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O75019

- LIRA1_HUMAN

UniProt

O75019 - LIRA1_HUMAN

Protein

Leukocyte immunoglobulin-like receptor subfamily A member 1

Gene

LILRA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    May act as receptor for class I MHC antigens.

    GO - Molecular functioni

    1. antigen binding Source: ProtInc
    2. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: ProtInc
    2. defense response Source: ProtInc
    3. immune system process Source: UniProtKB-KW
    4. regulation of immune response Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukocyte immunoglobulin-like receptor subfamily A member 1
    Alternative name(s):
    CD85 antigen-like family member I
    Leukocyte immunoglobulin-like receptor 6
    Short name:
    LIR-6
    CD_antigen: CD85i
    Gene namesi
    Name:LILRA1
    Synonyms:LIR6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6602. LILRA1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30376.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 489473Leukocyte immunoglobulin-like receptor subfamily A member 1PRO_0000014816Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 98PROSITE-ProRule annotation
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi145 ↔ 197PROSITE-ProRule annotation
    Disulfide bondi157 ↔ 167PROSITE-ProRule annotation
    Disulfide bondi246 ↔ 297PROSITE-ProRule annotation
    Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi341 – 3411N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi346 ↔ 397PROSITE-ProRule annotation
    Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO75019.
    PRIDEiO75019.

    PTM databases

    PhosphoSiteiO75019.

    Expressioni

    Tissue specificityi

    Detected in monocytes and B-cells.1 Publication

    Gene expression databases

    BgeeiO75019.
    CleanExiHS_LILRA1.
    GenevestigatoriO75019.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000251372.

    Structurei

    3D structure databases

    ProteinModelPortaliO75019.
    SMRiO75019. Positions 26-450.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 461445ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini483 – 4897CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei462 – 48221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 11690Ig-like C2-type 1Add
    BLAST
    Domaini119 – 224106Ig-like C2-type 2Add
    BLAST
    Domaini226 – 31590Ig-like C2-type 3Add
    BLAST
    Domaini326 – 41590Ig-like C2-type 4Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG25855.
    HOGENOMiHOG000234395.
    HOVERGENiHBG074353.
    InParanoidiO75019.
    KOiK06512.
    OMAiNAYLLTH.
    OrthoDBiEOG7R56S3.
    PhylomeDBiO75019.
    TreeFamiTF336644.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR016332. A1B_glyco/leuk_Ig-like_rcpt.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    PIRSFiPIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
    SMARTiSM00409. IG. 3 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O75019-1) [UniParc]FASTAAdd to Basket

    Also known as: LIR-6a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTPIVTVLIC LRLSLGPRTH VQAGTLPKPT LWAEPGSVIT QGSPVTLWCQ    50
    GILETQEYRL YREKKTAPWI TRIPQEIVKK GQFPIPSITW EHTGRYRCFY 100
    GSHTAGWSEP SDPLELVVTG AYIKPTLSAL PSPVVTSGGN VTLHCVSQVA 150
    FGSFILCKEG EDEHPQCLNS QPRTHGWSRA IFSVGPVSPS RRWSYRCYAY 200
    DSNSPHVWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPGE SLTLQCVSDV 250
    SYDRFVLYKE GERDFLQLPG PQPQAGLSQA NFTLGPVSRS YGGQYRCSGA 300
    YNLSSEWSAP SDPLDILIAG QFRGRPFISV HPGPTVASGE NVTLLCQSWG 350
    PFHTFLLTKA GAADAPLRLR SIHEYPKYQA EFPMSPVTSA HSGTYRCYGS 400
    LSSNPYLLSH PSDSLELMVS GAAETLSPPQ NKSDSKAGAA NTLSPSQNKT 450
    ASHPQDYTVE NLIRMGIAGL VLVVLGILLF EAQHSQRSL 489
    Length:489
    Mass (Da):53,275
    Last modified:November 1, 1998 - v1
    Checksum:i44469FD4884EA068
    GO
    Isoform 2 (identifier: O75019-2) [UniParc]FASTAAdd to Basket

    Also known as: LIR-6b

    The sequence of this isoform differs from the canonical sequence as follows:
         221-420: Missing.

    Show »
    Length:289
    Mass (Da):31,724
    Checksum:iB26E3FE090250FE0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti5 – 51V → L in AAB87663. (PubMed:9548455)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti12 – 121R → G.1 Publication
    Corresponds to variant rs1974982 [ dbSNP | Ensembl ].
    VAR_059396
    Natural varianti153 – 1531S → G.
    Corresponds to variant rs10417589 [ dbSNP | Ensembl ].
    VAR_049886
    Natural varianti220 – 2201L → P.1 Publication
    Corresponds to variant rs373854 [ dbSNP | Ensembl ].
    VAR_049887

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei221 – 420200Missing in isoform 2. 1 PublicationVSP_008454Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF025529 mRNA. Translation: AAB87663.1.
    AF025530 mRNA. Translation: AAB87664.1.
    BC101514 mRNA. Translation: AAI01515.1.
    CCDSiCCDS12901.1. [O75019-1]
    CCDS62802.1. [O75019-2]
    RefSeqiNP_001265247.1. NM_001278318.1. [O75019-2]
    NP_001265248.1. NM_001278319.1.
    NP_006854.1. NM_006863.3. [O75019-1]
    UniGeneiHs.710507.

    Genome annotation databases

    EnsembliENST00000251372; ENSP00000251372; ENSG00000104974. [O75019-1]
    ENST00000453777; ENSP00000413715; ENSG00000104974. [O75019-2]
    GeneIDi11024.
    KEGGihsa:11024.
    UCSCiuc002qgh.2. human. [O75019-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF025529 mRNA. Translation: AAB87663.1 .
    AF025530 mRNA. Translation: AAB87664.1 .
    BC101514 mRNA. Translation: AAI01515.1 .
    CCDSi CCDS12901.1. [O75019-1 ]
    CCDS62802.1. [O75019-2 ]
    RefSeqi NP_001265247.1. NM_001278318.1. [O75019-2 ]
    NP_001265248.1. NM_001278319.1.
    NP_006854.1. NM_006863.3. [O75019-1 ]
    UniGenei Hs.710507.

    3D structure databases

    ProteinModelPortali O75019.
    SMRi O75019. Positions 26-450.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000251372.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei O75019.

    Proteomic databases

    PaxDbi O75019.
    PRIDEi O75019.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000251372 ; ENSP00000251372 ; ENSG00000104974 . [O75019-1 ]
    ENST00000453777 ; ENSP00000413715 ; ENSG00000104974 . [O75019-2 ]
    GeneIDi 11024.
    KEGGi hsa:11024.
    UCSCi uc002qgh.2. human. [O75019-1 ]

    Organism-specific databases

    CTDi 11024.
    GeneCardsi GC19P055105.
    HGNCi HGNC:6602. LILRA1.
    MIMi 604810. gene.
    neXtProti NX_O75019.
    PharmGKBi PA30376.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25855.
    HOGENOMi HOG000234395.
    HOVERGENi HBG074353.
    InParanoidi O75019.
    KOi K06512.
    OMAi NAYLLTH.
    OrthoDBi EOG7R56S3.
    PhylomeDBi O75019.
    TreeFami TF336644.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    GenomeRNAii 11024.
    NextBioi 41892.
    PROi O75019.
    SOURCEi Search...

    Gene expression databases

    Bgeei O75019.
    CleanExi HS_LILRA1.
    Genevestigatori O75019.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR016332. A1B_glyco/leuk_Ig-like_rcpt.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    PIRSFi PIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
    SMARTi SM00409. IG. 3 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules."
      Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D.
      J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, VARIANTS GLY-12 AND PRO-220.
      Tissue: Peripheral blood leukocyte.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiLIRA1_HUMAN
    AccessioniPrimary (citable) accession number: O75019
    Secondary accession number(s): O75018, Q3MJA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3