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O75078 (ADA11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Disintegrin and metalloproteinase domain-containing protein 11

Short name=ADAM 11
Alternative name(s):
Metalloproteinase-like, disintegrin-like, and cysteine-rich protein
Short name=MDC
Gene names
Name:ADAM11
Synonyms:MDC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length769 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

Subunit structure

Can bind to LGI1 and LGI4 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed predominantly in brain. Slightly detected or not at all in other tissues.

Domain

A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.

Post-translational modification

The precursor is cleaved by a furin endopeptidase By similarity.

Sequence similarities

Contains 1 disintegrin domain.

Contains 1 EGF-like domain.

Contains 1 peptidase M12B domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: O75078-1)

Also known as: MDC-769;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: O75078-2)

Also known as: MDC-524;

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
     100-104: DLELN → MCWLS
     595-623: DVLCGFLLCVNISGAPRLGDLVGDISSVT → PQQGRAVWLPPLCQHLWSSSARGPGGRHQ
     624-769: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Propeptide24 – 225202 By similarity
PRO_0000029074
Chain226 – 769544Disintegrin and metalloproteinase domain-containing protein 11
PRO_0000029075

Regions

Topological domain226 – 734509Extracellular Potential
Transmembrane735 – 75521Helical; Potential
Topological domain756 – 76914Cytoplasmic Potential
Domain239 – 438200Peptidase M12B
Domain444 – 53188Disintegrin
Domain677 – 70933EGF-like
Compositional bias532 – 676145Cys-rich

Amino acid modifications

Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation6051N-linked (GlcNAc...) Potential
Glycosylation6731N-linked (GlcNAc...) Potential
Disulfide bond349 ↔ 433 By similarity
Disulfide bond392 ↔ 417 By similarity
Disulfide bond394 ↔ 401 By similarity
Disulfide bond503 ↔ 523 By similarity
Disulfide bond677 ↔ 692 By similarity
Disulfide bond686 ↔ 698 By similarity
Disulfide bond700 ↔ 709 By similarity

Natural variations

Alternative sequence1 – 9999Missing in isoform Short.
VSP_005472
Alternative sequence100 – 1045DLELN → MCWLS in isoform Short.
VSP_005473
Alternative sequence595 – 62329DVLCG…ISSVT → PQQGRAVWLPPLCQHLWSSS ARGPGGRHQ in isoform Short.
VSP_005474
Alternative sequence624 – 769146Missing in isoform Short.
VSP_005475
Natural variant6931S → R in a pancreatic ductal adenocarcinoma sample; somatic mutation. Ref.5
VAR_062669

Experimental info

Sequence conflict1061H → Q in BAA06670. Ref.2
Sequence conflict1061H → Q in BAA06671. Ref.3
Sequence conflict3251D → N in BAA04213. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform Long (MDC-769) [UniParc].

Last modified October 3, 2006. Version 3.
Checksum: EEB091EB6730AC36

FASTA76983,418
        10         20         30         40         50         60 
MRLLRRWAFA ALLLSLLPTP GLGTQGPAGA LRWGGLPQLG GPGAPEVTEP SRLVRESSGG 

        70         80         90        100        110        120 
EVRKQQLDTR VRQEPPGGPP VHLAQVSFVI PAFNSNFTLD LELNHHLLSS QYVERHFSRE 

       130        140        150        160        170        180 
GTTQHSTGAG DHCYYQGKLR GNPHSFAALS TCQGLHGVFS DGNLTYIVEP QEVAGPWGAP 

       190        200        210        220        230        240 
QGPLPHLIYR TPLLPDPLGC REPGCLFAVP AQSAPPNRPR LRRKRQVRRG HPTVHSETKY 

       250        260        270        280        290        300 
VELIVINDHQ LFEQMRQSVV LTSNFAKSVV NLADVIYKEQ LNTRIVLVAM ETWADGDKIQ 

       310        320        330        340        350        360 
VQDDLLETLA RLMVYRREGL PEPSDATHLF SGRTFQSTSS GAAYVGGICS LSHGGGVNEY 

       370        380        390        400        410        420 
GNMGAMAVTL AQTLGQNLGM MWNKHRSSAG DCKCPDIWLG CIMEDTGFYL PRKFSRCSID 

       430        440        450        460        470        480 
EYNQFLQEGG GSCLFNKPLK LLDPPECGNG FVEAGEECDC GSVQECSRAG GNCCKKCTLT 

       490        500        510        520        530        540 
HDAMCSDGLC CRRCKYEPRG VSCREAVNEC DIAETCTGDS SQCPPNLHKL DGYYCDHEQG 

       550        560        570        580        590        600 
RCYGGRCKTR DRQCQVLWGH AAADRFCYEK LNVEGTERGS CGRKGSGWVQ CSKQDVLCGF 

       610        620        630        640        650        660 
LLCVNISGAP RLGDLVGDIS SVTFYHQGKE LDCRGGHVQL ADGSDLSYVE DGTACGPNML 

       670        680        690        700        710        720 
CLDHRCLPAS AFNFSTCPGS GERRICSHHG VCSNEGKCIC QPDWTGKDCS IHNPLPTSPP 

       730        740        750        760 
TGETERYKGP SGTNIIIGSI AGAVLVAAIV LGGTGWGFKN IRRGRSGGA 

« Hide

Isoform Short (MDC-524) [UniParc].

Checksum: CC3756772F1EB346
Show »

FASTA52457,911

References

« Hide 'large scale' references
[1]"Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain."
Sagane K., Ohya Y., Hasegawa Y., Tanaka I.
Biochem. J. 334:93-98(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
Tissue: Brain.
[2]"A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers."
Emi M., Katagiri T., Harada Y., Saito H., Inazawa J., Ito I., Kasumi F., Nakamura Y.
Nat. Genet. 5:151-157(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
Tissue: Cerebellum.
[3]"Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing."
Katagiri T., Harada Y., Emi M., Nakamura Y.
Cytogenet. Cell Genet. 68:39-44(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-769 (ISOFORMS LONG AND SHORT).
Tissue: Brain, Mammary gland, Ovary and Testis.
[4]"An unappreciated role for RNA surveillance."
Hillman R.T., Green R.E., Brenner S.E.
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[5]"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses."
Jones S., Zhang X., Parsons D.W., Lin J.C., Leary R.J., Angenendt P., Mankoo P., Carter H., Kamiyama H., Jimeno A., Hong S.M., Fu B., Lin M.T., Calhoun E.S., Kamiyama M., Walter K., Nikolskaya T., Nikolsky Y. expand/collapse author list , Hartigan J., Smith D.R., Hidalgo M., Leach S.D., Klein A.P., Jaffee E.M., Goggins M., Maitra A., Iacobuzio-Donahue C., Eshleman J.R., Kern S.E., Hruban R.H., Karchin R., Papadopoulos N., Parmigiani G., Vogelstein B., Velculescu V.E., Kinzler K.W.
Science 321:1801-1806(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-693.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB009675 mRNA. Translation: BAA32352.1.
D17390 mRNA. Translation: BAA04213.1.
D31872 Genomic DNA. Translation: BAA06670.1.
D31872 Genomic DNA. Translation: BAA06671.1.
CCDSCCDS11486.1. [O75078-1]
PIRI65967.
S38539.
RefSeqNP_002381.2. NM_002390.4. [O75078-1]
UniGeneHs.6088.

3D structure databases

ProteinModelPortalO75078.
SMRO75078. Positions 234-714.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110351. 1 interaction.
IntActO75078. 1 interaction.
MINTMINT-1432866.
STRING9606.ENSP00000200557.

Protein family/group databases

MEROPSM12.976.

PTM databases

PhosphoSiteO75078.

Proteomic databases

PaxDbO75078.
PRIDEO75078.

Protocols and materials databases

DNASU4185.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000200557; ENSP00000200557; ENSG00000073670. [O75078-1]
GeneID4185.
KEGGhsa:4185.
UCSCuc002ihh.3. human. [O75078-1]

Organism-specific databases

CTD4185.
GeneCardsGC17P042847.
HGNCHGNC:189. ADAM11.
HPAHPA053299.
MIM155120. gene.
neXtProtNX_O75078.
PharmGKBPA24506.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG256419.
HOGENOMHOG000231962.
HOVERGENHBG050456.
InParanoidO75078.
KOK16067.
OMAELDCRGG.
OrthoDBEOG7B31M6.
PhylomeDBO75078.
TreeFamTF314733.

Gene expression databases

ArrayExpressO75078.
BgeeO75078.
CleanExHS_ADAM11.
GenevestigatorO75078.

Family and domain databases

Gene3D3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProIPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamPF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSPR00289. DISINTEGRIN.
SMARTSM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]
SUPFAMSSF57552. SSF57552. 1 hit.
PROSITEPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiADAM11.
GenomeRNAi4185.
NextBio16498.
PROO75078.
SOURCESearch...

Entry information

Entry nameADA11_HUMAN
AccessionPrimary (citable) accession number: O75078
Secondary accession number(s): Q14808, Q14809, Q14810
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM