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Protein

Leukocyte immunoglobulin-like receptor subfamily B member 5

Gene

LILRB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as receptor for class I MHC antigens.

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: ProtInc
  • defense response Source: ProtInc
  • immune system process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 5
Alternative name(s):
CD85 antigen-like family member C
Leukocyte immunoglobulin-like receptor 8
Short name:
LIR-8
CD_antigen: CD85c
Gene namesi
Name:LILRB5
Synonyms:LIR8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 19, Unplaced

Organism-specific databases

HGNCiHGNC:6609. LILRB5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 458435ExtracellularSequence AnalysisAdd
BLAST
Transmembranei459 – 47921HelicalSequence AnalysisAdd
BLAST
Topological domaini480 – 590111CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30383.

Polymorphism and mutation databases

BioMutaiLILRB5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 590567Leukocyte immunoglobulin-like receptor subfamily B member 5PRO_0000014825Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi144 ↔ 195PROSITE-ProRule annotation
Disulfide bondi244 ↔ 295PROSITE-ProRule annotation
Glycosylationi279 – 2791N-linked (GlcNAc...)1 Publication
Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi344 ↔ 395PROSITE-ProRule annotation
Modified residuei514 – 5141Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO75023.
PRIDEiO75023.

PTM databases

PhosphoSiteiO75023.

Expressioni

Tissue specificityi

Detected in a natural killer (NK) cells.1 Publication

Gene expression databases

BgeeiO75023.
CleanExiHS_LILRB5.
GenevestigatoriO75023.

Organism-specific databases

HPAiHPA012069.

Interactioni

Protein-protein interaction databases

IntActiO75023. 1 interaction.
STRINGi9606.ENSP00000406478.

Structurei

3D structure databases

ProteinModelPortaliO75023.
SMRiO75023. Positions 26-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11690Ig-like C2-type 1Add
BLAST
Domaini111 – 228118Ig-like C2-type 2Add
BLAST
Domaini224 – 31390Ig-like C2-type 3Add
BLAST
Domaini337 – 41882Ig-like C2-type 4Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi552 – 5576ITIM motif 1
Motifi582 – 5876ITIM motif 2

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25855.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiO75023.
KOiK06512.
PhylomeDBiO75023.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75023-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLTLSVLIC LGLSVGPRTC VQAGTLPKPT LWAEPASVIA RGKPVTLWCQ
60 70 80 90 100
GPLETEEYRL DKEGLPWARK RQNPLEPGAK AKFHIPSTVY DSAGRYRCYY
110 120 130 140 150
ETPAGWSEPS DPLELVATGF YAEPTLLALP SPVVASGGNV TLQCDTLDGL
160 170 180 190 200
LTFVLVEEEQ KLPRTLYSQK LPKGPSQALF PVGPVTPSCR WRFRCYYYYR
210 220 230 240 250
KNPQVWSNPS DLLEILVPGV SRKPSLLIPQ GSVVARGGSL TLQCRSDVGY
260 270 280 290 300
DIFVLYKEGE HDLVQGSGQQ PQAGLSQANF TLGPVSRSHG GQYRCYGAHN
310 320 330 340 350
LSPRWSAPSD PLDILIAGLI PDIPALSVQP GPKVASGENV TLLCQSWHQI
360 370 380 390 400
DTFFLTKEGA AHPPLCLKSK YQSYRHQAEF SMSPVTSAQG GTYRCYSAIR
410 420 430 440 450
SYPYLLSSPS YPQELVVSGP SGDPSLSPTG STPTPGPEDQ PLTPTGLDPQ
460 470 480 490 500
SGLGRHLGVV TGVSVAFVLL LFLLLFLLLR HRHQSKHRTS AHFYRPAGAA
510 520 530 540 550
GPEPKDQGLQ KRASPVADIQ EEILNAAVKD TQPKDGVEMD ARAAASEAPQ
560 570 580 590
DVTYAQLHSL TLRREATEPP PSQEREPPAE PSIYAPLAIH
Length:590
Mass (Da):64,126
Last modified:November 1, 1998 - v1
Checksum:i8E7AB249F12E44CD
GO
Isoform 2 (identifier: O75023-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-218: Missing.
     435-435: P → PA

Note: No experimental confirmation available.

Show »
Length:491
Mass (Da):52,969
Checksum:iBDE0FEC49A5CD587
GO
Isoform 3 (identifier: O75023-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     435-435: P → PA

Note: No experimental confirmation available.

Show »
Length:591
Mass (Da):64,197
Checksum:i201FDB50AB43ACF7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121G → W in AK223296 (PubMed:14702039).Curated
Sequence conflicti255 – 2551L → R in AK223296 (PubMed:14702039).Curated
Sequence conflicti355 – 3551L → S in BAB71361 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti247 – 2471D → G.
Corresponds to variant rs12975366 [ dbSNP | Ensembl ].
VAR_061316

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei119 – 218100Missing in isoform 2. 1 PublicationVSP_008461Add
BLAST
Alternative sequencei435 – 4351P → PA in isoform 2 and isoform 3. 1 PublicationVSP_008462

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025534 mRNA. Translation: AAB87668.1.
AK057072 mRNA. Translation: BAB71361.1.
AK223296 mRNA. No translation available.
AC010492 Genomic DNA. No translation available.
BC025704 mRNA. Translation: AAH25704.1.
CCDSiCCDS12885.1. [O75023-1]
CCDS42611.1. [O75023-2]
CCDS46176.1. [O75023-3]
RefSeqiNP_001074911.1. NM_001081442.2. [O75023-3]
NP_001074912.1. NM_001081443.2. [O75023-2]
NP_006831.1. NM_006840.4. [O75023-1]
UniGeneiHs.655338.

Genome annotation databases

EnsembliENST00000316219; ENSP00000320390; ENSG00000105609.
ENST00000345866; ENSP00000263430; ENSG00000105609.
ENST00000449561; ENSP00000406478; ENSG00000105609.
ENST00000610764; ENSP00000479022; ENSG00000277414. [O75023-2]
ENST00000614318; ENSP00000483649; ENSG00000278437. [O75023-3]
ENST00000615429; ENSP00000482404; ENSG00000274311. [O75023-2]
ENST00000615837; ENSP00000478835; ENSG00000277414. [O75023-1]
ENST00000616618; ENSP00000478912; ENSG00000274311. [O75023-3]
ENST00000616805; ENSP00000483502; ENSG00000273991. [O75023-1]
ENST00000617355; ENSP00000483481; ENSG00000274311. [O75023-1]
ENST00000619608; ENSP00000479413; ENSG00000277414. [O75023-3]
ENST00000620714; ENSP00000480909; ENSG00000273991. [O75023-2]
ENST00000621193; ENSP00000482062; ENSG00000278437. [O75023-1]
ENST00000621867; ENSP00000481263; ENSG00000273991. [O75023-3]
ENST00000622596; ENSP00000482535; ENSG00000278437. [O75023-2]
GeneIDi10990.
KEGGihsa:10990.
UCSCiuc002qex.3. human. [O75023-1]
uc002qey.3. human. [O75023-3]
uc002qez.3. human. [O75023-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025534 mRNA. Translation: AAB87668.1.
AK057072 mRNA. Translation: BAB71361.1.
AK223296 mRNA. No translation available.
AC010492 Genomic DNA. No translation available.
BC025704 mRNA. Translation: AAH25704.1.
CCDSiCCDS12885.1. [O75023-1]
CCDS42611.1. [O75023-2]
CCDS46176.1. [O75023-3]
RefSeqiNP_001074911.1. NM_001081442.2. [O75023-3]
NP_001074912.1. NM_001081443.2. [O75023-2]
NP_006831.1. NM_006840.4. [O75023-1]
UniGeneiHs.655338.

3D structure databases

ProteinModelPortaliO75023.
SMRiO75023. Positions 26-418.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO75023. 1 interaction.
STRINGi9606.ENSP00000406478.

Protein family/group databases

MEROPSiI43.001.

PTM databases

PhosphoSiteiO75023.

Polymorphism and mutation databases

BioMutaiLILRB5.

Proteomic databases

PaxDbiO75023.
PRIDEiO75023.

Protocols and materials databases

DNASUi10990.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316219; ENSP00000320390; ENSG00000105609.
ENST00000345866; ENSP00000263430; ENSG00000105609.
ENST00000449561; ENSP00000406478; ENSG00000105609.
ENST00000610764; ENSP00000479022; ENSG00000277414. [O75023-2]
ENST00000614318; ENSP00000483649; ENSG00000278437. [O75023-3]
ENST00000615429; ENSP00000482404; ENSG00000274311. [O75023-2]
ENST00000615837; ENSP00000478835; ENSG00000277414. [O75023-1]
ENST00000616618; ENSP00000478912; ENSG00000274311. [O75023-3]
ENST00000616805; ENSP00000483502; ENSG00000273991. [O75023-1]
ENST00000617355; ENSP00000483481; ENSG00000274311. [O75023-1]
ENST00000619608; ENSP00000479413; ENSG00000277414. [O75023-3]
ENST00000620714; ENSP00000480909; ENSG00000273991. [O75023-2]
ENST00000621193; ENSP00000482062; ENSG00000278437. [O75023-1]
ENST00000621867; ENSP00000481263; ENSG00000273991. [O75023-3]
ENST00000622596; ENSP00000482535; ENSG00000278437. [O75023-2]
GeneIDi10990.
KEGGihsa:10990.
UCSCiuc002qex.3. human. [O75023-1]
uc002qey.3. human. [O75023-3]
uc002qez.3. human. [O75023-2]

Organism-specific databases

CTDi10990.
GeneCardsiGC19M054754.
HGNCiHGNC:6609. LILRB5.
HPAiHPA012069.
MIMi604814. gene.
neXtProtiNX_O75023.
PharmGKBiPA30383.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25855.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiO75023.
KOiK06512.
PhylomeDBiO75023.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikiiLILRB5.
GenomeRNAii10990.
NextBioi41759.
PROiO75023.
SOURCEiSearch...

Gene expression databases

BgeeiO75023.
CleanExiHS_LILRB5.
GenevestigatoriO75023.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
    Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.
    J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Peripheral blood leukocyte.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Small intestine and Synovium.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas and Spleen.
  5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-279.
    Tissue: Plasma.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-514, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiLIRB5_HUMAN
AccessioniPrimary (citable) accession number: O75023
Secondary accession number(s): Q8N760
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1998
Last modified: April 29, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.