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O75038

- PLCH2_HUMAN

UniProt

O75038 - PLCH2_HUMAN

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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

Gene
PLCH2, KIAA0450, PLCL4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain By similarity.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Calcium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei341 – 3411 By similarity
Metal bindingi342 – 3421Calcium 1; catalytic By similarity
Metal bindingi371 – 3711Calcium 1; catalytic By similarity
Metal bindingi373 – 3731Calcium 1; catalytic By similarity
Active sitei385 – 3851 By similarity
Metal bindingi420 – 4201Calcium 1; catalytic By similarity
Binding sitei469 – 4691Substrate By similarity
Binding sitei471 – 4711Substrate By similarity
Binding sitei653 – 6531Substrate By similarity
Binding sitei680 – 6801Substrate By similarity
Metal bindingi784 – 7841Calcium 2; via carbonyl oxygen By similarity
Metal bindingi786 – 7861Calcium 2 By similarity
Metal bindingi810 – 8101Calcium 2 By similarity
Metal bindingi839 – 8391Calcium 3 By similarity
Metal bindingi840 – 8401Calcium 3; via carbonyl oxygen By similarity
Metal bindingi841 – 8411Calcium 3 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi182 – 19312 Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
  3. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. inositol phosphate metabolic process Source: Reactome
  2. intracellular signal transduction Source: InterPro
  3. lipid catabolic process Source: UniProtKB-KW
  4. phosphatidylinositol metabolic process Source: Ensembl
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_150312. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-eta-2
Phosphoinositide phospholipase C-like 4
Short name:
PLC-L4
Short name:
Phospholipase C-like protein 4
Phospholipase C-eta-2
Short name:
PLC-eta2
Gene namesi
Name:PLCH2
Synonyms:KIAA0450, PLCL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29037. PLCH2.

Subcellular locationi

Cytoplasm. Cell membrane
Note: Localized predominantly at the plasma membrane By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914471.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141614161-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2PRO_0000088507Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei595 – 5951Phosphoserine By similarity
Modified residuei605 – 6051Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO75038.
PRIDEiO75038.

PTM databases

PhosphoSiteiO75038.

Expressioni

Tissue specificityi

Expressed in retina and kidney.1 Publication

Gene expression databases

ArrayExpressiO75038.
BgeeiO75038.
CleanExiHS_PLCH2.
GenevestigatoriO75038.

Organism-specific databases

HPAiHPA003346.

Interactioni

Protein-protein interaction databases

BioGridi115009. 1 interaction.
STRINGi9606.ENSP00000367747.

Structurei

3D structure databases

ProteinModelPortaliO75038.
SMRiO75038. Positions 46-494, 626-883.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 155109PHAdd
BLAST
Domaini169 – 20436EF-hand 1Add
BLAST
Domaini205 – 24137EF-hand 2Add
BLAST
Domaini326 – 471146PI-PLC X-boxAdd
BLAST
Domaini626 – 740115PI-PLC Y-boxAdd
BLAST
Domaini745 – 852108C2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 155155Necessary for plasma membrane localization By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.
Contains 2 EF-hand domains.
Contains 1 PH domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG149692.
HOVERGENiHBG107105.
InParanoidiO75038.
OMAiCSLETIT.
OrthoDBiEOG7PGDQ0.
PhylomeDBiO75038.
TreeFamiTF313216.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR028393. PLC-eta2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF21. PTHR10336:SF21. 1 hit.
PfamiPF00168. C2. 1 hit.
PF13499. EF-hand_7. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75038-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSGPWPSPDS RTKGTVAWLA EVLLWVGGSV VLSSEWQLGP LVERCMGAMQ     50
EGMQMVKLRG GSKGLVRFYY LDEHRSCIRW RPSRKNEKAK ISIDSIQEVS 100
EGRQSEVFQR YPDGSFDPNC CFSIYHGSHR ESLDLVSTSS EVARTWVTGL 150
RYLMAGISDE DSLARRQRTR DQWLKQTFDE ADKNGDGSLS IGEVLQLLHK 200
LNVNLPRQRV KQMFREADTD DHQGTLGFEE FCAFYKMMST RRDLYLLMLT 250
YSNHKDHLDA ASLQRFLQVE QKMAGVTLES CQDIIEQFEP CPENKSKGLL 300
GIDGFTNYTR SPAGDIFNPE HHHVHQDMTQ PLSHYFITSS HNTYLVGDQL 350
MSQSRVDMYA WVLQAGCRCV EVDCWDGPDG EPIVHHGYTL TSKILFKDVI 400
ETINKYAFIK NEYPVILSIE NHCSVIQQKK MAQYLTDILG DKLDLSSVSS 450
EDATTLPSPQ MLKGKILVKG KKLPANISED AEEGEVSDED SADEIDDDCK 500
LLNGDASTNR KRVENTAKRK LDSLIKESKI RDCEDPNNFS VSTLSPSGKL 550
GRKSKAEEDV ESGEDAGASR RNGRLVVGSF SRRKKKGSKL KKAASVEEGD 600
EGQDSPGGQS RGATRQKKTM KLSRALSDLV KYTKSVATHD IEMEAASSWQ 650
VSSFSETKAH QILQQKPAQY LRFNQQQLSR IYPSSYRVDS SNYNPQPFWN 700
AGCQMVALNY QSEGRMLQLN RAKFSANGGC GYVLKPGCMC QGVFNPNSED 750
PLPGQLKKQL VLRIISGQQL PKPRDSMLGD RGEIIDPFVE VEIIGLPVDC 800
SREQTRVVDD NGFNPTWEET LVFMVHMPEI ALVRFLVWDH DPIGRDFIGQ 850
RTLAFSSMMP GYRHVYLEGM EEASIFVHVA VSDISGKVKQ ALGLKGLFLR 900
GPKPGSLDSH AAGRPPARPS VSQRILRRTA SAPTKSQKPG RRGFPELVLG 950
TRDTGSKGVA DDVVPPGPGP APEAPAQEGP GSGSPRDTRP LSTQRPLPPL 1000
CSLETIAEEP APGPGPPPPA AVPTSSSQGR PPYPTGPGAN VASPLEDTEE 1050
PRDSRPRPCN GEGAGGAYER APGSQTDGRS QPRTLGHLPV IRRVKSEGQV 1100
PTEPLGGWRP LAAPFPAPAV YSDATGSDPL WQRLEPCGHR DSVSSSSSMS 1150
SSDTVIDLSL PSLGLGRSRE NLAGAHMGRL PPRPHSASAA RPDLPPVTKS 1200
KSNPNLRATG QRPPIPDELQ PRSLAPRMAG LPFRPPWGCL SLVGVQDCPV 1250
AAKSKSLGDL TADDFAPSFE GGSRRLSHSL GLPGGTRRVS GPGVRRDTLT 1300
EQLRWLTVFQ QAGDITSPTS LGPAGEGVAG GPGFVRRSSS RSHSRVRAIA 1350
SRARQAQERQ QRLQGLGRQG PPEEERGTPE GACSVGHEGS VDAPAPSKGA 1400
LGPASAAAEN LVLLRL 1416
Length:1,416
Mass (Da):154,668
Last modified:November 13, 2007 - v3
Checksum:i05088ACD9C45AE87
GO
Isoform 2 (identifier: O75038-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPL → MEEPGPPGGLSQDQ
     987-1156: DTRPLSTQRP...SSMSSSDTVI → GKAPAAVAEK...KSPMFSAVRN
     1157-1416: Missing.

Show »
Length:1,129
Mass (Da):124,302
Checksum:iAE28DDFBEE739B2A
GO
Isoform 3 (identifier: O75038-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     706-741: Missing.

Note: No experimental confirmation available.

Show »
Length:1,380
Mass (Da):150,778
Checksum:i7828287338AF8201
GO
Isoform 4 (identifier: O75038-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     987-1211: DTRPLSTQRP...SNPNLRATGQ → GKAPAAVAEK...TLLPWLACGP
     1212-1416: Missing.

Note: No experimental confirmation available.

Show »
Length:1,211
Mass (Da):132,836
Checksum:i1472D389D2CF4707
GO
Isoform 5 (identifier: O75038-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-45: Missing.
     117-785: Missing.
     987-1211: DTRPLSTQRP...SNPNLRATGQ → GKAPAAVAEK...TLLPWLACGP
     1212-1416: Missing.

Note: No experimental confirmation available.

Show »
Length:497
Mass (Da):52,942
Checksum:i843420D08D2C3A9F
GO

Sequence cautioni

The sequence AAH43358.1 differs from that shown. Reason: Frameshift at position 172.
The sequence BAA32295.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAC56932.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4545Missing in isoform 5. VSP_029067Add
BLAST
Alternative sequencei1 – 4141MSGPW…QLGPL → MEEPGPPGGLSQDQ in isoform 2. VSP_029068Add
BLAST
Alternative sequencei117 – 785669Missing in isoform 5. VSP_029069Add
BLAST
Alternative sequencei706 – 74136Missing in isoform 3. VSP_029070Add
BLAST
Alternative sequencei987 – 1211225DTRPL…RATGQ → GKAPAAVAEKSPVRVRPPRV LDGPGPAGMAATCMKCVVGS CAGVNTGGLQRERPPSPGPA SRQAAIRQQPRARADSLGAP CCGLDPHAIPGRSREAPKGP GAWRQGPGGSGSMSSDSSSP DSPGIPERSPRWPEGACRQP GALQGEMSALFAQKLEEIRS KSPMFSAGKPLLPCVVLPHA PGMAGPGSPAAASAWTVSPR VLVLVALYPWHCLRGTLLPW LACGP in isoform 4 and isoform 5. VSP_029071Add
BLAST
Alternative sequencei987 – 1156170DTRPL…SDTVI → GKAPAAVAEKSPVRVRPPRV LDGPGPAGMAATCMKCVVGS CAGVNTGGLQRERPPSPGPA SRQAAIRQQPRARADSLGAP CCGLDPHAIPGRSREAPKGP GAWRQGPGGSGSMSSDSSSP DSPGIPERSPRWPEGACRQP GALQGEMSALFAQKLEEIRS KSPMFSAVRN in isoform 2. VSP_029072Add
BLAST
Alternative sequencei1157 – 1416260Missing in isoform 2. VSP_029073Add
BLAST
Alternative sequencei1212 – 1416205Missing in isoform 4 and isoform 5. VSP_029074Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti559 – 5591D → E in BAB84975. 1 Publication
Sequence conflicti560 – 5601V → M in BAB84975. 1 Publication
Isoform 5 (identifier: O75038-5)
Sequence conflicti209 – 2091Q → L in BAC56932. 1 Publication
Isoform 4 (identifier: O75038-4)
Sequence conflicti1004 – 10041P → L in BAB84975. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ176850 mRNA. Translation: ABA12209.1.
AK074149 mRNA. Translation: BAB84975.1.
AK122591 mRNA. Translation: BAC56932.2. Different initiation.
AB007919 mRNA. Translation: BAA32295.3. Different initiation.
AL139246 Genomic DNA. Translation: CAX30815.1.
BC019679 mRNA. Translation: AAH19679.1.
BC043358 mRNA. Translation: AAH43358.1. Frameshift.
BC050037 mRNA. Translation: AAH50037.1.
BC128207 mRNA. Translation: AAI28208.1.
CCDSiCCDS59959.1. [O75038-1]
RefSeqiNP_055453.2. NM_014638.2. [O75038-1]
XP_006711118.1. XM_006711055.1. [O75038-2]
XP_006725014.1. XM_006724951.1. [O75038-2]
UniGeneiHs.170156.

Genome annotation databases

EnsembliENST00000378486; ENSP00000367747; ENSG00000149527. [O75038-1]
ENST00000378488; ENSP00000367749; ENSG00000149527. [O75038-3]
ENST00000419816; ENSP00000389803; ENSG00000149527. [O75038-1]
ENST00000449969; ENSP00000397289; ENSG00000149527. [O75038-2]
GeneIDi9651.
KEGGihsa:9651.
UCSCiuc001aji.1. human. [O75038-1]
uc001ajj.1. human. [O75038-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ176850 mRNA. Translation: ABA12209.1 .
AK074149 mRNA. Translation: BAB84975.1 .
AK122591 mRNA. Translation: BAC56932.2 . Different initiation.
AB007919 mRNA. Translation: BAA32295.3 . Different initiation.
AL139246 Genomic DNA. Translation: CAX30815.1 .
BC019679 mRNA. Translation: AAH19679.1 .
BC043358 mRNA. Translation: AAH43358.1 . Frameshift.
BC050037 mRNA. Translation: AAH50037.1 .
BC128207 mRNA. Translation: AAI28208.1 .
CCDSi CCDS59959.1. [O75038-1 ]
RefSeqi NP_055453.2. NM_014638.2. [O75038-1 ]
XP_006711118.1. XM_006711055.1. [O75038-2 ]
XP_006725014.1. XM_006724951.1. [O75038-2 ]
UniGenei Hs.170156.

3D structure databases

ProteinModelPortali O75038.
SMRi O75038. Positions 46-494, 626-883.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115009. 1 interaction.
STRINGi 9606.ENSP00000367747.

PTM databases

PhosphoSitei O75038.

Proteomic databases

PaxDbi O75038.
PRIDEi O75038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378486 ; ENSP00000367747 ; ENSG00000149527 . [O75038-1 ]
ENST00000378488 ; ENSP00000367749 ; ENSG00000149527 . [O75038-3 ]
ENST00000419816 ; ENSP00000389803 ; ENSG00000149527 . [O75038-1 ]
ENST00000449969 ; ENSP00000397289 ; ENSG00000149527 . [O75038-2 ]
GeneIDi 9651.
KEGGi hsa:9651.
UCSCi uc001aji.1. human. [O75038-1 ]
uc001ajj.1. human. [O75038-2 ]

Organism-specific databases

CTDi 9651.
GeneCardsi GC01P002397.
H-InvDB HIX0000057.
HGNCi HGNC:29037. PLCH2.
HPAi HPA003346.
MIMi 612836. gene.
neXtProti NX_O75038.
PharmGKBi PA134914471.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149692.
HOVERGENi HBG107105.
InParanoidi O75038.
OMAi CSLETIT.
OrthoDBi EOG7PGDQ0.
PhylomeDBi O75038.
TreeFami TF313216.

Enzyme and pathway databases

Reactomei REACT_150312. Synthesis of IP3 and IP4 in the cytosol.

Miscellaneous databases

GenomeRNAii 9651.
NextBioi 36229.
PROi O75038.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75038.
Bgeei O75038.
CleanExi HS_PLCH2.
Genevestigatori O75038.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR028393. PLC-eta2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
PTHR10336:SF21. PTHR10336:SF21. 1 hit.
Pfami PF00168. C2. 1 hit.
PF13499. EF-hand_7. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view ]
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00054. EFh. 2 hits.
SM00233. PH. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEi PS50004. C2. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of PLC-eta2."
    Zhou Y., Wing M.R., Sondek J., Harden T.K.
    Biochem. J. 391:667-676(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 556-1403 (ISOFORM 4).
    Tissue: Spleen.
  3. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
    Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 116-1416 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-1416 (ISOFORM 3).
    Tissue: Brain, Pancreas and Skin.

Entry informationi

Entry nameiPLCH2_HUMAN
AccessioniPrimary (citable) accession number: O75038
Secondary accession number(s): A2VCM3
, B9DI80, Q3LUA8, Q86XJ2, Q86XU1, Q86YU7, Q8TEH5, Q8WUS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 13, 2007
Last modified: September 3, 2014
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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