O75019 (LIRA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leukocyte immunoglobulin-like receptor subfamily A member 1

Alternative name(s):
CD85 antigen-like family member I
Leukocyte immunoglobulin-like receptor 6
Short name=LIR-6
CD_antigen=CD85i

Gene names

Name:	LILRA1
Synonyms:	LIR6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May act as receptor for class I MHC antigens.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Detected in monocytes and B-cells. Ref.1
Sequence similarities	Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Biological process	Adaptive immunity Immunity
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell surface receptor signaling pathway Traceable author statement Ref.1. Source: ProtInc defense response Traceable author statement Ref.1. Source: ProtInc regulation of immune response Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	antigen binding Traceable author statement Ref.1. Source: ProtInc transmembrane signaling receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O75019-1)

Also known as: LIR-6a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O75019-2)

Also known as: LIR-6b;

The sequence of this isoform differs from the canonical sequence as follows:
     221-420: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 489	473	Leukocyte immunoglobulin-like receptor subfamily A member 1		PRO_0000014816
Regions
	Topological domain	17 – 461	445	Extracellular Potential
	Transmembrane	462 – 482	21	Helical; Potential
	Topological domain	483 – 489	7	Cytoplasmic Potential
	Domain	27 – 116	90	Ig-like C2-type 1
	Domain	119 – 224	106	Ig-like C2-type 2
	Domain	226 – 315	90	Ig-like C2-type 3
	Domain	326 – 415	90	Ig-like C2-type 4
Amino acid modifications
	Glycosylation	140	1	N-linked (GlcNAc...) Potential
	Glycosylation	281	1	N-linked (GlcNAc...) Potential
	Glycosylation	302	1	N-linked (GlcNAc...) Potential
	Glycosylation	341	1	N-linked (GlcNAc...) Potential
	Glycosylation	431	1	N-linked (GlcNAc...) Potential
	Glycosylation	448	1	N-linked (GlcNAc...) Potential
	Disulfide bond	49 ↔ 98		By similarity
	Disulfide bond	145 ↔ 197		By similarity
	Disulfide bond	157 ↔ 167		By similarity
	Disulfide bond	246 ↔ 297		Potential
	Disulfide bond	346 ↔ 397		Potential
Natural variations
	Alternative sequence	221 – 420	200	Missing in isoform 2.		VSP_008454
	Natural variant	12	1	R → G. Ref.1 Corresponds to variant rs1974982 [ dbSNP | Ensembl ].		VAR_059396
	Natural variant	153	1	S → G. Corresponds to variant rs10417589 [ dbSNP | Ensembl ].		VAR_049886
	Natural variant	220	1	L → P. Ref.1 Corresponds to variant rs373854 [ dbSNP | Ensembl ].		VAR_049887
Experimental info
	Sequence conflict	5	1	V → L in AAB87663. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (LIR-6a) [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 44469FD4884EA068	FASTA	489	53,275
	10 20 30 40 50 60 MTPIVTVLIC LRLSLGPRTH VQAGTLPKPT LWAEPGSVIT QGSPVTLWCQ GILETQEYRL 70 80 90 100 110 120 YREKKTAPWI TRIPQEIVKK GQFPIPSITW EHTGRYRCFY GSHTAGWSEP SDPLELVVTG 130 140 150 160 170 180 AYIKPTLSAL PSPVVTSGGN VTLHCVSQVA FGSFILCKEG EDEHPQCLNS QPRTHGWSRA 190 200 210 220 230 240 IFSVGPVSPS RRWSYRCYAY DSNSPHVWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPGE 250 260 270 280 290 300 SLTLQCVSDV SYDRFVLYKE GERDFLQLPG PQPQAGLSQA NFTLGPVSRS YGGQYRCSGA 310 320 330 340 350 360 YNLSSEWSAP SDPLDILIAG QFRGRPFISV HPGPTVASGE NVTLLCQSWG PFHTFLLTKA 370 380 390 400 410 420 GAADAPLRLR SIHEYPKYQA EFPMSPVTSA HSGTYRCYGS LSSNPYLLSH PSDSLELMVS 430 440 450 460 470 480 GAAETLSPPQ NKSDSKAGAA NTLSPSQNKT ASHPQDYTVE NLIRMGIAGL VLVVLGILLF EAQHSQRSL
	Isoform 2 (LIR-6b) [UniParc]. Checksum: B26E3FE090250FE0	FASTA	289	31,724
	10 20 30 40 50 60 MTPIVTVLIC LRLSLGPRTH VQAGTLPKPT LWAEPGSVIT QGSPVTLWCQ GILETQEYRL 70 80 90 100 110 120 YREKKTAPWI TRIPQEIVKK GQFPIPSITW EHTGRYRCFY GSHTAGWSEP SDPLELVVTG 130 140 150 160 170 180 AYIKPTLSAL PSPVVTSGGN VTLHCVSQVA FGSFILCKEG EDEHPQCLNS QPRTHGWSRA 190 200 210 220 230 240 IFSVGPVSPS RRWSYRCYAY DSNSPHVWSL PSDLLELLVL GAAETLSPPQ NKSDSKAGAA 250 260 270 280 NTLSPSQNKT ASHPQDYTVE NLIRMGIAGL VLVVLGILLF EAQHSQRSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules." Borges L., Hsu M.-L., Fanger N., Kubin M., Cosman D. J. Immunol. 159:5192-5196(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, VARIANTS GLY-12 AND PRO-220. Tissue: Peripheral blood leukocyte.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF025529 mRNA. Translation: AAB87663.1. AF025530 mRNA. Translation: AAB87664.1. BC101514 mRNA. Translation: AAI01515.1.
IPI	IPI00009984. IPI00852687.
RefSeq	NP_006854.1. NM_006863.2.
UniGene	Hs.710507.
3D structure databases
ProteinModelPortal	O75019.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000251372.
Protein family/group databases
MEROPS	I43.001.
PTM databases
PhosphoSite	O75019.
Proteomic databases
PaxDb	O75019.
PRIDE	O75019.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000251372; ENSP00000251372; ENSG00000104974. ENST00000453777; ENSP00000413715; ENSG00000104974. ENST00000571445; ENSP00000458659; ENSG00000262462. ENST00000573402; ENSP00000459711; ENSG00000262900. ENST00000575013; ENSP00000460409; ENSG00000262900. ENST00000576139; ENSP00000461399; ENSG00000262462.
GeneID	11024.
KEGG	hsa:11024.
UCSC	uc002qgh.1. human.
Organism-specific databases
CTD	11024.
GeneCards	GC19P055105.
HGNC	HGNC:6602. LILRA1.
MIM	604810. gene.
neXtProt	NX_O75019.
PharmGKB	PA30376.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG25855.
HOGENOM	HOG000234395.
HOVERGEN	HBG074353.
InParanoid	O75019.
KO	K06512.
OMA	KWIPREL.
OrthoDB	EOG4VQ9Q0.
PhylomeDB	O75019.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Bgee	O75019.
CleanEx	HS_LILRA1.
Genevestigator	O75019.
GermOnline	ENSG00000104974. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR016332. A1B_glyco/leuk_Ig-like_rcpt. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view]
PIRSF	PIRSF001979. Alpha_1B_glycoprot_prd. 1 hit.
SMART	SM00409. IG. 3 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	11024.
NextBio	41892.
SOURCE	Search...

Entry information

Entry name

LIRA1_HUMAN

Accession

Primary (citable) accession number: O75019
Secondary accession number(s): O75018, Q3MJA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.