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O75019

- LIRA1_HUMAN

UniProt

O75019 - LIRA1_HUMAN

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Protein
Leukocyte immunoglobulin-like receptor subfamily A member 1
Gene
LILRA1, LIR6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May act as receptor for class I MHC antigens.

GO - Molecular functioni

  1. antigen binding Source: ProtInc
  2. transmembrane signaling receptor activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
  2. defense response Source: ProtInc
  3. immune system process Source: UniProtKB-KW
  4. regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Adaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte immunoglobulin-like receptor subfamily A member 1
Alternative name(s):
CD85 antigen-like family member I
Leukocyte immunoglobulin-like receptor 6
Short name:
LIR-6
CD_antigen: CD85i
Gene namesi
Name:LILRA1
Synonyms:LIR6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6602. LILRA1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 461445Extracellular Reviewed prediction
Add
BLAST
Transmembranei462 – 48221Helical; Reviewed prediction
Add
BLAST
Topological domaini483 – 4897Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 489473Leukocyte immunoglobulin-like receptor subfamily A member 1
PRO_0000014816Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 98 By similarity
Glycosylationi140 – 1401N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi145 ↔ 197 By similarity
Disulfide bondi157 ↔ 167 By similarity
Disulfide bondi246 ↔ 297 Reviewed prediction
Glycosylationi281 – 2811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi341 – 3411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi346 ↔ 397 Reviewed prediction
Glycosylationi431 – 4311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi448 – 4481N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO75019.
PRIDEiO75019.

PTM databases

PhosphoSiteiO75019.

Expressioni

Tissue specificityi

Detected in monocytes and B-cells.1 Publication

Gene expression databases

BgeeiO75019.
CleanExiHS_LILRA1.
GenevestigatoriO75019.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000251372.

Structurei

3D structure databases

ProteinModelPortaliO75019.
SMRiO75019. Positions 26-450.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11690Ig-like C2-type 1
Add
BLAST
Domaini119 – 224106Ig-like C2-type 2
Add
BLAST
Domaini226 – 31590Ig-like C2-type 3
Add
BLAST
Domaini326 – 41590Ig-like C2-type 4
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25855.
HOGENOMiHOG000234395.
HOVERGENiHBG074353.
InParanoidiO75019.
KOiK06512.
OMAiNAYLLTH.
OrthoDBiEOG7R56S3.
PhylomeDBiO75019.
TreeFamiTF336644.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTiSM00409. IG. 3 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O75019-1) [UniParc]FASTAAdd to Basket

Also known as: LIR-6a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTPIVTVLIC LRLSLGPRTH VQAGTLPKPT LWAEPGSVIT QGSPVTLWCQ    50
GILETQEYRL YREKKTAPWI TRIPQEIVKK GQFPIPSITW EHTGRYRCFY 100
GSHTAGWSEP SDPLELVVTG AYIKPTLSAL PSPVVTSGGN VTLHCVSQVA 150
FGSFILCKEG EDEHPQCLNS QPRTHGWSRA IFSVGPVSPS RRWSYRCYAY 200
DSNSPHVWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPGE SLTLQCVSDV 250
SYDRFVLYKE GERDFLQLPG PQPQAGLSQA NFTLGPVSRS YGGQYRCSGA 300
YNLSSEWSAP SDPLDILIAG QFRGRPFISV HPGPTVASGE NVTLLCQSWG 350
PFHTFLLTKA GAADAPLRLR SIHEYPKYQA EFPMSPVTSA HSGTYRCYGS 400
LSSNPYLLSH PSDSLELMVS GAAETLSPPQ NKSDSKAGAA NTLSPSQNKT 450
ASHPQDYTVE NLIRMGIAGL VLVVLGILLF EAQHSQRSL 489
Length:489
Mass (Da):53,275
Last modified:November 1, 1998 - v1
Checksum:i44469FD4884EA068
GO
Isoform 2 (identifier: O75019-2) [UniParc]FASTAAdd to Basket

Also known as: LIR-6b

The sequence of this isoform differs from the canonical sequence as follows:
     221-420: Missing.

