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Protein

Leukocyte immunoglobulin-like receptor subfamily A member 1

Gene

LILRA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May act as receptor for class I MHC antigens.

GO - Molecular functioni

  1. antigen binding Source: ProtInc
  2. transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
  2. defense response Source: ProtInc
  3. immune system process Source: UniProtKB-KW
  4. regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily A member 1
Alternative name(s):
CD85 antigen-like family member I
Leukocyte immunoglobulin-like receptor 6
Short name:
LIR-6
CD_antigen: CD85i
Gene namesi
Name:LILRA1
Synonyms:LIR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:6602. LILRA1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 461445ExtracellularSequence AnalysisAdd
BLAST
Transmembranei462 – 48221HelicalSequence AnalysisAdd
BLAST
Topological domaini483 – 4897CytoplasmicSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 489473Leukocyte immunoglobulin-like receptor subfamily A member 1PRO_0000014816Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi145 ↔ 197PROSITE-ProRule annotation
Disulfide bondi157 ↔ 167PROSITE-ProRule annotation
Disulfide bondi246 ↔ 297PROSITE-ProRule annotation
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi346 ↔ 397PROSITE-ProRule annotation
Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75019.
PRIDEiO75019.

PTM databases

PhosphoSiteiO75019.

Expressioni

Tissue specificityi

Detected in monocytes and B-cells.1 Publication

Gene expression databases

BgeeiO75019.
CleanExiHS_LILRA1.
GenevestigatoriO75019.

Interactioni

Protein-protein interaction databases

BioGridi116214. 1 interaction.
STRINGi9606.ENSP00000251372.

Structurei

3D structure databases

ProteinModelPortaliO75019.
SMRiO75019. Positions 26-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11690Ig-like C2-type 1Add
BLAST
Domaini119 – 224106Ig-like C2-type 2Add
BLAST
Domaini226 – 31590Ig-like C2-type 3Add
BLAST
Domaini326 – 41590Ig-like C2-type 4Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25855.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiO75019.
KOiK06512.
OMAiNAYLLTH.
OrthoDBiEOG7R56S3.
PhylomeDBiO75019.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 3 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75019-1) [UniParc]FASTAAdd to Basket

Also known as: LIR-6a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPIVTVLIC LRLSLGPRTH VQAGTLPKPT LWAEPGSVIT QGSPVTLWCQ
60 70 80 90 100
GILETQEYRL YREKKTAPWI TRIPQEIVKK GQFPIPSITW EHTGRYRCFY
110 120 130 140 150
GSHTAGWSEP SDPLELVVTG AYIKPTLSAL PSPVVTSGGN VTLHCVSQVA
160 170 180 190 200
FGSFILCKEG EDEHPQCLNS QPRTHGWSRA IFSVGPVSPS RRWSYRCYAY
210 220 230 240 250
DSNSPHVWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPGE SLTLQCVSDV
260 270 280 290 300
SYDRFVLYKE GERDFLQLPG PQPQAGLSQA NFTLGPVSRS YGGQYRCSGA
310 320 330 340 350
YNLSSEWSAP SDPLDILIAG QFRGRPFISV HPGPTVASGE NVTLLCQSWG
360 370 380 390 400
PFHTFLLTKA GAADAPLRLR SIHEYPKYQA EFPMSPVTSA HSGTYRCYGS
410 420 430 440 450
LSSNPYLLSH PSDSLELMVS GAAETLSPPQ NKSDSKAGAA NTLSPSQNKT
460 470 480
ASHPQDYTVE NLIRMGIAGL VLVVLGILLF EAQHSQRSL
Length:489
Mass (Da):53,275
Last modified:November 1, 1998 - v1
Checksum:i44469FD4884EA068
GO
Isoform 2 (identifier: O75019-2) [UniParc]FASTAAdd to Basket

Also known as: LIR-6b

The sequence of this isoform differs from the canonical sequence as follows:
     221-420: Missing.

Show »
Length:289
Mass (Da):31,724
Checksum:iB26E3FE090250FE0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51V → L in AAB87663. (PubMed:9548455)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121R → G.1 Publication
Corresponds to variant rs1974982 [ dbSNP | Ensembl ].
VAR_059396
Natural varianti153 – 1531S → G.
Corresponds to variant rs10417589 [ dbSNP | Ensembl ].
VAR_049886
Natural varianti220 – 2201L → P.1 Publication
Corresponds to variant rs373854 [ dbSNP | Ensembl ].
VAR_049887

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei221 – 420200Missing in isoform 2. 1 PublicationVSP_008454Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025529 mRNA. Translation: AAB87663.1.
AF025530 mRNA. Translation: AAB87664.1.
BC101514 mRNA. Translation: AAI01515.1.
CCDSiCCDS12901.1. [O75019-1]
CCDS62802.1. [O75019-2]
RefSeqiNP_001265247.1. NM_001278318.1. [O75019-2]
NP_001265248.1. NM_001278319.1.
NP_006854.1. NM_006863.3. [O75019-1]
UniGeneiHs.710507.

Genome annotation databases

EnsembliENST00000251372; ENSP00000251372; ENSG00000104974. [O75019-1]
ENST00000453777; ENSP00000413715; ENSG00000104974. [O75019-2]
ENST00000617170; ENSP00000477637; ENSG00000275525. [O75019-1]
ENST00000620606; ENSP00000478666; ENSG00000275525. [O75019-2]
GeneIDi11024.
KEGGihsa:11024.
UCSCiuc002qgh.2. human. [O75019-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025529 mRNA. Translation: AAB87663.1.
AF025530 mRNA. Translation: AAB87664.1.
BC101514 mRNA. Translation: AAI01515.1.
CCDSiCCDS12901.1. [O75019-1]
CCDS62802.1. [O75019-2]
RefSeqiNP_001265247.1. NM_001278318.1. [O75019-2]
NP_001265248.1. NM_001278319.1.
NP_006854.1. NM_006863.3. [O75019-1]
UniGeneiHs.710507.

3D structure databases

ProteinModelPortaliO75019.
SMRiO75019. Positions 26-450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116214. 1 interaction.
STRINGi9606.ENSP00000251372.

PTM databases

PhosphoSiteiO75019.

Proteomic databases

PaxDbiO75019.
PRIDEiO75019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251372; ENSP00000251372; ENSG00000104974. [O75019-1]
ENST00000453777; ENSP00000413715; ENSG00000104974. [O75019-2]
ENST00000617170; ENSP00000477637; ENSG00000275525. [O75019-1]
ENST00000620606; ENSP00000478666; ENSG00000275525. [O75019-2]
GeneIDi11024.
KEGGihsa:11024.
UCSCiuc002qgh.2. human. [O75019-1]

Organism-specific databases

CTDi11024.
GeneCardsiGC19P055105.
HGNCiHGNC:6602. LILRA1.
MIMi604810. gene.
neXtProtiNX_O75019.
PharmGKBiPA30376.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25855.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiO75019.
KOiK06512.
OMAiNAYLLTH.
OrthoDBiEOG7R56S3.
PhylomeDBiO75019.
TreeFamiTF336644.

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GenomeRNAii11024.
NextBioi41892.
PROiO75019.
SOURCEiSearch...

Gene expression databases

BgeeiO75019.
CleanExiHS_LILRA1.
GenevestigatoriO75019.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 3 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
    Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.
    J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, VARIANTS GLY-12 AND PRO-220.
    Tissue: Peripheral blood leukocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiLIRA1_HUMAN
AccessioniPrimary (citable) accession number: O75019
Secondary accession number(s): O75018, Q3MJA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.