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O75074 (LRP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low-density lipoprotein receptor-related protein 3

Short name=LRP-3
Alternative name(s):
105 kDa low-density lipoprotein receptor-related protein
Short name=hLRp105
Gene names
Name:LRP3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length770 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.

Subunit structure

Binds GGA1 and GGA2 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential. Membranecoated pit By similarity.

Tissue specificity

Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte. Ref.1

Sequence similarities

Belongs to the LDLR family.

Contains 2 CUB domains.

Contains 4 LDL-receptor class A domains.

Sequence caution

The sequence BAG51998.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAG59164.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processEndocytosis
   Cellular componentCoated pit
Membrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processreceptor-mediated endocytosis

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentcoated pit

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3636 Potential
Chain37 – 770734Low-density lipoprotein receptor-related protein 3
PRO_0000017323

Regions

Topological domain37 – 496460Extracellular Potential
Transmembrane497 – 51721Helical; Potential
Topological domain518 – 770253Cytoplasmic Potential
Domain43 – 159117CUB 1
Domain165 – 20137LDL-receptor class A 1
Domain211 – 25040LDL-receptor class A 2
Domain254 – 365112CUB 2
Domain415 – 45339LDL-receptor class A 3
Domain454 – 49037LDL-receptor class A 4
Compositional bias751 – 7544Poly-Pro

Amino acid modifications

Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation3591N-linked (GlcNAc...) Potential
Disulfide bond43 ↔ 72 By similarity
Disulfide bond99 ↔ 120 By similarity
Disulfide bond166 ↔ 178 By similarity
Disulfide bond173 ↔ 191 By similarity
Disulfide bond185 ↔ 200 By similarity
Disulfide bond212 ↔ 227 By similarity
Disulfide bond219 ↔ 240 By similarity
Disulfide bond234 ↔ 249 By similarity
Disulfide bond254 ↔ 282 By similarity
Disulfide bond416 ↔ 430 By similarity
Disulfide bond423 ↔ 443 By similarity
Disulfide bond437 ↔ 452 By similarity
Disulfide bond455 ↔ 467 By similarity
Disulfide bond462 ↔ 480 By similarity
Disulfide bond474 ↔ 489 By similarity

Natural variations

Natural variant2131P → L.
Corresponds to variant rs3745978 [ dbSNP | Ensembl ].
VAR_049764
Natural variant7081V → A. Ref.1 Ref.2 Ref.3 Ref.4
Corresponds to variant rs3745974 [ dbSNP | Ensembl ].
VAR_018171

Experimental info

Sequence conflict851T → I in BAG51998. Ref.4
Sequence conflict4581G → D in BAG51998. Ref.4

Sequences

Sequence LengthMass (Da)Tools
O75074 [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: 5175EDCB7A7D22EE

FASTA77082,884
        10         20         30         40         50         60 
MEKRAAAGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH TERRGVIYSP 

        70         80         90        100        110        120 
AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS LDWLLLGPAA PPRQEAFRLC 

       130        140        150        160        170        180 
GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ GFRLSYIRGK LGQASCQADE FRCDNGKCLP 

       190        200        210        220        230        240 
GPWQCNTVDE CGDGSDEGNC SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC 

       250        260        270        280        290        300 
GDGSDEAGCP DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD SRRVLLQLEL 

       310        320        330        340        350        360 
RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR ARSAGHGFNA 

       370        380        390        400        410        420 
TYQVKGYCLP WEQPCGSSSD SDGGSLGDQG CFSEPQRCDG WWHCASGRDE QGCPACPPDQ 

       430        440        450        460        470        480 
YPCEGGSGLC YTPADRCNNQ KSCPDGADEK NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC 

       490        500        510        520        530        540 
QDGSDEHGCL AAVPRKVITA ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL 

       550        560        570        580        590        600 
EAEFVRREAP PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS 

       610        620        630        640        650        660 
RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGFL QPAPGAAPDP PAPLMDTGST 

       670        680        690        700        710        720 
RAAGDRPPSA PGRAPEVGPS GPPLPSGLRD PECRPVDKDR KVCREPLVDG PAPADAPREP 

       730        740        750        760        770 
CSAQDPHPQV STASSTLGPH SPEPLGVCRN PPPPCSPMLE ASDDEALLVC 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13. 2."
Ishii H., Kim D.-H., Fujita T., Endo Y., Saeki S., Yamamoto T.T.
Genomics 51:132-135(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ALA-708.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-708.
Tissue: Muscle.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-770, VARIANT ALA-708.
Tissue: Thalamus.
[4]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-770, VARIANT ALA-708.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB009462 mRNA. Translation: BAA32330.1.
BC007408 mRNA. Translation: AAH07408.1.
AK074751 mRNA. Translation: BAG51998.1. Different initiation.
AK296536 mRNA. Translation: BAG59164.1. Different initiation.
CCDSCCDS12430.1.
PIRT00204.
RefSeqNP_002324.2. NM_002333.3.
UniGeneHs.515340.

3D structure databases

ProteinModelPortalO75074.
SMRO75074. Positions 43-156, 165-495.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110217. 1 interaction.
IntActO75074. 2 interactions.
MINTMINT-201005.
STRING9606.ENSP00000253193.

PTM databases

PhosphoSiteO75074.

Proteomic databases

PaxDbO75074.
PRIDEO75074.

Protocols and materials databases

DNASU4037.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000253193; ENSP00000253193; ENSG00000130881.
GeneID4037.
KEGGhsa:4037.
UCSCuc002nuk.4. human.

Organism-specific databases

CTD4037.
GeneCardsGC19P033685.
H-InvDBHIX0014999.
HGNCHGNC:6695. LRP3.
MIM603159. gene.
neXtProtNX_O75074.
PharmGKBPA30453.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG242928.
HOGENOMHOG000013017.
HOVERGENHBG049162.
InParanoidO75074.
OMADMITISF.
OrthoDBEOG7PCJG4.
PhylomeDBO75074.
TreeFamTF332149.

Gene expression databases

ArrayExpressO75074.
BgeeO75074.
CleanExHS_LRP3.
GenevestigatorO75074.

Family and domain databases

Gene3D2.60.120.290. 2 hits.
4.10.400.10. 5 hits.
InterProIPR000859. CUB_dom.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamPF00431. CUB. 2 hits.
PF00057. Ldl_recept_a. 3 hits.
[Graphical view]
PRINTSPR00261. LDLRECEPTOR.
SMARTSM00042. CUB. 2 hits.
SM00192. LDLa. 5 hits.
[Graphical view]
SUPFAMSSF49854. SSF49854. 2 hits.
SSF57424. SSF57424. 4 hits.
PROSITEPS01180. CUB. 2 hits.
PS01209. LDLRA_1. 3 hits.
PS50068. LDLRA_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLRP3. human.
GeneWikiLRP3.
GenomeRNAi4037.
NextBio15814.
PROO75074.
SOURCESearch...

Entry information

Entry nameLRP3_HUMAN
AccessionPrimary (citable) accession number: O75074
Secondary accession number(s): B3KQD6, B4DKF2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 20, 2005
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM