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Protein

Leukocyte immunoglobulin-like receptor subfamily B member 5

Gene

LILRB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as receptor for class I MHC antigens.

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • cell surface receptor signaling pathway Source: ProtInc
  • defense response Source: ProtInc

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 5
Alternative name(s):
CD85 antigen-like family member C
Leukocyte immunoglobulin-like receptor 8
Short name:
LIR-8
CD_antigen: CD85c
Gene namesi
Name:LILRB5
Synonyms:LIR8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105609.16
HGNCiHGNC:6609 LILRB5
MIMi604814 gene
neXtProtiNX_O75023

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 458ExtracellularSequence analysisAdd BLAST435
Transmembranei459 – 479HelicalSequence analysisAdd BLAST21
Topological domaini480 – 590CytoplasmicSequence analysisAdd BLAST111

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30383

Polymorphism and mutation databases

BioMutaiLILRB5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001482524 – 590Leukocyte immunoglobulin-like receptor subfamily B member 5Add BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 195PROSITE-ProRule annotation
Disulfide bondi244 ↔ 295PROSITE-ProRule annotation
Glycosylationi279N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi344 ↔ 395PROSITE-ProRule annotation
Modified residuei514PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO75023
PeptideAtlasiO75023
PRIDEiO75023
ProteomicsDBi49699
49700 [O75023-2]
49701 [O75023-3]

PTM databases

iPTMnetiO75023
PhosphoSitePlusiO75023

Expressioni

Tissue specificityi

Detected in a natural killer (NK) cells.1 Publication

Gene expression databases

BgeeiENSG00000105609
CleanExiHS_LILRB5
GenevisibleiO75023 HS

Organism-specific databases

HPAiHPA012069

Interactioni

Protein-protein interaction databases

BioGridi116186, 1 interactor
IntActiO75023, 1 interactor
MINTiO75023
STRINGi9606.ENSP00000406478

Structurei

3D structure databases

ProteinModelPortaliO75023
SMRiO75023
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 116Ig-like C2-type 1Add BLAST90
Domaini111 – 228Ig-like C2-type 2Add BLAST118
Domaini224 – 313Ig-like C2-type 3Add BLAST90
Domaini337 – 418Ig-like C2-type 4Add BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi552 – 557ITIM motif 16
Motifi582 – 587ITIM motif 26

Domaini

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJD Eukaryota
ENOG41116BR LUCA
HOGENOMiHOG000234395
HOVERGENiHBG074353
InParanoidiO75023
KOiK06512
OrthoDBiEOG091G0D6W
PhylomeDBiO75023
TreeFamiTF336644

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 2 hits
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75023-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLTLSVLIC LGLSVGPRTC VQAGTLPKPT LWAEPASVIA RGKPVTLWCQ
60 70 80 90 100
GPLETEEYRL DKEGLPWARK RQNPLEPGAK AKFHIPSTVY DSAGRYRCYY
110 120 130 140 150
ETPAGWSEPS DPLELVATGF YAEPTLLALP SPVVASGGNV TLQCDTLDGL
160 170 180 190 200
LTFVLVEEEQ KLPRTLYSQK LPKGPSQALF PVGPVTPSCR WRFRCYYYYR
210 220 230 240 250
KNPQVWSNPS DLLEILVPGV SRKPSLLIPQ GSVVARGGSL TLQCRSDVGY
260 270 280 290 300
DIFVLYKEGE HDLVQGSGQQ PQAGLSQANF TLGPVSRSHG GQYRCYGAHN
310 320 330 340 350
LSPRWSAPSD PLDILIAGLI PDIPALSVQP GPKVASGENV TLLCQSWHQI
360 370 380 390 400
DTFFLTKEGA AHPPLCLKSK YQSYRHQAEF SMSPVTSAQG GTYRCYSAIR
410 420 430 440 450
SYPYLLSSPS YPQELVVSGP SGDPSLSPTG STPTPGPEDQ PLTPTGLDPQ
460 470 480 490 500
SGLGRHLGVV TGVSVAFVLL LFLLLFLLLR HRHQSKHRTS AHFYRPAGAA
510 520 530 540 550
GPEPKDQGLQ KRASPVADIQ EEILNAAVKD TQPKDGVEMD ARAAASEAPQ
560 570 580 590
DVTYAQLHSL TLRREATEPP PSQEREPPAE PSIYAPLAIH
Length:590
Mass (Da):64,126
Last modified:November 1, 1998 - v1
Checksum:i8E7AB249F12E44CD
GO
Isoform 2 (identifier: O75023-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-218: Missing.
     435-435: P → PA

Note: No experimental confirmation available.
Show »
Length:491
Mass (Da):52,969
Checksum:iBDE0FEC49A5CD587
GO
Isoform 3 (identifier: O75023-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     435-435: P → PA

Note: No experimental confirmation available.
Show »
Length:591
Mass (Da):64,197
Checksum:i201FDB50AB43ACF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12G → W in AK223296 (PubMed:14702039).Curated1
Sequence conflicti255L → R in AK223296 (PubMed:14702039).Curated1
Sequence conflicti355L → S in BAB71361 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061316247D → G. Corresponds to variant dbSNP:rs12975366Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008461119 – 218Missing in isoform 2. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_008462435P → PA in isoform 2 and isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025534 mRNA Translation: AAB87668.1
AK057072 mRNA Translation: BAB71361.1
AK223296 mRNA No translation available.
AC010492 Genomic DNA No translation available.
BC025704 mRNA Translation: AAH25704.1
CCDSiCCDS12885.1 [O75023-1]
CCDS42611.1 [O75023-2]
CCDS46176.1 [O75023-3]
RefSeqiNP_001074911.1, NM_001081442.2 [O75023-3]
NP_001074912.1, NM_001081443.2 [O75023-2]
NP_001291386.1, NM_001304457.1
NP_006831.1, NM_006840.4 [O75023-1]
UniGeneiHs.655338

Genome annotation databases

EnsembliENST00000316219; ENSP00000320390; ENSG00000105609
ENST00000345866; ENSP00000263430; ENSG00000105609
ENST00000449561; ENSP00000406478; ENSG00000105609
ENST00000610764; ENSP00000479022; ENSG00000277414 [O75023-2]
ENST00000614318; ENSP00000483649; ENSG00000278437 [O75023-3]
ENST00000615429; ENSP00000482404; ENSG00000274311 [O75023-2]
ENST00000615837; ENSP00000478835; ENSG00000277414 [O75023-1]
ENST00000616618; ENSP00000478912; ENSG00000274311 [O75023-3]
ENST00000616805; ENSP00000483502; ENSG00000273991 [O75023-1]
ENST00000617355; ENSP00000483481; ENSG00000274311 [O75023-1]
ENST00000619608; ENSP00000479413; ENSG00000277414 [O75023-3]
ENST00000620714; ENSP00000480909; ENSG00000273991 [O75023-2]
ENST00000621193; ENSP00000482062; ENSG00000278437 [O75023-1]
ENST00000621867; ENSP00000481263; ENSG00000273991 [O75023-3]
ENST00000622596; ENSP00000482535; ENSG00000278437 [O75023-2]
GeneIDi10990
KEGGihsa:10990
UCSCiuc002qex.4 human [O75023-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLIRB5_HUMAN
AccessioniPrimary (citable) accession number: O75023
Secondary accession number(s): Q8N760
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1998
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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