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O75023

- LIRB5_HUMAN

UniProt

O75023 - LIRB5_HUMAN

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Protein
Leukocyte immunoglobulin-like receptor subfamily B member 5
Gene
LILRB5, LIR8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act as receptor for class I MHC antigens.

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
  2. defense response Source: ProtInc
  3. immune system process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 5
Alternative name(s):
CD85 antigen-like family member C
Leukocyte immunoglobulin-like receptor 8
Short name:
LIR-8
CD_antigen: CD85c
Gene namesi
Name:LILRB5
Synonyms:LIR8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6609. LILRB5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 458435Extracellular Reviewed prediction
Add
BLAST
Transmembranei459 – 47921Helical; Reviewed prediction
Add
BLAST
Topological domaini480 – 590111Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30383.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 590567Leukocyte immunoglobulin-like receptor subfamily B member 5
PRO_0000014825Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 98 By similarity
Glycosylationi139 – 1391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi144 ↔ 195 By similarity
Disulfide bondi244 ↔ 295 Reviewed prediction
Glycosylationi279 – 2791N-linked (GlcNAc...)1 Publication
Glycosylationi339 – 3391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi344 ↔ 395 Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75023.
PRIDEiO75023.

PTM databases

PhosphoSiteiO75023.

Expressioni

Tissue specificityi

Detected in a natural killer (NK) cells.1 Publication

Gene expression databases

ArrayExpressiO75023.
BgeeiO75023.
CleanExiHS_LILRB5.
GenevestigatoriO75023.

Organism-specific databases

HPAiHPA012069.

Interactioni

Protein-protein interaction databases

IntActiO75023. 1 interaction.
STRINGi9606.ENSP00000406478.

Structurei

3D structure databases

ProteinModelPortaliO75023.
SMRiO75023. Positions 26-418.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11690Ig-like C2-type 1
Add
BLAST
Domaini111 – 228118Ig-like C2-type 2
Add
BLAST
Domaini224 – 31390Ig-like C2-type 3
Add
BLAST
Domaini337 – 41882Ig-like C2-type 4
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi552 – 5576ITIM motif 1
Motifi582 – 5876ITIM motif 2

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25855.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiO75023.
KOiK06512.
PhylomeDBiO75023.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75023-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTLTLSVLIC LGLSVGPRTC VQAGTLPKPT LWAEPASVIA RGKPVTLWCQ    50
GPLETEEYRL DKEGLPWARK RQNPLEPGAK AKFHIPSTVY DSAGRYRCYY 100
ETPAGWSEPS DPLELVATGF YAEPTLLALP SPVVASGGNV TLQCDTLDGL 150
LTFVLVEEEQ KLPRTLYSQK LPKGPSQALF PVGPVTPSCR WRFRCYYYYR 200
KNPQVWSNPS DLLEILVPGV SRKPSLLIPQ GSVVARGGSL TLQCRSDVGY 250
DIFVLYKEGE HDLVQGSGQQ PQAGLSQANF TLGPVSRSHG GQYRCYGAHN 300
LSPRWSAPSD PLDILIAGLI PDIPALSVQP GPKVASGENV TLLCQSWHQI 350
DTFFLTKEGA AHPPLCLKSK YQSYRHQAEF SMSPVTSAQG GTYRCYSAIR 400
SYPYLLSSPS YPQELVVSGP SGDPSLSPTG STPTPGPEDQ PLTPTGLDPQ 450
SGLGRHLGVV TGVSVAFVLL LFLLLFLLLR HRHQSKHRTS AHFYRPAGAA 500
GPEPKDQGLQ KRASPVADIQ EEILNAAVKD TQPKDGVEMD ARAAASEAPQ 550
DVTYAQLHSL TLRREATEPP PSQEREPPAE PSIYAPLAIH 590
Length:590
Mass (Da):64,126
Last modified:November 1, 1998 - v1
Checksum:i8E7AB249F12E44CD
GO
Isoform 2 (identifier: O75023-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-218: Missing.
     435-435: P → PA

Note: No experimental confirmation available.

Show »
Length:491
Mass (Da):52,969
Checksum:iBDE0FEC49A5CD587
GO
Isoform 3 (identifier: O75023-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     435-435: P → PA

Note: No experimental confirmation available.

Show »
Length:591
Mass (Da):64,197
Checksum:i201FDB50AB43ACF7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti247 – 2471D → G.
Corresponds to variant rs12975366 [ dbSNP | Ensembl ].
VAR_061316

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei119 – 218100Missing in isoform 2.
VSP_008461Add
BLAST
Alternative sequencei435 – 4351P → PA in isoform 2 and isoform 3.
VSP_008462

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121G → W in AK223296. 1 Publication
Sequence conflicti255 – 2551L → R in AK223296. 1 Publication
Sequence conflicti355 – 3551L → S in BAB71361. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF025534 mRNA. Translation: AAB87668.1.
AK057072 mRNA. Translation: BAB71361.1.
AK223296 mRNA. No translation available.
AC010492 Genomic DNA. No translation available.
BC025704 mRNA. Translation: AAH25704.1.
CCDSiCCDS12885.1. [O75023-1]
CCDS42611.1. [O75023-2]
CCDS46176.1. [O75023-3]
RefSeqiNP_001074911.1. NM_001081442.1. [O75023-3]
NP_001074912.1. NM_001081443.1. [O75023-2]
NP_006831.1. NM_006840.3. [O75023-1]
UniGeneiHs.655338.

Genome annotation databases

EnsembliENST00000316219; ENSP00000320390; ENSG00000105609. [O75023-1]
ENST00000345866; ENSP00000263430; ENSG00000105609. [O75023-2]
ENST00000449561; ENSP00000406478; ENSG00000105609. [O75023-3]
ENST00000571036; ENSP00000461240; ENSG00000263021. [O75023-2]
ENST00000575516; ENSP00000460244; ENSG00000263021. [O75023-1]
ENST00000576654; ENSP00000460669; ENSG00000263021. [O75023-3]
GeneIDi10990.
KEGGihsa:10990.
UCSCiuc002qex.3. human. [O75023-1]
uc002qey.3. human. [O75023-3]
uc002qez.3. human. [O75023-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF025534 mRNA. Translation: AAB87668.1 .
AK057072 mRNA. Translation: BAB71361.1 .
AK223296 mRNA. No translation available.
AC010492 Genomic DNA. No translation available.
BC025704 mRNA. Translation: AAH25704.1 .
CCDSi CCDS12885.1. [O75023-1 ]
CCDS42611.1. [O75023-2 ]
CCDS46176.1. [O75023-3 ]
RefSeqi NP_001074911.1. NM_001081442.1. [O75023-3 ]
NP_001074912.1. NM_001081443.1. [O75023-2 ]
NP_006831.1. NM_006840.3. [O75023-1 ]
UniGenei Hs.655338.

3D structure databases

ProteinModelPortali O75023.
SMRi O75023. Positions 26-418.
ModBasei Search...

Protein-protein interaction databases

IntActi O75023. 1 interaction.
STRINGi 9606.ENSP00000406478.

PTM databases

PhosphoSitei O75023.

Proteomic databases

PaxDbi O75023.
PRIDEi O75023.

Protocols and materials databases

DNASUi 10990.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316219 ; ENSP00000320390 ; ENSG00000105609 . [O75023-1 ]
ENST00000345866 ; ENSP00000263430 ; ENSG00000105609 . [O75023-2 ]
ENST00000449561 ; ENSP00000406478 ; ENSG00000105609 . [O75023-3 ]
ENST00000571036 ; ENSP00000461240 ; ENSG00000263021 . [O75023-2 ]
ENST00000575516 ; ENSP00000460244 ; ENSG00000263021 . [O75023-1 ]
ENST00000576654 ; ENSP00000460669 ; ENSG00000263021 . [O75023-3 ]
GeneIDi 10990.
KEGGi hsa:10990.
UCSCi uc002qex.3. human. [O75023-1 ]
uc002qey.3. human. [O75023-3 ]
uc002qez.3. human. [O75023-2 ]

Organism-specific databases

CTDi 10990.
GeneCardsi GC19M054754.
HGNCi HGNC:6609. LILRB5.
HPAi HPA012069.
MIMi 604814. gene.
neXtProti NX_O75023.
PharmGKBi PA30383.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25855.
HOGENOMi HOG000234395.
HOVERGENi HBG074353.
InParanoidi O75023.
KOi K06512.
PhylomeDBi O75023.
TreeFami TF336644.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikii LILRB5.
GenomeRNAii 10990.
NextBioi 41759.
PROi O75023.
SOURCEi Search...

Gene expression databases

ArrayExpressi O75023.
Bgeei O75023.
CleanExi HS_LILRB5.
Genevestigatori O75023.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
    Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.
    J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Peripheral blood leukocyte.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Small intestine and Synovium.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas and Spleen.
  5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-279.
    Tissue: Plasma.

Entry informationi

Entry nameiLIRB5_HUMAN
AccessioniPrimary (citable) accession number: O75023
Secondary accession number(s): Q8N760
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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