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O75023

- LIRB5_HUMAN

UniProt

O75023 - LIRB5_HUMAN

Protein

Leukocyte immunoglobulin-like receptor subfamily B member 5

Gene

LILRB5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    May act as receptor for class I MHC antigens.

    GO - Molecular functioni

    1. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: ProtInc
    2. defense response Source: ProtInc
    3. immune system process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily B member 5
    Alternative name(s):
    CD85 antigen-like family member C
    Leukocyte immunoglobulin-like receptor 8
    Short name:
    LIR-8
    CD_antigen: CD85c
    Gene namesi
    Name:LILRB5
    Synonyms:LIR8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6609. LILRB5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30383.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 590567Leukocyte immunoglobulin-like receptor subfamily B member 5PRO_0000014825Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
    Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi144 ↔ 195PROSITE-ProRule annotation
    Disulfide bondi244 ↔ 295PROSITE-ProRule annotation
    Glycosylationi279 – 2791N-linked (GlcNAc...)1 Publication
    Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi344 ↔ 395PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO75023.
    PRIDEiO75023.

    PTM databases

    PhosphoSiteiO75023.

    Expressioni

    Tissue specificityi

    Detected in a natural killer (NK) cells.1 Publication

    Gene expression databases

    ArrayExpressiO75023.
    BgeeiO75023.
    CleanExiHS_LILRB5.
    GenevestigatoriO75023.

    Organism-specific databases

    HPAiHPA012069.

    Interactioni

    Protein-protein interaction databases

    IntActiO75023. 1 interaction.
    STRINGi9606.ENSP00000406478.

    Structurei

    3D structure databases

    ProteinModelPortaliO75023.
    SMRiO75023. Positions 26-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 458435ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini480 – 590111CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei459 – 47921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 11690Ig-like C2-type 1Add
    BLAST
    Domaini111 – 228118Ig-like C2-type 2Add
    BLAST
    Domaini224 – 31390Ig-like C2-type 3Add
    BLAST
    Domaini337 – 41882Ig-like C2-type 4Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi552 – 5576ITIM motif 1
    Motifi582 – 5876ITIM motif 2

    Domaini

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG25855.
    HOGENOMiHOG000234395.
    HOVERGENiHBG074353.
    InParanoidiO75023.
    KOiK06512.
    PhylomeDBiO75023.
    TreeFamiTF336644.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75023-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTLTLSVLIC LGLSVGPRTC VQAGTLPKPT LWAEPASVIA RGKPVTLWCQ    50
    GPLETEEYRL DKEGLPWARK RQNPLEPGAK AKFHIPSTVY DSAGRYRCYY 100
    ETPAGWSEPS DPLELVATGF YAEPTLLALP SPVVASGGNV TLQCDTLDGL 150
    LTFVLVEEEQ KLPRTLYSQK LPKGPSQALF PVGPVTPSCR WRFRCYYYYR 200
    KNPQVWSNPS DLLEILVPGV SRKPSLLIPQ GSVVARGGSL TLQCRSDVGY 250
    DIFVLYKEGE HDLVQGSGQQ PQAGLSQANF TLGPVSRSHG GQYRCYGAHN 300
    LSPRWSAPSD PLDILIAGLI PDIPALSVQP GPKVASGENV TLLCQSWHQI 350
    DTFFLTKEGA AHPPLCLKSK YQSYRHQAEF SMSPVTSAQG GTYRCYSAIR 400
    SYPYLLSSPS YPQELVVSGP SGDPSLSPTG STPTPGPEDQ PLTPTGLDPQ 450
    SGLGRHLGVV TGVSVAFVLL LFLLLFLLLR HRHQSKHRTS AHFYRPAGAA 500
    GPEPKDQGLQ KRASPVADIQ EEILNAAVKD TQPKDGVEMD ARAAASEAPQ 550
    DVTYAQLHSL TLRREATEPP PSQEREPPAE PSIYAPLAIH 590
    Length:590
    Mass (Da):64,126
    Last modified:November 1, 1998 - v1
    Checksum:i8E7AB249F12E44CD
    GO
    Isoform 2 (identifier: O75023-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         119-218: Missing.
         435-435: P → PA

    Note: No experimental confirmation available.

    Show »
    Length:491
    Mass (Da):52,969
    Checksum:iBDE0FEC49A5CD587
    GO
    Isoform 3 (identifier: O75023-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         435-435: P → PA

    Note: No experimental confirmation available.

    Show »
    Length:591
    Mass (Da):64,197
    Checksum:i201FDB50AB43ACF7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121G → W in AK223296. (PubMed:14702039)Curated
    Sequence conflicti255 – 2551L → R in AK223296. (PubMed:14702039)Curated
    Sequence conflicti355 – 3551L → S in BAB71361. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti247 – 2471D → G.
    Corresponds to variant rs12975366 [ dbSNP | Ensembl ].
    VAR_061316

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei119 – 218100Missing in isoform 2. 1 PublicationVSP_008461Add
    BLAST
    Alternative sequencei435 – 4351P → PA in isoform 2 and isoform 3. 1 PublicationVSP_008462

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF025534 mRNA. Translation: AAB87668.1.
    AK057072 mRNA. Translation: BAB71361.1.
    AK223296 mRNA. No translation available.
    AC010492 Genomic DNA. No translation available.
    BC025704 mRNA. Translation: AAH25704.1.
    CCDSiCCDS12885.1. [O75023-1]
    CCDS42611.1. [O75023-2]
    CCDS46176.1. [O75023-3]
    RefSeqiNP_001074911.1. NM_001081442.1. [O75023-3]
    NP_001074912.1. NM_001081443.1. [O75023-2]
    NP_006831.1. NM_006840.3. [O75023-1]
    UniGeneiHs.655338.

    Genome annotation databases

    EnsembliENST00000316219; ENSP00000320390; ENSG00000105609. [O75023-1]
    ENST00000345866; ENSP00000263430; ENSG00000105609. [O75023-2]
    ENST00000449561; ENSP00000406478; ENSG00000105609. [O75023-3]
    GeneIDi10990.
    KEGGihsa:10990.
    UCSCiuc002qex.3. human. [O75023-1]
    uc002qey.3. human. [O75023-3]
    uc002qez.3. human. [O75023-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF025534 mRNA. Translation: AAB87668.1 .
    AK057072 mRNA. Translation: BAB71361.1 .
    AK223296 mRNA. No translation available.
    AC010492 Genomic DNA. No translation available.
    BC025704 mRNA. Translation: AAH25704.1 .
    CCDSi CCDS12885.1. [O75023-1 ]
    CCDS42611.1. [O75023-2 ]
    CCDS46176.1. [O75023-3 ]
    RefSeqi NP_001074911.1. NM_001081442.1. [O75023-3 ]
    NP_001074912.1. NM_001081443.1. [O75023-2 ]
    NP_006831.1. NM_006840.3. [O75023-1 ]
    UniGenei Hs.655338.

    3D structure databases

    ProteinModelPortali O75023.
    SMRi O75023. Positions 26-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O75023. 1 interaction.
    STRINGi 9606.ENSP00000406478.

    PTM databases

    PhosphoSitei O75023.

    Proteomic databases

    PaxDbi O75023.
    PRIDEi O75023.

    Protocols and materials databases

    DNASUi 10990.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316219 ; ENSP00000320390 ; ENSG00000105609 . [O75023-1 ]
    ENST00000345866 ; ENSP00000263430 ; ENSG00000105609 . [O75023-2 ]
    ENST00000449561 ; ENSP00000406478 ; ENSG00000105609 . [O75023-3 ]
    GeneIDi 10990.
    KEGGi hsa:10990.
    UCSCi uc002qex.3. human. [O75023-1 ]
    uc002qey.3. human. [O75023-3 ]
    uc002qez.3. human. [O75023-2 ]

    Organism-specific databases

    CTDi 10990.
    GeneCardsi GC19M054754.
    HGNCi HGNC:6609. LILRB5.
    HPAi HPA012069.
    MIMi 604814. gene.
    neXtProti NX_O75023.
    PharmGKBi PA30383.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25855.
    HOGENOMi HOG000234395.
    HOVERGENi HBG074353.
    InParanoidi O75023.
    KOi K06512.
    PhylomeDBi O75023.
    TreeFami TF336644.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    GeneWikii LILRB5.
    GenomeRNAii 10990.
    NextBioi 41759.
    PROi O75023.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O75023.
    Bgeei O75023.
    CleanExi HS_LILRB5.
    Genevestigatori O75023.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
      Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.
      J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Peripheral blood leukocyte.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Small intestine and Synovium.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pancreas and Spleen.
    5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-279.
      Tissue: Plasma.

    Entry informationi

    Entry nameiLIRB5_HUMAN
    AccessioniPrimary (citable) accession number: O75023
    Secondary accession number(s): Q8N760
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3