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Protein

Low-density lipoprotein receptor-related protein 3

Gene

LRP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.

GO - Biological processi

  • receptor-mediated endocytosis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130881-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 3
Short name:
LRP-3
Alternative name(s):
105 kDa low-density lipoprotein receptor-related protein
Short name:
hLRp105
Gene namesi
Name:LRP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6695. LRP3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini37 – 496ExtracellularSequence analysisAdd BLAST460
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21
Topological domaini518 – 770CytoplasmicSequence analysisAdd BLAST253

GO - Cellular componenti

  • clathrin-coated pit Source: UniProtKB-SubCell
  • integral component of membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000130881.
PharmGKBiPA30453.

Polymorphism and mutation databases

BioMutaiLRP3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Sequence analysisAdd BLAST36
ChainiPRO_000001732337 – 770Low-density lipoprotein receptor-related protein 3Add BLAST734

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 72By similarity
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi99 ↔ 120By similarity
Disulfide bondi166 ↔ 178By similarity
Disulfide bondi173 ↔ 191By similarity
Disulfide bondi185 ↔ 200By similarity
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi212 ↔ 227By similarity
Disulfide bondi219 ↔ 240By similarity
Disulfide bondi234 ↔ 249By similarity
Disulfide bondi254 ↔ 282By similarity
Glycosylationi359N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi416 ↔ 430By similarity
Disulfide bondi423 ↔ 443By similarity
Disulfide bondi437 ↔ 452By similarity
Disulfide bondi455 ↔ 467By similarity
Disulfide bondi462 ↔ 480By similarity
Disulfide bondi474 ↔ 489By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75074.
PeptideAtlasiO75074.
PRIDEiO75074.

PTM databases

iPTMnetiO75074.
PhosphoSitePlusiO75074.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte.1 Publication

Gene expression databases

BgeeiENSG00000130881.
CleanExiHS_LRP3.
ExpressionAtlasiO75074. baseline and differential.
GenevisibleiO75074. HS.

Interactioni

Subunit structurei

Binds GGA1 and GGA2.By similarity

Protein-protein interaction databases

BioGridi110217. 1 interactor.
IntActiO75074. 3 interactors.
MINTiMINT-201005.
STRINGi9606.ENSP00000253193.

Structurei

3D structure databases

ProteinModelPortaliO75074.
SMRiO75074.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 159CUB 1PROSITE-ProRule annotationAdd BLAST117
Domaini165 – 201LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST37
Domaini211 – 250LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST40
Domaini254 – 365CUB 2PROSITE-ProRule annotationAdd BLAST112
Domaini415 – 453LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST39
Domaini454 – 490LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi751 – 754Poly-Pro4

Sequence similaritiesi

Belongs to the LDLR family.Curated
Contains 2 CUB domains.PROSITE-ProRule annotation
Contains 4 LDL-receptor class A domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1215. Eukaryota.
ENOG410XP34. LUCA.
GeneTreeiENSGT00810000125405.
HOGENOMiHOG000013017.
HOVERGENiHBG049162.
InParanoidiO75074.
KOiK20050.
OMAiEPCSAQD.
OrthoDBiEOG091G0I9Q.
PhylomeDBiO75074.
TreeFamiTF332149.

Family and domain databases

CDDicd00041. CUB. 2 hits.
Gene3Di2.60.120.290. 2 hits.
4.10.400.10. 5 hits.
InterProiIPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 3 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00042. CUB. 2 hits.
SM00192. LDLa. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF57424. SSF57424. 4 hits.
PROSITEiPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75074-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKRAAAGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH
60 70 80 90 100
TERRGVIYSP AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS
110 120 130 140 150
LDWLLLGPAA PPRQEAFRLC GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ
160 170 180 190 200
GFRLSYIRGK LGQASCQADE FRCDNGKCLP GPWQCNTVDE CGDGSDEGNC
210 220 230 240 250
SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC GDGSDEAGCP
260 270 280 290 300
DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD SRRVLLQLEL
310 320 330 340 350
RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR
360 370 380 390 400
ARSAGHGFNA TYQVKGYCLP WEQPCGSSSD SDGGSLGDQG CFSEPQRCDG
410 420 430 440 450
WWHCASGRDE QGCPACPPDQ YPCEGGSGLC YTPADRCNNQ KSCPDGADEK
460 470 480 490 500
NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC QDGSDEHGCL AAVPRKVITA
510 520 530 540 550
ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL EAEFVRREAP
560 570 580 590 600
PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS
610 620 630 640 650
RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGFL QPAPGAAPDP
660 670 680 690 700
PAPLMDTGST RAAGDRPPSA PGRAPEVGPS GPPLPSGLRD PECRPVDKDR
710 720 730 740 750
KVCREPLVDG PAPADAPREP CSAQDPHPQV STASSTLGPH SPEPLGVCRN
760 770
PPPPCSPMLE ASDDEALLVC
Length:770
Mass (Da):82,884
Last modified:December 20, 2005 - v2
Checksum:i5175EDCB7A7D22EE
GO

Sequence cautioni

The sequence BAG51998 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAG59164 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85T → I in BAG51998 (PubMed:16303743).Curated1
Sequence conflicti458G → D in BAG51998 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049764213P → L.Corresponds to variant rs3745978dbSNPEnsembl.1
Natural variantiVAR_018171708V → A.4 PublicationsCorresponds to variant rs3745974dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009462 mRNA. Translation: BAA32330.1.
BC007408 mRNA. Translation: AAH07408.1.
AK074751 mRNA. Translation: BAG51998.1. Different initiation.
AK296536 mRNA. Translation: BAG59164.1. Different initiation.
CCDSiCCDS12430.1.
PIRiT00204.
RefSeqiNP_002324.2. NM_002333.3.
UniGeneiHs.515340.

Genome annotation databases

EnsembliENST00000253193; ENSP00000253193; ENSG00000130881.
GeneIDi4037.
KEGGihsa:4037.
UCSCiuc010edh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009462 mRNA. Translation: BAA32330.1.
BC007408 mRNA. Translation: AAH07408.1.
AK074751 mRNA. Translation: BAG51998.1. Different initiation.
AK296536 mRNA. Translation: BAG59164.1. Different initiation.
CCDSiCCDS12430.1.
PIRiT00204.
RefSeqiNP_002324.2. NM_002333.3.
UniGeneiHs.515340.

3D structure databases

ProteinModelPortaliO75074.
SMRiO75074.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110217. 1 interactor.
IntActiO75074. 3 interactors.
MINTiMINT-201005.
STRINGi9606.ENSP00000253193.

PTM databases

iPTMnetiO75074.
PhosphoSitePlusiO75074.

Polymorphism and mutation databases

BioMutaiLRP3.

Proteomic databases

PaxDbiO75074.
PeptideAtlasiO75074.
PRIDEiO75074.

Protocols and materials databases

DNASUi4037.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253193; ENSP00000253193; ENSG00000130881.
GeneIDi4037.
KEGGihsa:4037.
UCSCiuc010edh.4. human.

Organism-specific databases

CTDi4037.
GeneCardsiLRP3.
H-InvDBHIX0014999.
HGNCiHGNC:6695. LRP3.
MIMi603159. gene.
neXtProtiNX_O75074.
OpenTargetsiENSG00000130881.
PharmGKBiPA30453.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1215. Eukaryota.
ENOG410XP34. LUCA.
GeneTreeiENSGT00810000125405.
HOGENOMiHOG000013017.
HOVERGENiHBG049162.
InParanoidiO75074.
KOiK20050.
OMAiEPCSAQD.
OrthoDBiEOG091G0I9Q.
PhylomeDBiO75074.
TreeFamiTF332149.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130881-MONOMER.

Miscellaneous databases

ChiTaRSiLRP3. human.
GeneWikiiLRP3.
GenomeRNAii4037.
PROiO75074.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130881.
CleanExiHS_LRP3.
ExpressionAtlasiO75074. baseline and differential.
GenevisibleiO75074. HS.

Family and domain databases

CDDicd00041. CUB. 2 hits.
Gene3Di2.60.120.290. 2 hits.
4.10.400.10. 5 hits.
InterProiIPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 3 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00042. CUB. 2 hits.
SM00192. LDLa. 5 hits.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF57424. SSF57424. 4 hits.
PROSITEiPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRP3_HUMAN
AccessioniPrimary (citable) accession number: O75074
Secondary accession number(s): B3KQD6, B4DKF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 20, 2005
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.