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Protein

EF-hand calcium-binding domain-containing protein 14

Gene

EFCAB14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi477 – 48913PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand calcium-binding domain-containing protein 14
Gene namesi
Name:EFCAB14
Synonyms:KIAA0494
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29051. EFCAB14.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671630.

Polymorphism and mutation databases

BioMutaiEFCAB14.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495EF-hand calcium-binding domain-containing protein 14PRO_0000073882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei17 – 171PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75071.
MaxQBiO75071.
PaxDbiO75071.
PeptideAtlasiO75071.
PRIDEiO75071.

PTM databases

iPTMnetiO75071.
PhosphoSiteiO75071.
SwissPalmiO75071.

Expressioni

Gene expression databases

BgeeiO75071.
CleanExiHS_KIAA0494.
ExpressionAtlasiO75071. baseline and differential.
GenevisibleiO75071. HS.

Organism-specific databases

HPAiHPA011224.
HPA011938.

Interactioni

Protein-protein interaction databases

BioGridi115152. 4 interactions.
IntActiO75071. 4 interactions.
STRINGi9606.ENSP00000361001.

Structurei

3D structure databases

ProteinModelPortaliO75071.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini434 – 46330EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini464 – 49532EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIIA. Eukaryota.
ENOG4110MGQ. LUCA.
GeneTreeiENSGT00390000011196.
HOGENOMiHOG000231138.
HOVERGENiHBG052185.
InParanoidiO75071.
OMAiFSMMGDR.
OrthoDBiEOG7V766F.
PhylomeDBiO75071.
TreeFamiTF331353.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKRKELNAL IGLAGDSRRK KPKKGPSSHR LLRTEPPDSD SESSSEEEEE
60 70 80 90 100
FGVVGNRSRF AKGDYLRCCK ICYPLCGFVI LAACVVACVG LVWMQVALKE
110 120 130 140 150
DLDALKEKFR TMESNQKSSF QEIPKLNEEL LSKQKQLEKI ESGEMGLNKV
160 170 180 190 200
WINITEMNKQ ISLLTSAVNH LKANVKSAAD LISLPTTVEG LQKSVASIGN
210 220 230 240 250
TLNSVHLAVE ALQKTVDEHK KTMELLQSDM NQHFLKETPG SNQIIPSPSA
260 270 280 290 300
TSELDNKTHS ENLKQDILYL HNSLEEVNSA LVGYQRQNDL KLEGMNETVS
310 320 330 340 350
NLTQRVNLIE SDVVAMSKVE KKANLSFSMM GDRSATLKRQ SLDQVTNRTD
360 370 380 390 400
TVKIQSIKKE DSSNSQVSKL REKLQLISAL TNKPESNRPP ETADEEQVES
410 420 430 440 450
FTSKPSALPK FSQFLGDPVE KAAQLRPISL PGVSSTEDLQ DLFRKTGQDV
460 470 480 490
DGKLTYQEIW TSLGSAMPEP ESLRAFDSDG DGRYSFLELR VALGI
Length:495
Mass (Da):55,031
Last modified:November 1, 1998 - v1
Checksum:i81170A5169D4B46F
GO

Sequence cautioni

The sequence BAA32328.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti239 – 2391P → S.1 Publication
VAR_074176
Natural varianti337 – 3371L → P.
Corresponds to variant rs6665021 [ dbSNP | Ensembl ].
VAR_048669

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007963 mRNA. Translation: BAA32328.2. Different initiation.
AL593856 Genomic DNA. Translation: CAI16979.1.
CH471059 Genomic DNA. Translation: EAX06893.1.
CH471059 Genomic DNA. Translation: EAX06894.1.
BC002525 mRNA. Translation: AAH02525.1.
CCDSiCCDS30706.1.
RefSeqiNP_055589.1. NM_014774.2.
UniGeneiHs.707688.

Genome annotation databases

EnsembliENST00000371933; ENSP00000361001; ENSG00000159658.
GeneIDi9813.
KEGGihsa:9813.
UCSCiuc001cqk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007963 mRNA. Translation: BAA32328.2. Different initiation.
AL593856 Genomic DNA. Translation: CAI16979.1.
CH471059 Genomic DNA. Translation: EAX06893.1.
CH471059 Genomic DNA. Translation: EAX06894.1.
BC002525 mRNA. Translation: AAH02525.1.
CCDSiCCDS30706.1.
RefSeqiNP_055589.1. NM_014774.2.
UniGeneiHs.707688.

3D structure databases

ProteinModelPortaliO75071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115152. 4 interactions.
IntActiO75071. 4 interactions.
STRINGi9606.ENSP00000361001.

PTM databases

iPTMnetiO75071.
PhosphoSiteiO75071.
SwissPalmiO75071.

Polymorphism and mutation databases

BioMutaiEFCAB14.

Proteomic databases

EPDiO75071.
MaxQBiO75071.
PaxDbiO75071.
PeptideAtlasiO75071.
PRIDEiO75071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371933; ENSP00000361001; ENSG00000159658.
GeneIDi9813.
KEGGihsa:9813.
UCSCiuc001cqk.4. human.

Organism-specific databases

CTDi9813.
GeneCardsiEFCAB14.
HGNCiHGNC:29051. EFCAB14.
HPAiHPA011224.
HPA011938.
neXtProtiNX_O75071.
PharmGKBiPA142671630.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIIA. Eukaryota.
ENOG4110MGQ. LUCA.
GeneTreeiENSGT00390000011196.
HOGENOMiHOG000231138.
HOVERGENiHBG052185.
InParanoidiO75071.
OMAiFSMMGDR.
OrthoDBiEOG7V766F.
PhylomeDBiO75071.
TreeFamiTF331353.

Miscellaneous databases

GenomeRNAii9813.
PROiO75071.

Gene expression databases

BgeeiO75071.
CleanExiHS_KIAA0494.
ExpressionAtlasiO75071. baseline and differential.
GenevisibleiO75071. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.
  6. Cited for: VARIANT SER-239.

Entry informationi

Entry nameiEFC14_HUMAN
AccessioniPrimary (citable) accession number: O75071
Secondary accession number(s): D3DQ23, Q5SXB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.