O75038 (PLCH2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-2
EC=3.1.4.11

Alternative name(s):
Phosphoinositide phospholipase C-eta-2
Phosphoinositide phospholipase C-like 4
Short name=PLC-L4
Short name=Phospholipase C-like protein 4
Phospholipase C-eta-2
Short name=PLC-eta2

Gene names

Name:	PLCH2
Synonyms:	KIAA0450, PLCL4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1416 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain By similarity.
Catalytic activity	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor	Calcium By similarity.
Subcellular location	Cytoplasm. Cell membrane. Note: Localized predominantly at the plasma membrane By similarity.
Tissue specificity	Expressed in retina and kidney. Ref.1
Sequence similarities	Contains 1 C2 domain. Contains 2 EF-hand domains. Contains 1 PH domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain.
Sequence caution	The sequence AAH43358.1 differs from that shown. Reason: Frameshift at position 172. The sequence BAA32295.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAC56932.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	Calcium Metal-binding
Molecular function	Hydrolase Transducer
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro phosphatidylinositol phospholipase C activity Inferred from electronic annotation. Source: EC signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O75038-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O75038-2) The sequence of this isoform differs from the canonical sequence as follows:      1-41: MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPL → MEEPGPPGGLSQDQ      987-1156: DTRPLSTQRP...SSMSSSDTVI → GKAPAAVAEK...KSPMFSAVRN      1157-1416: Missing.
Isoform 3 (identifier: O75038-3) The sequence of this isoform differs from the canonical sequence as follows:      706-741: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: O75038-4) The sequence of this isoform differs from the canonical sequence as follows:      987-1211: DTRPLSTQRP...SNPNLRATGQ → GKAPAAVAEK...TLLPWLACGP      1212-1416: Missing.
Note: No experimental confirmation available.
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	1004	1	P → L in BAB84975. Ref.2
Isoform 5 (identifier: O75038-5) The sequence of this isoform differs from the canonical sequence as follows:      1-45: Missing.      117-785: Missing.      987-1211: DTRPLSTQRP...SNPNLRATGQ → GKAPAAVAEK...TLLPWLACGP      1212-1416: Missing.
Note: No experimental confirmation available.
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Sequence conflict	209	1	Q → L in BAC56932. Ref.2

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1416	1416	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-2		PRO_0000088507
Regions
	Domain	47 – 155	109	PH
	Domain	169 – 204	36	EF-hand 1
	Domain	205 – 241	37	EF-hand 2
	Domain	326 – 471	146	PI-PLC X-box
	Domain	626 – 740	115	PI-PLC Y-box
	Domain	745 – 852	108	C2
	Calcium binding	182 – 193	12	Potential
	Region	1 – 155	155	Necessary for plasma membrane localization By similarity
Sites
	Active site	341	1	By similarity
	Active site	385	1	By similarity
	Metal binding	342	1	Calcium 1; catalytic By similarity
	Metal binding	371	1	Calcium 1; catalytic By similarity
	Metal binding	373	1	Calcium 1; catalytic By similarity
	Metal binding	420	1	Calcium 1; catalytic By similarity
	Metal binding	784	1	Calcium 2; via carbonyl oxygen By similarity
	Metal binding	786	1	Calcium 2 By similarity
	Metal binding	810	1	Calcium 2 By similarity
	Metal binding	839	1	Calcium 3 By similarity
	Metal binding	840	1	Calcium 3; via carbonyl oxygen By similarity
	Metal binding	841	1	Calcium 3 By similarity
	Binding site	469	1	Substrate By similarity
	Binding site	471	1	Substrate By similarity
	Binding site	653	1	Substrate By similarity
	Binding site	680	1	Substrate By similarity
Amino acid modifications
	Modified residue	595	1	Phosphoserine By similarity
	Modified residue	605	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 45	45	Missing in isoform 5.		VSP_029067
	Alternative sequence	1 – 41	41	MSGPW…QLGPL → MEEPGPPGGLSQDQ in isoform 2.		VSP_029068
	Alternative sequence	117 – 785	669	Missing in isoform 5.		VSP_029069
	Alternative sequence	706 – 741	36	Missing in isoform 3.		VSP_029070
	Alternative sequence	987 – 1211	225	DTRPL…RATGQ → GKAPAAVAEKSPVRVRPPRV LDGPGPAGMAATCMKCVVGS CAGVNTGGLQRERPPSPGPA SRQAAIRQQPRARADSLGAP CCGLDPHAIPGRSREAPKGP GAWRQGPGGSGSMSSDSSSP DSPGIPERSPRWPEGACRQP GALQGEMSALFAQKLEEIRS KSPMFSAGKPLLPCVVLPHA PGMAGPGSPAAASAWTVSPR VLVLVALYPWHCLRGTLLPW LACGP in isoform 4 and isoform 5.		VSP_029071
	Alternative sequence	987 – 1156	170	DTRPL…SDTVI → GKAPAAVAEKSPVRVRPPRV LDGPGPAGMAATCMKCVVGS CAGVNTGGLQRERPPSPGPA SRQAAIRQQPRARADSLGAP CCGLDPHAIPGRSREAPKGP GAWRQGPGGSGSMSSDSSSP DSPGIPERSPRWPEGACRQP GALQGEMSALFAQKLEEIRS KSPMFSAVRN in isoform 2.		VSP_029072
	Alternative sequence	1157 – 1416	260	Missing in isoform 2.		VSP_029073
	Alternative sequence	1212 – 1416	205	Missing in isoform 4 and isoform 5.		VSP_029074
Experimental info
	Sequence conflict	559	1	D → E in BAB84975. Ref.2
	Sequence conflict	560	1	V → M in BAB84975. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 13, 2007. Version 3. Checksum: 05088ACD9C45AE87	FASTA	1,416	154,668
	10 20 30 40 50 60 MSGPWPSPDS RTKGTVAWLA EVLLWVGGSV VLSSEWQLGP LVERCMGAMQ EGMQMVKLRG 70 80 90 100 110 120 GSKGLVRFYY LDEHRSCIRW RPSRKNEKAK ISIDSIQEVS EGRQSEVFQR YPDGSFDPNC 130 140 150 160 170 180 CFSIYHGSHR ESLDLVSTSS EVARTWVTGL RYLMAGISDE DSLARRQRTR DQWLKQTFDE 190 200 210 220 230 240 ADKNGDGSLS IGEVLQLLHK LNVNLPRQRV KQMFREADTD DHQGTLGFEE FCAFYKMMST 250 260 270 280 290 300 RRDLYLLMLT YSNHKDHLDA ASLQRFLQVE QKMAGVTLES CQDIIEQFEP CPENKSKGLL 310 320 330 340 350 360 GIDGFTNYTR SPAGDIFNPE HHHVHQDMTQ PLSHYFITSS HNTYLVGDQL MSQSRVDMYA 370 380 390 400 410 420 WVLQAGCRCV EVDCWDGPDG EPIVHHGYTL TSKILFKDVI ETINKYAFIK NEYPVILSIE 430 440 450 460 470 480 NHCSVIQQKK MAQYLTDILG DKLDLSSVSS EDATTLPSPQ MLKGKILVKG KKLPANISED 490 500 510 520 530 540 AEEGEVSDED SADEIDDDCK LLNGDASTNR KRVENTAKRK LDSLIKESKI RDCEDPNNFS 550 560 570 580 590 600 VSTLSPSGKL GRKSKAEEDV ESGEDAGASR RNGRLVVGSF SRRKKKGSKL KKAASVEEGD 610 620 630 640 650 660 EGQDSPGGQS RGATRQKKTM KLSRALSDLV KYTKSVATHD IEMEAASSWQ VSSFSETKAH 670 680 690 700 710 720 QILQQKPAQY LRFNQQQLSR IYPSSYRVDS SNYNPQPFWN AGCQMVALNY QSEGRMLQLN 730 740 750 760 770 780 RAKFSANGGC GYVLKPGCMC QGVFNPNSED PLPGQLKKQL VLRIISGQQL PKPRDSMLGD 790 800 810 820 830 840 RGEIIDPFVE VEIIGLPVDC SREQTRVVDD NGFNPTWEET LVFMVHMPEI ALVRFLVWDH 850 860 870 880 890 900 DPIGRDFIGQ RTLAFSSMMP GYRHVYLEGM EEASIFVHVA VSDISGKVKQ ALGLKGLFLR 910 920 930 940 950 960 GPKPGSLDSH AAGRPPARPS VSQRILRRTA SAPTKSQKPG RRGFPELVLG TRDTGSKGVA 970 980 990 1000 1010 1020 DDVVPPGPGP APEAPAQEGP GSGSPRDTRP LSTQRPLPPL CSLETIAEEP APGPGPPPPA 1030 1040 1050 1060 1070 1080 AVPTSSSQGR PPYPTGPGAN VASPLEDTEE PRDSRPRPCN GEGAGGAYER APGSQTDGRS 1090 1100 1110 1120 1130 1140 QPRTLGHLPV IRRVKSEGQV PTEPLGGWRP LAAPFPAPAV YSDATGSDPL WQRLEPCGHR 1150 1160 1170 1180 1190 1200 DSVSSSSSMS SSDTVIDLSL PSLGLGRSRE NLAGAHMGRL PPRPHSASAA RPDLPPVTKS 1210 1220 1230 1240 1250 1260 KSNPNLRATG QRPPIPDELQ PRSLAPRMAG LPFRPPWGCL SLVGVQDCPV AAKSKSLGDL 1270 1280 1290 1300 1310 1320 TADDFAPSFE GGSRRLSHSL GLPGGTRRVS GPGVRRDTLT EQLRWLTVFQ QAGDITSPTS 1330 1340 1350 1360 1370 1380 LGPAGEGVAG GPGFVRRSSS RSHSRVRAIA SRARQAQERQ QRLQGLGRQG PPEEERGTPE 1390 1400 1410 GACSVGHEGS VDAPAPSKGA LGPASAAAEN LVLLRL
	Isoform 2 [UniParc]. Checksum: AE28DDFBEE739B2A	FASTA	1,129	124,302
	10 20 30 40 50 60 MEEPGPPGGL SQDQVERCMG AMQEGMQMVK LRGGSKGLVR FYYLDEHRSC IRWRPSRKNE 70 80 90 100 110 120 KAKISIDSIQ EVSEGRQSEV FQRYPDGSFD PNCCFSIYHG SHRESLDLVS TSSEVARTWV 130 140 150 160 170 180 TGLRYLMAGI SDEDSLARRQ RTRDQWLKQT FDEADKNGDG SLSIGEVLQL LHKLNVNLPR 190 200 210 220 230 240 QRVKQMFREA DTDDHQGTLG FEEFCAFYKM MSTRRDLYLL MLTYSNHKDH LDAASLQRFL 250 260 270 280 290 300 QVEQKMAGVT LESCQDIIEQ FEPCPENKSK GLLGIDGFTN YTRSPAGDIF NPEHHHVHQD 310 320 330 340 350 360 MTQPLSHYFI TSSHNTYLVG DQLMSQSRVD MYAWVLQAGC RCVEVDCWDG PDGEPIVHHG 370 380 390 400 410 420 YTLTSKILFK DVIETINKYA FIKNEYPVIL SIENHCSVIQ QKKMAQYLTD ILGDKLDLSS 430 440 450 460 470 480 VSSEDATTLP SPQMLKGKIL VKGKKLPANI SEDAEEGEVS DEDSADEIDD DCKLLNGDAS 490 500 510 520 530 540 TNRKRVENTA KRKLDSLIKE SKIRDCEDPN NFSVSTLSPS GKLGRKSKAE EDVESGEDAG 550 560 570 580 590 600 ASRRNGRLVV GSFSRRKKKG SKLKKAASVE EGDEGQDSPG GQSRGATRQK KTMKLSRALS 610 620 630 640 650 660 DLVKYTKSVA THDIEMEAAS SWQVSSFSET KAHQILQQKP AQYLRFNQQQ LSRIYPSSYR 670 680 690 700 710 720 VDSSNYNPQP FWNAGCQMVA LNYQSEGRML QLNRAKFSAN GGCGYVLKPG CMCQGVFNPN 730 740 750 760 770 780 SEDPLPGQLK KQLVLRIISG QQLPKPRDSM LGDRGEIIDP FVEVEIIGLP VDCSREQTRV 790 800 810 820 830 840 VDDNGFNPTW EETLVFMVHM PEIALVRFLV WDHDPIGRDF IGQRTLAFSS MMPGYRHVYL 850 860 870 880 890 900 EGMEEASIFV HVAVSDISGK VKQALGLKGL FLRGPKPGSL DSHAAGRPPA RPSVSQRILR 910 920 930 940 950 960 RTASAPTKSQ KPGRRGFPEL VLGTRDTGSK GVADDVVPPG PGPAPEAPAQ EGPGSGSPRG 970 980 990 1000 1010 1020 KAPAAVAEKS PVRVRPPRVL DGPGPAGMAA TCMKCVVGSC AGVNTGGLQR ERPPSPGPAS 1030 1040 1050 1060 1070 1080 RQAAIRQQPR ARADSLGAPC CGLDPHAIPG RSREAPKGPG AWRQGPGGSG SMSSDSSSPD 1090 1100 1110 1120 SPGIPERSPR WPEGACRQPG ALQGEMSALF AQKLEEIRSK SPMFSAVRN
	Isoform 3 [UniParc]. Checksum: 7828287338AF8201	FASTA	1,380	150,778
