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O75078

- ADA11_HUMAN

UniProt

O75078 - ADA11_HUMAN

Protein

Disintegrin and metalloproteinase domain-containing protein 11

Gene

ADAM11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 3 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.

    GO - Molecular functioni

    1. integrin binding Source: ProtInc
    2. metalloendopeptidase activity Source: InterPro
    3. metallopeptidase activity Source: ProtInc
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. integrin-mediated signaling pathway Source: ProtInc

    Protein family/group databases

    MEROPSiM12.976.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 11
    Short name:
    ADAM 11
    Alternative name(s):
    Metalloproteinase-like, disintegrin-like, and cysteine-rich protein
    Short name:
    MDC
    Gene namesi
    Name:ADAM11
    Synonyms:MDC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:189. ADAM11.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24506.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 225202By similarityPRO_0000029074Add
    BLAST
    Chaini226 – 769544Disintegrin and metalloproteinase domain-containing protein 11PRO_0000029075Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi349 ↔ 433By similarity
    Disulfide bondi392 ↔ 417By similarity
    Disulfide bondi394 ↔ 401By similarity
    Disulfide bondi503 ↔ 523By similarity
    Glycosylationi605 – 6051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi673 – 6731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi677 ↔ 692By similarity
    Disulfide bondi686 ↔ 698By similarity
    Disulfide bondi700 ↔ 709By similarity

    Post-translational modificationi

    The precursor is cleaved by a furin endopeptidase.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO75078.
    PRIDEiO75078.

    PTM databases

    PhosphoSiteiO75078.

    Expressioni

    Tissue specificityi

    Expressed predominantly in brain. Slightly detected or not at all in other tissues.

    Gene expression databases

    ArrayExpressiO75078.
    BgeeiO75078.
    CleanExiHS_ADAM11.
    GenevestigatoriO75078.

    Organism-specific databases

    HPAiHPA053299.

    Interactioni

    Subunit structurei

    Can bind to LGI1 and LGI4.By similarity

    Protein-protein interaction databases

    BioGridi110351. 1 interaction.
    IntActiO75078. 1 interaction.
    MINTiMINT-1432866.
    STRINGi9606.ENSP00000200557.

    Structurei

    3D structure databases

    ProteinModelPortaliO75078.
    SMRiO75078. Positions 234-714.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini226 – 734509ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini756 – 76914CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei735 – 75521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini239 – 438200Peptidase M12BPROSITE-ProRule annotationAdd
    BLAST
    Domaini444 – 53188DisintegrinPROSITE-ProRule annotationAdd
    BLAST
    Domaini677 – 70933EGF-likePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi532 – 676145Cys-richAdd
    BLAST

    Domaini

    A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.

    Sequence similaritiesi

    Contains 1 disintegrin domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG256419.
    HOGENOMiHOG000231962.
    HOVERGENiHBG050456.
    InParanoidiO75078.
    KOiK16067.
    OMAiELDCRGG.
    OrthoDBiEOG7B31M6.
    PhylomeDBiO75078.
    TreeFamiTF314733.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProiIPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view]
    PfamiPF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view]
    PRINTSiPR00289. DISINTEGRIN.
    SMARTiSM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57552. SSF57552. 1 hit.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: O75078-1) [UniParc]FASTAAdd to Basket

    Also known as: MDC-769

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLLRRWAFA ALLLSLLPTP GLGTQGPAGA LRWGGLPQLG GPGAPEVTEP    50
    SRLVRESSGG EVRKQQLDTR VRQEPPGGPP VHLAQVSFVI PAFNSNFTLD 100
    LELNHHLLSS QYVERHFSRE GTTQHSTGAG DHCYYQGKLR GNPHSFAALS 150
    TCQGLHGVFS DGNLTYIVEP QEVAGPWGAP QGPLPHLIYR TPLLPDPLGC 200
    REPGCLFAVP AQSAPPNRPR LRRKRQVRRG HPTVHSETKY VELIVINDHQ 250
    LFEQMRQSVV LTSNFAKSVV NLADVIYKEQ LNTRIVLVAM ETWADGDKIQ 300
    VQDDLLETLA RLMVYRREGL PEPSDATHLF SGRTFQSTSS GAAYVGGICS 350
    LSHGGGVNEY GNMGAMAVTL AQTLGQNLGM MWNKHRSSAG DCKCPDIWLG 400
    CIMEDTGFYL PRKFSRCSID EYNQFLQEGG GSCLFNKPLK LLDPPECGNG 450
    FVEAGEECDC GSVQECSRAG GNCCKKCTLT HDAMCSDGLC CRRCKYEPRG 500
    VSCREAVNEC DIAETCTGDS SQCPPNLHKL DGYYCDHEQG RCYGGRCKTR 550
    DRQCQVLWGH AAADRFCYEK LNVEGTERGS CGRKGSGWVQ CSKQDVLCGF 600
    LLCVNISGAP RLGDLVGDIS SVTFYHQGKE LDCRGGHVQL ADGSDLSYVE 650
    DGTACGPNML CLDHRCLPAS AFNFSTCPGS GERRICSHHG VCSNEGKCIC 700
    QPDWTGKDCS IHNPLPTSPP TGETERYKGP SGTNIIIGSI AGAVLVAAIV 750
    LGGTGWGFKN IRRGRSGGA 769
    Length:769
    Mass (Da):83,418
    Last modified:October 3, 2006 - v3
    Checksum:iEEB091EB6730AC36
    GO
    Isoform Short (identifier: O75078-2) [UniParc]FASTAAdd to Basket

    Also known as: MDC-524

    The sequence of this isoform differs from the canonical sequence as follows:
         1-99: Missing.
         100-104: DLELN → MCWLS
         595-623: DVLCGFLLCVNISGAPRLGDLVGDISSVT → PQQGRAVWLPPLCQHLWSSSARGPGGRHQ
         624-769: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:524
    Mass (Da):57,911
    Checksum:iCC3756772F1EB346
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti106 – 1061H → Q in BAA06670. (PubMed:8252040)Curated
    Sequence conflicti106 – 1061H → Q in BAA06671. (PubMed:7956356)Curated
    Sequence conflicti325 – 3251D → N in BAA04213. (PubMed:8252040)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti693 – 6931S → R in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_062669

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9999Missing in isoform Short. 1 PublicationVSP_005472Add
    BLAST
    Alternative sequencei100 – 1045DLELN → MCWLS in isoform Short. 1 PublicationVSP_005473
    Alternative sequencei595 – 62329DVLCG…ISSVT → PQQGRAVWLPPLCQHLWSSS ARGPGGRHQ in isoform Short. 1 PublicationVSP_005474Add
    BLAST
    Alternative sequencei624 – 769146Missing in isoform Short. 1 PublicationVSP_005475Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009675 mRNA. Translation: BAA32352.1.
    D17390 mRNA. Translation: BAA04213.1.
    D31872 Genomic DNA. Translation: BAA06670.1.
    D31872 Genomic DNA. Translation: BAA06671.1.
    CCDSiCCDS11486.1. [O75078-1]
    PIRiI65967.
    S38539.
    RefSeqiNP_002381.2. NM_002390.4. [O75078-1]
    UniGeneiHs.6088.

    Genome annotation databases

    EnsembliENST00000200557; ENSP00000200557; ENSG00000073670. [O75078-1]
    GeneIDi4185.
    KEGGihsa:4185.
    UCSCiuc002ihh.3. human. [O75078-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009675 mRNA. Translation: BAA32352.1 .
    D17390 mRNA. Translation: BAA04213.1 .
    D31872 Genomic DNA. Translation: BAA06670.1 .
    D31872 Genomic DNA. Translation: BAA06671.1 .
    CCDSi CCDS11486.1. [O75078-1 ]
    PIRi I65967.
    S38539.
    RefSeqi NP_002381.2. NM_002390.4. [O75078-1 ]
    UniGenei Hs.6088.

    3D structure databases

    ProteinModelPortali O75078.
    SMRi O75078. Positions 234-714.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110351. 1 interaction.
    IntActi O75078. 1 interaction.
    MINTi MINT-1432866.
    STRINGi 9606.ENSP00000200557.

    Protein family/group databases

    MEROPSi M12.976.

    PTM databases

    PhosphoSitei O75078.

    Proteomic databases

    PaxDbi O75078.
    PRIDEi O75078.

    Protocols and materials databases

    DNASUi 4185.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000200557 ; ENSP00000200557 ; ENSG00000073670 . [O75078-1 ]
    GeneIDi 4185.
    KEGGi hsa:4185.
    UCSCi uc002ihh.3. human. [O75078-1 ]

    Organism-specific databases

    CTDi 4185.
    GeneCardsi GC17P042847.
    HGNCi HGNC:189. ADAM11.
    HPAi HPA053299.
    MIMi 155120. gene.
    neXtProti NX_O75078.
    PharmGKBi PA24506.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG256419.
    HOGENOMi HOG000231962.
    HOVERGENi HBG050456.
    InParanoidi O75078.
    KOi K16067.
    OMAi ELDCRGG.
    OrthoDBi EOG7B31M6.
    PhylomeDBi O75078.
    TreeFami TF314733.

    Miscellaneous databases

    GeneWikii ADAM11.
    GenomeRNAii 4185.
    NextBioi 16498.
    PROi O75078.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75078.
    Bgeei O75078.
    CleanExi HS_ADAM11.
    Genevestigatori O75078.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    4.10.70.10. 1 hit.
    InterProi IPR006586. ADAM_Cys-rich.
    IPR001762. Blood-coag_inhib_Disintegrin.
    IPR018358. Disintegrin_CS.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR002870. Peptidase_M12B_N.
    [Graphical view ]
    Pfami PF08516. ADAM_CR. 1 hit.
    PF00200. Disintegrin. 1 hit.
    PF01562. Pep_M12B_propep. 1 hit.
    PF01421. Reprolysin. 1 hit.
    [Graphical view ]
    PRINTSi PR00289. DISINTEGRIN.
    SMARTi SM00608. ACR. 1 hit.
    SM00050. DISIN. 1 hit.
    SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57552. SSF57552. 1 hit.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS00427. DISINTEGRIN_1. 1 hit.
    PS50214. DISINTEGRIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain."
      Sagane K., Ohya Y., Hasegawa Y., Tanaka I.
      Biochem. J. 334:93-98(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
      Tissue: Brain.
    2. "A novel metalloprotease/disintegrin-like gene at 17q21.3 is somatically rearranged in two primary breast cancers."
      Emi M., Katagiri T., Harada Y., Saito H., Inazawa J., Ito I., Kasumi F., Nakamura Y.
      Nat. Genet. 5:151-157(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
      Tissue: Cerebellum.
    3. "Human metalloprotease/disintegrin-like (MDC) gene: exon-intron organization and alternative splicing."
      Katagiri T., Harada Y., Emi M., Nakamura Y.
      Cytogenet. Cell Genet. 68:39-44(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 106-769 (ISOFORMS LONG AND SHORT).
      Tissue: Brain, Mammary gland, Ovary and Testis.
    4. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-693.

    Entry informationi

    Entry nameiADA11_HUMAN
    AccessioniPrimary (citable) accession number: O75078
    Secondary accession number(s): Q14808, Q14809, Q14810
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 134 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3