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O75074

- LRP3_HUMAN

UniProt

O75074 - LRP3_HUMAN

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Protein

Low-density lipoprotein receptor-related protein 3

Gene

LRP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.

GO - Biological processi

  1. receptor-mediated endocytosis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 3
Short name:
LRP-3
Alternative name(s):
105 kDa low-density lipoprotein receptor-related protein
Short name:
hLRp105
Gene namesi
Name:LRP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6695. LRP3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini37 – 496460ExtracellularSequence AnalysisAdd
BLAST
Transmembranei497 – 51721HelicalSequence AnalysisAdd
BLAST
Topological domaini518 – 770253CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. coated pit Source: UniProtKB-KW
  2. integral component of membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636Sequence AnalysisAdd
BLAST
Chaini37 – 770734Low-density lipoprotein receptor-related protein 3PRO_0000017323Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 72By similarity
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 120By similarity
Disulfide bondi166 ↔ 178By similarity
Disulfide bondi173 ↔ 191By similarity
Disulfide bondi185 ↔ 200By similarity
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi212 ↔ 227By similarity
Disulfide bondi219 ↔ 240By similarity
Disulfide bondi234 ↔ 249By similarity
Disulfide bondi254 ↔ 282By similarity
Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi416 ↔ 430By similarity
Disulfide bondi423 ↔ 443By similarity
Disulfide bondi437 ↔ 452By similarity
Disulfide bondi455 ↔ 467By similarity
Disulfide bondi462 ↔ 480By similarity
Disulfide bondi474 ↔ 489By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75074.
PRIDEiO75074.

PTM databases

PhosphoSiteiO75074.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte.1 Publication

Gene expression databases

BgeeiO75074.
CleanExiHS_LRP3.
ExpressionAtlasiO75074. baseline.
GenevestigatoriO75074.

Interactioni

Subunit structurei

Binds GGA1 and GGA2.By similarity

Protein-protein interaction databases

BioGridi110217. 1 interaction.
IntActiO75074. 2 interactions.
MINTiMINT-201005.
STRINGi9606.ENSP00000253193.

Structurei

3D structure databases

ProteinModelPortaliO75074.
SMRiO75074. Positions 43-156, 165-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 159117CUB 1PROSITE-ProRule annotationAdd
BLAST
Domaini165 – 20137LDL-receptor class A 1PROSITE-ProRule annotationAdd
BLAST
Domaini211 – 25040LDL-receptor class A 2PROSITE-ProRule annotationAdd
BLAST
Domaini254 – 365112CUB 2PROSITE-ProRule annotationAdd
BLAST
Domaini415 – 45339LDL-receptor class A 3PROSITE-ProRule annotationAdd
BLAST
Domaini454 – 49037LDL-receptor class A 4PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi751 – 7544Poly-Pro

Sequence similaritiesi

Belongs to the LDLR family.Curated
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 4 LDL-receptor class A domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG242928.
GeneTreeiENSGT00760000119194.
HOGENOMiHOG000013017.
HOVERGENiHBG049162.
InParanoidiO75074.
OMAiDMITISF.
OrthoDBiEOG7PCJG4.
PhylomeDBiO75074.
TreeFamiTF332149.

Family and domain databases

Gene3Di2.60.120.290. 2 hits.
4.10.400.10. 5 hits.
InterProiIPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 3 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00042. CUB. 2 hits.
SM00192. LDLa. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF57424. SSF57424. 4 hits.
PROSITEiPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75074-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKRAAAGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH
60 70 80 90 100
TERRGVIYSP AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS
110 120 130 140 150
LDWLLLGPAA PPRQEAFRLC GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ
160 170 180 190 200
GFRLSYIRGK LGQASCQADE FRCDNGKCLP GPWQCNTVDE CGDGSDEGNC
210 220 230 240 250
SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC GDGSDEAGCP
260 270 280 290 300
DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD SRRVLLQLEL
310 320 330 340 350
RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR
360 370 380 390 400
ARSAGHGFNA TYQVKGYCLP WEQPCGSSSD SDGGSLGDQG CFSEPQRCDG
410 420 430 440 450
WWHCASGRDE QGCPACPPDQ YPCEGGSGLC YTPADRCNNQ KSCPDGADEK
460 470 480 490 500
NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC QDGSDEHGCL AAVPRKVITA
510 520 530 540 550
ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL EAEFVRREAP
560 570 580 590 600
PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS
610 620 630 640 650
RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGFL QPAPGAAPDP
660 670 680 690 700
PAPLMDTGST RAAGDRPPSA PGRAPEVGPS GPPLPSGLRD PECRPVDKDR
710 720 730 740 750
KVCREPLVDG PAPADAPREP CSAQDPHPQV STASSTLGPH SPEPLGVCRN
760 770
PPPPCSPMLE ASDDEALLVC
Length:770
Mass (Da):82,884
Last modified:December 20, 2005 - v2
Checksum:i5175EDCB7A7D22EE
GO

Sequence cautioni

The sequence BAG51998.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAG59164.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851T → I in BAG51998. (PubMed:16303743)Curated
Sequence conflicti458 – 4581G → D in BAG51998. (PubMed:16303743)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti213 – 2131P → L.
Corresponds to variant rs3745978 [ dbSNP | Ensembl ].
VAR_049764
Natural varianti708 – 7081V → A.4 Publications
Corresponds to variant rs3745974 [ dbSNP | Ensembl ].
VAR_018171

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009462 mRNA. Translation: BAA32330.1.
BC007408 mRNA. Translation: AAH07408.1.
AK074751 mRNA. Translation: BAG51998.1. Different initiation.
AK296536 mRNA. Translation: BAG59164.1. Different initiation.
CCDSiCCDS12430.1.
PIRiT00204.
RefSeqiNP_002324.2. NM_002333.3.
UniGeneiHs.515340.

Genome annotation databases

EnsembliENST00000253193; ENSP00000253193; ENSG00000130881.
GeneIDi4037.
KEGGihsa:4037.
UCSCiuc002nuk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009462 mRNA. Translation: BAA32330.1 .
BC007408 mRNA. Translation: AAH07408.1 .
AK074751 mRNA. Translation: BAG51998.1 . Different initiation.
AK296536 mRNA. Translation: BAG59164.1 . Different initiation.
CCDSi CCDS12430.1.
PIRi T00204.
RefSeqi NP_002324.2. NM_002333.3.
UniGenei Hs.515340.

3D structure databases

ProteinModelPortali O75074.
SMRi O75074. Positions 43-156, 165-495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110217. 1 interaction.
IntActi O75074. 2 interactions.
MINTi MINT-201005.
STRINGi 9606.ENSP00000253193.

PTM databases

PhosphoSitei O75074.

Proteomic databases

PaxDbi O75074.
PRIDEi O75074.

Protocols and materials databases

DNASUi 4037.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253193 ; ENSP00000253193 ; ENSG00000130881 .
GeneIDi 4037.
KEGGi hsa:4037.
UCSCi uc002nuk.4. human.

Organism-specific databases

CTDi 4037.
GeneCardsi GC19P033685.
H-InvDB HIX0014999.
HGNCi HGNC:6695. LRP3.
MIMi 603159. gene.
neXtProti NX_O75074.
PharmGKBi PA30453.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG242928.
GeneTreei ENSGT00760000119194.
HOGENOMi HOG000013017.
HOVERGENi HBG049162.
InParanoidi O75074.
OMAi DMITISF.
OrthoDBi EOG7PCJG4.
PhylomeDBi O75074.
TreeFami TF332149.

Miscellaneous databases

ChiTaRSi LRP3. human.
GeneWikii LRP3.
GenomeRNAii 4037.
NextBioi 15814.
PROi O75074.
SOURCEi Search...

Gene expression databases

Bgeei O75074.
CleanExi HS_LRP3.
ExpressionAtlasi O75074. baseline.
Genevestigatori O75074.

Family and domain databases

Gene3Di 2.60.120.290. 2 hits.
4.10.400.10. 5 hits.
InterProi IPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view ]
Pfami PF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 3 hits.
[Graphical view ]
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00042. CUB. 2 hits.
SM00192. LDLa. 5 hits.
[Graphical view ]
SUPFAMi SSF49854. SSF49854. 2 hits.
SSF57424. SSF57424. 4 hits.
PROSITEi PS01180. CUB. 2 hits.
PS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13. 2."
    Ishii H., Kim D.-H., Fujita T., Endo Y., Saeki S., Yamamoto T.T.
    Genomics 51:132-135(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ALA-708.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-708.
    Tissue: Muscle.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-770, VARIANT ALA-708.
    Tissue: Thalamus.
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-770, VARIANT ALA-708.

Entry informationi

Entry nameiLRP3_HUMAN
AccessioniPrimary (citable) accession number: O75074
Secondary accession number(s): B3KQD6, B4DKF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3