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O75081

- MTG16_HUMAN

UniProt

O75081 - MTG16_HUMAN

Protein

Protein CBFA2T3

Gene

CBFA2T3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation.
    Isoform 2 functions as an A-kinase-anchoring protein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei51 – 522Breakpoint for translocation to form type-1 RUNX1-CBFA2T3 fusion protein
    Sitei127 – 1282Breakpoint for translocation to form type-2 RUNX1-CBFA2T3 fusion protein

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri556 – 59237MYND-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. cell proliferation Source: ProtInc
    2. granulocyte differentiation Source: MGI
    3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein CBFA2T3
    Alternative name(s):
    MTG8-related protein 2
    Myeloid translocation gene on chromosome 16 protein
    Short name:
    hMTG16
    Zinc finger MYND domain-containing protein 4
    Gene namesi
    Name:CBFA2T3
    Synonyms:MTG16, MTGR2, ZMYND4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:1537. CBFA2T3.

    Subcellular locationi

    Isoform 1 : Nucleusnucleolus
    Note: The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.
    Isoform 2 : Nucleusnucleoplasm 1 Publication. Golgi apparatus membrane 1 Publication

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. nucleolus Source: UniProtKB-SubCell
    3. nucleoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Golgi apparatus, Membrane, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi494 – 4941V → P or A: Loss of interaction with PRKAR2A. 1 Publication

    Organism-specific databases

    Orphaneti329469. Acute megakaryoblastic leukemia without Down syndrome.
    PharmGKBiPA26113.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 653653Protein CBFA2T3PRO_0000307173Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki535 – 535Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiO75081.
    PaxDbiO75081.
    PRIDEiO75081.

    PTM databases

    PhosphoSiteiO75081.

    Expressioni

    Tissue specificityi

    Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level).3 Publications

    Inductioni

    Down-regulated by all-trans retinoic acid (ATRA).1 Publication

    Gene expression databases

    ArrayExpressiO75081.
    BgeeiO75081.
    GenevestigatoriO75081.

    Interactioni

    Subunit structurei

    Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 By similarity. Heterodimer with RUNX1T1 and CBFA2T2. Interacts with ERBB4, HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, NCOR1, NCOR2, and ZNF652. According to PubMed:12242670, may not interact with HDAC6. Interacts with PLXNA1, PLXNA3 and PRKAR1A. Isoform 2 interacts with PRKAR2A, PDE7A and probably PDE4A.By similarity8 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PLXNA3P518052EBI-1190217,EBI-7135904
    ZNF652Q9Y2D92EBI-1190217,EBI-1190229

    Protein-protein interaction databases

    BioGridi107311. 20 interactions.
    DIPiDIP-48898N.
    IntActiO75081. 11 interactions.
    MINTiMINT-3000909.

    Structurei

    3D structure databases

    ProteinModelPortaliO75081.
    SMRiO75081. Positions 170-267, 383-442, 479-508, 551-598.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini171 – 26696TAFHPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 435435Mediates localization to the nucleusBy similarityAdd
    BLAST
    Regioni1 – 430430Mediates interaction with PDE7A (in isoform 2)Add
    BLAST
    Regioni1 – 127127Required for nucleolar targeting (in isoform 1)Add
    BLAST
    Regioni485 – 50622Mediates interaction with PRKAR2AAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili488 – 54356Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi42 – 9958Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CBFA2T family.Curated
    Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation
    Contains 1 TAFH (NHR1) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri556 – 59237MYND-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG79810.
    HOVERGENiHBG000169.
    InParanoidiO75081.
    OMAiDMAMAHH.
    OrthoDBiEOG70W3D2.
    PhylomeDBiO75081.
    TreeFamiTF106303.

    Family and domain databases

    InterProiIPR013289. ETO.
    IPR013292. MTG16.
    IPR014896. NHR2.
    IPR003894. TAFH_NHR1.
    IPR002893. Znf_MYND.
    [Graphical view]
    PfamiPF08788. NHR2. 1 hit.
    PF07531. TAFH. 1 hit.
    PF01753. zf-MYND. 1 hit.
    [Graphical view]
    PRINTSiPR01875. ETOFAMILY.
    PR01878. MTG16PROTEIN.
    SMARTiSM00549. TAFH. 1 hit.
    [Graphical view]
    PROSITEiPS51119. TAFH. 1 hit.
    PS01360. ZF_MYND_1. 1 hit.
    PS50865. ZF_MYND_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75081-1) [UniParc]FASTAAdd to Basket

