SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O75069

- TMCC2_HUMAN

UniProt

O75069 - TMCC2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Transmembrane and coiled-coil domains protein 2
Gene
TMCC2, KIAA0481, hucep-11
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane and coiled-coil domains protein 2
Alternative name(s):
Cerebral protein 11
Gene namesi
Name:TMCC2
Synonyms:KIAA0481
ORF Names:hucep-11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:24239. TMCC2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei649 – 66921Helical; Reviewed prediction
Add
BLAST
Transmembranei682 – 70221Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134963344.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 709709Transmembrane and coiled-coil domains protein 2
PRO_0000184597Add
BLAST

Proteomic databases

MaxQBiO75069.
PaxDbiO75069.
PRIDEiO75069.

PTM databases

PhosphoSiteiO75069.

Expressioni

Gene expression databases

ArrayExpressiO75069.
BgeeiO75069.
CleanExiHS_TMCC2.
GenevestigatoriO75069.

Organism-specific databases

HPAiHPA014254.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APOEP026495EBI-726731,EBI-1222467

Protein-protein interaction databases

BioGridi115240. 2 interactions.
IntActiO75069. 4 interactions.
STRINGi9606.ENSP00000350718.

Structurei

3D structure databases

ProteinModelPortaliO75069.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili333 – 36836 Reviewed prediction
Add
BLAST
Coiled coili514 – 633120 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the TEX28 family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG319116.
HOGENOMiHOG000294160.
HOVERGENiHBG057342.
InParanoidiO75069.
OMAiSKPPDLK.
OrthoDBiEOG7W6WKN.
PhylomeDBiO75069.
TreeFamiTF316292.

Family and domain databases

InterProiIPR019394. Predicted_TM_coiled-coil_2.
[Graphical view]
PfamiPF10267. Tmemb_cc2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75069-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKRCRSDELQ QQQGEEDGAG LEDAASHLPG ADLRPGETTG ANSAGGPTSD    50
AGAAAAPNPG PRSKPPDLKK IQQLSEGSMF GHGLKHLFHS RRRSREREHQ 100
TSQDSQQHQQ QQGMSDHDSP DEKERSPEMH RVSYAMSLHD LPARPTAFNR 150
VLQQIRSRPS IKRGASLHSS SGGGSSGSSS RRTKSSSLEP QRGSPHLLRK 200
APQDSSLAAI LHQHQCRPRS SSTTDTALLL ADGSNVYLLA EEAEGIGDKV 250
DKGDLVALSL PAGHGDTDGP ISLDVPDGAP DPQRTKAAID HLHQKILKIT 300
EQIKIEQEAR DDNVAEYLKL ANNADKQQVS RIKQVFEKKN QKSAQTIAQL 350
HKKLEHYRRR LKEIEQNGPS RQPKDVLRDM QQGLKDVGAN VRAGISGFGG 400
GVVEGVKGSL SGLSQATHTA VVSKPREFAS LIRNKFGSAD NIAHLKDPLE 450
DGPPEEAARA LSGSATLVSS PKYGSDDECS SASASSAGAG SNSGAGPGGA 500
LGSPKSNALY GAPGNLDALL EELREIKEGQ SHLEDSMEDL KTQLQRDYTY 550
MTQCLQEERY RYERLEEQLN DLTELHQNEM TNLKQELASM EEKVAYQSYE 600
RARDIQEAVE SCLTRVTKLE LQQQQQQVVQ LEGVENANAR ALLGKFINVI 650
LALMAVLLVF VSTIANFITP LMKTRLRITS TTLLVLVLFL LWKHWDSLTY 700
LLEHVLLPS 709
Length:709
Mass (Da):77,449
Last modified:April 12, 2005 - v3
Checksum:i002993EA6B0E4546
GO
Isoform 2 (identifier: O75069-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.

Note: No experimental confirmation available.

Show »
Length:631
Mass (Da):69,586
Checksum:iB8F8F066BDBB8AFA
GO

Sequence cautioni

The sequence BAA32326.3 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7878Missing in isoform 2.
VSP_046245Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti226 – 24924TALLL…GIGDK → MNQVVQPLMSRHSACRGSQA HLSW in BAB46924. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007950 mRNA. Translation: BAA32326.3. Different initiation.
AK131419 mRNA. Translation: BAD18566.1.
AK293734 mRNA. Translation: BAH11583.1.
BC131629 mRNA. Translation: AAI31630.1.
AC093422 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW91548.1.
AB001596 mRNA. Translation: BAB46924.1.
CCDSiCCDS30984.1. [O75069-1]
CCDS55676.1. [O75069-2]
RefSeqiNP_001229854.1. NM_001242925.1. [O75069-2]
NP_055673.2. NM_014858.3. [O75069-1]
XP_005245741.1. XM_005245684.1. [O75069-2]
XP_005245742.1. XM_005245685.2. [O75069-2]
XP_006711757.1. XM_006711694.1. [O75069-2]
UniGeneiHs.6360.

Genome annotation databases

EnsembliENST00000330675; ENSP00000331842; ENSG00000133069.
ENST00000358024; ENSP00000350718; ENSG00000133069. [O75069-1]
ENST00000545499; ENSP00000437943; ENSG00000133069. [O75069-2]
GeneIDi9911.
KEGGihsa:9911.
UCSCiuc001hca.3. human. [O75069-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB007950 mRNA. Translation: BAA32326.3 . Different initiation.
AK131419 mRNA. Translation: BAD18566.1 .
AK293734 mRNA. Translation: BAH11583.1 .
BC131629 mRNA. Translation: AAI31630.1 .
AC093422 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW91548.1 .
AB001596 mRNA. Translation: BAB46924.1 .
CCDSi CCDS30984.1. [O75069-1 ]
CCDS55676.1. [O75069-2 ]
RefSeqi NP_001229854.1. NM_001242925.1. [O75069-2 ]
NP_055673.2. NM_014858.3. [O75069-1 ]
XP_005245741.1. XM_005245684.1. [O75069-2 ]
XP_005245742.1. XM_005245685.2. [O75069-2 ]
XP_006711757.1. XM_006711694.1. [O75069-2 ]
UniGenei Hs.6360.

3D structure databases

ProteinModelPortali O75069.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115240. 2 interactions.
IntActi O75069. 4 interactions.
STRINGi 9606.ENSP00000350718.

PTM databases

PhosphoSitei O75069.

Proteomic databases

MaxQBi O75069.
PaxDbi O75069.
PRIDEi O75069.

Protocols and materials databases

DNASUi 9911.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330675 ; ENSP00000331842 ; ENSG00000133069 .
ENST00000358024 ; ENSP00000350718 ; ENSG00000133069 . [O75069-1 ]
ENST00000545499 ; ENSP00000437943 ; ENSG00000133069 . [O75069-2 ]
GeneIDi 9911.
KEGGi hsa:9911.
UCSCi uc001hca.3. human. [O75069-1 ]

Organism-specific databases

CTDi 9911.
GeneCardsi GC01P205197.
H-InvDB HIX0160023.
HGNCi HGNC:24239. TMCC2.
HPAi HPA014254.
neXtProti NX_O75069.
PharmGKBi PA134963344.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG319116.
HOGENOMi HOG000294160.
HOVERGENi HBG057342.
InParanoidi O75069.
OMAi SKPPDLK.
OrthoDBi EOG7W6WKN.
PhylomeDBi O75069.
TreeFami TF316292.

Miscellaneous databases

ChiTaRSi TMCC2. human.
GenomeRNAii 9911.
NextBioi 37387.
PROi O75069.

Gene expression databases

ArrayExpressi O75069.
Bgeei O75069.
CleanExi HS_TMCC2.
Genevestigatori O75069.

Family and domain databases

InterProi IPR019394. Predicted_TM_coiled-coil_2.
[Graphical view ]
Pfami PF10267. Tmemb_cc2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. Ohara O., Nagase T., Kikuno R.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Cerebellum.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "Molecular cloning of a gene specifically expressed in human central nervous system."
    Yoshimoto M., Yazaki M., Takayama K., Matsumoto K., Tsuritani K.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 226-709 (ISOFORMS 1/2).
    Tissue: Brain.

Entry informationi

Entry nameiTMCC2_HUMAN
AccessioniPrimary (citable) accession number: O75069
Secondary accession number(s): A2RRH3, B7Z1P7, Q6ZN09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 12, 2005
Last modified: July 9, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi