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O75078

- ADA11_HUMAN

UniProt

O75078 - ADA11_HUMAN

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Protein

Disintegrin and metalloproteinase domain-containing protein 11

Gene

ADAM11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

GO - Molecular functioni

  1. integrin binding Source: ProtInc
  2. metalloendopeptidase activity Source: InterPro
  3. metallopeptidase activity Source: ProtInc
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. integrin-mediated signaling pathway Source: ProtInc
Complete GO annotation...

Protein family/group databases

MEROPSiM12.976.

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 11
Short name:
ADAM 11
Alternative name(s):
Metalloproteinase-like, disintegrin-like, and cysteine-rich protein
Short name:
MDC
Gene namesi
Name:ADAM11
Synonyms:MDC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:189. ADAM11.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24506.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 225202By similarityPRO_0000029074Add
BLAST
Chaini226 – 769544Disintegrin and metalloproteinase domain-containing protein 11PRO_0000029075Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi349 ↔ 433By similarity
Disulfide bondi392 ↔ 417By similarity
Disulfide bondi394 ↔ 401By similarity
Disulfide bondi503 ↔ 523By similarity
Glycosylationi605 – 6051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi673 – 6731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi677 ↔ 692By similarity
Disulfide bondi686 ↔ 698By similarity
Disulfide bondi700 ↔ 709By similarity

Post-translational modificationi

The precursor is cleaved by a furin endopeptidase.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75078.
PRIDEiO75078.

PTM databases

PhosphoSiteiO75078.

Expressioni

Tissue specificityi

Expressed predominantly in brain. Slightly detected or not at all in other tissues.

Gene expression databases

BgeeiO75078.
CleanExiHS_ADAM11.
ExpressionAtlasiO75078. baseline and differential.
GenevestigatoriO75078.

Organism-specific databases

HPAiHPA053299.

Interactioni

Subunit structurei

Can bind to LGI1 and LGI4.By similarity

Protein-protein interaction databases

BioGridi110351. 2 interactions.
IntActiO75078. 1 interaction.
MINTiMINT-1432866.
STRINGi9606.ENSP00000200557.

Structurei

3D structure databases

ProteinModelPortaliO75078.
SMRiO75078. Positions 234-714.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini226 – 734509ExtracellularSequence AnalysisAdd
BLAST
Topological domaini756 – 76914CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei735 – 75521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini239 – 438200Peptidase M12BPROSITE-ProRule annotationAdd
BLAST
Domaini444 – 53188DisintegrinPROSITE-ProRule annotationAdd
BLAST
Domaini677 – 70933EGF-likePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi532 – 676145Cys-richAdd
BLAST

Domaini

A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256419.
GeneTreeiENSGT00760000119181.
HOGENOMiHOG000231962.
HOVERGENiHBG050456.
InParanoidiO75078.
KOiK16067.
OMAiELDCRGG.
OrthoDBiEOG7B31M6.
PhylomeDBiO75078.
TreeFamiTF314733.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: O75078-1) [UniParc]FASTAAdd to Basket

Also known as: MDC-769

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLLRRWAFA ALLLSLLPTP GLGTQGPAGA LRWGGLPQLG GPGAPEVTEP
60 70 80 90 100
SRLVRESSGG EVRKQQLDTR VRQEPPGGPP VHLAQVSFVI PAFNSNFTLD
110 120 130 140 150
LELNHHLLSS QYVERHFSRE GTTQHSTGAG DHCYYQGKLR GNPHSFAALS
160 170 180 190 200
TCQGLHGVFS DGNLTYIVEP QEVAGPWGAP QGPLPHLIYR TPLLPDPLGC
210 220 230 240 250
REPGCLFAVP AQSAPPNRPR LRRKRQVRRG HPTVHSETKY VELIVINDHQ
260 270 280 290 300
LFEQMRQSVV LTSNFAKSVV NLADVIYKEQ LNTRIVLVAM ETWADGDKIQ
310 320 330 340 350
VQDDLLETLA RLMVYRREGL PEPSDATHLF SGRTFQSTSS GAAYVGGICS
360 370 380 390 400
LSHGGGVNEY GNMGAMAVTL AQTLGQNLGM MWNKHRSSAG DCKCPDIWLG
410 420 430 440 450
CIMEDTGFYL PRKFSRCSID EYNQFLQEGG GSCLFNKPLK LLDPPECGNG
460 470 480 490 500
FVEAGEECDC GSVQECSRAG GNCCKKCTLT HDAMCSDGLC CRRCKYEPRG
510 520 530 540 550
VSCREAVNEC DIAETCTGDS SQCPPNLHKL DGYYCDHEQG RCYGGRCKTR
560 570 580 590 600
DRQCQVLWGH AAADRFCYEK LNVEGTERGS CGRKGSGWVQ CSKQDVLCGF
610 620 630 640 650
LLCVNISGAP RLGDLVGDIS SVTFYHQGKE LDCRGGHVQL ADGSDLSYVE
660 670 680 690 700
DGTACGPNML CLDHRCLPAS AFNFSTCPGS GERRICSHHG VCSNEGKCIC
710 720 730 740 750
QPDWTGKDCS IHNPLPTSPP TGETERYKGP SGTNIIIGSI AGAVLVAAIV
760
LGGTGWGFKN IRRGRSGGA
Length:769
Mass (Da):83,418
Last modified:October 3, 2006 - v3
Checksum:iEEB091EB6730AC36
GO
Isoform Short (identifier: O75078-2) [UniParc]FASTAAdd to Basket

Also known as: MDC-524

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
     100-104: DLELN → MCWLS
     595-623: DVLCGFLLCVNISGAPRLGDLVGDISSVT → PQQGRAVWLPPLCQHLWSSSARGPGGRHQ
     624-769: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:524
Mass (Da):57,911
Checksum:iCC3756772F1EB346
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061H → Q in BAA06670. (PubMed:8252040)Curated
Sequence conflicti106 – 1061H → Q in BAA06671. (PubMed:7956356)Curated
Sequence conflicti325 – 3251D → N in BAA04213. (PubMed:8252040)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti693 – 6931S → R in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 Publication
VAR_062669

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9999Missing in isoform Short. 1 PublicationVSP_005472Add
BLAST
Alternative sequencei100 – 1045DLELN → MCWLS in isoform Short. 1 PublicationVSP_005473
Alternative sequencei595 – 62329DVLCG…ISSVT → PQQGRAVWLPPLCQHLWSSS ARGPGGRHQ in isoform Short. 1 PublicationVSP_005474Add
BLAST
Alternative sequencei624 – 769146Missing in isoform Short. 1 PublicationVSP_005475Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009675 mRNA. Translation: BAA32352.1.
D17390 mRNA. Translation: BAA04213.1.
D31872 Genomic DNA. Translation: BAA06670.1.
D31872 Genomic DNA. Translation: BAA06671.1.
CCDSiCCDS11486.1. [O75078-1]
PIRiI65967.
S38539.
RefSeqiNP_002381.2. NM_002390.4. [O75078-1]
UniGeneiHs.6088.

Genome annotation databases

EnsembliENST00000200557; ENSP00000200557; ENSG00000073670. [O75078-1]
GeneIDi4185.
KEGGihsa:4185.
UCSCiuc002ihh.3. human. [O75078-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB009675 mRNA. Translation: BAA32352.1 .
D17390 mRNA. Translation: BAA04213.1 .
D31872 Genomic DNA. Translation: BAA06670.1 .
D31872 Genomic DNA. Translation: BAA06671.1 .
CCDSi CCDS11486.1. [O75078-1 ]
PIRi I65967.
S38539.
RefSeqi NP_002381.2. NM_002390.4. [O75078-1 ]
UniGenei Hs.6088.

3D structure databases

ProteinModelPortali O75078.
SMRi O75078. Positions 234-714.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110351. 2 interactions.
IntActi O75078. 1 interaction.
MINTi MINT-1432866.
STRINGi 9606.ENSP00000200557.

Protein family/group databases

MEROPSi M12.976.

PTM databases

PhosphoSitei O75078.

Proteomic databases

PaxDbi O75078.
PRIDEi O75078.

Protocols and materials databases

DNASUi 4185.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000200557 ; ENSP00000200557 ; ENSG00000073670 . [O75078-1 ]
GeneIDi 4185.
KEGGi hsa:4185.
UCSCi uc002ihh.3. human. [O75078-1 ]

Organism-specific databases

CTDi 4185.
GeneCardsi GC17P042847.
HGNCi HGNC:189. ADAM11.
HPAi HPA053299.
MIMi 155120. gene.
neXtProti NX_O75078.
PharmGKBi PA24506.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256419.
GeneTreei ENSGT00760000119181.
HOGENOMi HOG000231962.
HOVERGENi HBG050456.
InParanoidi O75078.
KOi K16067.
OMAi ELDCRGG.
OrthoDBi EOG7B31M6.
PhylomeDBi O75078.
TreeFami TF314733.

Miscellaneous databases

GeneWikii ADAM11.
GenomeRNAii 4185.
NextBioi 16498.
PROi O75078.
SOURCEi Search...

Gene expression databases

Bgeei O75078.
CleanExi HS_ADAM11.
ExpressionAtlasi O75078. baseline and differential.
Genevestigatori O75078.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProi IPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view ]
Pfami PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view ]
PRINTSi PR00289. DISINTEGRIN.
SMARTi SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57552. SSF57552. 1 hit.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain."
    Sagane K., Ohya Y., Hasegawa Y., Tanaka I.
    Biochem. J. 334:93-98(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    Tissue: Brain.
  2. "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers."
    Emi M., Katagiri T., Harada Y., Saito H., Inazawa J., Ito I., Kasumi F., Nakamura Y.
    Nat. Genet. 5:151-157(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Tissue: Cerebellum.
  3. "Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing."
    Katagiri T., Harada Y., Emi M., Nakamura Y.
    Cytogenet. Cell Genet. 68:39-44(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-769 (ISOFORMS LONG AND SHORT).
    Tissue: Brain, Mammary gland, Ovary and Testis.
  4. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-693.

Entry informationi

Entry nameiADA11_HUMAN
AccessioniPrimary (citable) accession number: O75078
Secondary accession number(s): Q14808, Q14809, Q14810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3