	10 20 30 40 50 60 MSGPWPSPDS RTKGTVAWLA EVLLWVGGSV VLSSEWQLGP LVERCMGAMQ EGMQMVKLRG 70 80 90 100 110 120 GSKGLVRFYY LDEHRSCIRW RPSRKNEKAK ISIDSIQEVS EGRQSEVFQR YPDGSFDPNC 130 140 150 160 170 180 CFSIYHGSHR ESLDLVSTSS EVARTWVTGL RYLMAGISDE DSLARRQRTR DQWLKQTFDE 190 200 210 220 230 240 ADKNGDGSLS IGEVLQLLHK LNVNLPRQRV KQMFREADTD DHQGTLGFEE FCAFYKMMST 250 260 270 280 290 300 RRDLYLLMLT YSNHKDHLDA ASLQRFLQVE QKMAGVTLES CQDIIEQFEP CPENKSKGLL 310 320 330 340 350 360 GIDGFTNYTR SPAGDIFNPE HHHVHQDMTQ PLSHYFITSS HNTYLVGDQL MSQSRVDMYA 370 380 390 400 410 420 WVLQAGCRCV EVDCWDGPDG EPIVHHGYTL TSKILFKDVI ETINKYAFIK NEYPVILSIE 430 440 450 460 470 480 NHCSVIQQKK MAQYLTDILG DKLDLSSVSS EDATTLPSPQ MLKGKILVKG KKLPANISED 490 500 510 520 530 540 AEEGEVSDED SADEIDDDCK LLNGDASTNR KRVENTAKRK LDSLIKESKI RDCEDPNNFS 550 560 570 580 590 600 VSTLSPSGKL GRKSKAEEDV ESGEDAGASR RNGRLVVGSF SRRKKKGSKL KKAASVEEGD 610 620 630 640 650 660 EGQDSPGGQS RGATRQKKTM KLSRALSDLV KYTKSVATHD IEMEAASSWQ VSSFSETKAH 670 680 690 700 710 720 QILQQKPAQY LRFNQQQLSR IYPSSYRVDS SNYNPQPFWN AGCQMGVFNP NSEDPLPGQL 730 740 750 760 770 780 KKQLVLRIIS GQQLPKPRDS MLGDRGEIID PFVEVEIIGL PVDCSREQTR VVDDNGFNPT 790 800 810 820 830 840 WEETLVFMVH MPEIALVRFL VWDHDPIGRD FIGQRTLAFS SMMPGYRHVY LEGMEEASIF 850 860 870 880 890 900 VHVAVSDISG KVKQALGLKG LFLRGPKPGS LDSHAAGRPP ARPSVSQRIL RRTASAPTKS 910 920 930 940 950 960 QKPGRRGFPE LVLGTRDTGS KGVADDVVPP GPGPAPEAPA QEGPGSGSPR DTRPLSTQRP 970 980 990 1000 1010 1020 LPPLCSLETI AEEPAPGPGP PPPAAVPTSS SQGRPPYPTG PGANVASPLE DTEEPRDSRP 1030 1040 1050 1060 1070 1080 RPCNGEGAGG AYERAPGSQT DGRSQPRTLG HLPVIRRVKS EGQVPTEPLG GWRPLAAPFP 1090 1100 1110 1120 1130 1140 APAVYSDATG SDPLWQRLEP CGHRDSVSSS SSMSSSDTVI DLSLPSLGLG RSRENLAGAH 1150 1160 1170 1180 1190 1200 MGRLPPRPHS ASAARPDLPP VTKSKSNPNL RATGQRPPIP DELQPRSLAP RMAGLPFRPP 1210 1220 1230 1240 1250 1260 WGCLSLVGVQ DCPVAAKSKS LGDLTADDFA PSFEGGSRRL SHSLGLPGGT RRVSGPGVRR 1270 1280 1290 1300 1310 1320 DTLTEQLRWL TVFQQAGDIT SPTSLGPAGE GVAGGPGFVR RSSSRSHSRV RAIASRARQA 1330 1340 1350 1360 1370 1380 QERQQRLQGL GRQGPPEEER GTPEGACSVG HEGSVDAPAP SKGALGPASA AAENLVLLRL
	Isoform 4 [UniParc]. Checksum: 1472D389D2CF4707	FASTA	1,211	132,836
	10 20 30 40 50 60 MSGPWPSPDS RTKGTVAWLA EVLLWVGGSV VLSSEWQLGP LVERCMGAMQ EGMQMVKLRG 70 80 90 100 110 120 GSKGLVRFYY LDEHRSCIRW RPSRKNEKAK ISIDSIQEVS EGRQSEVFQR YPDGSFDPNC 130 140 150 160 170 180 CFSIYHGSHR ESLDLVSTSS EVARTWVTGL RYLMAGISDE DSLARRQRTR DQWLKQTFDE 190 200 210 220 230 240 ADKNGDGSLS IGEVLQLLHK LNVNLPRQRV KQMFREADTD DHQGTLGFEE FCAFYKMMST 250 260 270 280 290 300 RRDLYLLMLT YSNHKDHLDA ASLQRFLQVE QKMAGVTLES CQDIIEQFEP CPENKSKGLL 310 320 330 340 350 360 GIDGFTNYTR SPAGDIFNPE HHHVHQDMTQ PLSHYFITSS HNTYLVGDQL MSQSRVDMYA 370 380 390 400 410 420 WVLQAGCRCV EVDCWDGPDG EPIVHHGYTL TSKILFKDVI ETINKYAFIK NEYPVILSIE 430 440 450 460 470 480 NHCSVIQQKK MAQYLTDILG DKLDLSSVSS EDATTLPSPQ MLKGKILVKG KKLPANISED 490 500 510 520 530 540 AEEGEVSDED SADEIDDDCK LLNGDASTNR KRVENTAKRK LDSLIKESKI RDCEDPNNFS 550 560 570 580 590 600 VSTLSPSGKL GRKSKAEEDV ESGEDAGASR RNGRLVVGSF SRRKKKGSKL KKAASVEEGD 610 620 630 640 650 660 EGQDSPGGQS RGATRQKKTM KLSRALSDLV KYTKSVATHD IEMEAASSWQ VSSFSETKAH 670 680 690 700 710 720 QILQQKPAQY LRFNQQQLSR IYPSSYRVDS SNYNPQPFWN AGCQMVALNY QSEGRMLQLN 730 740 750 760 770 780 RAKFSANGGC GYVLKPGCMC QGVFNPNSED PLPGQLKKQL VLRIISGQQL PKPRDSMLGD 790 800 810 820 830 840 RGEIIDPFVE VEIIGLPVDC SREQTRVVDD NGFNPTWEET LVFMVHMPEI ALVRFLVWDH 850 860 870 880 890 900 DPIGRDFIGQ RTLAFSSMMP GYRHVYLEGM EEASIFVHVA VSDISGKVKQ ALGLKGLFLR 910 920 930 940 950 960 GPKPGSLDSH AAGRPPARPS VSQRILRRTA SAPTKSQKPG RRGFPELVLG TRDTGSKGVA 970 980 990 1000 1010 1020 DDVVPPGPGP APEAPAQEGP GSGSPRGKAP AAVAEKSPVR VRPPRVLDGP GPAGMAATCM 1030 1040 1050 1060 1070 1080 KCVVGSCAGV NTGGLQRERP PSPGPASRQA AIRQQPRARA DSLGAPCCGL DPHAIPGRSR 1090 1100 1110 1120 1130 1140 EAPKGPGAWR QGPGGSGSMS SDSSSPDSPG IPERSPRWPE GACRQPGALQ GEMSALFAQK 1150 1160 1170 1180 1190 1200 LEEIRSKSPM FSAGKPLLPC VVLPHAPGMA GPGSPAAASA WTVSPRVLVL VALYPWHCLR 1210 GTLLPWLACG P
	Isoform 5 [UniParc]. Checksum: 843420D08D2C3A9F	FASTA	497	52,942
	10 20 30 40 50 60 MGAMQEGMQM VKLRGGSKGL VRFYYLDEHR SCIRWRPSRK NEKAKISIDS IQEVSEGRQS 70 80 90 100 110 120 EVFQRYPDGS FDPFVEVEII GLPVDCSREQ TRVVDDNGFN PTWEETLVFM VHMPEIALVR 130 140 150 160 170 180 FLVWDHDPIG RDFIGQRTLA FSSMMPGYRH VYLEGMEEAS IFVHVAVSDI SGKVKQALGL 190 200 210 220 230 240 KGLFLRGPKP GSLDSHAAGR PPARPSVSQR ILRRTASAPT KSQKPGRRGF PELVLGTRDT 250 260 270 280 290 300 GSKGVADDVV PPGPGPAPEA PAQEGPGSGS PRGKAPAAVA EKSPVRVRPP RVLDGPGPAG 310 320 330 340 350 360 MAATCMKCVV GSCAGVNTGG LQRERPPSPG PASRQAAIRQ QPRARADSLG APCCGLDPHA 370 380 390 400 410 420 IPGRSREAPK GPGAWRQGPG GSGSMSSDSS SPDSPGIPER SPRWPEGACR QPGALQGEMS 430 440 450 460 470 480 ALFAQKLEEI RSKSPMFSAG KPLLPCVVLP HAPGMAGPGS PAAASAWTVS PRVLVLVALY 490 PWHCLRGTLL PWLACGP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of PLC-eta2." Zhou Y., Wing M.R., Sondek J., Harden T.K. Biochem. J. 391:667-676(2005) [PubMed: 16107206] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 556-1403 (ISOFORM 4). Tissue: Spleen.
[3]	"Characterization of cDNA clones in size-fractionated cDNA libraries from human brain." Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O. DNA Res. 4:345-349(1997) [PubMed: 9455484] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[5]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-1416 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-1416 (ISOFORM 3). Tissue: Brain, Pancreas and Skin.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ176850 mRNA. Translation: ABA12209.1. AK074149 mRNA. Translation: BAB84975.1. AK122591 mRNA. Translation: BAC56932.2. Different initiation. AB007919 mRNA. Translation: BAA32295.3. Different initiation. AL139246 Genomic DNA. Translation: CAX30815.1. BC019679 mRNA. Translation: AAH19679.1. BC043358 mRNA. Translation: AAH43358.1. Frameshift. BC050037 mRNA. Translation: AAH50037.1. BC128207 mRNA. Translation: AAI28208.1.
IPI	IPI00384764. IPI00409676. IPI00654552. IPI00744887. IPI00873071.
RefSeq	NP_055453.2. NM_014638.2.
UniGene	Hs.170156.
3D structure databases
ProteinModelPortal	O75038.
SMR	O75038. Positions 39-915.
ModBase	Search...
Protein-protein interaction databases
STRING	O75038.
PTM databases
PhosphoSite	O75038.
Proteomic databases
PRIDE	O75038.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378483; ENSP00000367744; ENSG00000149527. ENST00000378486; ENSP00000367747; ENSG00000149527.
GeneID	9651.
KEGG	hsa:9651.
UCSC	uc001ajj.1. human. uc009vle.1. human.
Organism-specific databases
CTD	9651.
GeneCards	GC01P002397.
H-InvDB	HIX0000057.
HGNC	HGNC:29037. PLCH2.
HPA	HPA003346.
MIM	612836. gene.
neXtProt	NX_O75038.
PharmGKB	PA134914471.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14209.
GeneTree	ENSGT00600000084266.
HOVERGEN	HBG107105.
InParanoid	O75038.
OMA	TEVASSW.
PhylomeDB	O75038.
Gene expression databases
ArrayExpress	O75038.
Bgee	O75038.
CleanEx	HS_PLCH2.
Genevestigator	O75038.
GermOnline	ENSG00000149527. Homo sapiens.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca-bd. IPR011993. PH_type. IPR001192. Pinositol_PLipase_C. IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR001849. Pleckstrin_homology. IPR015359. PLipase_C_EF-hand-like. IPR000909. PLipase_C_PInositol-sp_X_dom. IPR001711. PLipase_C_Pinositol-sp_Y. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 2 hits. G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 2 hits.
Pfam	PF00168. C2. 1 hit. PF09279. efhand_like. 1 hit. PF00388. PI-PLC-X. 1 hit. PF00387. PI-PLC-Y. 1 hit. [Graphical view]
PRINTS	PR00390. PHPHLIPASEC.
SMART	SM00239. C2. 1 hit. SM00054. EFh. 2 hits. SM00233. PH. 1 hit. SM00148. PLCXc. 1 hit. SM00149. PLCYc. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF51695. PLC-like_Pdiesterase_TIM-brl. 1 hit.
PROSITE	PS50004. C2. 1 hit. PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 2 hits. PS50003. PH_DOMAIN. 1 hit. PS50007. PIPLC_X_DOMAIN. 1 hit. PS50008. PIPLC_Y_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	36229.
SOURCE	Search...

Entry information

Entry name

PLCH2_HUMAN

Accession

Primary (citable) accession number: O75038
Secondary accession number(s): A2VCM3 , B9DI80, Q3LUA8, Q86XJ2, Q86XU1, Q86YU7, Q8TEH5, Q8WUS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	November 13, 2007
Last modified:	January 25, 2012
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.