Show »
Length:289
Mass (Da):31,724
Checksum:iB26E3FE090250FE0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti12 – 121R → G.1 Publication
Corresponds to variant rs1974982 [ dbSNP | Ensembl ].
VAR_059396
Natural varianti153 – 1531S → G.
Corresponds to variant rs10417589 [ dbSNP | Ensembl ].
VAR_049886
Natural varianti220 – 2201L → P.1 Publication
Corresponds to variant rs373854 [ dbSNP | Ensembl ].
VAR_049887

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei221 – 420200Missing in isoform 2.
VSP_008454Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51V → L in AAB87663. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF025529 mRNA. Translation: AAB87663.1.
AF025530 mRNA. Translation: AAB87664.1.
BC101514 mRNA. Translation: AAI01515.1.
CCDSiCCDS12901.1. [O75019-1]
CCDS62802.1. [O75019-2]
RefSeqiNP_001265247.1. NM_001278318.1. [O75019-2]
NP_001265248.1. NM_001278319.1.
NP_006854.1. NM_006863.3. [O75019-1]
UniGeneiHs.710507.

Genome annotation databases

EnsembliENST00000251372; ENSP00000251372; ENSG00000104974. [O75019-1]
ENST00000453777; ENSP00000413715; ENSG00000104974. [O75019-2]
ENST00000571445; ENSP00000458659; ENSG00000262462. [O75019-2]
ENST00000573402; ENSP00000459711; ENSG00000262900. [O75019-1]
ENST00000575013; ENSP00000460409; ENSG00000262900. [O75019-2]
ENST00000576139; ENSP00000461399; ENSG00000262462. [O75019-1]
ENST00000605207; ENSP00000474227; ENSG00000271188. [O75019-1]
ENST00000605433; ENSP00000474345; ENSG00000271188. [O75019-2]
GeneIDi11024.
KEGGihsa:11024.
UCSCiuc002qgh.2. human. [O75019-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF025529 mRNA. Translation: AAB87663.1 .
AF025530 mRNA. Translation: AAB87664.1 .
BC101514 mRNA. Translation: AAI01515.1 .
CCDSi CCDS12901.1. [O75019-1 ]
CCDS62802.1. [O75019-2 ]
RefSeqi NP_001265247.1. NM_001278318.1. [O75019-2 ]
NP_001265248.1. NM_001278319.1.
NP_006854.1. NM_006863.3. [O75019-1 ]
UniGenei Hs.710507.

3D structure databases

ProteinModelPortali O75019.
SMRi O75019. Positions 26-450.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000251372.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei O75019.

Proteomic databases

PaxDbi O75019.
PRIDEi O75019.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000251372 ; ENSP00000251372 ; ENSG00000104974 . [O75019-1 ]
ENST00000453777 ; ENSP00000413715 ; ENSG00000104974 . [O75019-2 ]
ENST00000571445 ; ENSP00000458659 ; ENSG00000262462 . [O75019-2 ]
ENST00000573402 ; ENSP00000459711 ; ENSG00000262900 . [O75019-1 ]
ENST00000575013 ; ENSP00000460409 ; ENSG00000262900 . [O75019-2 ]
ENST00000576139 ; ENSP00000461399 ; ENSG00000262462 . [O75019-1 ]
ENST00000605207 ; ENSP00000474227 ; ENSG00000271188 . [O75019-1 ]
ENST00000605433 ; ENSP00000474345 ; ENSG00000271188 . [O75019-2 ]
GeneIDi 11024.
KEGGi hsa:11024.
UCSCi uc002qgh.2. human. [O75019-1 ]

Organism-specific databases

CTDi 11024.
GeneCardsi GC19P055105.
HGNCi HGNC:6602. LILRA1.
MIMi 604810. gene.
neXtProti NX_O75019.
PharmGKBi PA30376.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25855.
HOGENOMi HOG000234395.
HOVERGENi HBG074353.
InParanoidi O75019.
KOi K06512.
OMAi NAYLLTH.
OrthoDBi EOG7R56S3.
PhylomeDBi O75019.
TreeFami TF336644.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GenomeRNAii 11024.
NextBioi 41892.
PROi O75019.
SOURCEi Search...

Gene expression databases

Bgeei O75019.
CleanExi HS_LILRA1.
Genevestigatori O75019.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR016332. A1B_glyco/leuk_Ig-like_rcpt.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
PIRSFi PIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMARTi SM00409. IG. 3 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
    Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.
    J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, VARIANTS GLY-12 AND PRO-220.
    Tissue: Peripheral blood leukocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiLIRA1_HUMAN
AccessioniPrimary (citable) accession number: O75019
Secondary accession number(s): O75018, Q3MJA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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