O75023 (LIRB5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 5

Alternative name(s):
CD85 antigen-like family member C
Leukocyte immunoglobulin-like receptor 8
Short name=LIR-8
CD_antigen=CD85c

Gene names

Name:	LILRB5
Synonyms:	LIR8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	590 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as receptor for class I MHC antigens.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Detected in a natural killer (NK) cells. Ref.1
Domain	Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Sequence similarities	Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Biological process	Adaptive immunity Immunity
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell surface receptor signaling pathway Traceable author statement Ref.1. Source: ProtInc defense response Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	transmembrane signaling receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75023-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75023-2)

The sequence of this isoform differs from the canonical sequence as follows:
     119-218: Missing.
     435-435: P → PA

Note: No experimental confirmation available.

Isoform 3 (identifier: O75023-3)

The sequence of this isoform differs from the canonical sequence as follows:
     435-435: P → PA

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 590	567	Leukocyte immunoglobulin-like receptor subfamily B member 5		PRO_0000014825
Regions
	Topological domain	24 – 458	435	Extracellular Potential
	Transmembrane	459 – 479	21	Helical; Potential
	Topological domain	480 – 590	111	Cytoplasmic Potential
	Domain	27 – 116	90	Ig-like C2-type 1
	Domain	111 – 228	118	Ig-like C2-type 2
	Domain	224 – 313	90	Ig-like C2-type 3
	Domain	337 – 418	82	Ig-like C2-type 4
	Motif	552 – 557	6	ITIM motif 1
	Motif	582 – 587	6	ITIM motif 2
Amino acid modifications
	Glycosylation	139	1	N-linked (GlcNAc...) Potential
	Glycosylation	279	1	N-linked (GlcNAc...) Ref.5
	Glycosylation	339	1	N-linked (GlcNAc...) Potential
	Disulfide bond	49 ↔ 98		By similarity
	Disulfide bond	144 ↔ 195		By similarity
	Disulfide bond	244 ↔ 295		Potential
	Disulfide bond	344 ↔ 395		Potential
Natural variations
	Alternative sequence	119 – 218	100	Missing in isoform 2.		VSP_008461
	Alternative sequence	435	1	P → PA in isoform 2 and isoform 3.		VSP_008462
	Natural variant	247	1	D → G. Corresponds to variant rs12975366 [ dbSNP | Ensembl ].		VAR_061316
Experimental info
	Sequence conflict	12	1	G → W in AK223296. Ref.2
	Sequence conflict	255	1	L → R in AK223296. Ref.2
	Sequence conflict	355	1	L → S in BAB71361. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 8E7AB249F12E44CD	FASTA	590	64,126
	10 20 30 40 50 60 MTLTLSVLIC LGLSVGPRTC VQAGTLPKPT LWAEPASVIA RGKPVTLWCQ GPLETEEYRL 70 80 90 100 110 120 DKEGLPWARK RQNPLEPGAK AKFHIPSTVY DSAGRYRCYY ETPAGWSEPS DPLELVATGF 130 140 150 160 170 180 YAEPTLLALP SPVVASGGNV TLQCDTLDGL LTFVLVEEEQ KLPRTLYSQK LPKGPSQALF 190 200 210 220 230 240 PVGPVTPSCR WRFRCYYYYR KNPQVWSNPS DLLEILVPGV SRKPSLLIPQ GSVVARGGSL 250 260 270 280 290 300 TLQCRSDVGY DIFVLYKEGE HDLVQGSGQQ PQAGLSQANF TLGPVSRSHG GQYRCYGAHN 310 320 330 340 350 360 LSPRWSAPSD PLDILIAGLI PDIPALSVQP GPKVASGENV TLLCQSWHQI DTFFLTKEGA 370 380 390 400 410 420 AHPPLCLKSK YQSYRHQAEF SMSPVTSAQG GTYRCYSAIR SYPYLLSSPS YPQELVVSGP 430 440 450 460 470 480 SGDPSLSPTG STPTPGPEDQ PLTPTGLDPQ SGLGRHLGVV TGVSVAFVLL LFLLLFLLLR 490 500 510 520 530 540 HRHQSKHRTS AHFYRPAGAA GPEPKDQGLQ KRASPVADIQ EEILNAAVKD TQPKDGVEMD 550 560 570 580 590 ARAAASEAPQ DVTYAQLHSL TLRREATEPP PSQEREPPAE PSIYAPLAIH
	Isoform 2 [UniParc]. Checksum: BDE0FEC49A5CD587	FASTA	491	52,969
	10 20 30 40 50 60 MTLTLSVLIC LGLSVGPRTC VQAGTLPKPT LWAEPASVIA RGKPVTLWCQ GPLETEEYRL 70 80 90 100 110 120 DKEGLPWARK RQNPLEPGAK AKFHIPSTVY DSAGRYRCYY ETPAGWSEPS DPLELVATGV 130 140 150 160 170 180 SRKPSLLIPQ GSVVARGGSL TLQCRSDVGY DIFVLYKEGE HDLVQGSGQQ PQAGLSQANF 190 200 210 220 230 240 TLGPVSRSHG GQYRCYGAHN LSPRWSAPSD PLDILIAGLI PDIPALSVQP GPKVASGENV 250 260 270 280 290 300 TLLCQSWHQI DTFFLTKEGA AHPPLCLKSK YQSYRHQAEF SMSPVTSAQG GTYRCYSAIR 310 320 330 340 350 360 SYPYLLSSPS YPQELVVSGP SGDPSLSPTG STPTPAGPED QPLTPTGLDP QSGLGRHLGV 370 380 390 400 410 420 VTGVSVAFVL LLFLLLFLLL RHRHQSKHRT SAHFYRPAGA AGPEPKDQGL QKRASPVADI 430 440 450 460 470 480 QEEILNAAVK DTQPKDGVEM DARAAASEAP QDVTYAQLHS LTLRREATEP PPSQEREPPA 490 EPSIYAPLAI H
	Isoform 3 [UniParc]. Checksum: 201FDB50AB43ACF7	FASTA	591	64,197
	10 20 30 40 50 60 MTLTLSVLIC LGLSVGPRTC VQAGTLPKPT LWAEPASVIA RGKPVTLWCQ GPLETEEYRL 70 80 90 100 110 120 DKEGLPWARK RQNPLEPGAK AKFHIPSTVY DSAGRYRCYY ETPAGWSEPS DPLELVATGF 130 140 150 160 170 180 YAEPTLLALP SPVVASGGNV TLQCDTLDGL LTFVLVEEEQ KLPRTLYSQK LPKGPSQALF 190 200 210 220 230 240 PVGPVTPSCR WRFRCYYYYR KNPQVWSNPS DLLEILVPGV SRKPSLLIPQ GSVVARGGSL 250 260 270 280 290 300 TLQCRSDVGY DIFVLYKEGE HDLVQGSGQQ PQAGLSQANF TLGPVSRSHG GQYRCYGAHN 310 320 330 340 350 360 LSPRWSAPSD PLDILIAGLI PDIPALSVQP GPKVASGENV TLLCQSWHQI DTFFLTKEGA 370 380 390 400 410 420 AHPPLCLKSK YQSYRHQAEF SMSPVTSAQG GTYRCYSAIR SYPYLLSSPS YPQELVVSGP 430 440 450 460 470 480 SGDPSLSPTG STPTPAGPED QPLTPTGLDP QSGLGRHLGV VTGVSVAFVL LLFLLLFLLL 490 500 510 520 530 540 RHRHQSKHRT SAHFYRPAGA AGPEPKDQGL QKRASPVADI QEEILNAAVK DTQPKDGVEM 550 560 570 580 590 DARAAASEAP QDVTYAQLHS LTLRREATEP PPSQEREPPA EPSIYAPLAI H

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules." Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D. J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Peripheral blood leukocyte.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Small intestine and Synovium.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Pancreas and Spleen.
[5]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-279, MASS SPECTROMETRY. Tissue: Plasma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF025534 mRNA. Translation: AAB87668.1. AK057072 mRNA. Translation: BAB71361.1. AK223296 mRNA. No translation available. AC010492 Genomic DNA. No translation available. BC025704 mRNA. Translation: AAH25704.1.
IPI	IPI00009961. IPI00376862. IPI00829955.
RefSeq	NP_001074911.1. NM_001081442.1. NP_001074912.1. NM_001081443.1. NP_006831.1. NM_006840.3.
UniGene	Hs.655338.
3D structure databases
ProteinModelPortal	O75023.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000406478.
PTM databases
PhosphoSite	O75023.
Proteomic databases
PaxDb	O75023.
PRIDE	O75023.
Protocols and materials databases
DNASU	10990.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000316219; ENSP00000320390; ENSG00000105609. ENST00000345866; ENSP00000263430; ENSG00000105609. ENST00000449561; ENSP00000406478; ENSG00000105609. ENST00000571036; ENSP00000461240; ENSG00000263021. ENST00000575516; ENSP00000460244; ENSG00000263021. ENST00000576654; ENSP00000460669; ENSG00000263021.
GeneID	10990.
KEGG	hsa:10990.
UCSC	uc002qex.3. human. uc002qey.3. human. uc002qez.3. human.
Organism-specific databases
CTD	10990.
GeneCards	GC19M054754.
HGNC	HGNC:6609. LILRB5.
HPA	HPA012069.
MIM	604814. gene.
neXtProt	NX_O75023.
PharmGKB	PA30383.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG25855.
HOGENOM	HOG000234395.
HOVERGEN	HBG074353.
InParanoid	O75023.
KO	K06512.
OrthoDB	EOG47WNNF.
PhylomeDB	O75023.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	O75023.
Bgee	O75023.
CleanEx	HS_LILRB5.
Genevestigator	O75023.
GermOnline	ENSG00000105609. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view]
SMART	SM00409. IG. 2 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10990.
NextBio	41759.
SOURCE	Search...

Entry information

Entry name

LIRB5_HUMAN

Accession

Primary (citable) accession number: O75023
Secondary accession number(s): Q8N760

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.