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O75023 (LIRB5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 5
Alternative name(s):
CD85 antigen-like family member C
Leukocyte immunoglobulin-like receptor 8
Short name=LIR-8
CD_antigen=CD85c
Gene names
Name:LILRB5
Synonyms:LIR8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length590 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as receptor for class I MHC antigens.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Detected in a natural killer (NK) cells. Ref.1

Domain

Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Sequence similarities

Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O75023-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O75023-2)

The sequence of this isoform differs from the canonical sequence as follows:
     119-218: Missing.
     435-435: P → PA
Note: No experimental confirmation available.
Isoform 3 (identifier: O75023-3)

The sequence of this isoform differs from the canonical sequence as follows:
     435-435: P → PA
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 590567Leukocyte immunoglobulin-like receptor subfamily B member 5
PRO_0000014825

Regions

Topological domain24 – 458435Extracellular Potential
Transmembrane459 – 47921Helical; Potential
Topological domain480 – 590111Cytoplasmic Potential
Domain27 – 11690Ig-like C2-type 1
Domain111 – 228118Ig-like C2-type 2
Domain224 – 31390Ig-like C2-type 3
Domain337 – 41882Ig-like C2-type 4
Motif552 – 5576ITIM motif 1
Motif582 – 5876ITIM motif 2

Amino acid modifications

Glycosylation1391N-linked (GlcNAc...) Potential
Glycosylation2791N-linked (GlcNAc...) Ref.5
Glycosylation3391N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 98 By similarity
Disulfide bond144 ↔ 195 By similarity
Disulfide bond244 ↔ 295 Potential
Disulfide bond344 ↔ 395 Potential

Natural variations

Alternative sequence119 – 218100Missing in isoform 2.
VSP_008461
Alternative sequence4351P → PA in isoform 2 and isoform 3.
VSP_008462
Natural variant2471D → G.
Corresponds to variant rs12975366 [ dbSNP | Ensembl ].
VAR_061316

Experimental info

Sequence conflict121G → W in AK223296. Ref.2
Sequence conflict2551L → R in AK223296. Ref.2
Sequence conflict3551L → S in BAB71361. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 8E7AB249F12E44CD

FASTA59064,126
        10         20         30         40         50         60 
MTLTLSVLIC LGLSVGPRTC VQAGTLPKPT LWAEPASVIA RGKPVTLWCQ GPLETEEYRL 

        70         80         90        100        110        120 
DKEGLPWARK RQNPLEPGAK AKFHIPSTVY DSAGRYRCYY ETPAGWSEPS DPLELVATGF 

       130        140        150        160        170        180 
YAEPTLLALP SPVVASGGNV TLQCDTLDGL LTFVLVEEEQ KLPRTLYSQK LPKGPSQALF 

       190        200        210        220        230        240 
PVGPVTPSCR WRFRCYYYYR KNPQVWSNPS DLLEILVPGV SRKPSLLIPQ GSVVARGGSL 

       250        260        270        280        290        300 
TLQCRSDVGY DIFVLYKEGE HDLVQGSGQQ PQAGLSQANF TLGPVSRSHG GQYRCYGAHN 

       310        320        330        340        350        360 
LSPRWSAPSD PLDILIAGLI PDIPALSVQP GPKVASGENV TLLCQSWHQI DTFFLTKEGA 

       370        380        390        400        410        420 
AHPPLCLKSK YQSYRHQAEF SMSPVTSAQG GTYRCYSAIR SYPYLLSSPS YPQELVVSGP 

       430        440        450        460        470        480 
SGDPSLSPTG STPTPGPEDQ PLTPTGLDPQ SGLGRHLGVV TGVSVAFVLL LFLLLFLLLR 

       490        500        510        520        530        540 
HRHQSKHRTS AHFYRPAGAA GPEPKDQGLQ KRASPVADIQ EEILNAAVKD TQPKDGVEMD 

       550        560        570        580        590 
ARAAASEAPQ DVTYAQLHSL TLRREATEPP PSQEREPPAE PSIYAPLAIH 

« Hide

Isoform 2 [UniParc].

Checksum: BDE0FEC49A5CD587
Show »

FASTA49152,969
Isoform 3 [UniParc].

Checksum: 201FDB50AB43ACF7
Show »

FASTA59164,197

References

« Hide 'large scale' references
[1]"A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.
J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Tissue: Peripheral blood leukocyte.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Tissue: Small intestine and Synovium.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Pancreas and Spleen.
[5]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-279.
Tissue: Plasma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF025534 mRNA. Translation: AAB87668.1.
AK057072 mRNA. Translation: BAB71361.1.
AK223296 mRNA. No translation available.
AC010492 Genomic DNA. No translation available.
BC025704 mRNA. Translation: AAH25704.1.
CCDSCCDS12885.1. [O75023-1]
CCDS42611.1. [O75023-2]
CCDS46176.1. [O75023-3]
RefSeqNP_001074911.1. NM_001081442.1. [O75023-3]
NP_001074912.1. NM_001081443.1. [O75023-2]
NP_006831.1. NM_006840.3. [O75023-1]
UniGeneHs.655338.

3D structure databases

ProteinModelPortalO75023.
SMRO75023. Positions 26-418.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO75023. 1 interaction.
STRING9606.ENSP00000406478.

PTM databases

PhosphoSiteO75023.

Proteomic databases

PaxDbO75023.
PRIDEO75023.

Protocols and materials databases

DNASU10990.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316219; ENSP00000320390; ENSG00000105609. [O75023-1]
ENST00000345866; ENSP00000263430; ENSG00000105609. [O75023-2]
ENST00000449561; ENSP00000406478; ENSG00000105609. [O75023-3]
ENST00000571036; ENSP00000461240; ENSG00000263021. [O75023-2]
ENST00000575516; ENSP00000460244; ENSG00000263021. [O75023-1]
ENST00000576654; ENSP00000460669; ENSG00000263021. [O75023-3]
GeneID10990.
KEGGhsa:10990.
UCSCuc002qex.3. human. [O75023-1]
uc002qey.3. human. [O75023-3]
uc002qez.3. human. [O75023-2]

Organism-specific databases

CTD10990.
GeneCardsGC19M054754.
HGNCHGNC:6609. LILRB5.
HPAHPA012069.
MIM604814. gene.
neXtProtNX_O75023.
PharmGKBPA30383.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25855.
HOGENOMHOG000234395.
HOVERGENHBG074353.
InParanoidO75023.
KOK06512.
PhylomeDBO75023.
TreeFamTF336644.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressO75023.
BgeeO75023.
CleanExHS_LILRB5.
GenevestigatorO75023.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTSM00409. IG. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiLILRB5.
GenomeRNAi10990.
NextBio41759.
PROO75023.
SOURCESearch...

Entry information

Entry nameLIRB5_HUMAN
AccessionPrimary (citable) accession number: O75023
Secondary accession number(s): Q8N760
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries