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Protein

DENN domain-containing protein 4B

Gene

DENND4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.1 Publication

GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  • membrane organization Source: Reactome
  • regulation of Rab protein signal transduction Source: FlyBase

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-HSA-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
DENN domain-containing protein 4B
Gene namesi
Name:DENND4B
Synonyms:KIAA0476
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000198837.9.
HGNCiHGNC:29044. DENND4B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198837.
PharmGKBiPA142671629.

Polymorphism and mutation databases

BioMutaiDENND4B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003046781 – 1496DENN domain-containing protein 4BAdd BLAST1496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei953PhosphoserineCombined sources1
Modified residuei1092PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO75064.
MaxQBiO75064.
PaxDbiO75064.
PeptideAtlasiO75064.
PRIDEiO75064.

PTM databases

iPTMnetiO75064.
PhosphoSitePlusiO75064.

Expressioni

Gene expression databases

BgeeiENSG00000198837.
CleanExiHS_DENND4B.
ExpressionAtlasiO75064. baseline and differential.
GenevisibleiO75064. HS.

Organism-specific databases

HPAiHPA040188.

Interactioni

GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

Protein-protein interaction databases

BioGridi115238. 2 interactors.
IntActiO75064. 4 interactors.
STRINGi9606.ENSP00000354597.

Structurei

3D structure databases

ProteinModelPortaliO75064.
SMRiO75064.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 203MABPAdd BLAST160
Domaini195 – 369uDENNAdd BLAST175
Domaini390 – 526cDENNAdd BLAST137
Domaini528 – 644dDENNAdd BLAST117
Repeati775 – 811PPR 1Add BLAST37
Repeati812 – 846PPR 2Add BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi886 – 923Gln-richAdd BLAST38
Compositional biasi1106 – 1158Ser-richAdd BLAST53

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IQM7. Eukaryota.
ENOG410XRZT. LUCA.
GeneTreeiENSGT00760000118819.
HOGENOMiHOG000231590.
HOVERGENiHBG058313.
InParanoidiO75064.
KOiK20163.
OMAiYSVSGPH.
OrthoDBiEOG091G00CV.
PhylomeDBiO75064.
TreeFamiTF313237.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR005112. dDENN_dom.
IPR001194. DENN_dom.
IPR023341. MABP.
IPR002885. Pentatricopeptide_repeat.
IPR005113. uDENN_dom.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
PfamiView protein in Pfam
PF03455. dDENN. 1 hit.
PF02141. DENN. 1 hit.
PF03456. uDENN. 1 hit.
SMARTiView protein in SMART
SM00801. dDENN. 1 hit.
SM00799. DENN. 1 hit.
SM00800. uDENN. 1 hit.
PROSITEiView protein in PROSITE
PS50211. DENN. 1 hit.
PS51498. MABP. 1 hit.
PS51375. PPR. 1 hit.

Sequencei

Sequence statusi: Complete.

O75064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEERPPRLV DYFVVAGLAG NGAPIPEETW VPEPSGPLRP PRPAEPITDV
60 70 80 90 100
AVIARALGEE VPQGYTCIQA SAGGHPLELS AGLLGGTQPV ICYRRGRDKP
110 120 130 140 150
PLVELGVLYE GKERPKPGFQ VLDTTPYSHS ANLAPPGPGH PRTYLTYRRA
160 170 180 190 200
AEGAGLHALG ITDLCLVLPS KGEGTPHTYC RLPRNLNPGM WGPAVYLCYK
210 220 230 240 250
VGLAKANTLV YEAELLGRYP EEDNEAFPLP ESVPVFCLPM GATIECWPAQ
260 270 280 290 300
TKYPVPVFST FVLTGAAGDK VYGAALQFYE AFPRARLSER QARALGLLSA
310 320 330 340 350
VERGRALGGR AVRSRRAIAV LSRWPAFPAF RAFLTFLYRY SVSGPHRLPL
360 370 380 390 400
EAHISHFIHN VPFPSPQRPR ILVQMSPYDN LLLCQPVSSP LPLSGASFLQ
410 420 430 440 450
LLQSLGPELA ITLLLAVLTE HKLLVHSLRP DLLTSVCEAL VSMIFPLHWQ
460 470 480 490 500
CPYIPLCPLV LADVLSAPVP FIVGIHSSYF DLHDPPADVI CVDLDTNTLF
510 520 530 540 550
QTEEKKLLSP RTLPRRPYKV LLATLTNLYQ QLDQTYTGPE EEASLEFLLT
560 570 580 590 600
DYEAVCGRRA RLEREVQGAF LRFMACLLKG YRVFLRPLTQ APSEGARDVD
610 620 630 640 650
NLFFLQGFLK SRERSSHKLY SQLLHTQMFS QFIEECSFGS ARHAALEFFD
660 670 680 690 700
SCVEKVHPEQ EKPEPTPLVE LEELSGSELT VFITPPEEPA LPEGSESTPQ
710 720 730 740 750
YCYDGFPELR AELFESLQEQ PGALPVPGPS RSAPSSPAPR RTKQEMKVAQ
760 770 780 790 800
RMAQKSAAVP ELWARCLLGH CYGLWFLCLP AYVRSAPSRV QALHTAYHVL
810 820 830 840 850
RQMESGKVVL PDEVCYRVLM QLCSHYGQPV LSVRVMLEMR QAGIVPNTIT
860 870 880 890 900
YGYYNKAVLE SKWPSGTPGG RLRWAKLRNV VLGAAQFRQP LRERQQQQQQ
910 920 930 940 950
QQQQQQQQQQ EQVSAHQEAG SSQAEPYLER PSPTRPLQRQ TTWAGRSLRD
960 970 980 990 1000
PASPPGRLVK SGSLGSARGA QPTVEAGVAH MIEALGVLEP RGSPVPWHDG
1010 1020 1030 1040 1050
SLSDLSLTGE EPLPGGSPGG SGSALSAQST EALEGLSGRG PKAGGRQDEA
1060 1070 1080 1090 1100
GTPRRGLGAR LQQLLTPSRH SPASRIPPPE LPPDLPPPAR RSPMDSLLHP
1110 1120 1130 1140 1150
RERPGSTASE SSASLGSEWD LSESSLSNLS LRRSSERLSD TPGSFQSPSL
1160 1170 1180 1190 1200
EILLSSCSLC RACDSLVYDE EIMAGWAPDD SNLNTTCPFC ACPFVPLLSV
1210 1220 1230 1240 1250
QTLDSRPSVP SPKSAGASGS KDAPVPGGPG PVLSDRRLCL ALDEPQLCNG
1260 1270 1280 1290 1300
HMGGASRRVE SGAWAYLSPL VLRKELESLV ENEGSEVLAL PELPSAHPII
1310 1320 1330 1340 1350
FWNLLWYFQR LRLPSILPGL VLASCDGPSH SQAPSPWLTP DPASVQVRLL
1360 1370 1380 1390 1400
WDVLTPDPNS CPPLYVLWRV HSQIPQRVVW PGPVPASLSL ALLESVLRHV
1410 1420 1430 1440 1450
GLNEVHKAVG LLLETLGPPP TGLHLQRGIY REILFLTMAA LGKDHVDIVA
1460 1470 1480 1490
FDKKYKSAFN KLASSMGKEE LRHRRAQMPT PKAIDCRKCF GAPPEC
Length:1,496
Mass (Da):163,847
Last modified:September 11, 2007 - v4
Checksum:iA852570682E7C62A
GO

Sequence cautioni

The sequence BAA32321 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI14016 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAW53268 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007945 mRNA. Translation: BAA32321.3. Different initiation.
AL358472 Genomic DNA. Translation: CAI14016.1. Sequence problems.
CH471121 Genomic DNA. Translation: EAW53268.1. Sequence problems.
CCDSiCCDS44228.1.
PIRiT00257.
RefSeqiNP_055671.2. NM_014856.2.
XP_005245736.1. XM_005245679.2.
UniGeneiHs.744878.

Genome annotation databases

EnsembliENST00000361217; ENSP00000354597; ENSG00000198837.
GeneIDi9909.
KEGGihsa:9909.
UCSCiuc001fdd.2. human.

Similar proteinsi

Entry informationi

Entry nameiDEN4B_HUMAN
AccessioniPrimary (citable) accession number: O75064
Secondary accession number(s): Q5T4K0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 22, 2017
This is version 123 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM