-CBFA2T3 fusion protein

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri556 – 59237MYND-typeAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: IntAct
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. cell proliferation Source: ProtInc
  2. granulocyte differentiation Source: MGI
  3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CBFA2T3
Alternative name(s):
MTG8-related protein 2
Myeloid translocation gene on chromosome 16 protein
Short name:
hMTG16
Zinc finger MYND domain-containing protein 4
Gene namesi
Name:CBFA2T3
Synonyms:MTG16, MTGR2, ZMYND4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:1537. CBFA2T3.

Subcellular locationi

Isoform 1 : Nucleusnucleolus
Note: The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.2 Publications
Isoform 2 : Nucleusnucleoplasm. Golgi apparatus membrane 2 Publications

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. nucleolus Source: UniProtKB-SubCell
  3. nucleoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi494 – 4941V → P or A: Loss of interaction with PRKAR2A. 1 Publication

Organism-specific databases

Orphaneti329469. Acute megakaryoblastic leukemia without Down syndrome.
PharmGKBiPA26113.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 653653Protein CBFA2T3PRO_0000307173Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki535 – 535Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiO75081.
PaxDbiO75081.
PRIDEiO75081.

PTM databases

PhosphoSiteiO75081.

Expressioni

Tissue specificityi

Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).3 Publications

Inductioni

Down-regulated by all-trans retinoic acid (ATRA).1 Publication

Gene expression databases

ArrayExpressiO75081.
BgeeiO75081.
GenevestigatoriO75081.

Interactioni

Subunit structurei

Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 By similarity. Heterodimer with RUNX1T1 and CBFA2T2. Interacts with ERBB4, HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, NCOR1, NCOR2, and ZNF652. According to 1 Publication, may not interact with HDAC6. Interacts with PLXNA1, PLXNA3 and PRKAR1A. Isoform 2 interacts with PRKAR2A, PDE7A and probably PDE4A.8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PLXNA3P518052EBI-1190217,EBI-7135904
ZNF652Q9Y2D92EBI-1190217,EBI-1190229

Protein-protein interaction databases

BioGridi107311. 20 interactions.
DIPiDIP-48898N.
IntActiO75081. 11 interactions.
MINTiMINT-3000909.

Structurei

3D structure databases

ProteinModelPortaliO75081.
SMRiO75081. Positions 170-267, 383-442, 479-508, 551-598.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini171 – 26696TAFHAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 435435Mediates localization to the nucleus By similarityAdd
BLAST
Regioni1 – 430430Mediates interaction with PDE7A (in isoform 2)Add
BLAST
Regioni1 – 127127Required for nucleolar targeting (in isoform 1)Add
BLAST
Regioni485 – 50622Mediates interaction with PRKAR2AAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili488 – 54356 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 9958Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the CBFA2T family.
Contains 1 TAFH (NHR1) domain.

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG79810.
HOVERGENiHBG000169.
InParanoidiO75081.
OMAiDMAMAHH.
OrthoDBiEOG70W3D2.
PhylomeDBiO75081.
TreeFamiTF106303.

Family and domain databases

InterProiIPR013289. ETO.
IPR013292. MTG16.
IPR014896. NHR2.
IPR003894. TAFH_NHR1.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF08788. NHR2. 1 hit.
PF07531. TAFH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PRINTSiPR01875. ETOFAMILY.
PR01878. MTG16PROTEIN.
SMARTiSM00549. TAFH. 1 hit.
[Graphical view]
PROSITEiPS51119. TAFH. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75081-1) [UniParc]FASTAAdd to Basket

Also known as: CBFA2T3A, MTG16a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPASRLRDRA ASSASGSTCG SMSQTHPVLE SGLLASAGCS APRGPRKGGP    50
APVDRKAKAS AMPDSPAEVK TQPRSTPPSM PPPPPAASQG ATRPPSFTPH 100
THREDGPATL PHGRFHGCLK WSMVCLLMNG SSHSPTAING APCTPNGFSN 150
GPATSSTASL STQHLPPACG ARQLSKLKRF LTTLQQFGSD ISPEIGERVR 200
TLVLGLVNST LTIEEFHSKL QEATNFPLRP FVIPFLKANL PLLQRELLHC 250
ARLAKQTPAQ YLAQHEQLLL DASASSPIDS SELLLEVNEN GKRRTPDRTK 300
ENGSDRDPLH PEHLSKRPCT LNPAQRYSPS NGPPQPTPPP HYRLEDIAMA 350
HHFRDAYRHP DPRELRERHR PLVVPGSRQE EVIDHKLTER EWAEEWKHLN 400
NLLNCIMDMV EKTRRSLTVL RRCQEADREE LNHWARRYSD AEDTKKGPAP 450
AAARPRSSSA GPEGPQLDVP REFLPRTLTG YVPEDIWRKA EEAVNEVKRQ 500
AMSELQKAVS DAERKAHELI TTERAKMERA LAEAKRQASE DALTVINQQE 550
DSSESCWNCG RKASETCSGC NAARYCGSFC QHRDWEKHHH VCGQSLQGPT 600
AVVADPVPGP PEAAHSLGPS LPVGAASPSE AGSAGPSRPG SPSPPGPLDT 650
VPR 653
Length:653
Mass (Da):71,192
Last modified:October 23, 2007 - v2
Checksum:i0B72B602120FA5DE
GO
Isoform 2 (identifier: O75081-2) [UniParc]FASTAAdd to Basket

Also known as: CBFA2T3B, MTG16b

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.
     102-126: Missing.

Show »
Length:567
Mass (Da):62,372
Checksum:i6BF84FE5AA33B71B
GO
Isoform 3 (identifier: O75081-4) [UniParc]FASTAAdd to Basket

Also known as: MTG16c

The sequence of this isoform differs from the canonical sequence as follows:
     51-127: APVDRKAKAS...CLKWSMVCLL → V

Note: No experimental confirmation available.

Show »
Length:577
Mass (Da):63,121
Checksum:iD8F4F45B7DE9C0B7
GO
Isoform 4 (identifier: O75081-5) [UniParc]FASTAAdd to Basket

Also known as: MTG16HEL

The sequence of this isoform differs from the canonical sequence as follows:
     51-51: A → GKPALAAAGAPALCTPGQADARPVLGPA
     52-653: Missing.

Note: No experimental confirmation available.

Show »
Length:78
Mass (Da):7,436
Checksum:i03A1369FCDF569CA
GO

Sequence cautioni

The sequence AAH62624.1 differs from that shown. Reason: Aberrant splicing.
The sequence BAA31276.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence BAA31277.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti306 – 3061R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035447
Natural varianti429 – 4291E → G.1 Publication
Corresponds to variant rs1053526 [ dbSNP | Ensembl ].
VAR_035374
Natural varianti518 – 5181E → K in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035448
Natural varianti534 – 5341A → V in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035449

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6161Missing in isoform 2. VSP_028620Add
BLAST
Alternative sequencei51 – 12777APVDR…MVCLL → V in isoform 3. VSP_028621Add
BLAST
Alternative sequencei51 – 511A → GKPALAAAGAPALCTPGQAD ARPVLGPA in isoform 4. VSP_028622
Alternative sequencei52 – 653602Missing in isoform 4. VSP_028623Add
BLAST
Alternative sequencei102 – 12625Missing in isoform 2. VSP_028624Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti231 – 2311F → L in AAH47019. 1 Publication
Sequence conflicti295 – 2951T → S in AAC64702. 1 Publication
Sequence conflicti305 – 3051D → E in BAA29061. 1 Publication
Sequence conflicti370 – 3701R → P in AAC64698. 1 Publication
Sequence conflicti420 – 4201L → V in AAC64698. 1 Publication
Sequence conflicti542 – 5421A → D in AAC64701. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010419 mRNA. Translation: BAA29061.1.
AB010420 mRNA. Translation: BAA29062.1.
AB013286 Genomic DNA. Translation: BAA31276.1. Sequence problems.
AB013286 Genomic DNA. Translation: BAA31277.1. Sequence problems.
CH471184 Genomic DNA. Translation: EAW66748.1.
CH471184 Genomic DNA. Translation: EAW66752.1.
BC047019 mRNA. Translation: AAH47019.1.
BC062624 mRNA. Translation: AAH62624.1. Sequence problems.
AF052217, AF052216 Genomic DNA. Translation: AAC64701.1.
AF052215, AF052213, AF052214 Genomic DNA. Translation: AAC64702.1.
AF052220 mRNA. Translation: AAC64698.1.
CCDSiCCDS10972.1. [O75081-1]
CCDS10973.1. [O75081-2]
RefSeqiNP_005178.4. NM_005187.5. [O75081-1]
NP_787127.1. NM_175931.2. [O75081-2]
UniGeneiHs.513811.

Genome annotation databases

EnsembliENST00000268679; ENSP00000268679; ENSG00000129993. [O75081-1]
ENST00000327483; ENSP00000332122; ENSG00000129993. [O75081-2]
ENST00000360302; ENSP00000353449; ENSG00000129993. [O75081-2]
ENST00000448839; ENSP00000401254; ENSG00000129993. [O75081-4]
GeneIDi863.
KEGGihsa:863.
UCSCiuc002fml.2. human. [O75081-2]
uc002fmm.2. human. [O75081-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010419 mRNA. Translation: BAA29061.1 .
AB010420 mRNA. Translation: BAA29062.1 .
AB013286 Genomic DNA. Translation: BAA31276.1 . Sequence problems.
AB013286 Genomic DNA. Translation: BAA31277.1 . Sequence problems.
CH471184 Genomic DNA. Translation: EAW66748.1 .
CH471184 Genomic DNA. Translation: EAW66752.1 .
BC047019 mRNA. Translation: AAH47019.1 .
BC062624 mRNA. Translation: AAH62624.1 . Sequence problems.
AF052217 , AF052216 Genomic DNA. Translation: AAC64701.1 .
AF052215 , AF052213 , AF052214 Genomic DNA. Translation: AAC64702.1 .
AF052220 mRNA. Translation: AAC64698.1 .
CCDSi CCDS10972.1. [O75081-1 ]
CCDS10973.1. [O75081-2 ]
RefSeqi NP_005178.4. NM_005187.5. [O75081-1 ]
NP_787127.1. NM_175931.2. [O75081-2 ]
UniGenei Hs.513811.

3D structure databases

ProteinModelPortali O75081.
SMRi O75081. Positions 170-267, 383-442, 479-508, 551-598.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107311. 20 interactions.
DIPi DIP-48898N.
IntActi O75081. 11 interactions.
MINTi MINT-3000909.

PTM databases

PhosphoSitei O75081.

Proteomic databases

MaxQBi O75081.
PaxDbi O75081.
PRIDEi O75081.

Protocols and materials databases

DNASUi 863.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000268679 ; ENSP00000268679 ; ENSG00000129993 . [O75081-1 ]
ENST00000327483 ; ENSP00000332122 ; ENSG00000129993 . [O75081-2 ]
ENST00000360302 ; ENSP00000353449 ; ENSG00000129993 . [O75081-2 ]
ENST00000448839 ; ENSP00000401254 ; ENSG00000129993 . [O75081-4 ]
GeneIDi 863.
KEGGi hsa:863.
UCSCi uc002fml.2. human. [O75081-2 ]
uc002fmm.2. human. [O75081-1 ]

Organism-specific databases

CTDi 863.
GeneCardsi GC16M088941.
H-InvDB HIX0013342.
HGNCi HGNC:1537. CBFA2T3.
MIMi 603870. gene.
neXtProti NX_O75081.
Orphaneti 329469. Acute megakaryoblastic leukemia without Down syndrome.
PharmGKBi PA26113.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79810.
HOVERGENi HBG000169.
InParanoidi O75081.
OMAi DMAMAHH.
OrthoDBi EOG70W3D2.
PhylomeDBi O75081.
TreeFami TF106303.

Miscellaneous databases

ChiTaRSi CBFA2T3. human.
GeneWikii CBFA2T3.
GenomeRNAii 863.
NextBioi 3596.
PROi O75081.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75081.
Bgeei O75081.
Genevestigatori O75081.

