Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O75015

- FCG3B_HUMAN

UniProt

O75015 - FCG3B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Low affinity immunoglobulin gamma Fc region receptor III-B

Gene

FCGR3B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

GO - Biological processi

  1. immune response Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

IgG-binding protein

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor III-B
Alternative name(s):
Fc-gamma RIII-beta
Short name:
Fc-gamma RIII
Short name:
Fc-gamma RIIIb
Short name:
FcRIII
Short name:
FcRIIIb
FcR-10
IgG Fc receptor III-1
CD_antigen: CD16b
Gene namesi
Name:FCGR3B
Synonyms:CD16B, FCG3, FCGR3, IGFR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3620. FCGR3B.

Subcellular locationi

Cell membrane; Lipid-anchorGPI-anchor. Secreted
Note: Secreted after cleavage.

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: UniProtKB
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

Orphaneti855. Hashimoto struma.
536. Systemic lupus erythematosus.
PharmGKBiPA28066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 200184Low affinity immunoglobulin gamma Fc region receptor III-BPRO_0000015151Add
BLAST
Propeptidei201 – 23333Removed in mature formSequence AnalysisPRO_0000015152Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 89
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi128 ↔ 172
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
Lipidationi200 – 2001GPI-anchor amidated serineSequence Analysis

Post-translational modificationi

Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.
The soluble form is produced by a proteolytic cleavage.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO75015.
PRIDEiO75015.

Expressioni

Tissue specificityi

Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.

Gene expression databases

BgeeiO75015.
CleanExiHS_FCGR3B.
ExpressionAtlasiO75015. baseline and differential.
GenevestigatoriO75015.

Interactioni

Subunit structurei

Monomer. Interacts with INPP5D/SHIP1 (By similarity).By similarity

Protein-protein interaction databases

IntActiO75015. 1 interaction.
STRINGi9606.ENSP00000294800.

Structurei

Secondary structure

1
233
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 326
Beta strandi35 – 384
Beta strandi43 – 486
Beta strandi59 – 624
Beta strandi65 – 706
Beta strandi72 – 787
Helixi81 – 833
Beta strandi85 – 906
Beta strandi92 – 943
Beta strandi100 – 1056
Beta strandi107 – 1126
Beta strandi116 – 1194
Beta strandi120 – 1223
Beta strandi124 – 1307
Helixi131 – 1333
Beta strandi137 – 1437
Beta strandi146 – 1538
Beta strandi157 – 1615
Helixi164 – 1663
Beta strandi168 – 1769
Beta strandi179 – 1824
Beta strandi186 – 1916

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E4JX-ray2.50A18-193[»]
1E4KX-ray3.20C18-193[»]
1FNLX-ray1.80A19-192[»]
1T83X-ray3.00C19-194[»]
1T89X-ray3.50C19-194[»]
ProteinModelPortaliO75015.
SMRiO75015. Positions 23-193.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO75015.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 9657Ig-like C2-type 1Add
BLAST
Domaini121 – 17959Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG47725.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiO75015.
KOiK06463.
OrthoDBiEOG7SXW4Z.
PhylomeDBiO75015.
TreeFamiTF335097.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O75015-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWQLLLPTAL LLLVSAGMRT EDLPKAVVFL EPQWYSVLEK DSVTLKCQGA
60 70 80 90 100
YSPEDNSTQW FHNESLISSQ ASSYFIDAAT VNDSGEYRCQ TNLSTLSDPV
110 120 130 140 150
QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKDRKY
160 170 180 190 200
FHHNSDFHIP KATLKDSGSY FCRGLVGSKN VSSETVNITI TQGLAVSTIS
210 220 230
SFSPPGYQVS FCLVMVLLFA VDTGLYFSVK TNI
Length:233
Mass (Da):26,216
Last modified:November 1, 1999 - v2
Checksum:i7AB5159432761726
GO

Polymorphismi

There are three allelic forms of FCGR3B: FCGR3B*01 (NA-1), FCGR3B*02 (HNA-1b, NA-2) (shown here) and SH. FCGR3B*01 and FCGR3B*02 are detectable with antibodies against the biallelic neutrophil-specific antigen system NA. The more active FCGR3B*01 allele has been associated with severe renal disease in certain systemic vasculitides.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361S → R in allele FCGR3B*01.
VAR_003956
Natural varianti65 – 651S → N in allele FCGR3B*01. 1 Publication
Corresponds to variant rs448740 [ dbSNP | Ensembl ].
VAR_003963
Natural varianti78 – 781A → D in allele SH. 1 Publication
Corresponds to variant rs5030738 [ dbSNP | Ensembl ].
VAR_008802
Natural varianti82 – 821N → D in allele FCGR3B*01.
VAR_003957
Natural varianti106 – 1061I → V in allele FCGR3B*01.
VAR_003964

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16863 mRNA. Translation: CAA34753.1.
X07934 mRNA. Translation: CAA30758.1.
J04162 mRNA. Translation: AAA35881.1.
M24854 mRNA. Translation: AAA53507.1.
AJ581669 mRNA. Translation: CAE46408.1.
AL451067 Genomic DNA. No translation available.
Z46223 Genomic DNA. Translation: CAA86296.1.
CCDSiCCDS41433.1.
PIRiJU0284.
RefSeqiNP_000561.3. NM_000570.4.
NP_001231682.1. NM_001244753.1.
NP_001257964.1. NM_001271035.1.
NP_001257965.1. NM_001271036.1.
NP_001257966.1. NM_001271037.1.
UniGeneiHs.372679.
Hs.694258.
Hs.736230.

Genome annotation databases

EnsembliENST00000294800; ENSP00000294800; ENSG00000162747.
ENST00000367964; ENSP00000356941; ENSG00000162747.
GeneIDi2215.
KEGGihsa:2215.
UCSCiuc021pdo.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16863 mRNA. Translation: CAA34753.1 .
X07934 mRNA. Translation: CAA30758.1 .
J04162 mRNA. Translation: AAA35881.1 .
M24854 mRNA. Translation: AAA53507.1 .
AJ581669 mRNA. Translation: CAE46408.1 .
AL451067 Genomic DNA. No translation available.
Z46223 Genomic DNA. Translation: CAA86296.1 .
CCDSi CCDS41433.1.
PIRi JU0284.
RefSeqi NP_000561.3. NM_000570.4.
NP_001231682.1. NM_001244753.1.
NP_001257964.1. NM_001271035.1.
NP_001257965.1. NM_001271036.1.
NP_001257966.1. NM_001271037.1.
UniGenei Hs.372679.
Hs.694258.
Hs.736230.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1E4J X-ray 2.50 A 18-193 [» ]
1E4K X-ray 3.20 C 18-193 [» ]
1FNL X-ray 1.80 A 19-192 [» ]
1T83 X-ray 3.00 C 19-194 [» ]
1T89 X-ray 3.50 C 19-194 [» ]
ProteinModelPortali O75015.
SMRi O75015. Positions 23-193.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O75015. 1 interaction.
STRINGi 9606.ENSP00000294800.

Chemistry

BindingDBi O75015.
ChEMBLi CHEMBL5842.
DrugBanki DB00054. Abciximab.
DB00051. Adalimumab.
DB00092. Alefacept.
DB00087. Alemtuzumab.
DB00074. Basiliximab.
DB00112. Bevacizumab.
DB00002. Cetuximab.
DB00111. Daclizumab.
DB00095. Efalizumab.
DB00005. Etanercept.
DB00056. Gemtuzumab ozogamicin.
DB00078. Ibritumomab.
DB00028. Intravenous Immunoglobulin.
DB00075. Muromonab.
DB00108. Natalizumab.
DB00110. Palivizumab.
DB00073. Rituximab.
DB00081. Tositumomab.
DB00072. Trastuzumab.

