Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heat shock factor 2-binding protein

Gene

HSF2BP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in modulating HSF2 activation in testis (PubMed:9651507). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity).By similarity1 Publication

GO - Biological processi

  • spermatogenesis Source: ProtInc
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160207-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock factor 2-binding protein
Gene namesi
Name:HSF2BP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:5226. HSF2BP.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi11077.
OpenTargetsiENSG00000160207.
PharmGKBiPA29495.

Polymorphism and mutation databases

BioMutaiHSF2BP.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000840771 – 334Heat shock factor 2-binding proteinAdd BLAST334

Post-translational modificationi

Sumoylated by UBE2I in response to MEKK1-mediated stimuli.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiO75031.
PaxDbiO75031.
PeptideAtlasiO75031.
PRIDEiO75031.

PTM databases

iPTMnetiO75031.
PhosphoSitePlusiO75031.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSG00000160207.
CleanExiHS_HSF2BP.
ExpressionAtlasiO75031. baseline and differential.
GenevisibleiO75031. HS.

Organism-specific databases

HPAiHPA031724.

Interactioni

Subunit structurei

Associates with HSF2 (PubMed:9651507). The interaction seems to occur between the trimerization domain of HSF2 and the N-terminal hydrophilic region of HSF2BP (PubMed:9651507). Interacts (via C-terminus) with BNC1 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC120Q96HB54EBI-7116203,EBI-744556
CDC73Q6P1J93EBI-7116203,EBI-930143
RALYQ53GL64EBI-7116203,EBI-9512693
TRAF5O004634EBI-7116203,EBI-523498

Protein-protein interaction databases

BioGridi116260. 4 interactors.
IntActiO75031. 202 interactors.
MINTiMINT-8247411.
STRINGi9606.ENSP00000291560.

Structurei

3D structure databases

ProteinModelPortaliO75031.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili49 – 122Sequence analysisAdd BLAST74

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHB3. Eukaryota.
ENOG4111NEH. LUCA.
GeneTreeiENSGT00390000008490.
HOGENOMiHOG000112955.
HOVERGENiHBG051932.
InParanoidiO75031.
OMAiMLMALYN.
OrthoDBiEOG091G0UCZ.
PhylomeDBiO75031.
TreeFamiTF331782.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75031-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEAGAAEEA CRHMGTKEEF VKVRKKDLER LTTEVMQIRD FLPRILNGEV
60 70 80 90 100
LESFQKLKIV EKNLERKEQE LEQLKMDCEH FKARLETVQA DNIREKKEKL
110 120 130 140 150
ALRQQLNEAK QQLLQQAEYC TEMGAAACTL LWGVSSSEEV VKAILGGDKA
160 170 180 190 200
LKFFSITGQT MESFVKSLDG DVQELDSDES QFVFALAGIV TNVAAIACGR
210 220 230 240 250
EFLVNSSRVL LDTILQLLGD LKPGQCTKLK VLMLMSLYNV SINLKGLKYI
260 270 280 290 300
SESPGFIPLL WWLLSDPDAE VCLHVLRLVQ SVVLEPEVFS KSASEFRSSL
310 320 330
PLQRILAMSK SRNPRLQTAA QELLEDLRTL EHNV
Length:334
Mass (Da):37,645
Last modified:November 1, 1998 - v1
Checksum:iF07981999F576E86
GO
Isoform 2 (identifier: O75031-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Note: No experimental confirmation available.
Show »
Length:259
Mass (Da):28,846
Checksum:iEC2D2F3ECBF6FF2B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti232 – 233LM → YG in BAA95539 (PubMed:10830953).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0541581 – 75Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007131 mRNA. Translation: BAA31967.1.
AK301795 mRNA. Translation: BAG63248.1.
AP001050 Genomic DNA. No translation available.
AP001751 Genomic DNA. Translation: BAA95537.1.
AP001752 Genomic DNA. Translation: BAA95539.1.
BC000153 mRNA. Translation: AAH00153.1.
CCDSiCCDS13697.1. [O75031-1]
RefSeqiNP_008962.1. NM_007031.1. [O75031-1]
XP_011527748.1. XM_011529446.2. [O75031-2]
UniGeneiHs.406157.

Genome annotation databases

EnsembliENST00000291560; ENSP00000291560; ENSG00000160207. [O75031-1]
GeneIDi11077.
KEGGihsa:11077.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007131 mRNA. Translation: BAA31967.1.
AK301795 mRNA. Translation: BAG63248.1.
AP001050 Genomic DNA. No translation available.
AP001751 Genomic DNA. Translation: BAA95537.1.
AP001752 Genomic DNA. Translation: BAA95539.1.
BC000153 mRNA. Translation: AAH00153.1.
CCDSiCCDS13697.1. [O75031-1]
RefSeqiNP_008962.1. NM_007031.1. [O75031-1]
XP_011527748.1. XM_011529446.2. [O75031-2]
UniGeneiHs.406157.

3D structure databases

ProteinModelPortaliO75031.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116260. 4 interactors.
IntActiO75031. 202 interactors.
MINTiMINT-8247411.
STRINGi9606.ENSP00000291560.

PTM databases

iPTMnetiO75031.
PhosphoSitePlusiO75031.

Polymorphism and mutation databases

BioMutaiHSF2BP.

Proteomic databases

EPDiO75031.
PaxDbiO75031.
PeptideAtlasiO75031.
PRIDEiO75031.

Protocols and materials databases

DNASUi11077.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291560; ENSP00000291560; ENSG00000160207. [O75031-1]
GeneIDi11077.
KEGGihsa:11077.

Organism-specific databases

CTDi11077.
DisGeNETi11077.
GeneCardsiHSF2BP.
HGNCiHGNC:5226. HSF2BP.
HPAiHPA031724.
MIMi604554. gene.
neXtProtiNX_O75031.
OpenTargetsiENSG00000160207.
PharmGKBiPA29495.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHB3. Eukaryota.
ENOG4111NEH. LUCA.
GeneTreeiENSGT00390000008490.
HOGENOMiHOG000112955.
HOVERGENiHBG051932.
InParanoidiO75031.
OMAiMLMALYN.
OrthoDBiEOG091G0UCZ.
PhylomeDBiO75031.
TreeFamiTF331782.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160207-MONOMER.

Miscellaneous databases

GenomeRNAii11077.
PROiO75031.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160207.
CleanExiHS_HSF2BP.
ExpressionAtlasiO75031. baseline and differential.
GenevisibleiO75031. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHSF2B_HUMAN
AccessioniPrimary (citable) accession number: O75031
Secondary accession number(s): B4DX36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.