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Protein

Leukocyte immunoglobulin-like receptor subfamily A member 1

Gene

LILRA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May act as receptor for class I MHC antigens.

GO - Molecular functioni

  • antigen binding Source: ProtInc
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • cell surface receptor signaling pathway Source: ProtInc
  • defense response Source: ProtInc
  • regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104974-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily A member 1
Alternative name(s):
CD85 antigen-like family member I
Leukocyte immunoglobulin-like receptor 6
Short name:
LIR-6
CD_antigen: CD85i
Gene namesi
Name:LILRA1
Synonyms:LIR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6602. LILRA1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 461ExtracellularSequence analysisAdd BLAST445
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 489CytoplasmicSequence analysis7

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11024.
OpenTargetsiENSG00000104974.
ENSG00000274935.
ENSG00000275525.
ENSG00000277398.
PharmGKBiPA30376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001481617 – 489Leukocyte immunoglobulin-like receptor subfamily A member 1Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
Glycosylationi140N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi145 ↔ 197PROSITE-ProRule annotation
Disulfide bondi157 ↔ 167PROSITE-ProRule annotation
Disulfide bondi246 ↔ 297PROSITE-ProRule annotation
Glycosylationi281N-linked (GlcNAc...)Sequence analysis1
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Glycosylationi341N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi346 ↔ 397PROSITE-ProRule annotation
Modified residuei406Nitrated tyrosineBy similarity1
Glycosylationi431N-linked (GlcNAc...)Sequence analysis1
Glycosylationi448N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Nitration

Proteomic databases

PaxDbiO75019.
PeptideAtlasiO75019.
PRIDEiO75019.

PTM databases

iPTMnetiO75019.
PhosphoSitePlusiO75019.

Expressioni

Tissue specificityi

Detected in monocytes and B-cells.1 Publication

Gene expression databases

BgeeiENSG00000104974.
CleanExiHS_LILRA1.
ExpressionAtlasiO75019. baseline and differential.
GenevisibleiO75019. HS.

Organism-specific databases

HPAiCAB033274.

Interactioni

Protein-protein interaction databases

BioGridi116214. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliO75019.
SMRiO75019.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 116Ig-like C2-type 1Add BLAST90
Domaini119 – 224Ig-like C2-type 2Add BLAST106
Domaini226 – 315Ig-like C2-type 3Add BLAST90
Domaini326 – 415Ig-like C2-type 4Add BLAST90

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKJD. Eukaryota.
ENOG41116BR. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiO75019.
KOiK06512.
OrthoDBiEOG091G020P.
PhylomeDBiO75019.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O75019-1) [UniParc]FASTAAdd to basket
Also known as: LIR-6a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTPIVTVLIC LRLSLGPRTH VQAGTLPKPT LWAEPGSVIT QGSPVTLWCQ
60 70 80 90 100
GILETQEYRL YREKKTAPWI TRIPQEIVKK GQFPIPSITW EHTGRYRCFY
110 120 130 140 150
GSHTAGWSEP SDPLELVVTG AYIKPTLSAL PSPVVTSGGN VTLHCVSQVA
160 170 180 190 200
FGSFILCKEG EDEHPQCLNS QPRTHGWSRA IFSVGPVSPS RRWSYRCYAY
210 220 230 240 250
DSNSPHVWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPGE SLTLQCVSDV
260 270 280 290 300
SYDRFVLYKE GERDFLQLPG PQPQAGLSQA NFTLGPVSRS YGGQYRCSGA
310 320 330 340 350
YNLSSEWSAP SDPLDILIAG QFRGRPFISV HPGPTVASGE NVTLLCQSWG
360 370 380 390 400
PFHTFLLTKA GAADAPLRLR SIHEYPKYQA EFPMSPVTSA HSGTYRCYGS
410 420 430 440 450
LSSNPYLLSH PSDSLELMVS GAAETLSPPQ NKSDSKAGAA NTLSPSQNKT
460 470 480
ASHPQDYTVE NLIRMGIAGL VLVVLGILLF EAQHSQRSL
Length:489
Mass (Da):53,275
Last modified:November 1, 1998 - v1
Checksum:i44469FD4884EA068
GO
Isoform 2 (identifier: O75019-2) [UniParc]FASTAAdd to basket
Also known as: LIR-6b

The sequence of this isoform differs from the canonical sequence as follows:
     221-420: Missing.

Show »
Length:289
Mass (Da):31,724
Checksum:iB26E3FE090250FE0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5V → L in AAB87663 (PubMed:9548455).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05939612R → G.1 PublicationCorresponds to variant rs1974982dbSNPEnsembl.1
Natural variantiVAR_049886153S → G.Corresponds to variant rs10417589dbSNPEnsembl.1
Natural variantiVAR_049887220L → P.1 PublicationCorresponds to variant rs373854dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008454221 – 420Missing in isoform 2. 1 PublicationAdd BLAST200

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025529 mRNA. Translation: AAB87663.1.
AF025530 mRNA. Translation: AAB87664.1.
BC101514 mRNA. Translation: AAI01515.1.
CCDSiCCDS12901.1. [O75019-1]
CCDS62802.1. [O75019-2]
RefSeqiNP_001265247.1. NM_001278318.1. [O75019-2]
NP_001265248.1. NM_001278319.1.
NP_006854.1. NM_006863.3. [O75019-1]
UniGeneiHs.710507.

Genome annotation databases

EnsembliENST00000251372; ENSP00000251372; ENSG00000104974. [O75019-1]
ENST00000453777; ENSP00000413715; ENSG00000104974. [O75019-2]
ENST00000617170; ENSP00000477637; ENSG00000275525. [O75019-1]
ENST00000620606; ENSP00000478666; ENSG00000275525. [O75019-2]
ENST00000628480; ENSP00000487229; ENSG00000277398. [O75019-2]
ENST00000631007; ENSP00000487011; ENSG00000274935. [O75019-2]
GeneIDi11024.
KEGGihsa:11024.
UCSCiuc002qgh.4. human. [O75019-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF025529 mRNA. Translation: AAB87663.1.
AF025530 mRNA. Translation: AAB87664.1.
BC101514 mRNA. Translation: AAI01515.1.
CCDSiCCDS12901.1. [O75019-1]
CCDS62802.1. [O75019-2]
RefSeqiNP_001265247.1. NM_001278318.1. [O75019-2]
NP_001265248.1. NM_001278319.1.
NP_006854.1. NM_006863.3. [O75019-1]
UniGeneiHs.710507.

3D structure databases

ProteinModelPortaliO75019.
SMRiO75019.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116214. 1 interactor.

PTM databases

iPTMnetiO75019.
PhosphoSitePlusiO75019.

Proteomic databases

PaxDbiO75019.
PeptideAtlasiO75019.
PRIDEiO75019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251372; ENSP00000251372; ENSG00000104974. [O75019-1]
ENST00000453777; ENSP00000413715; ENSG00000104974. [O75019-2]
ENST00000617170; ENSP00000477637; ENSG00000275525. [O75019-1]
ENST00000620606; ENSP00000478666; ENSG00000275525. [O75019-2]
ENST00000628480; ENSP00000487229; ENSG00000277398. [O75019-2]
ENST00000631007; ENSP00000487011; ENSG00000274935. [O75019-2]
GeneIDi11024.
KEGGihsa:11024.
UCSCiuc002qgh.4. human. [O75019-1]

Organism-specific databases

CTDi11024.
DisGeNETi11024.
GeneCardsiLILRA1.
HGNCiHGNC:6602. LILRA1.
HPAiCAB033274.
MIMi604810. gene.
neXtProtiNX_O75019.
OpenTargetsiENSG00000104974.
ENSG00000274935.
ENSG00000275525.
ENSG00000277398.
PharmGKBiPA30376.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKJD. Eukaryota.
ENOG41116BR. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiO75019.
KOiK06512.
OrthoDBiEOG091G020P.
PhylomeDBiO75019.
TreeFamiTF336644.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104974-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GenomeRNAii11024.
PROiO75019.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104974.
CleanExiHS_LILRA1.
ExpressionAtlasiO75019. baseline and differential.
GenevisibleiO75019. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIRA1_HUMAN
AccessioniPrimary (citable) accession number: O75019
Secondary accession number(s): O75018, Q3MJA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.