O75037 (KI21B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF21B

Gene names

Name:	KIF21B
Synonyms:	KIAA0449

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1637 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Microtubule-binding motor protein probably involved in neuronal dendritic transport. In vitro, has a plus-end directed motor activity By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Sequence similarities	Belongs to the kinesin-like protein family. Contains 1 kinesin-motor domain. Contains 7 WD repeats.
Sequence caution	The sequence BAA32294.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat WD repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	microtubule-based movement Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75037-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75037-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1269-1281: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1637	1637	Kinesin-like protein KIF21B		PRO_0000125464
Regions
	Domain	5 – 298	294	Kinesin-motor
	Repeat	1306 – 1343	38	WD 1
	Repeat	1346 – 1384	39	WD 2
	Repeat	1410 – 1448	39	WD 3
	Repeat	1451 – 1493	43	WD 4
	Repeat	1502 – 1539	38	WD 5
	Repeat	1543 – 1582	40	WD 6
	Repeat	1585 – 1622	38	WD 7
	Nucleotide binding	87 – 94	8	ATP By similarity
	Coiled coil	376 – 604	229	Potential
	Coiled coil	631 – 824	194	Potential
	Coiled coil	928 – 1016	89	Potential
Amino acid modifications
	Modified residue	579	1	Phosphoserine By similarity
	Modified residue	582	1	Phosphothreonine By similarity
	Modified residue	1237	1	Phosphothreonine Ref.4 Ref.5
	Modified residue	1241	1	Phosphoserine Ref.5
	Modified residue	1244	1	Phosphothreonine Ref.4
Natural variations
	Alternative sequence	1269 – 1281	13	Missing in isoform 2.		VSP_016217

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 1, 2005. Version 2. Checksum: 792647EA1D909C24	FASTA	1,637	182,662
	10 20 30 40 50 60 MAGQGDCCVK VAVRIRPQLS KEKIEGCHIC TSVTPGEPQV LLGKDKAFTY DFVFDLDTWQ 70 80 90 100 110 120 EQIYSTCVSK LIEGCFEGYN ATVLAYGQTG AGKTYTMGTG FDMATSEEEQ GIIPRAIAHL 130 140 150 160 170 180 FGGIAERKRR AQEQGVAGPE FKVSAQFLEL YNEEILDLFD STRDPDTRHR RSNIKIHEDA 190 200 210 220 230 240 NGGIYTTGVT SRLIHSQEEL IQCLKQGALS RTTASTQMNV QSSRSHAIFT IHLCQMRMCT 250 260 270 280 290 300 QPDLVNEAVT GLPDGTPPSS EYETLTAKFH FVDLAGSERL KRTGATGERA KEGISINCGL 310 320 330 340 350 360 LALGNVISAL GDQSKKVVHV PYRDSKLTRL LQDSLGGNSQ TIMIACVSPS DRDFMETLNT 370 380 390 400 410 420 LKYANRARNI KNKVVVNQDK TSQQISALRA EIARLQMELM EYKAGKRVIG EDGAEGYSDL 430 440 450 460 470 480 FRENAMLQKE NGALRLRVKA MQEAIDAINN RVTQLMSQEA NLLLAKAGDG NEAIGALIQN 490 500 510 520 530 540 YIREIEELRT KLLESEAMNE SLRRSLSRAS ARSPYSLGAS PAAPAFGGSP ASSMEDASEV 550 560 570 580 590 600 IRRAKQDLER LKKKEVRQRR KSPEKEAFKK RAKLQQENSE ETDENEAEEE EEERDESGCE 610 620 630 640 650 660 EEEGREDEDE DSGSEESLVD SDSDPEEKEV NFQADLADLT CEIEIKQKLI DELENSQRRL 670 680 690 700 710 720 QTLKHQYEEK LILLQNKIRD TQLERDRVLQ NLSTMECYTE EKANKIKADY EKRLREMNRD 730 740 750 760 770 780 LQKLQAAQKE HARLLKNQSR YERELKKLQA EVAEMKKAKV ALMKQMREEQ QRRRLVETKR 790 800 810 820 830 840 NREIAQLKKE QRRQEFQIRA LESQKRQQEM VLRRKTQEVS ALRRLAKPMS ERVAGRAGLK 850 860 870 880 890 900 PPMLDSGAEV SASTTSSEAE SGARSVSSIV RQWNRKINHF LGDHPAPTVN GTRPARKKFQ 910 920 930 940 950 960 KKGASQSFSK AARLKWQSLE RRIIDIVMQR MTIVNLEADM ERLIKKREEL FLLQEALRRK 970 980 990 1000 1010 1020 RERLQAESPE EEKGLQELAE EIEVLAANID YINDGITDCQ ATIVQLEETK EELDSTDTSV 1030 1040 1050 1060 1070 1080 VISSCSLAEA RLLLDNFLKA SIDKGLQVAQ KEAQIRLLEG RLRQTDMAGS SQNHLLLDAL 1090 1100 1110 1120 1130 1140 REKAEAHPEL QALIYNVQQE NGYASTDEEI SEFSEGSFSQ SFTMKGSTSH DDFKFKSEPK 1150 1160 1170 1180 1190 1200 LSAQMKAVSA ECLGPPLDIS TKNITKSLAS LVEIKEDGVG FSVRDPYYRD RVSRTVSLPT 1210 1220 1230 1240 1250 1260 RGSTFPRQSR ATETSPLTRR KSYDRGQPIR STDVGFTPPS SPPTRPRNDR NVFSRLTSNQ 1270 1280 1290 1300 1310 1320 SQGSALDKSD DSDSSLSEVL RGIISPVGGA KGARTAPLQC VSMAEGHTKP ILCLDATDEL 1330 1340 1350 1360 1370 1380 LFTGSKDRSC KMWNLVTGQE IAALKGHPNN VVSIKYCSHS GLVFSVSTSY IKVWDIRDSA 1390 1400 1410 1420 1430 1440 KCIRTLTSSG QVISGDACAA TSTRAITSAQ GEHQINQIAL SPSGTMLYAA SGNAVRIWEL 1450 1460 1470 1480 1490 1500 SRFQPVGKLT GHIGPVMCLT VTQTASQHDL VVTGSKDHYV KMFELGECVT GTIGPTHNFE 1510 1520 1530 1540 1550 1560 PPHYDGIECL AIQGDILFSG SRDNGIKKWD LDQQELIQQI PNAHKDWVCA LAFIPGRPML 1570 1580 1590 1600 1610 1620 LSACRAGVIK VWNVDNFTPI GEIKGHDSPI NAICTNAKHI FTASSDCRVK LWNYVPGLTP 1630 CLPRRVLAIK GRATTLP
	Isoform 2 [UniParc]. Checksum: 827B497E8ECAC6A1	FASTA	1,624	181,270
	10 20 30 40 50 60 MAGQGDCCVK VAVRIRPQLS KEKIEGCHIC TSVTPGEPQV LLGKDKAFTY DFVFDLDTWQ 70 80 90 100 110 120 EQIYSTCVSK LIEGCFEGYN ATVLAYGQTG AGKTYTMGTG FDMATSEEEQ GIIPRAIAHL 130 140 150 160 170 180 FGGIAERKRR AQEQGVAGPE FKVSAQFLEL YNEEILDLFD STRDPDTRHR RSNIKIHEDA 190 200 210 220 230 240 NGGIYTTGVT SRLIHSQEEL IQCLKQGALS RTTASTQMNV QSSRSHAIFT IHLCQMRMCT 250 260 270 280 290 300 QPDLVNEAVT GLPDGTPPSS EYETLTAKFH FVDLAGSERL KRTGATGERA KEGISINCGL 310 320 330 340 350 360 LALGNVISAL GDQSKKVVHV PYRDSKLTRL LQDSLGGNSQ TIMIACVSPS DRDFMETLNT 370 380 390 400 410 420 LKYANRARNI KNKVVVNQDK TSQQISALRA EIARLQMELM EYKAGKRVIG EDGAEGYSDL 430 440 450 460 470 480 FRENAMLQKE NGALRLRVKA MQEAIDAINN RVTQLMSQEA NLLLAKAGDG NEAIGALIQN 490 500 510 520 530 540 YIREIEELRT KLLESEAMNE SLRRSLSRAS ARSPYSLGAS PAAPAFGGSP ASSMEDASEV 550 560 570 580 590 600 IRRAKQDLER LKKKEVRQRR KSPEKEAFKK RAKLQQENSE ETDENEAEEE EEERDESGCE 610 620 630 640 650 660 EEEGREDEDE DSGSEESLVD SDSDPEEKEV NFQADLADLT CEIEIKQKLI DELENSQRRL 670 680 690 700 710 720 QTLKHQYEEK LILLQNKIRD TQLERDRVLQ NLSTMECYTE EKANKIKADY EKRLREMNRD 730 740 750 760 770 780 LQKLQAAQKE HARLLKNQSR YERELKKLQA EVAEMKKAKV ALMKQMREEQ QRRRLVETKR 790 800 810 820 830 840 NREIAQLKKE QRRQEFQIRA LESQKRQQEM VLRRKTQEVS ALRRLAKPMS ERVAGRAGLK 850 860 870 880 890 900 PPMLDSGAEV SASTTSSEAE SGARSVSSIV RQWNRKINHF LGDHPAPTVN GTRPARKKFQ 910 920 930 940 950 960 KKGASQSFSK AARLKWQSLE RRIIDIVMQR MTIVNLEADM ERLIKKREEL FLLQEALRRK 970 980 990 1000 1010 1020 RERLQAESPE EEKGLQELAE EIEVLAANID YINDGITDCQ ATIVQLEETK EELDSTDTSV 1030 1040 1050 1060 1070 1080 VISSCSLAEA RLLLDNFLKA SIDKGLQVAQ KEAQIRLLEG RLRQTDMAGS SQNHLLLDAL 1090 1100 1110 1120 1130 1140 REKAEAHPEL QALIYNVQQE NGYASTDEEI SEFSEGSFSQ SFTMKGSTSH DDFKFKSEPK 1150 1160 1170 1180 1190 1200 LSAQMKAVSA ECLGPPLDIS TKNITKSLAS LVEIKEDGVG FSVRDPYYRD RVSRTVSLPT 1210 1220 1230 1240 1250 1260 RGSTFPRQSR ATETSPLTRR KSYDRGQPIR STDVGFTPPS SPPTRPRNDR NVFSRLTSNQ 1270 1280 1290 1300 1310 1320 SQGSALDKGI ISPVGGAKGA RTAPLQCVSM AEGHTKPILC LDATDELLFT GSKDRSCKMW 1330 1340 1350 1360 1370 1380 NLVTGQEIAA LKGHPNNVVS IKYCSHSGLV FSVSTSYIKV WDIRDSAKCI RTLTSSGQVI 1390 1400 1410 1420 1430 1440 SGDACAATST RAITSAQGEH QINQIALSPS GTMLYAASGN AVRIWELSRF QPVGKLTGHI 1450 1460 1470 1480 1490 1500 GPVMCLTVTQ TASQHDLVVT GSKDHYVKMF ELGECVTGTI GPTHNFEPPH YDGIECLAIQ 1510 1520 1530 1540 1550 1560 GDILFSGSRD NGIKKWDLDQ QELIQQIPNA HKDWVCALAF IPGRPMLLSA CRAGVIKVWN 1570 1580 1590 1600 1610 1620 VDNFTPIGEI KGHDSPINAI CTNAKHIFTA SSDCRVKLWN YVPGLTPCLP RRVLAIKGRA TTLP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of cDNA clones in size-fractionated cDNA libraries from human brain." Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D., Nomura N., Ohara O. DNA Res. 4:345-349(1997) [PubMed: 9455484] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	Ohara O., Nagase T., Kikuno R. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1237 AND THR-1244, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1237 AND SER-1241, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB007918 mRNA. Translation: BAA32294.2. Different initiation. AL358473 Genomic DNA. No translation available.
IPI	IPI00657775. IPI01011101.
PIR	T00066.
RefSeq	NP_001239029.1. NM_001252100.1. NP_001239031.1. NM_001252102.1. NP_001239032.1. NM_001252103.1. NP_060066.2. NM_017596.3.
UniGene	Hs.169182.
3D structure databases
ProteinModelPortal	O75037.
SMR	O75037. Positions 7-370, 1298-1620.
ModBase	Search...
Protein-protein interaction databases
STRING	O75037.
PTM databases
PhosphoSite	O75037.
Proteomic databases
PRIDE	O75037.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000332129; ENSP00000328494; ENSG00000116852.
GeneID	23046.
KEGG	hsa:23046.
UCSC	uc001gvr.1. human. uc001gvs.1. human.
Organism-specific databases
CTD	23046.
GeneCards	GC01M200938.
H-InvDB	HIX0001452.
HGNC	HGNC:29442. KIF21B.
HPA	HPA027249. HPA027274.
MIM	608322. gene.
neXtProt	NX_O75037.
PharmGKB	PA134925106.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12241.
HOVERGEN	HBG052247.
OrthoDB	EOG4THVS6.
PhylomeDB	O75037.
Gene expression databases
ArrayExpress	O75037.
Bgee	O75037.
CleanEx	HS_KIF21B.
Genevestigator	O75037.
GermOnline	ENSG00000116852. Homo sapiens.
Family and domain databases
InterPro	IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. IPR009053. Prefoldin. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:3.40.850.10. kinesin_motor. 1 hit. G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KO	K10395.
Pfam	PF00225. Kinesin. 1 hit. PF00400. WD40. 7 hits. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00129. KISc. 1 hit. SM00320. WD40. 7 hits. [Graphical view]
SUPFAM	SSF46579. Prefoldin. 1 hit. SSF50978. WD40_like. 1 hit.
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	44080.
SOURCE	Search...

Entry information

Entry name

KI21B_HUMAN

Accession

Primary (citable) accession number: O75037
Secondary accession number(s): Q5T4J3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	February 1, 2005
Last modified:	January 25, 2012
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.