O75074 (LRP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low-density lipoprotein receptor-related protein 3
Short name=LRP-3

Alternative name(s):
105 kDa low-density lipoprotein receptor-related protein
Short name=hLRp105

Gene names

Name:

LRP3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	770 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.
Subunit structure	Binds GGA1 and GGA2 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein Potential. Membrane › coated pit By similarity.
Tissue specificity	Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte. Ref.1
Sequence similarities	Belongs to the LDLR family. Contains 2 CUB domains. Contains 4 LDL-receptor class A domains.
Sequence caution	The sequence BAG51998.1 differs from that shown. Reason: Erroneous initiation. The sequence BAG59164.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Coated pit Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	receptor-mediated endocytosis Traceable author statement Ref.1. Source: ProtInc
Cellular_component	coated pit Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 36	36	Potential
	Chain	37 – 770	734	Low-density lipoprotein receptor-related protein 3		PRO_0000017323
Regions
	Topological domain	37 – 496	460	Extracellular Potential
	Transmembrane	497 – 517	21	Helical; Potential
	Topological domain	518 – 770	253	Cytoplasmic Potential
	Domain	43 – 159	117	CUB 1
	Domain	165 – 201	37	LDL-receptor class A 1
	Domain	211 – 250	40	LDL-receptor class A 2
	Domain	254 – 365	112	CUB 2
	Domain	415 – 453	39	LDL-receptor class A 3
	Domain	454 – 490	37	LDL-receptor class A 4
	Compositional bias	751 – 754	4	Poly-Pro
Amino acid modifications
	Glycosylation	71	1	N-linked (GlcNAc...) Potential
	Glycosylation	199	1	N-linked (GlcNAc...) Potential
	Glycosylation	359	1	N-linked (GlcNAc...) Potential
	Disulfide bond	43 ↔ 72		By similarity
	Disulfide bond	99 ↔ 120		By similarity
	Disulfide bond	166 ↔ 178		By similarity
	Disulfide bond	173 ↔ 191		By similarity
	Disulfide bond	185 ↔ 200		By similarity
	Disulfide bond	212 ↔ 227		By similarity
	Disulfide bond	219 ↔ 240		By similarity
	Disulfide bond	234 ↔ 249		By similarity
	Disulfide bond	254 ↔ 282		By similarity
	Disulfide bond	416 ↔ 430		By similarity
	Disulfide bond	423 ↔ 443		By similarity
	Disulfide bond	437 ↔ 452		By similarity
	Disulfide bond	455 ↔ 467		By similarity
	Disulfide bond	462 ↔ 480		By similarity
	Disulfide bond	474 ↔ 489		By similarity
Natural variations
	Natural variant	213	1	P → L. Corresponds to variant rs3745978 [ dbSNP | Ensembl ].		VAR_049764
	Natural variant	708	1	V → A. Ref.1 Ref.2 Ref.3 Ref.4 Corresponds to variant rs3745974 [ dbSNP | Ensembl ].		VAR_018171
Experimental info
	Sequence conflict	85	1	T → I in BAG51998. Ref.4
	Sequence conflict	458	1	G → D in BAG51998. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	O75074 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: 5175EDCB7A7D22EE	FASTA	770	82,884
	10 20 30 40 50 60 MEKRAAAGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH TERRGVIYSP 70 80 90 100 110 120 AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS LDWLLLGPAA PPRQEAFRLC 130 140 150 160 170 180 GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ GFRLSYIRGK LGQASCQADE FRCDNGKCLP 190 200 210 220 230 240 GPWQCNTVDE CGDGSDEGNC SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC 250 260 270 280 290 300 GDGSDEAGCP DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD SRRVLLQLEL 310 320 330 340 350 360 RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR ARSAGHGFNA 370 380 390 400 410 420 TYQVKGYCLP WEQPCGSSSD SDGGSLGDQG CFSEPQRCDG WWHCASGRDE QGCPACPPDQ 430 440 450 460 470 480 YPCEGGSGLC YTPADRCNNQ KSCPDGADEK NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC 490 500 510 520 530 540 QDGSDEHGCL AAVPRKVITA ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL 550 560 570 580 590 600 EAEFVRREAP PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS 610 620 630 640 650 660 RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGFL QPAPGAAPDP PAPLMDTGST 670 680 690 700 710 720 RAAGDRPPSA PGRAPEVGPS GPPLPSGLRD PECRPVDKDR KVCREPLVDG PAPADAPREP 730 740 750 760 770 CSAQDPHPQV STASSTLGPH SPEPLGVCRN PPPPCSPMLE ASDDEALLVC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13. 2." Ishii H., Kim D.-H., Fujita T., Endo Y., Saeki S., Yamamoto T.T. Genomics 51:132-135(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ALA-708.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-708. Tissue: Muscle.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-770, VARIANT ALA-708. Tissue: Thalamus.
[4]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-770, VARIANT ALA-708.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB009462 mRNA. Translation: BAA32330.1. BC007408 mRNA. Translation: AAH07408.1. AK074751 mRNA. Translation: BAG51998.1. Different initiation. AK296536 mRNA. Translation: BAG59164.1. Different initiation.
IPI	IPI00000201.
PIR	T00204.
RefSeq	NP_002324.2. NM_002333.3.
UniGene	Hs.515340.
3D structure databases
ProteinModelPortal	O75074.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-201005.
STRING	9606.ENSP00000253193.
PTM databases
PhosphoSite	O75074.
Proteomic databases
PaxDb	O75074.
PRIDE	O75074.
Protocols and materials databases
DNASU	4037.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000253193; ENSP00000253193; ENSG00000130881.
GeneID	4037.
KEGG	hsa:4037.
UCSC	uc002nuk.4. human.
Organism-specific databases
CTD	4037.
GeneCards	GC19P033685.
H-InvDB	HIX0014999.
HGNC	HGNC:6695. LRP3.
MIM	603159. gene.
neXtProt	NX_O75074.
PharmGKB	PA30453.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG242928.
HOGENOM	HOG000013017.
HOVERGEN	HBG049162.
InParanoid	O75074.
OMA	EPLGVCR.
OrthoDB	EOG4BG8VG.
PhylomeDB	O75074.
Gene expression databases
ArrayExpress	O75074.
Bgee	O75074.
CleanEx	HS_LRP3.
Genevestigator	O75074.
GermOnline	ENSG00000130881. Homo sapiens.
Family and domain databases
Gene3D	2.60.120.290. 2 hits. 4.10.400.10. 5 hits.
InterPro	IPR000859. CUB_dom. IPR023415. LDLR_class-A_CS. IPR002172. LDrepeatLR_classA_rpt. [Graphical view]
Pfam	PF00431. CUB. 2 hits. PF00057. Ldl_recept_a. 3 hits. [Graphical view]
SMART	SM00042. CUB. 2 hits. SM00192. LDLa. 5 hits. [Graphical view]
SUPFAM	SSF49854. CUB. 2 hits. SSF57424. LDL_rcpt_classA_cys-rich. 4 hits.
PROSITE	PS01180. CUB. 2 hits. PS01209. LDLRA_1. 3 hits. PS50068. LDLRA_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	LRP3. human.
GenomeRNAi	4037.
NextBio	15814.
SOURCE	Search...

Entry information

Entry name

LRP3_HUMAN

Accession

Primary (citable) accession number: O75074
Secondary accession number(s): B3KQD6, B4DKF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	December 20, 2005
Last modified:	May 1, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.