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O75074

- LRP3_HUMAN

UniProt

O75074 - LRP3_HUMAN

Protein

Low-density lipoprotein receptor-related protein 3

Gene

LRP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.

    GO - Biological processi

    1. receptor-mediated endocytosis Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Endocytosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low-density lipoprotein receptor-related protein 3
    Short name:
    LRP-3
    Alternative name(s):
    105 kDa low-density lipoprotein receptor-related protein
    Short name:
    hLRp105
    Gene namesi
    Name:LRP3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6695. LRP3.

    Subcellular locationi

    GO - Cellular componenti

    1. coated pit Source: UniProtKB-SubCell
    2. integral component of membrane Source: ProtInc

    Keywords - Cellular componenti

    Coated pit, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30453.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3636Sequence AnalysisAdd
    BLAST
    Chaini37 – 770734Low-density lipoprotein receptor-related protein 3PRO_0000017323Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 72By similarity
    Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 120By similarity
    Disulfide bondi166 ↔ 178By similarity
    Disulfide bondi173 ↔ 191By similarity
    Disulfide bondi185 ↔ 200By similarity
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi212 ↔ 227By similarity
    Disulfide bondi219 ↔ 240By similarity
    Disulfide bondi234 ↔ 249By similarity
    Disulfide bondi254 ↔ 282By similarity
    Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi416 ↔ 430By similarity
    Disulfide bondi423 ↔ 443By similarity
    Disulfide bondi437 ↔ 452By similarity
    Disulfide bondi455 ↔ 467By similarity
    Disulfide bondi462 ↔ 480By similarity
    Disulfide bondi474 ↔ 489By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO75074.
    PRIDEiO75074.

    PTM databases

    PhosphoSiteiO75074.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte.1 Publication

    Gene expression databases

    ArrayExpressiO75074.
    BgeeiO75074.
    CleanExiHS_LRP3.
    GenevestigatoriO75074.

    Interactioni

    Subunit structurei

    Binds GGA1 and GGA2.By similarity

    Protein-protein interaction databases

    BioGridi110217. 1 interaction.
    IntActiO75074. 2 interactions.
    MINTiMINT-201005.
    STRINGi9606.ENSP00000253193.

    Structurei

    3D structure databases

    ProteinModelPortaliO75074.
    SMRiO75074. Positions 43-156, 165-495.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini37 – 496460ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini518 – 770253CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei497 – 51721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 159117CUB 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini165 – 20137LDL-receptor class A 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini211 – 25040LDL-receptor class A 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini254 – 365112CUB 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini415 – 45339LDL-receptor class A 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini454 – 49037LDL-receptor class A 4PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi751 – 7544Poly-Pro

    Sequence similaritiesi

    Belongs to the LDLR family.Curated
    Contains 2 CUB domains.PROSITE-ProRule annotation
    Contains 4 LDL-receptor class A domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG242928.
    HOGENOMiHOG000013017.
    HOVERGENiHBG049162.
    InParanoidiO75074.
    OMAiDMITISF.
    OrthoDBiEOG7PCJG4.
    PhylomeDBiO75074.
    TreeFamiTF332149.

    Family and domain databases

    Gene3Di2.60.120.290. 2 hits.
    4.10.400.10. 5 hits.
    InterProiIPR000859. CUB_dom.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    [Graphical view]
    PfamiPF00431. CUB. 2 hits.
    PF00057. Ldl_recept_a. 3 hits.
    [Graphical view]
    PRINTSiPR00261. LDLRECEPTOR.
    SMARTiSM00042. CUB. 2 hits.
    SM00192. LDLa. 5 hits.
    [Graphical view]
    SUPFAMiSSF49854. SSF49854. 2 hits.
    SSF57424. SSF57424. 4 hits.
    PROSITEiPS01180. CUB. 2 hits.
    PS01209. LDLRA_1. 3 hits.
    PS50068. LDLRA_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O75074-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKRAAAGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH    50
    TERRGVIYSP AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS 100
    LDWLLLGPAA PPRQEAFRLC GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ 150
    GFRLSYIRGK LGQASCQADE FRCDNGKCLP GPWQCNTVDE CGDGSDEGNC 200
    SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC GDGSDEAGCP 250
    DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD SRRVLLQLEL 300
    RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR 350
    ARSAGHGFNA TYQVKGYCLP WEQPCGSSSD SDGGSLGDQG CFSEPQRCDG 400
    WWHCASGRDE QGCPACPPDQ YPCEGGSGLC YTPADRCNNQ KSCPDGADEK 450
    NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC QDGSDEHGCL AAVPRKVITA 500
    ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL EAEFVRREAP 550
    PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS 600
    RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGFL QPAPGAAPDP 650
    PAPLMDTGST RAAGDRPPSA PGRAPEVGPS GPPLPSGLRD PECRPVDKDR 700
    KVCREPLVDG PAPADAPREP CSAQDPHPQV STASSTLGPH SPEPLGVCRN 750
    PPPPCSPMLE ASDDEALLVC 770
    Length:770
    Mass (Da):82,884
    Last modified:December 20, 2005 - v2
    Checksum:i5175EDCB7A7D22EE
    GO

    Sequence cautioni

    The sequence BAG51998.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAG59164.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti85 – 851T → I in BAG51998. (PubMed:16303743)Curated
    Sequence conflicti458 – 4581G → D in BAG51998. (PubMed:16303743)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti213 – 2131P → L.
    Corresponds to variant rs3745978 [ dbSNP | Ensembl ].
    VAR_049764
    Natural varianti708 – 7081V → A.4 Publications
    Corresponds to variant rs3745974 [ dbSNP | Ensembl ].
    VAR_018171

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009462 mRNA. Translation: BAA32330.1.
    BC007408 mRNA. Translation: AAH07408.1.
    AK074751 mRNA. Translation: BAG51998.1. Different initiation.
    AK296536 mRNA. Translation: BAG59164.1. Different initiation.
    CCDSiCCDS12430.1.
    PIRiT00204.
    RefSeqiNP_002324.2. NM_002333.3.
    UniGeneiHs.515340.

    Genome annotation databases

    EnsembliENST00000253193; ENSP00000253193; ENSG00000130881.
    GeneIDi4037.
    KEGGihsa:4037.
    UCSCiuc002nuk.4. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB009462 mRNA. Translation: BAA32330.1 .
    BC007408 mRNA. Translation: AAH07408.1 .
    AK074751 mRNA. Translation: BAG51998.1 . Different initiation.
    AK296536 mRNA. Translation: BAG59164.1 . Different initiation.
    CCDSi CCDS12430.1.
    PIRi T00204.
    RefSeqi NP_002324.2. NM_002333.3.
    UniGenei Hs.515340.

    3D structure databases

    ProteinModelPortali O75074.
    SMRi O75074. Positions 43-156, 165-495.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110217. 1 interaction.
    IntActi O75074. 2 interactions.
    MINTi MINT-201005.
    STRINGi 9606.ENSP00000253193.

    PTM databases

    PhosphoSitei O75074.

    Proteomic databases

    PaxDbi O75074.
    PRIDEi O75074.

    Protocols and materials databases

    DNASUi 4037.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253193 ; ENSP00000253193 ; ENSG00000130881 .
    GeneIDi 4037.
    KEGGi hsa:4037.
    UCSCi uc002nuk.4. human.

    Organism-specific databases

    CTDi 4037.
    GeneCardsi GC19P033685.
    H-InvDB HIX0014999.
    HGNCi HGNC:6695. LRP3.
    MIMi 603159. gene.
    neXtProti NX_O75074.
    PharmGKBi PA30453.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG242928.
    HOGENOMi HOG000013017.
    HOVERGENi HBG049162.
    InParanoidi O75074.
    OMAi DMITISF.
    OrthoDBi EOG7PCJG4.
    PhylomeDBi O75074.
    TreeFami TF332149.

    Miscellaneous databases

    ChiTaRSi LRP3. human.
    GeneWikii LRP3.
    GenomeRNAii 4037.
    NextBioi 15814.
    PROi O75074.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75074.
    Bgeei O75074.
    CleanExi HS_LRP3.
    Genevestigatori O75074.

    Family and domain databases

    Gene3Di 2.60.120.290. 2 hits.
    4.10.400.10. 5 hits.
    InterProi IPR000859. CUB_dom.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    [Graphical view ]
    Pfami PF00431. CUB. 2 hits.
    PF00057. Ldl_recept_a. 3 hits.
    [Graphical view ]
    PRINTSi PR00261. LDLRECEPTOR.
    SMARTi SM00042. CUB. 2 hits.
    SM00192. LDLa. 5 hits.
    [Graphical view ]
    SUPFAMi SSF49854. SSF49854. 2 hits.
    SSF57424. SSF57424. 4 hits.
    PROSITEi PS01180. CUB. 2 hits.
    PS01209. LDLRA_1. 3 hits.
    PS50068. LDLRA_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13. 2."
      Ishii H., Kim D.-H., Fujita T., Endo Y., Saeki S., Yamamoto T.T.
      Genomics 51:132-135(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT ALA-708.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-708.
      Tissue: Muscle.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-770, VARIANT ALA-708.
      Tissue: Thalamus.
    4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-770, VARIANT ALA-708.

    Entry informationi

    Entry nameiLRP3_HUMAN
    AccessioniPrimary (citable) accession number: O75074
    Secondary accession number(s): B3KQD6, B4DKF2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3