O75061 (AUXI_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative tyrosine-protein phosphatase auxilin
EC=3.1.3.48

Alternative name(s):
DnaJ homolog subfamily C member 6

Gene names

Name:	DNAJC6
Synonyms:	KIAA0473

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	913 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subunit structure	Interacts with HSPA8/HSC70. Interacts with CLTC. Interacts with AP2A2 By similarity.
Sequence similarities	Contains 1 C2 tensin-type domain. Contains 1 J domain. Contains 1 phosphatase tensin-type domain.
Sequence caution	The sequence BAA32318.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat SH3-binding
Molecular function	Chaperone Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular membrane organization Traceable author statement. Source: Reactome peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC post-Golgi vesicle-mediated transport Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75061-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75061-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MKDSENK → MSLLGSYRKKTSNDGYESLQLVDSNGDLSAGSGGVGGKQRVNAGAAARSPARQPPDRASTMDSS

Isoform 3 (identifier: O75061-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.
     456-913: Missing.

Isoform 4 (identifier: O75061-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 913	913	Putative tyrosine-protein phosphatase auxilin		PRO_0000244516
Regions
	Repeat	36 – 39	4	1
	Repeat	40 – 43	4	2
	Repeat	44 – 47	4	3
	Domain	55 – 222	168	Phosphatase tensin-type
	Domain	228 – 366	139	C2 tensin-type
	Domain	849 – 913	65	J
	Region	36 – 47	12	3 X 4 AA approximate tandem repeats
	Motif	409 – 417	9	SH3-binding Potential
	Compositional bias	466 – 760	295	Pro-rich
	Compositional bias	529 – 532	4	Poly-Gly
Sites
	Active site	164	1	Phosphocysteine intermediate Potential
Amino acid modifications
	Modified residue	563	1	Phosphoserine Ref.6
	Modified residue	570	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	1 – 13	13	Missing in isoform 3 and isoform 4.		VSP_019579
	Alternative sequence	1 – 7	7	MKDSENK → MSLLGSYRKKTSNDGYESLQ LVDSNGDLSAGSGGVGGKQR VNAGAAARSPARQPPDRAST MDSS in isoform 2.		VSP_019580
	Alternative sequence	456 – 913	458	Missing in isoform 3.		VSP_019581
	Natural variant	671	1	S → N. Corresponds to variant rs4915691 [ dbSNP | Ensembl ].		VAR_026908
Experimental info
	Sequence conflict	178	1	M → V in BAH12344. Ref.2
	Sequence conflict	425	1	F → S in AAH51722. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 27, 2006. Version 3. Checksum: 7B7187AAC8ADF2E4	FASTA	913	99,997
	10 20 30 40 50 60 MKDSENKGAS SPDMEPSYGG GLFDMVKGGA GRLFSNLKDN LKDTLKDTSS RVIQSVTSYT 70 80 90 100 110 120 KGDLDFTYVT SRIIVMSFPL DNVDIGFRNQ VDDIRSFLDS RHLDHYTVYN LSPKSYRTAK 130 140 150 160 170 180 FHSRVSECSW PIRQAPSLHN LFAVCRNMYN WLLQNPKNVC VVHCLDGRAA SSILVGAMFI 190 200 210 220 230 240 FCNLYSTPGP AIRLLYAKRP GIGLSPSHRR YLGYMCDLLA DKPYRPHFKP LTIKSITVSP 250 260 270 280 290 300 IPFFNKQRNG CRPYCDVLIG ETKIYSTCTD FERMKEYRVQ DGKIFIPLNI TVQGDVVVSM 310 320 330 340 350 360 YHLRSTIGSR LQAKVTNTQI FQLQFHTGFI PLDTTVLKFT KPELDACDVP EKYPQLFQVT 370 380 390 400 410 420 LDVELQPHDK VIDLTPPWEH YCTKDVNPSI LFSSHQEHQD TLALGGQAPI DIPPDNPRHY 430 440 450 460 470 480 GQSGFFASLC WQDQKSEKSF CEEDHAALVN QESEQSDDEL LTLSSPHGNA NGDKPHGVKK 490 500 510 520 530 540 PSKKQQEPAA PPPPEDVDLL GLEGSAMSNS FSPPAAPPTN SELLSDLFGG GGAAGPTQAG 550 560 570 580 590 600 QSGVEDVFHP SGPASTQSTP RRSATSTSAS PTLRVGEGAT FDPFGAPSKP SGQDLLGSFL 610 620 630 640 650 660 NTSSASSDPF LQPTRSPSPT VHASSTPAVN IQPDVSGGWD WHAKPGGFGM GSKSAATSPT 670 680 690 700 710 720 GSSHGTPTHQ SKPQTLDPFA DLGTLGSSSF ASKPTTPTGL GGGFPPLSSP QKASPQPMGG 730 740 750 760 770 780 GWQQGGAYNW QQPQPKPQPS MPHSSPQNRP NYNVSFSAMP GGQNERGKGS SNLEGKQKAA 790 800 810 820 830 840 DFEDLLSGQG FNAHKDKKGP RTIAEMRKEE MAKEMDPEKL KILEWIEGKE RNIRALLSTM 850 860 870 880 890 900 HTVLWAGETK WKPVGMADLV TPEQVKKVYR KAVLVVHPDK ATGQPYEQYA KMIFMELNDA 910 WSEFENQGQK PLY
	Isoform 2 [UniParc]. Checksum: C976C4BB3072DCC7	FASTA	970	105,675
	10 20 30 40 50 60 MSLLGSYRKK TSNDGYESLQ LVDSNGDLSA GSGGVGGKQR VNAGAAARSP ARQPPDRAST 70 80 90 100 110 120 MDSSGASSPD MEPSYGGGLF DMVKGGAGRL FSNLKDNLKD TLKDTSSRVI QSVTSYTKGD 130 140 150 160 170 180 LDFTYVTSRI IVMSFPLDNV DIGFRNQVDD IRSFLDSRHL DHYTVYNLSP KSYRTAKFHS 190 200 210 220 230 240 RVSECSWPIR QAPSLHNLFA VCRNMYNWLL QNPKNVCVVH CLDGRAASSI LVGAMFIFCN 250 260 270 280 290 300 LYSTPGPAIR LLYAKRPGIG LSPSHRRYLG YMCDLLADKP YRPHFKPLTI KSITVSPIPF 310 320 330 340 350 360 FNKQRNGCRP YCDVLIGETK IYSTCTDFER MKEYRVQDGK IFIPLNITVQ GDVVVSMYHL 370 380 390 400 410 420 RSTIGSRLQA KVTNTQIFQL QFHTGFIPLD TTVLKFTKPE LDACDVPEKY PQLFQVTLDV 430 440 450 460 470 480 ELQPHDKVID LTPPWEHYCT KDVNPSILFS SHQEHQDTLA LGGQAPIDIP PDNPRHYGQS 490 500 510 520 530 540 GFFASLCWQD QKSEKSFCEE DHAALVNQES EQSDDELLTL SSPHGNANGD KPHGVKKPSK 550 560 570 580 590 600 KQQEPAAPPP PEDVDLLGLE GSAMSNSFSP PAAPPTNSEL LSDLFGGGGA AGPTQAGQSG 610 620 630 640 650 660 VEDVFHPSGP ASTQSTPRRS ATSTSASPTL RVGEGATFDP FGAPSKPSGQ DLLGSFLNTS 670 680 690 700 710 720 SASSDPFLQP TRSPSPTVHA SSTPAVNIQP DVSGGWDWHA KPGGFGMGSK SAATSPTGSS 730 740 750 760 770 780 HGTPTHQSKP QTLDPFADLG TLGSSSFASK PTTPTGLGGG FPPLSSPQKA SPQPMGGGWQ 790 800 810 820 830 840 QGGAYNWQQP QPKPQPSMPH SSPQNRPNYN VSFSAMPGGQ NERGKGSSNL EGKQKAADFE 850 860 870 880 890 900 DLLSGQGFNA HKDKKGPRTI AEMRKEEMAK EMDPEKLKIL EWIEGKERNI RALLSTMHTV 910 920 930 940 950 960 LWAGETKWKP VGMADLVTPE QVKKVYRKAV LVVHPDKATG QPYEQYAKMI FMELNDAWSE 970 FENQGQKPLY
	Isoform 3 [UniParc]. Checksum: 5E7AB1E840DADD6A	FASTA	442	50,302
	10 20 30 40 50 60 MEPSYGGGLF DMVKGGAGRL FSNLKDNLKD TLKDTSSRVI QSVTSYTKGD LDFTYVTSRI 70 80 90 100 110 120 IVMSFPLDNV DIGFRNQVDD IRSFLDSRHL DHYTVYNLSP KSYRTAKFHS RVSECSWPIR 130 140 150 160 170 180 QAPSLHNLFA VCRNMYNWLL QNPKNVCVVH CLDGRAASSI LVGAMFIFCN LYSTPGPAIR 190 200 210 220 230 240 LLYAKRPGIG LSPSHRRYLG YMCDLLADKP YRPHFKPLTI KSITVSPIPF FNKQRNGCRP 250 260 270 280 290 300 YCDVLIGETK IYSTCTDFER MKEYRVQDGK IFIPLNITVQ GDVVVSMYHL RSTIGSRLQA 310 320 330 340 350 360 KVTNTQIFQL QFHTGFIPLD TTVLKFTKPE LDACDVPEKY PQLFQVTLDV ELQPHDKVID 370 380 390 400 410 420 LTPPWEHYCT KDVNPSILFS SHQEHQDTLA LGGQAPIDIP PDNPRHYGQS GFFASLCWQD 430 440 QKSEKSFCEE DHAALVNQES EQ
	Isoform 4 [UniParc]. Checksum: 6FD4AB1358FF52E9	FASTA	900	98,649
	10 20 30 40 50 60 MEPSYGGGLF DMVKGGAGRL FSNLKDNLKD TLKDTSSRVI QSVTSYTKGD LDFTYVTSRI 70 80 90 100 110 120 IVMSFPLDNV DIGFRNQVDD IRSFLDSRHL DHYTVYNLSP KSYRTAKFHS RVSECSWPIR 130 140 150 160 170 180 QAPSLHNLFA VCRNMYNWLL QNPKNVCVVH CLDGRAASSI LVGAMFIFCN LYSTPGPAIR 190 200 210 220 230 240 LLYAKRPGIG LSPSHRRYLG YMCDLLADKP YRPHFKPLTI KSITVSPIPF FNKQRNGCRP 250 260 270 280 290 300 YCDVLIGETK IYSTCTDFER MKEYRVQDGK IFIPLNITVQ GDVVVSMYHL RSTIGSRLQA 310 320 330 340 350 360 KVTNTQIFQL QFHTGFIPLD TTVLKFTKPE LDACDVPEKY PQLFQVTLDV ELQPHDKVID 370 380 390 400 410 420 LTPPWEHYCT KDVNPSILFS SHQEHQDTLA LGGQAPIDIP PDNPRHYGQS GFFASLCWQD 430 440 450 460 470 480 QKSEKSFCEE DHAALVNQES EQSDDELLTL SSPHGNANGD KPHGVKKPSK KQQEPAAPPP 490 500 510 520 530 540 PEDVDLLGLE GSAMSNSFSP PAAPPTNSEL LSDLFGGGGA AGPTQAGQSG VEDVFHPSGP 550 560 570 580 590 600 ASTQSTPRRS ATSTSASPTL RVGEGATFDP FGAPSKPSGQ DLLGSFLNTS SASSDPFLQP 610 620 630 640 650 660 TRSPSPTVHA SSTPAVNIQP DVSGGWDWHA KPGGFGMGSK SAATSPTGSS HGTPTHQSKP 670 680 690 700 710 720 QTLDPFADLG TLGSSSFASK PTTPTGLGGG FPPLSSPQKA SPQPMGGGWQ QGGAYNWQQP 730 740 750 760 770 780 QPKPQPSMPH SSPQNRPNYN VSFSAMPGGQ NERGKGSSNL EGKQKAADFE DLLSGQGFNA 790 800 810 820 830 840 HKDKKGPRTI AEMRKEEMAK EMDPEKLKIL EWIEGKERNI RALLSTMHTV LWAGETKWKP 850 860 870 880 890 900 VGMADLVTPE QVKKVYRKAV LVVHPDKATG QPYEQYAKMI FMELNDAWSE FENQGQKPLY

References

[1]	"Characterization of cDNA clones in size-fractionated cDNA libraries from human brain." Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O. DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Thalamus.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-563 AND SER-570, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB007942 mRNA. Translation: BAA32318.2. Different initiation. AK296408 mRNA. Translation: BAH12344.1. AL139294, AL355487, AC119800 Genomic DNA. Translation: CAI18997.1. AL139294, AL355487, AC119800 Genomic DNA. Translation: CAI18999.1. AL355487, AC119800, AL139294 Genomic DNA. Translation: CAI23547.1. AL355487, AC119800, AL139294 Genomic DNA. Translation: CAI23548.1. AL356212 Genomic DNA. No translation available. CH471059 Genomic DNA. Translation: EAX06533.1. CH471059 Genomic DNA. Translation: EAX06534.1. CH471059 Genomic DNA. Translation: EAX06536.1. CH471059 Genomic DNA. Translation: EAX06537.1. BC051722 mRNA. Translation: AAH51722.1. BC109279 mRNA. Translation: AAI09280.2. BC109280 mRNA. Translation: AAI09281.2.
IPI	IPI00184119. IPI00639806. IPI00760699.
RefSeq	NP_001243793.1. NM_001256864.1. NP_001243794.1. NM_001256865.1. NP_055602.1. NM_014787.3.
UniGene	Hs.647643.
3D structure databases
ProteinModelPortal	O75061.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000378735.
PTM databases
PhosphoSite	O75061.
Proteomic databases
PaxDb	O75061.
PRIDE	O75061.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263441; ENSP00000263441; ENSG00000116675. ENST00000371069; ENSP00000360108; ENSG00000116675. ENST00000395325; ENSP00000378735; ENSG00000116675.
GeneID	9829.
KEGG	hsa:9829.
UCSC	uc001dcc.1. human. uc001dce.1. human.
Organism-specific databases
CTD	9829.
GeneCards	GC01P065714.
HGNC	HGNC:15469. DNAJC6.
HPA	HPA031182.
MIM	608375. gene.
neXtProt	NX_O75061.
PharmGKB	PA27423.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG269956.
HOGENOM	HOG000034235.
HOVERGEN	HBG004322.
KO	K09526.
OMA	LCWQDQK.
OrthoDB	EOG4T4CTX.
Enzyme and pathway databases
Reactome	REACT_11123. Membrane Trafficking.
Gene expression databases
ArrayExpress	O75061.
Bgee	O75061.
CleanEx	HS_DNAJC6.
Genevestigator	O75061.
GermOnline	ENSG00000116675. Homo sapiens.
Family and domain databases
Gene3D	1.10.287.110. 1 hit.
InterPro	IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR001623. DnaJ_domain. IPR014019. Phosphatase_tensin-typ. IPR014020. Tensin_phosphatase_C2-dom. [Graphical view]
Pfam	PF00226. DnaJ. 1 hit. PF10409. PTEN_C2. 1 hit. [Graphical view]
SMART	SM00271. DnaJ. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF46565. DnaJ_N. 1 hit.
PROSITE	PS51182. C2_TENSIN. 1 hit. PS00636. DNAJ_1. False negative. PS50076. DNAJ_2. 1 hit. PS51181. PPASE_TENSIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9829.
NextBio	37030.
SOURCE	Search...

Entry information

Entry name

AUXI_HUMAN

Accession

Primary (citable) accession number: O75061
Secondary accession number(s): B7Z3V8 , D3DQ65, D3DQ66, Q32M66, Q4G0K1, Q5T614, Q5T615

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	May 1, 2013
This is version 105 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.