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O75069 (TMCC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane and coiled-coil domains protein 2
Alternative name(s):
Cerebral protein 11
Gene names
Name:TMCC2
Synonyms:KIAA0481
ORF Names:hucep-11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length709 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TEX28 family.

Sequence caution

The sequence BAA32326.3 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 21593558. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

APOEP026495EBI-726731,EBI-1222467

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O75069-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O75069-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 709709Transmembrane and coiled-coil domains protein 2
PRO_0000184597

Regions

Transmembrane649 – 66921Helical; Potential
Transmembrane682 – 70221Helical; Potential
Coiled coil333 – 36836 Potential
Coiled coil514 – 633120 Potential

Natural variations

Alternative sequence1 – 7878Missing in isoform 2.
VSP_046245

Experimental info

Sequence conflict226 – 24924TALLL…GIGDK → MNQVVQPLMSRHSACRGSQA HLSW in BAB46924. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 12, 2005. Version 3.
Checksum: 002993EA6B0E4546

FASTA70977,449
        10         20         30         40         50         60 
MKRCRSDELQ QQQGEEDGAG LEDAASHLPG ADLRPGETTG ANSAGGPTSD AGAAAAPNPG 

        70         80         90        100        110        120 
PRSKPPDLKK IQQLSEGSMF GHGLKHLFHS RRRSREREHQ TSQDSQQHQQ QQGMSDHDSP 

       130        140        150        160        170        180 
DEKERSPEMH RVSYAMSLHD LPARPTAFNR VLQQIRSRPS IKRGASLHSS SGGGSSGSSS 

       190        200        210        220        230        240 
RRTKSSSLEP QRGSPHLLRK APQDSSLAAI LHQHQCRPRS SSTTDTALLL ADGSNVYLLA 

       250        260        270        280        290        300 
EEAEGIGDKV DKGDLVALSL PAGHGDTDGP ISLDVPDGAP DPQRTKAAID HLHQKILKIT 

       310        320        330        340        350        360 
EQIKIEQEAR DDNVAEYLKL ANNADKQQVS RIKQVFEKKN QKSAQTIAQL HKKLEHYRRR 

       370        380        390        400        410        420 
LKEIEQNGPS RQPKDVLRDM QQGLKDVGAN VRAGISGFGG GVVEGVKGSL SGLSQATHTA 

       430        440        450        460        470        480 
VVSKPREFAS LIRNKFGSAD NIAHLKDPLE DGPPEEAARA LSGSATLVSS PKYGSDDECS 

       490        500        510        520        530        540 
SASASSAGAG SNSGAGPGGA LGSPKSNALY GAPGNLDALL EELREIKEGQ SHLEDSMEDL 

       550        560        570        580        590        600 
KTQLQRDYTY MTQCLQEERY RYERLEEQLN DLTELHQNEM TNLKQELASM EEKVAYQSYE 

       610        620        630        640        650        660 
RARDIQEAVE SCLTRVTKLE LQQQQQQVVQ LEGVENANAR ALLGKFINVI LALMAVLLVF 

       670        680        690        700 
VSTIANFITP LMKTRLRITS TTLLVLVLFL LWKHWDSLTY LLEHVLLPS 

« Hide

Isoform 2 [UniParc].

Checksum: B8F8F066BDBB8AFA
Show »

FASTA63169,586

References

« Hide 'large scale' references
[1]"Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]Ohara O., Nagase T., Kikuno R.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Cerebellum.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]"Molecular cloning of a gene specifically expressed in human central nervous system."
Yoshimoto M., Yazaki M., Takayama K., Matsumoto K., Tsuritani K.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 226-709 (ISOFORMS 1/2).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB007950 mRNA. Translation: BAA32326.3. Different initiation.
AK131419 mRNA. Translation: BAD18566.1.
AK293734 mRNA. Translation: BAH11583.1.
BC131629 mRNA. Translation: AAI31630.1.
AC093422 Genomic DNA. No translation available.
CH471067 Genomic DNA. Translation: EAW91548.1.
AB001596 mRNA. Translation: BAB46924.1.
CCDSCCDS30984.1. [O75069-1]
CCDS55676.1. [O75069-2]
RefSeqNP_001229854.1. NM_001242925.1. [O75069-2]
NP_055673.2. NM_014858.3. [O75069-1]
XP_005245741.1. XM_005245684.1. [O75069-2]
XP_005245742.1. XM_005245685.2. [O75069-2]
XP_006711757.1. XM_006711694.1. [O75069-2]
UniGeneHs.6360.

3D structure databases

ProteinModelPortalO75069.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115240. 2 interactions.
IntActO75069. 4 interactions.
STRING9606.ENSP00000350718.

PTM databases

PhosphoSiteO75069.

Proteomic databases

MaxQBO75069.
PaxDbO75069.
PRIDEO75069.

Protocols and materials databases

DNASU9911.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330675; ENSP00000331842; ENSG00000133069.
ENST00000358024; ENSP00000350718; ENSG00000133069. [O75069-1]
ENST00000545499; ENSP00000437943; ENSG00000133069. [O75069-2]
GeneID9911.
KEGGhsa:9911.
UCSCuc001hca.3. human. [O75069-1]

Organism-specific databases

CTD9911.
GeneCardsGC01P205197.
H-InvDBHIX0160023.
HGNCHGNC:24239. TMCC2.
HPAHPA014254.
neXtProtNX_O75069.
PharmGKBPA134963344.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG319116.
HOGENOMHOG000294160.
HOVERGENHBG057342.
InParanoidO75069.
OMASKPPDLK.
OrthoDBEOG7W6WKN.
PhylomeDBO75069.
TreeFamTF316292.

Gene expression databases

ArrayExpressO75069.
BgeeO75069.
CleanExHS_TMCC2.
GenevestigatorO75069.

Family and domain databases

InterProIPR019394. Predicted_TM_coiled-coil_2.
[Graphical view]
PfamPF10267. Tmemb_cc2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTMCC2. human.
GenomeRNAi9911.
NextBio37387.
PROO75069.

Entry information

Entry nameTMCC2_HUMAN
AccessionPrimary (citable) accession number: O75069
Secondary accession number(s): A2RRH3, B7Z1P7, Q6ZN09
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 12, 2005
Last modified: July 9, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM