##gff-version 3 O75027 UniProtKB Transit peptide 1 22 . . . Note=Mitochondrion;Ontology_term=ECO:0000255;evidence=ECO:0000255 O75027 UniProtKB Chain 23 752 . . . ID=PRO_0000000249;Note=Iron-sulfur clusters transporter ABCB7%2C mitochondrial O75027 UniProtKB Topological domain 23 140 . . . Note=Mitochondrial matrix;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P40416 O75027 UniProtKB Transmembrane 141 161 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 O75027 UniProtKB Topological domain 162 185 . . . Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P40416 O75027 UniProtKB Transmembrane 186 206 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 O75027 UniProtKB Topological domain 207 259 . . . Note=Mitochondrial matrix;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P40416 O75027 UniProtKB Transmembrane 260 280 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 O75027 UniProtKB Topological domain 281 290 . . . Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P40416 O75027 UniProtKB Transmembrane 291 311 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 O75027 UniProtKB Topological domain 312 382 . . . Note=Mitochondrial matrix;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P40416 O75027 UniProtKB Transmembrane 383 403 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 O75027 UniProtKB Topological domain 404 409 . . . Note=Mitochondrial intermembrane;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P40416 O75027 UniProtKB Transmembrane 410 430 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 O75027 UniProtKB Topological domain 431 752 . . . Note=Mitochondrial matrix;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P40416 O75027 UniProtKB Domain 140 436 . . . Note=ABC transmembrane type-1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00441 O75027 UniProtKB Domain 472 706 . . . Note=ABC transporter;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 O75027 UniProtKB Binding site 315 319 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P40416 O75027 UniProtKB Binding site 378 381 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P40416 O75027 UniProtKB Binding site 428 428 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q2G506 O75027 UniProtKB Binding site 481 481 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9NP58 O75027 UniProtKB Binding site 505 516 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00434 O75027 UniProtKB Modified residue 216 216 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 O75027 UniProtKB Modified residue 251 251 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 O75027 UniProtKB Modified residue 336 336 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q704E8 O75027 UniProtKB Modified residue 340 340 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q704E8 O75027 UniProtKB Modified residue 342 342 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q704E8 O75027 UniProtKB Alternative sequence 56 56 . . . ID=VSP_014635;Note=In isoform 2. Q->QQ;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|Ref.5;Dbxref=PMID:15489334 O75027 UniProtKB Alternative sequence 112 151 . . . ID=VSP_054700;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75027 UniProtKB Natural variant 208 208 . . . ID=VAR_067354;Note=In ASAT. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22398176;Dbxref=dbSNP:rs515726147,PMID:22398176 O75027 UniProtKB Natural variant 315 315 . . . ID=VAR_022872;Note=R->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11843825,ECO:0000269|PubMed:9621516;Dbxref=PMID:11843825,PMID:9621516 O75027 UniProtKB Natural variant 346 346 . . . ID=VAR_022873;Note=F->I;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11843825,ECO:0000269|PubMed:9621516;Dbxref=PMID:11843825,PMID:9621516 O75027 UniProtKB Natural variant 400 400 . . . ID=VAR_009156;Note=In ASAT. I->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10196363;Dbxref=dbSNP:rs72554634,PMID:10196363 O75027 UniProtKB Natural variant 411 411 . . . ID=VAR_022874;Note=In ASAT. V->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11843825;Dbxref=dbSNP:rs80356713,PMID:11843825 O75027 UniProtKB Natural variant 433 433 . . . ID=VAR_012640;Note=In ASAT%3B impaired maturation of cytosolic Fe/S proteins%2C loss of the ability to couple MgATP binding with stimulation of ATPase activity at the nucleotide binding domain%3B%3B loss of [2Fe-2S]-(GS)4 cluster transport. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11050011,ECO:0000269|PubMed:33157103;Dbxref=dbSNP:rs80356714,PMID:11050011,PMID:33157103 O75027 UniProtKB Natural variant 580 580 . . . ID=VAR_055471;Note=A->V;Dbxref=dbSNP:rs1340989 O75027 UniProtKB Natural variant 581 581 . . . ID=VAR_037972;Note=V->A;Dbxref=dbSNP:rs1340989 O75027 UniProtKB Mutagenesis 433 433 . . . Note=Significantly increases ATPase activity by [2Fe-2S]-(GS)4 cluster stimulation. Increases affinity for Mg-ATP. Does not affect affinity for Mg-ATP in the presence of the in the presence of [2Fe-2S]-(GS)4 cluster. Does not affect [2Fe-2S]-(GS)4 cluster transport. E->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33157103;Dbxref=PMID:33157103 O75027 UniProtKB Mutagenesis 433 433 . . . Note=Loss of ATPase activity stimulation by [2Fe-2S]-(GS)4 cluster stimulation. Loss of the ability to couple MgATP binding with stimulation of ATPase activity at the nucleotide binding domain. Loss of [2Fe-2S]-(GS)4 cluster transport. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33157103;Dbxref=PMID:33157103 O75027 UniProtKB Mutagenesis 433 433 . . . Note=Loss of ATPase activity stimulation by [2Fe-2S]-(GS)4 cluster stimulation. Loss of the ability to couple MgATP binding with stimulation of ATPase activity at the nucleotide binding domain. Loss of [2Fe-2S]-(GS)4 cluster transport. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33157103;Dbxref=PMID:33157103 O75027 UniProtKB Sequence conflict 141 141 . . . Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75027 UniProtKB Sequence conflict 258 258 . . . Note=R->K;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75027 UniProtKB Sequence conflict 271 276 . . . Note=LLPIMF->PLPNHV;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75027 UniProtKB Sequence conflict 280 280 . . . Note=L->LL;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75027 UniProtKB Sequence conflict 290 290 . . . Note=G->C;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75027 UniProtKB Sequence conflict 293 297 . . . Note=FALVT->LLGN;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75027 UniProtKB Sequence conflict 320 324 . . . Note=IEMNK->LEIDQ;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75027 UniProtKB Sequence conflict 542 542 . . . Note=E->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 O75027 UniProtKB Helix 134 170 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 186 233 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 238 243 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 248 288 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 291 338 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 340 345 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 350 401 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 410 421 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 424 431 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 434 449 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Turn 450 452 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Beta strand 473 479 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Beta strand 487 491 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Beta strand 500 504 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 513 518 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Beta strand 525 531 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 536 538 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 541 547 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Beta strand 548 551 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Beta strand 559 561 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 562 567 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 575 584 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 588 593 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Beta strand 594 597 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Beta strand 601 606 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 611 625 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Beta strand 628 633 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 641 655 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Beta strand 658 663 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 667 670 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Beta strand 674 680 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Beta strand 683 688 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF O75027 UniProtKB Helix 690 692 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7VGF