Family and domain databases

InterProi IPR013289. ETO.
IPR013292. MTG16.
IPR014896. NHR2.
IPR003894. TAFH_NHR1.
IPR002893. Znf_MYND.
[Graphical view ]
Pfami PF08788. NHR2. 1 hit.
PF07531. TAFH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view ]
PRINTSi PR01875. ETOFAMILY.
PR01878. MTG16PROTEIN.
SMARTi SM00549. TAFH. 1 hit.
[Graphical view ]
PROSITEi PS51119. TAFH. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family."
    Gamou T., Kitamura E., Hosoda F., Shimuzu K., Hayashi Y., Nagase T., Yokoyama Y., Ohki M.
    Blood 91:4028-4037(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), CHROMOSOMAL TRANSLOCATION WITH RUNX1, TISSUE SPECIFICITY, VARIANT GLY-429.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung and Pancreas.
  4. "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family."
    Calabi F., Cilli V.
    Genomics 52:332-341(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-297 AND 492-604, NUCLEOTIDE SEQUENCE [MRNA] OF 341-431, TISSUE SPECIFICITY.
    Tissue: Brain.
  5. "AML1-MTG16 fusion gene in therapy-related acute leukemia with t(16;21)(q24;q22): two new cases."
    Salomon-Nguyen F., Busson-Le Coniat M., Lafage Pochitaloff M., Mozziconacci J., Berger R., Bernard O.A.
    Leukemia 14:1704-1705(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH RUNX1.
  6. "AML1/MTG16 fusion gene from a t(16;21)(q24;q22) translocation in treatment-induced leukemia after breast cancer."
    La Starza R., Sambani C., Crescenzi B., Matteucci C., Martelli M.F., Mecucci C.
    Haematologica 86:212-213(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH RUNX1.
  7. "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
    Amann J.M., Nip J., Strom D.K., Lutterbach B., Harada H., Lenny N., Downing J.R., Meyers S., Hiebert S.W.
    Mol. Cell. Biol. 21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HDAC1; HDAC2; HDAC3; HDAC6; HDAC8; NCOR1 AND NCOR2.
  8. "CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3."
    Kochetkova M., McKenzie O.L.D., Bais A.J., Martin J.M., Secker G.A., Seshadri R., Powell J.A., Hinze S.J., Gardner A.E., Spendlove H.E., O'Callaghan N.J., Cleton-Jansen A.-M., Cornelisse C., Whitmore S.A., Crawford J., Kremmidiotis G., Sutherland G.R., Callen D.F.
    Cancer Res. 62:4599-4604(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes."
    Schillace R.V., Andrews S.F., Liberty G.A., Davey M.P., Carr D.W.
    J. Immunol. 168:1590-1599(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (ISOFORM 2), INTERACTION WITH PRKAR2A, MUTAGENESIS OF VAL-494, SUBCELLULAR LOCATION (ISOFORM 2).
  10. "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t(16; 21)-positive myeloid malignancies."
    Hoogeveen A.T., Rossetti S., Stoyanova V., Schonkeren J., Fenaroli A., Schiaffonati L., van Unen L., Sacchi N.
    Oncogene 21:6703-6712(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 3 AND 4), SUBCELLULAR LOCATION, INTERACTION WITH CBFA2T2; HDAC1; HDAC3 AND RUNX1T1.
  11. "AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation."
    Ibanez V., Sharma A., Buonamici S., Verma A., Kalakonda S., Wang J., Kadkol S., Saunthararajah Y.
    Cancer Res. 64:4547-4554(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NCOR1, TISSUE SPECIFICITY.
  12. "A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines."
    Asirvatham A.L., Galligan S.G., Schillace R.V., Davey M.P., Vasta V., Beavo J.A., Carr D.W.
    J. Immunol. 173:4806-4814(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDE4A AND PDE7A.
  13. "The leukemia-associated ETO homologues are differently expressed during hematopoietic differentiation."
    Lindberg S.R., Olsson A., Persson A.-M., Olsson I.
    Exp. Hematol. 33:189-198(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  14. "ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression."
    Linggi B., Carpenter G.
    J. Biol. Chem. 281:25373-25380(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ERBB4.
  15. "ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription."
    Kumar R., Manning J., Spendlove H.E., Kremmidiotis G., McKirdy R., Lee J., Millband D.N., Cheney K.M., Stampfer M.R., Dwivedi P.P., Morris H.A., Callen D.F.
    Mol. Cancer Res. 4:655-665(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ZNF652.
  16. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
    Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
    J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-535.
    Tissue: Lung adenocarcinoma.
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  18. "Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner."
    Fiedler S.E., Schillace R.V., Daniels C.J., Andrews S.F., Carr D.W.
    FEBS Lett. 584:873-877(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLXNA1; PLXNA3 AND PRKAR1A.
  19. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-306; LYS-518 AND VAL-534.

Entry informationi

Entry nameiMTG16_HUMAN
AccessioniPrimary (citable) accession number: O75081
Secondary accession number(s): D3DX78
, O60615, O60616, O60617, O75082, O75107, O75108, Q0P5Z6, Q6P5W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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