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Protein

Leukocyte immunoglobulin-like receptor subfamily B member 3

Gene

LILRB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).By similarity

GO - Molecular functioni

  • receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • cell surface receptor signaling pathway Source: ProtInc
  • defense response Source: ProtInc
  • negative regulation of osteoclast differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

BioCyciZFISH:G66-32553-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily B member 3
Short name:
LIR-3
Short name:
Leukocyte immunoglobulin-like receptor 3
Alternative name(s):
CD85 antigen-like family member A
Immunoglobulin-like transcript 5
Short name:
ILT-5
Monocyte inhibitory receptor HL9
CD_antigen: CD85a
Gene namesi
Name:LILRB3
Synonyms:ILT5, LIR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6607. LILRB3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 443ExtracellularSequence analysisAdd BLAST420
Transmembranei444 – 464HelicalSequence analysisAdd BLAST21
Topological domaini465 – 631CytoplasmicSequence analysisAdd BLAST167

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi102725035.
11025.
79168.
OpenTargetsiENSG00000274587.
PharmGKBiPA30381.

Polymorphism and mutation databases

BioMutaiLILRB3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001482224 – 631Leukocyte immunoglobulin-like receptor subfamily B member 3Add BLAST608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
Glycosylationi139N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi144 ↔ 196PROSITE-ProRule annotation
Disulfide bondi245 ↔ 296PROSITE-ProRule annotation
Glycosylationi280N-linked (GlcNAc...)Sequence analysis1
Glycosylationi301N-linked (GlcNAc...)Sequence analysis1
Glycosylationi340N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi345 ↔ 396PROSITE-ProRule annotation
Modified residuei595Phosphotyrosine; by LYNBy similarity1
Modified residuei625Phosphotyrosine; by LYNBy similarity1

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO75022.
PeptideAtlasiO75022.
PRIDEiO75022.

PTM databases

iPTMnetiO75022.
PhosphoSitePlusiO75022.

Expressioni

Tissue specificityi

Detected in monocytes and B-cells.1 Publication

Gene expression databases

BgeeiENSG00000204577.
CleanExiHS_LILRB3.
ExpressionAtlasiO75022. baseline and differential.
GenevisibleiO75022. HS.

Interactioni

Subunit structurei

Interacts with LYN, PTPN6/SHP-1 and PTPN11/SHP-2.By similarity

Protein-protein interaction databases

IntActiO75022. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliO75022.
SMRiO75022.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 100Ig-like C2-type 1Add BLAST59
Domaini111 – 229Ig-like C2-type 2Add BLAST119
Domaini225 – 314Ig-like C2-type 3Add BLAST90
Domaini338 – 419Ig-like C2-type 4Add BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi512 – 517ITIM motif 16
Motifi593 – 598ITIM motif 26
Motifi623 – 628ITIM motif 36

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJD. Eukaryota.
ENOG41116BR. LUCA.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiO75022.
KOiK06512.
PhylomeDBiO75022.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75022-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPALTALLC LGLSLGPRTR VQAGPFPKPT LWAEPGSVIS WGSPVTIWCQ
60 70 80 90 100
GSQEAQEYRL HKEGSPEPLD RNNPLEPKNK ARFSIPSMTE HHAGRYRCHY
110 120 130 140 150
YSSAGWSEPS DPLEMVMTGA YSKPTLSALP SPVVASGGNM TLRCGSQKGY
160 170 180 190 200
HHFVLMKEGE HQLPRTLDSQ QLHSRGFQAL FPVGPVTPSH RWRFTCYYYY
210 220 230 240 250
TNTPWVWSHP SDPLEILPSG VSRKPSLLTL QGPVLAPGQS LTLQCGSDVG
260 270 280 290 300
YNRFVLYKEG ERDFLQRPGQ QPQAGLSQAN FTLGPVSPSN GGQYRCYGAH
310 320 330 340 350
NLSSEWSAPS DPLNILMAGQ IYDTVSLSAQ PGPTVASGEN VTLLCQSWWQ
360 370 380 390 400
FDTFLLTKEG AAHPPLRLRS MYGAHKYQAE FPMSPVTSAH AGTYRCYGSY
410 420 430 440 450
SSNPHLLSHP SEPLELVVSG HSGGSSLPPT GPPSTPGLGR YLEVLIGVSV
460 470 480 490 500
AFVLLLFLLL FLLLRRQRHS KHRTSDQRKT DFQRPAGAAE TEPKDRGLLR
510 520 530 540 550
RSSPAADVQE ENLYAAVKDT QSEDRVELDS QSPHDEDPQA VTYAPVKHSS
560 570 580 590 600
PRREMASPPS SLSGEFLDTK DRQVEEDRQM DTEAAASEAS QDVTYAQLHS
610 620 630
LTLRRKATEP PPSQEGEPPA EPSIYATLAI H
Length:631
Mass (Da):69,386
Last modified:November 30, 2010 - v3
Checksum:i595B1BD5283A7E3E
GO
Isoform 2 (identifier: O75022-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     437-437: G → GGPEDQPLNPPGSGPQNG

Note: No experimental confirmation available.
Show »
Length:648
Mass (Da):71,029
Checksum:i3FAEB2EEC21105BD
GO
Isoform 3 (identifier: O75022-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     530-530: S → SQ

Show »
Length:632
Mass (Da):69,514
Checksum:iFF29920A9E55897D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53Q → L in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti53Q → L in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti61H → D in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti61H → D in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti115M → L in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti115M → L in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti120A → F in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti149G → R in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti175R → G in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti175R → G in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti187T → N in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti187T → N in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti187T → N in AAP30716 (Ref. 3) Curated1
Sequence conflicti201T → M in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti201T → M in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti205W → R in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti252N → D in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti252N → D in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti263D → A in AAP30716 (Ref. 3) Curated1
Sequence conflicti268P → S in AAP30716 (Ref. 3) Curated1
Sequence conflicti290N → H in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti409H → F in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti417V → M in AAB68668 (PubMed:9278324).Curated1
Sequence conflicti525R → G in AAB87667 (PubMed:9548455).Curated1
Sequence conflicti561S → P in AAB87667 (PubMed:9548455).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01700121V → M.Corresponds to variant rs1132588dbSNPEnsembl.1
Natural variantiVAR_01700259R → Q.1 PublicationCorresponds to variant rs678876dbSNPEnsembl.1
Natural variantiVAR_01700369L → W.Corresponds to variant rs620207dbSNPEnsembl.1
Natural variantiVAR_01700490E → Q.1 PublicationCorresponds to variant rs1052963dbSNPEnsembl.1
Natural variantiVAR_017005122S → N.1 PublicationCorresponds to variant rs3826750dbSNPEnsembl.1
Natural variantiVAR_017006205W → Q Requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant rs1063805dbSNPEnsembl.1
Natural variantiVAR_017009400Y → F.Corresponds to variant rs8105096dbSNPEnsembl.1
Natural variantiVAR_017008400Y → H.Corresponds to variant rs1052992dbSNPEnsembl.1
Natural variantiVAR_017007400Y → R Requires 2 nucleotide substitutions. 2 Publications1
Natural variantiVAR_017010405H → Y.1 PublicationCorresponds to variant rs1132604dbSNPEnsembl.1
Natural variantiVAR_017012539Q → H.1 PublicationCorresponds to variant rs1053002dbSNPEnsembl.1
Natural variantiVAR_017013574V → A.1 PublicationCorresponds to variant rs1053008dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008459437G → GGPEDQPLNPPGSGPQNG in isoform 2. Curated1
Alternative sequenceiVSP_040126530S → SQ in isoform 3. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91928 mRNA. Translation: AAB68668.1.
AF025533 mRNA. Translation: AAB87667.1.
AF256195 Genomic DNA. Translation: AAP30716.1.
AC010492 Genomic DNA. No translation available.
AC012314 Genomic DNA. No translation available.
CCDSiCCDS33105.1. [O75022-1]
CCDS46175.1. [O75022-3]
RefSeqiXP_006726377.1. XM_006726314.3.
XP_016885785.1. XM_017030296.1. [O75022-3]
XP_016885786.1. XM_017030297.1. [O75022-1]
UniGeneiHs.631592.
Hs.688335.

Genome annotation databases

EnsembliENST00000245620; ENSP00000245620; ENSG00000204577.
ENST00000391750; ENSP00000375630; ENSG00000204577.
ENST00000611086; ENSP00000483625; ENSG00000274587. [O75022-1]
ENST00000613698; ENSP00000479234; ENSG00000275019.
ENST00000621210; ENSP00000484925; ENSG00000275019.
GeneIDi102725035.
107987462.
KEGGihsa:102725035.
UCSCiuc032icw.2. human. [O75022-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91928 mRNA. Translation: AAB68668.1.
AF025533 mRNA. Translation: AAB87667.1.
AF256195 Genomic DNA. Translation: AAP30716.1.
AC010492 Genomic DNA. No translation available.
AC012314 Genomic DNA. No translation available.
CCDSiCCDS33105.1. [O75022-1]
CCDS46175.1. [O75022-3]
RefSeqiXP_006726377.1. XM_006726314.3.
XP_016885785.1. XM_017030296.1. [O75022-3]
XP_016885786.1. XM_017030297.1. [O75022-1]
UniGeneiHs.631592.
Hs.688335.

3D structure databases

ProteinModelPortaliO75022.
SMRiO75022.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO75022. 1 interactor.

PTM databases

iPTMnetiO75022.
PhosphoSitePlusiO75022.

Polymorphism and mutation databases

BioMutaiLILRB3.

Proteomic databases

PaxDbiO75022.
PeptideAtlasiO75022.
PRIDEiO75022.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245620; ENSP00000245620; ENSG00000204577.
ENST00000391750; ENSP00000375630; ENSG00000204577.
ENST00000611086; ENSP00000483625; ENSG00000274587. [O75022-1]
ENST00000613698; ENSP00000479234; ENSG00000275019.
ENST00000621210; ENSP00000484925; ENSG00000275019.
GeneIDi102725035.
107987462.
KEGGihsa:102725035.
UCSCiuc032icw.2. human. [O75022-1]

Organism-specific databases

DisGeNETi102725035.
11025.
79168.
GeneCardsiLILRB3.
H-InvDBHIX0015438.
HGNCiHGNC:6607. LILRB3.
MIMi604820. gene.
neXtProtiNX_O75022.
OpenTargetsiENSG00000274587.
PharmGKBiPA30381.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJD. Eukaryota.
ENOG41116BR. LUCA.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiO75022.
KOiK06512.
PhylomeDBiO75022.
TreeFamiTF336644.

Enzyme and pathway databases

BioCyciZFISH:G66-32553-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiLILRB3. human.
PROiO75022.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204577.
CleanExiHS_LILRB3.
ExpressionAtlasiO75022. baseline and differential.
GenevisibleiO75022. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIRB3_HUMAN
AccessioniPrimary (citable) accession number: O75022
Secondary accession number(s): C9J1P3
, C9JIP1, O15471, Q86U49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.