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O75019 (LIRA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leukocyte immunoglobulin-like receptor subfamily A member 1
Alternative name(s):
CD85 antigen-like family member I
Leukocyte immunoglobulin-like receptor 6
Short name=LIR-6
CD_antigen=CD85i
Gene names
Name:LILRA1
Synonyms:LIR6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as receptor for class I MHC antigens.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Detected in monocytes and B-cells. Ref.1

Sequence similarities

Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O75019-1)

Also known as: LIR-6a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O75019-2)

Also known as: LIR-6b;

The sequence of this isoform differs from the canonical sequence as follows:
     221-420: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 489473Leukocyte immunoglobulin-like receptor subfamily A member 1
PRO_0000014816

Regions

Topological domain17 – 461445Extracellular Potential
Transmembrane462 – 48221Helical; Potential
Topological domain483 – 4897Cytoplasmic Potential
Domain27 – 11690Ig-like C2-type 1
Domain119 – 224106Ig-like C2-type 2
Domain226 – 31590Ig-like C2-type 3
Domain326 – 41590Ig-like C2-type 4

Amino acid modifications

Glycosylation1401N-linked (GlcNAc...) Potential
Glycosylation2811N-linked (GlcNAc...) Potential
Glycosylation3021N-linked (GlcNAc...) Potential
Glycosylation3411N-linked (GlcNAc...) Potential
Glycosylation4311N-linked (GlcNAc...) Potential
Glycosylation4481N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 98 By similarity
Disulfide bond145 ↔ 197 By similarity
Disulfide bond157 ↔ 167 By similarity
Disulfide bond246 ↔ 297 Potential
Disulfide bond346 ↔ 397 Potential

Natural variations

Alternative sequence221 – 420200Missing in isoform 2.
VSP_008454
Natural variant121R → G. Ref.1
Corresponds to variant rs1974982 [ dbSNP | Ensembl ].
VAR_059396
Natural variant1531S → G.
Corresponds to variant rs10417589 [ dbSNP | Ensembl ].
VAR_049886
Natural variant2201L → P. Ref.1
Corresponds to variant rs373854 [ dbSNP | Ensembl ].
VAR_049887

Experimental info

Sequence conflict51V → L in AAB87663. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (LIR-6a) [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 44469FD4884EA068

FASTA48953,275
        10         20         30         40         50         60 
MTPIVTVLIC LRLSLGPRTH VQAGTLPKPT LWAEPGSVIT QGSPVTLWCQ GILETQEYRL 

        70         80         90        100        110        120 
YREKKTAPWI TRIPQEIVKK GQFPIPSITW EHTGRYRCFY GSHTAGWSEP SDPLELVVTG 

       130        140        150        160        170        180 
AYIKPTLSAL PSPVVTSGGN VTLHCVSQVA FGSFILCKEG EDEHPQCLNS QPRTHGWSRA 

       190        200        210        220        230        240 
IFSVGPVSPS RRWSYRCYAY DSNSPHVWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPGE 

       250        260        270        280        290        300 
SLTLQCVSDV SYDRFVLYKE GERDFLQLPG PQPQAGLSQA NFTLGPVSRS YGGQYRCSGA 

       310        320        330        340        350        360 
YNLSSEWSAP SDPLDILIAG QFRGRPFISV HPGPTVASGE NVTLLCQSWG PFHTFLLTKA 

       370        380        390        400        410        420 
GAADAPLRLR SIHEYPKYQA EFPMSPVTSA HSGTYRCYGS LSSNPYLLSH PSDSLELMVS 

       430        440        450        460        470        480 
GAAETLSPPQ NKSDSKAGAA NTLSPSQNKT ASHPQDYTVE NLIRMGIAGL VLVVLGILLF 


EAQHSQRSL 

« Hide

Isoform 2 (LIR-6b) [UniParc].

Checksum: B26E3FE090250FE0
Show »

FASTA28931,724

References

« Hide 'large scale' references
[1]"A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.
J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, VARIANTS GLY-12 AND PRO-220.
Tissue: Peripheral blood leukocyte.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF025529 mRNA. Translation: AAB87663.1.
AF025530 mRNA. Translation: AAB87664.1.
BC101514 mRNA. Translation: AAI01515.1.
RefSeqNP_001265247.1. NM_001278318.1.
NP_001265248.1. NM_001278319.1.
NP_006854.1. NM_006863.3.
UniGeneHs.710507.

3D structure databases

ProteinModelPortalO75019.
SMRO75019. Positions 26-450.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000251372.

Protein family/group databases

MEROPSI43.001.

PTM databases

PhosphoSiteO75019.

Proteomic databases

PaxDbO75019.
PRIDEO75019.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000251372; ENSP00000251372; ENSG00000104974. [O75019-1]
ENST00000453777; ENSP00000413715; ENSG00000104974. [O75019-2]
ENST00000571445; ENSP00000458659; ENSG00000262462. [O75019-2]
ENST00000573402; ENSP00000459711; ENSG00000262900. [O75019-1]
ENST00000575013; ENSP00000460409; ENSG00000262900. [O75019-2]
ENST00000576139; ENSP00000461399; ENSG00000262462. [O75019-1]
ENST00000605207; ENSP00000474227; ENSG00000271188. [O75019-1]
ENST00000605433; ENSP00000474345; ENSG00000271188. [O75019-2]
GeneID11024.
KEGGhsa:11024.
UCSCuc002qgh.2. human. [O75019-1]

Organism-specific databases

CTD11024.
GeneCardsGC19P055105.
HGNCHGNC:6602. LILRA1.
MIM604810. gene.
neXtProtNX_O75019.
PharmGKBPA30376.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25855.
HOGENOMHOG000234395.
HOVERGENHBG074353.
InParanoidO75019.
KOK06512.
OMANAYLLTH.
OrthoDBEOG7R56S3.
PhylomeDBO75019.
TreeFamTF336644.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeO75019.
CleanExHS_LILRA1.
GenevestigatorO75019.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PIRSFPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTSM00409. IG. 3 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi11024.
NextBio41892.
PROO75019.
SOURCESearch...

Entry information

Entry nameLIRA1_HUMAN
AccessionPrimary (citable) accession number: O75019
Secondary accession number(s): O75018, Q3MJA6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1998
Last modified: March 19, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries