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Protein

Heat shock factor 2-binding protein

Gene

HSF2BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in modulating HSF2 activation in testis.

GO - Biological processi

  • mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • spermatogenesis Source: ProtInc
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock factor 2-binding protein
Gene namesi
Name:HSF2BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:5226. HSF2BP.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29495.

Polymorphism and mutation databases

BioMutaiHSF2BP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Heat shock factor 2-binding proteinPRO_0000084077Add
BLAST

Post-translational modificationi

Sumoylated by UBE2I in response to MEKK1-mediated stimuli.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiO75031.
PaxDbiO75031.
PeptideAtlasiO75031.
PRIDEiO75031.

PTM databases

iPTMnetiO75031.
PhosphoSiteiO75031.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiO75031.
CleanExiHS_HSF2BP.
ExpressionAtlasiO75031. baseline and differential.
GenevisibleiO75031. HS.

Interactioni

Subunit structurei

Associates with HSF2. The interaction seems to occur between the trimerization domain of HSF2 and the N-terminal hydrophilic region of HSF2BP.

Protein-protein interaction databases

BioGridi116260. 4 interactions.
IntActiO75031. 1 interaction.
MINTiMINT-8247411.
STRINGi9606.ENSP00000291560.

Structurei

3D structure databases

ProteinModelPortaliO75031.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHB3. Eukaryota.
ENOG4111NEH. LUCA.
HOGENOMiHOG000112955.
HOVERGENiHBG051932.
InParanoidiO75031.
OMAiMLMALYN.
OrthoDBiEOG76473Z.
PhylomeDBiO75031.
TreeFamiTF331782.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75031-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEAGAAEEA CRHMGTKEEF VKVRKKDLER LTTEVMQIRD FLPRILNGEV
60 70 80 90 100
LESFQKLKIV EKNLERKEQE LEQLKMDCEH FKARLETVQA DNIREKKEKL
110 120 130 140 150
ALRQQLNEAK QQLLQQAEYC TEMGAAACTL LWGVSSSEEV VKAILGGDKA
160 170 180 190 200
LKFFSITGQT MESFVKSLDG DVQELDSDES QFVFALAGIV TNVAAIACGR
210 220 230 240 250
EFLVNSSRVL LDTILQLLGD LKPGQCTKLK VLMLMSLYNV SINLKGLKYI
260 270 280 290 300
SESPGFIPLL WWLLSDPDAE VCLHVLRLVQ SVVLEPEVFS KSASEFRSSL
310 320 330
PLQRILAMSK SRNPRLQTAA QELLEDLRTL EHNV
Length:334
Mass (Da):37,645
Last modified:November 1, 1998 - v1
Checksum:iF07981999F576E86
GO
Isoform 2 (identifier: O75031-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Note: No experimental confirmation available.
Show »
Length:259
Mass (Da):28,846
Checksum:iEC2D2F3ECBF6FF2B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2332LM → YG in BAA95539 (PubMed:10830953).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7575Missing in isoform 2. 1 PublicationVSP_054158Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007131 mRNA. Translation: BAA31967.1.
AK301795 mRNA. Translation: BAG63248.1.
AP001050 Genomic DNA. No translation available.
AP001751 Genomic DNA. Translation: BAA95537.1.
AP001752 Genomic DNA. Translation: BAA95539.1.
BC000153 mRNA. Translation: AAH00153.1.
CCDSiCCDS13697.1. [O75031-1]
RefSeqiNP_008962.1. NM_007031.1. [O75031-1]
XP_011527748.1. XM_011529446.1. [O75031-2]
UniGeneiHs.406157.

Genome annotation databases

EnsembliENST00000291560; ENSP00000291560; ENSG00000160207. [O75031-1]
GeneIDi11077.
KEGGihsa:11077.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007131 mRNA. Translation: BAA31967.1.
AK301795 mRNA. Translation: BAG63248.1.
AP001050 Genomic DNA. No translation available.
AP001751 Genomic DNA. Translation: BAA95537.1.
AP001752 Genomic DNA. Translation: BAA95539.1.
BC000153 mRNA. Translation: AAH00153.1.
CCDSiCCDS13697.1. [O75031-1]
RefSeqiNP_008962.1. NM_007031.1. [O75031-1]
XP_011527748.1. XM_011529446.1. [O75031-2]
UniGeneiHs.406157.

3D structure databases

ProteinModelPortaliO75031.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116260. 4 interactions.
IntActiO75031. 1 interaction.
MINTiMINT-8247411.
STRINGi9606.ENSP00000291560.

PTM databases

iPTMnetiO75031.
PhosphoSiteiO75031.

Polymorphism and mutation databases

BioMutaiHSF2BP.

Proteomic databases

EPDiO75031.
PaxDbiO75031.
PeptideAtlasiO75031.
PRIDEiO75031.

Protocols and materials databases

DNASUi11077.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291560; ENSP00000291560; ENSG00000160207. [O75031-1]
GeneIDi11077.
KEGGihsa:11077.

Organism-specific databases

CTDi11077.
GeneCardsiHSF2BP.
HGNCiHGNC:5226. HSF2BP.
MIMi604554. gene.
neXtProtiNX_O75031.
PharmGKBiPA29495.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHB3. Eukaryota.
ENOG4111NEH. LUCA.
HOGENOMiHOG000112955.
HOVERGENiHBG051932.
InParanoidiO75031.
OMAiMLMALYN.
OrthoDBiEOG76473Z.
PhylomeDBiO75031.
TreeFamiTF331782.

Miscellaneous databases

GenomeRNAii11077.
PROiO75031.
SOURCEiSearch...

Gene expression databases

BgeeiO75031.
CleanExiHS_HSF2BP.
ExpressionAtlasiO75031. baseline and differential.
GenevisibleiO75031. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel testis-specific protein that interacts with heat shock factor 2."
    Yoshima T., Yura T., Yanagi H.
    Gene 214:139-146(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  3. "The DNA sequence of human chromosome 21."
    Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A.
    , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
    Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cervix.
  5. "Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation."
    Jakobs A., Himstedt F., Funk M., Korn B., Gaestel M., Niedenthal R.
    Nucleic Acids Res. 35:E109-E109(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION.

Entry informationi

Entry nameiHSF2B_HUMAN
AccessioniPrimary (citable) accession number: O75031
Secondary accession number(s): B4DX36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.