Protein family/group databases

MEROPSi I43.001.

Proteomic databases

PaxDbi O75015.
PRIDEi O75015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000294800 ; ENSP00000294800 ; ENSG00000162747 .
ENST00000367964 ; ENSP00000356941 ; ENSG00000162747 .
GeneIDi 2215.
KEGGi hsa:2215.
UCSCi uc021pdo.1. human.

Organism-specific databases

CTDi 2215.
GeneCardsi GC01M161592.
H-InvDB HIX0056770.
HGNCi HGNC:3620. FCGR3B.
MIMi 610665. gene.
neXtProti NX_O75015.
Orphaneti 855. Hashimoto struma.
536. Systemic lupus erythematosus.
PharmGKBi PA28066.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47725.
HOGENOMi HOG000251632.
HOVERGENi HBG051602.
InParanoidi O75015.
KOi K06463.
OrthoDBi EOG7SXW4Z.
PhylomeDBi O75015.
TreeFami TF335097.

Miscellaneous databases

EvolutionaryTracei O75015.
GeneWikii FCGR3B.
GenomeRNAii 2215.
NextBioi 8985.
PROi O75015.
SOURCEi Search...

Gene expression databases

Bgeei O75015.
CleanExi HS_FCGR3B.
ExpressionAtlasi O75015. baseline and differential.
Genevestigatori O75015.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions."
    Ravetch J.V., Perussia B.
    J. Exp. Med. 170:481-497(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE FCGR3B*02).
  2. "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein."
    Simmons D., Seed B.
    Nature 333:568-570(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE FCGR3B*02).
    Tissue: Placenta.
  3. Erratum
    Simmons D., Seed B.
    Nature 340:662-662(1989)
  4. "Human Fc-gamma-RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG."
    Peltz G.A., Grundy H.O., Lebo R.V., Yssel H., Barsh G.S., Moore K.W.
    Proc. Natl. Acad. Sci. U.S.A. 86:1013-1017(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE FCGR3B*01).
    Tissue: Leukocyte.
  5. "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms."
    Scallon B.J., Scigliano E., Freedman V.H., Miedel M.C., Pan Y.C., Unkeless J.C., Kochan J.P.
    Proc. Natl. Acad. Sci. U.S.A. 86:5079-5083(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "Characterization of human FCGR3B*02 (HNA-1b, NA2) cDNAs and IMGT standardized description of FCGR3B alleles."
    Bertrand G., Duprat E., Lefranc M.-P., Marti J., Coste J.
    Tissue Antigens 64:119-131(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE FCGR3B*02).
    Tissue: Peripheral blood.
  7. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASN-65.
  8. "The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions."
    Gessner J.E., Grussenmeyer T., Kolanus W., Schmidt R.E.
    J. Biol. Chem. 270:1350-1361(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-72 (ALLELE FCGR3B*02).
    Tissue: Placenta.
  9. "The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex."
    Sondermann P., Huber R., Oosthuizen V., Jacob U.
    Nature 406:267-273(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) IN COMPLEX WITH IGG1 FC.
  10. "Crystal structure of the extracellular domain of a human Fc gamma RIII."
    Zhang Y., Boesen C.C., Radaev S., Brooks A.G., Fridman W.H., Sautes-Fridman C., Sun P.D.
    Immunity 13:387-395(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 19-192.
  11. "Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb."
    Bux J., Stein E.L., Bierling P., Fromont P., Clay M., Stroncek D., Santoso S.
    Blood 89:1027-1034(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SH ASP-78.

Entry informationi

Entry nameiFCG3B_HUMAN
AccessioniPrimary (citable) accession number: O75015
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B (Shown here) which are expressed in a tissue-specific manner. The 'Phe-203' in FCGR3A determines the transmembrane domains whereas the Ser-203 in FCGR3B determines the GPI-anchoring.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3