    Also known as: CBFA2T3A, MTG16a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPASRLRDRA ASSASGSTCG SMSQTHPVLE SGLLASAGCS APRGPRKGGP    50
    APVDRKAKAS AMPDSPAEVK TQPRSTPPSM PPPPPAASQG ATRPPSFTPH 100
    THREDGPATL PHGRFHGCLK WSMVCLLMNG SSHSPTAING APCTPNGFSN 150
    GPATSSTASL STQHLPPACG ARQLSKLKRF LTTLQQFGSD ISPEIGERVR 200
    TLVLGLVNST LTIEEFHSKL QEATNFPLRP FVIPFLKANL PLLQRELLHC 250
    ARLAKQTPAQ YLAQHEQLLL DASASSPIDS SELLLEVNEN GKRRTPDRTK 300
    ENGSDRDPLH PEHLSKRPCT LNPAQRYSPS NGPPQPTPPP HYRLEDIAMA 350
    HHFRDAYRHP DPRELRERHR PLVVPGSRQE EVIDHKLTER EWAEEWKHLN 400
    NLLNCIMDMV EKTRRSLTVL RRCQEADREE LNHWARRYSD AEDTKKGPAP 450
    AAARPRSSSA GPEGPQLDVP REFLPRTLTG YVPEDIWRKA EEAVNEVKRQ 500
    AMSELQKAVS DAERKAHELI TTERAKMERA LAEAKRQASE DALTVINQQE 550
    DSSESCWNCG RKASETCSGC NAARYCGSFC QHRDWEKHHH VCGQSLQGPT 600
    AVVADPVPGP PEAAHSLGPS LPVGAASPSE AGSAGPSRPG SPSPPGPLDT 650
    VPR 653
    Length:653
    Mass (Da):71,192
    Last modified:October 23, 2007 - v2
    Checksum:i0B72B602120FA5DE
    GO
    Isoform 2 (identifier: O75081-2) [UniParc]FASTAAdd to Basket

    Also known as: CBFA2T3B, MTG16b

    The sequence of this isoform differs from the canonical sequence as follows:
         1-61: Missing.
         102-126: Missing.

    Show »
    Length:567
    Mass (Da):62,372
    Checksum:i6BF84FE5AA33B71B
    GO
    Isoform 3 (identifier: O75081-4) [UniParc]FASTAAdd to Basket

    Also known as: MTG16c

    The sequence of this isoform differs from the canonical sequence as follows:
         51-127: APVDRKAKAS...CLKWSMVCLL → V

    Note: No experimental confirmation available.

    Show »
    Length:577
    Mass (Da):63,121
    Checksum:iD8F4F45B7DE9C0B7
    GO
    Isoform 4 (identifier: O75081-5) [UniParc]FASTAAdd to Basket

    Also known as: MTG16HEL

    The sequence of this isoform differs from the canonical sequence as follows:
         51-51: A → GKPALAAAGAPALCTPGQADARPVLGPA
         52-653: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:78
    Mass (Da):7,436
    Checksum:i03A1369FCDF569CA
    GO

    Sequence cautioni

    The sequence AAH62624.1 differs from that shown. Reason: Aberrant splicing.
    The sequence BAA31276.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence BAA31277.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti231 – 2311F → L in AAH47019. (PubMed:15489334)Curated
    Sequence conflicti295 – 2951T → S in AAC64702. (PubMed:9790752)Curated
    Sequence conflicti305 – 3051D → E in BAA29061. (PubMed:9596646)Curated
    Sequence conflicti370 – 3701R → P in AAC64698. (PubMed:9790752)Curated
    Sequence conflicti420 – 4201L → V in AAC64698. (PubMed:9790752)Curated
    Sequence conflicti542 – 5421A → D in AAC64701. (PubMed:9790752)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti306 – 3061R → H in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035447
    Natural varianti429 – 4291E → G.1 Publication
    Corresponds to variant rs1053526 [ dbSNP | Ensembl ].
    VAR_035374
    Natural varianti518 – 5181E → K in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035448
    Natural varianti534 – 5341A → V in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035449

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6161Missing in isoform 2. 1 PublicationVSP_028620Add
    BLAST
    Alternative sequencei51 – 12777APVDR…MVCLL → V in isoform 3. CuratedVSP_028621Add
    BLAST
    Alternative sequencei51 – 511A → GKPALAAAGAPALCTPGQAD ARPVLGPA in isoform 4. CuratedVSP_028622
    Alternative sequencei52 – 653602Missing in isoform 4. CuratedVSP_028623Add
    BLAST
    Alternative sequencei102 – 12625Missing in isoform 2. 1 PublicationVSP_028624Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010419 mRNA. Translation: BAA29061.1.
    AB010420 mRNA. Translation: BAA29062.1.
    AB013286 Genomic DNA. Translation: BAA31276.1. Sequence problems.
    AB013286 Genomic DNA. Translation: BAA31277.1. Sequence problems.
    CH471184 Genomic DNA. Translation: EAW66748.1.
    CH471184 Genomic DNA. Translation: EAW66752.1.
    BC047019 mRNA. Translation: AAH47019.1.
    BC062624 mRNA. Translation: AAH62624.1. Sequence problems.
    AF052217, AF052216 Genomic DNA. Translation: AAC64701.1.
    AF052215, AF052213, AF052214 Genomic DNA. Translation: AAC64702.1.
    AF052220 mRNA. Translation: AAC64698.1.
    CCDSiCCDS10972.1. [O75081-1]
    CCDS10973.1. [O75081-2]
    RefSeqiNP_005178.4. NM_005187.5. [O75081-1]
    NP_787127.1. NM_175931.2. [O75081-2]
    UniGeneiHs.513811.

    Genome annotation databases

    EnsembliENST00000268679; ENSP00000268679; ENSG00000129993. [O75081-1]
    ENST00000327483; ENSP00000332122; ENSG00000129993. [O75081-2]
    GeneIDi863.
    KEGGihsa:863.
    UCSCiuc002fml.2. human. [O75081-2]
    uc002fmm.2. human. [O75081-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010419 mRNA. Translation: BAA29061.1 .
    AB010420 mRNA. Translation: BAA29062.1 .
    AB013286 Genomic DNA. Translation: BAA31276.1 . Sequence problems.
    AB013286 Genomic DNA. Translation: BAA31277.1 . Sequence problems.
    CH471184 Genomic DNA. Translation: EAW66748.1 .
    CH471184 Genomic DNA. Translation: EAW66752.1 .
    BC047019 mRNA. Translation: AAH47019.1 .
    BC062624 mRNA. Translation: AAH62624.1 . Sequence problems.
    AF052217 , AF052216 Genomic DNA. Translation: AAC64701.1 .
    AF052215 , AF052213 , AF052214 Genomic DNA. Translation: AAC64702.1 .
    AF052220 mRNA. Translation: AAC64698.1 .
    CCDSi CCDS10972.1. [O75081-1 ]
    CCDS10973.1. [O75081-2 ]
    RefSeqi NP_005178.4. NM_005187.5. [O75081-1 ]
    NP_787127.1. NM_175931.2. [O75081-2 ]
    UniGenei Hs.513811.

    3D structure databases

    ProteinModelPortali O75081.
    SMRi O75081. Positions 170-267, 383-442, 479-508, 551-598.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107311. 20 interactions.
    DIPi DIP-48898N.
    IntActi O75081. 11 interactions.
    MINTi MINT-3000909.

    PTM databases

    PhosphoSitei O75081.

    Proteomic databases

    MaxQBi O75081.
    PaxDbi O75081.
    PRIDEi O75081.

    Protocols and materials databases

    DNASUi 863.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000268679 ; ENSP00000268679 ; ENSG00000129993 . [O75081-1 ]
    ENST00000327483 ; ENSP00000332122 ; ENSG00000129993 . [O75081-2 ]
    GeneIDi 863.
    KEGGi hsa:863.
    UCSCi uc002fml.2. human. [O75081-2 ]
    uc002fmm.2. human. [O75081-1 ]

    Organism-specific databases

    CTDi 863.
    GeneCardsi GC16M088941.
    H-InvDB HIX0013342.
    HGNCi HGNC:1537. CBFA2T3.
    MIMi 603870. gene.
    neXtProti NX_O75081.
    Orphaneti 329469. Acute megakaryoblastic leukemia without Down syndrome.
    PharmGKBi PA26113.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG79810.
    HOVERGENi HBG000169.
    InParanoidi O75081.
    OMAi DMAMAHH.
    OrthoDBi EOG70W3D2.
    PhylomeDBi O75081.
    TreeFami TF106303.

    Miscellaneous databases

    ChiTaRSi CBFA2T3. human.
    GeneWikii CBFA2T3.
    GenomeRNAii 863.
    NextBioi 3596.
    PROi O75081.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75081.
    Bgeei O75081.
    Genevestigatori O75081.

    Family and domain databases

    InterProi IPR013289. ETO.
    IPR013292. MTG16.
    IPR014896. NHR2.
    IPR003894. TAFH_NHR1.
    IPR002893. Znf_MYND.
    [Graphical view ]
    Pfami PF08788. NHR2. 1 hit.
    PF07531. TAFH. 1 hit.
    PF01753. zf-MYND. 1 hit.
    [Graphical view ]
    PRINTSi PR01875. ETOFAMILY.
    PR01878. MTG16PROTEIN.
    SMARTi SM00549. TAFH. 1 hit.
    [Graphical view ]
    PROSITEi PS51119. TAFH. 1 hit.
    PS01360. ZF_MYND_1. 1 hit.
    PS50865. ZF_MYND_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family."
      Gamou T., Kitamura E., Hosoda F., Shimuzu K., Hayashi Y., Nagase T., Yokoyama Y., Ohki M.
      Blood 91:4028-4037(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), CHROMOSOMAL TRANSLOCATION WITH RUNX1, TISSUE SPECIFICITY, VARIANT GLY-429.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung and Pancreas.
    4. "CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family."
      Calabi F., Cilli V.
      Genomics 52:332-341(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 128-297 AND 492-604, NUCLEOTIDE SEQUENCE [MRNA] OF 341-431, TISSUE SPECIFICITY.
      Tissue: Brain.
    5. "AML1-MTG16 fusion gene in therapy-related acute leukemia with t(16;21)(q24;q22): two new cases."
      Salomon-Nguyen F., Busson-Le Coniat M., Lafage Pochitaloff M., Mozziconacci J., Berger R., Bernard O.A.
      Leukemia 14:1704-1705(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION WITH RUNX1.
    6. "AML1/MTG16 fusion gene from a t(16;21)(q24;q22) translocation in treatment-induced leukemia after breast cancer."
      La Starza R., Sambani C., Crescenzi B., Matteucci C., Martelli M.F., Mecucci C.
      Haematologica 86:212-213(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL TRANSLOCATION WITH RUNX1.
    7. "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
      Amann J.M., Nip J., Strom D.K., Lutterbach B., Harada H., Lenny N., Downing J.R., Meyers S., Hiebert S.W.
      Mol. Cell. Biol. 21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HDAC1; HDAC2; HDAC3; HDAC6; HDAC8; NCOR1 AND NCOR2.
    8. "CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3."
      Kochetkova M., McKenzie O.L.D., Bais A.J., Martin J.M., Secker G.A., Seshadri R., Powell J.A., Hinze S.J., Gardner A.E., Spendlove H.E., O'Callaghan N.J., Cleton-Jansen A.-M., Cornelisse C., Whitmore S.A., Crawford J., Kremmidiotis G., Sutherland G.R., Callen D.F.
      Cancer Res. 62:4599-4604(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes."
      Schillace R.V., Andrews S.F., Liberty G.A., Davey M.P., Carr D.W.
      J. Immunol. 168:1590-1599(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION (ISOFORM 2), INTERACTION WITH PRKAR2A, MUTAGENESIS OF VAL-494, SUBCELLULAR LOCATION (ISOFORM 2).
    10. "The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t(16; 21)-positive myeloid malignancies."
      Hoogeveen A.T., Rossetti S., Stoyanova V., Schonkeren J., Fenaroli A., Schiaffonati L., van Unen L., Sacchi N.
      Oncogene 21:6703-6712(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORMS 3 AND 4), SUBCELLULAR LOCATION, INTERACTION WITH CBFA2T2; HDAC1; HDAC3 AND RUNX1T1.
    11. "AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation."
      Ibanez V., Sharma A., Buonamici S., Verma A., Kalakonda S., Wang J., Kadkol S., Saunthararajah Y.
      Cancer Res. 64:4547-4554(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NCOR1, TISSUE SPECIFICITY.
    12. "A-kinase anchoring proteins interact with phosphodiesterases in T lymphocyte cell lines."
      Asirvatham A.L., Galligan S.G., Schillace R.V., Davey M.P., Vasta V., Beavo J.A., Carr D.W.
      J. Immunol. 173:4806-4814(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PDE4A AND PDE7A.
    13. "The leukemia-associated ETO homologues are differently expressed during hematopoietic differentiation."
      Lindberg S.R., Olsson A., Persson A.-M., Olsson I.
      Exp. Hematol. 33:189-198(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    14. "ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression."
      Linggi B., Carpenter G.
      J. Biol. Chem. 281:25373-25380(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ERBB4.
    15. "ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription."
      Kumar R., Manning J., Spendlove H.E., Kremmidiotis G., McKirdy R., Lee J., Millband D.N., Cheney K.M., Stampfer M.R., Dwivedi P.P., Morris H.A., Callen D.F.
      Mol. Cancer Res. 4:655-665(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ZNF652.
    16. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
      Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
      J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-535.
      Tissue: Lung adenocarcinoma.
    17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    18. "Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner."
      Fiedler S.E., Schillace R.V., Daniels C.J., Andrews S.F., Carr D.W.
      FEBS Lett. 584:873-877(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PLXNA1; PLXNA3 AND PRKAR1A.
    19. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-306; LYS-518 AND VAL-534.

    Entry informationi

    Entry nameiMTG16_HUMAN
    AccessioniPrimary (citable) accession number: O75081
    Secondary accession number(s): D3DX78
    , O60615, O60616, O60617, O75082, O75107, O75108, Q0P5Z6, Q6P5W6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3