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Protein

Low affinity immunoglobulin gamma Fc region receptor III-B

Gene

FCGR3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

GO - Biological processi

  • immune response Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgG-binding protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162747-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor III-B
Alternative name(s):
Fc-gamma RIII-beta
Short name:
Fc-gamma RIII
Short name:
Fc-gamma RIIIb
Short name:
FcRIII
Short name:
FcRIIIb
FcR-10
IgG Fc receptor III-1
CD_antigen: CD16b
Gene namesi
Name:FCGR3B
Synonyms:CD16B, FCG3, FCGR3, IGFR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3620. FCGR3B.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2215.
Orphaneti855. Hashimoto struma.
536. Systemic lupus erythematosus.
PharmGKBiPA28066.

Chemistry databases

ChEMBLiCHEMBL5842.
DrugBankiDB00054. Abciximab.
DB00051. Adalimumab.
DB00092. Alefacept.
DB00087. Alemtuzumab.
DB00074. Basiliximab.
DB00112. Bevacizumab.
DB00002. Cetuximab.
DB00111. Daclizumab.
DB00095. Efalizumab.
DB00005. Etanercept.
DB00056. Gemtuzumab ozogamicin.
DB00078. Ibritumomab.
DB00028. Intravenous Immunoglobulin.
DB00075. Muromonab.
DB00108. Natalizumab.
DB00110. Palivizumab.
DB00073. Rituximab.
DB00081. Tositumomab.
DB00072. Trastuzumab.

Polymorphism and mutation databases

BioMutaiFCGR3B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000001515117 – 200Low affinity immunoglobulin gamma Fc region receptor III-BAdd BLAST184
PropeptideiPRO_0000015152201 – 233Removed in mature formSequence analysisAdd BLAST33

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 89Combined sources2 Publications
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Glycosylationi63N-linked (GlcNAc...)Sequence analysis1
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi128 ↔ 172Combined sources2 Publications
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Lipidationi200GPI-anchor amidated serineSequence analysis1

Post-translational modificationi

Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.
The soluble form is produced by a proteolytic cleavage.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO75015.
PeptideAtlasiO75015.
PRIDEiO75015.

PTM databases

iPTMnetiO75015.
PhosphoSitePlusiO75015.

Expressioni

Tissue specificityi

Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.

Gene expression databases

BgeeiENSG00000162747.
CleanExiHS_FCGR3B.
ExpressionAtlasiO75015. baseline and differential.
GenevisibleiO75015. HS.

Organism-specific databases

HPAiCAB015425.

Interactioni

Subunit structurei

Monomer. Interacts with INPP5D/SHIP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi108509. 21 interactors.
IntActiO75015. 1 interactor.
STRINGi9606.ENSP00000294800.

Chemistry databases

BindingDBiO75015.

Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 32Combined sources6
Beta strandi35 – 38Combined sources4
Beta strandi43 – 48Combined sources6
Beta strandi59 – 62Combined sources4
Beta strandi65 – 70Combined sources6
Beta strandi72 – 78Combined sources7
Helixi81 – 83Combined sources3
Beta strandi85 – 90Combined sources6
Beta strandi92 – 94Combined sources3
Beta strandi100 – 105Combined sources6
Beta strandi107 – 112Combined sources6
Beta strandi116 – 119Combined sources4
Beta strandi120 – 122Combined sources3
Beta strandi124 – 130Combined sources7
Helixi131 – 133Combined sources3
Beta strandi137 – 143Combined sources7
Beta strandi146 – 153Combined sources8
Beta strandi157 – 161Combined sources5
Helixi164 – 166Combined sources3
Beta strandi168 – 176Combined sources9
Beta strandi179 – 182Combined sources4
Beta strandi186 – 191Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E4JX-ray2.50A18-193[»]
1E4KX-ray3.20C18-193[»]
1FNLX-ray1.80A19-192[»]
1T83X-ray3.00C19-194[»]
1T89X-ray3.50C19-194[»]
ProteinModelPortaliO75015.
SMRiO75015.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75015.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 96Ig-like C2-type 1Add BLAST57
Domaini121 – 179Ig-like C2-type 2Add BLAST59

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IKYD. Eukaryota.
ENOG41114N1. LUCA.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiO75015.
KOiK06463.
PhylomeDBiO75015.
TreeFamiTF335097.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWQLLLPTAL LLLVSAGMRT EDLPKAVVFL EPQWYSVLEK DSVTLKCQGA
60 70 80 90 100
YSPEDNSTQW FHNESLISSQ ASSYFIDAAT VNDSGEYRCQ TNLSTLSDPV
110 120 130 140 150
QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKDRKY
160 170 180 190 200
FHHNSDFHIP KATLKDSGSY FCRGLVGSKN VSSETVNITI TQGLAVSTIS
210 220 230
SFSPPGYQVS FCLVMVLLFA VDTGLYFSVK TNI
Length:233
Mass (Da):26,216
Last modified:November 1, 1999 - v2
Checksum:i7AB5159432761726
GO

Polymorphismi

There are three allelic forms of FCGR3B: FCGR3B*01 (NA-1), FCGR3B*02 (HNA-1b, NA-2) (shown here) and SH. FCGR3B*01 and FCGR3B*02 are detectable with antibodies against the biallelic neutrophil-specific antigen system NA. The more active FCGR3B*01 allele has been associated with severe renal disease in certain systemic vasculitides.6 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00395636S → R in allele FCGR3B*01. 1
Natural variantiVAR_00396365S → N in allele FCGR3B*01. 1 PublicationCorresponds to variant rs448740dbSNPEnsembl.1
Natural variantiVAR_00880278A → D in allele SH. 1 PublicationCorresponds to variant rs5030738dbSNPEnsembl.1
Natural variantiVAR_00395782N → D in allele FCGR3B*01. 1
Natural variantiVAR_003964106I → V in allele FCGR3B*01. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16863 mRNA. Translation: CAA34753.1.
X07934 mRNA. Translation: CAA30758.1.
J04162 mRNA. Translation: AAA35881.1.
M24854 mRNA. Translation: AAA53507.1.
AJ581669 mRNA. Translation: CAE46408.1.
AL451067 Genomic DNA. No translation available.
Z46223 Genomic DNA. Translation: CAA86296.1.
CCDSiCCDS41433.1.
PIRiJU0284.
RefSeqiNP_000561.3. NM_000570.4.
NP_001231682.1. NM_001244753.1.
NP_001257964.1. NM_001271035.1.
NP_001257965.1. NM_001271036.1.
NP_001257966.1. NM_001271037.1.
UniGeneiHs.372679.
Hs.694258.
Hs.736230.

Genome annotation databases

EnsembliENST00000294800; ENSP00000294800; ENSG00000162747.
ENST00000367964; ENSP00000356941; ENSG00000162747.
GeneIDi2215.
KEGGihsa:2215.
UCSCiuc021pdo.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16863 mRNA. Translation: CAA34753.1.
X07934 mRNA. Translation: CAA30758.1.
J04162 mRNA. Translation: AAA35881.1.
M24854 mRNA. Translation: AAA53507.1.
AJ581669 mRNA. Translation: CAE46408.1.
AL451067 Genomic DNA. No translation available.
Z46223 Genomic DNA. Translation: CAA86296.1.
CCDSiCCDS41433.1.
PIRiJU0284.
RefSeqiNP_000561.3. NM_000570.4.
NP_001231682.1. NM_001244753.1.
NP_001257964.1. NM_001271035.1.
NP_001257965.1. NM_001271036.1.
NP_001257966.1. NM_001271037.1.
UniGeneiHs.372679.
Hs.694258.
Hs.736230.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E4JX-ray2.50A18-193[»]
1E4KX-ray3.20C18-193[»]
1FNLX-ray1.80A19-192[»]
1T83X-ray3.00C19-194[»]
1T89X-ray3.50C19-194[»]
ProteinModelPortaliO75015.
SMRiO75015.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108509. 21 interactors.
IntActiO75015. 1 interactor.
STRINGi9606.ENSP00000294800.

Chemistry databases

BindingDBiO75015.
ChEMBLiCHEMBL5842.
DrugBankiDB00054. Abciximab.
DB00051. Adalimumab.
DB00092. Alefacept.
DB00087. Alemtuzumab.
DB00074. Basiliximab.
DB00112. Bevacizumab.
DB00002. Cetuximab.
DB00111. Daclizumab.
DB00095. Efalizumab.
DB00005. Etanercept.
DB00056. Gemtuzumab ozogamicin.
DB00078. Ibritumomab.
DB00028. Intravenous Immunoglobulin.
DB00075. Muromonab.
DB00108. Natalizumab.
DB00110. Palivizumab.
DB00073. Rituximab.
DB00081. Tositumomab.
DB00072. Trastuzumab.

Protein family/group databases

MEROPSiI43.001.

PTM databases

iPTMnetiO75015.
PhosphoSitePlusiO75015.

Polymorphism and mutation databases

BioMutaiFCGR3B.

Proteomic databases

PaxDbiO75015.
PeptideAtlasiO75015.
PRIDEiO75015.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294800; ENSP00000294800; ENSG00000162747.
ENST00000367964; ENSP00000356941; ENSG00000162747.
GeneIDi2215.
KEGGihsa:2215.
UCSCiuc021pdo.2. human.

Organism-specific databases

CTDi2215.
DisGeNETi2215.
GeneCardsiFCGR3B.
H-InvDBHIX0056770.
HGNCiHGNC:3620. FCGR3B.
HPAiCAB015425.
MIMi610665. gene.
neXtProtiNX_O75015.
Orphaneti855. Hashimoto struma.
536. Systemic lupus erythematosus.
PharmGKBiPA28066.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKYD. Eukaryota.
ENOG41114N1. LUCA.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiO75015.
KOiK06463.
PhylomeDBiO75015.
TreeFamiTF335097.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162747-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiO75015.
GeneWikiiFCGR3B.
GenomeRNAii2215.
PROiO75015.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162747.
CleanExiHS_FCGR3B.
ExpressionAtlasiO75015. baseline and differential.
GenevisibleiO75015. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCG3B_HUMAN
AccessioniPrimary (citable) accession number: O75015
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 163 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B (Shown here) which are expressed in a tissue-specific manner. The 'Phe-203' in FCGR3A determines the transmembrane domains whereas the Ser-203 in FCGR3B determines the GPI-anchoring.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.