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Protein

Valine--tRNA ligase

Gene

vas2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei655 – 6551ATPBy similarity

GO - Molecular functioni

  • aminoacyl-tRNA editing activity Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • valine-tRNA ligase activity Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.1.1.9. 5613.

Names & Taxonomyi

Protein namesi
Recommended name:
Valine--tRNA ligase (EC:6.1.1.9)
Alternative name(s):
Valyl-tRNA synthetase
Short name:
ValRS
Gene namesi
Name:vas2
ORF Names:SPBC1709.02c, SPBC1734.18c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1709.02c.
PomBaseiSPBC1709.02c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 980980Valine--tRNA ligasePRO_0000035838Add
BLAST

Proteomic databases

MaxQBiO75005.

Interactioni

Protein-protein interaction databases

BioGridi276730. 1 interaction.
MINTiMINT-4682403.

Structurei

3D structure databases

ProteinModelPortaliO75005.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi139 – 14911"HIGH" regionAdd
BLAST
Motifi652 – 6565"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000020094.
InParanoidiO75005.
KOiK01873.
OMAiHEENIIY.
OrthoDBiEOG092C0H3K.
PhylomeDBiO75005.

Family and domain databases

CDDicd07962. Anticodon_Ia_Val. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_02004. Val_tRNA_synth_type1. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR033705. Anticodon_Ia_Val.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PANTHERiPTHR11946:SF5. PTHR11946:SF5. 2 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O75005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKGCEAAQ SKDSSAPGSG EPRPKTEKEL ERERQKAAKL EKYHAKLAAK
60 70 80 90 100
KAKEEARKPK LDKKAKIASP VAEYVEKTTP GEKKVLQDLD SPALKSYNPK
110 120 130 140 150
AVESAWYDWW VKSGFFEPEF GPDGKPKKEG VFVITSPPPN VTGALHIGHA
160 170 180 190 200
LTIAIQDSLA RWNRMLGKTV LFLGGFDHAG LSTQSVVEKK LWYTQKKTRH
210 220 230 240 250
DYPRDKFVDI VWEWKEEYHN RIKNQMSRLG GSFDWTREAF TMDENLSRAV
260 270 280 290 300
VETFVRLHEE NIIYRANRLV NWCTALQTTL SNLEVENVDV PGRTLLKVPG
310 320 330 340 350
YDEPVEVGVL TSIAYAVEGS DERIVIATTR PETLLGDTAV AVHPQDPRYK
360 370 380 390 400
HLHGKFVKHP FCNRSIPIIC DDIIVDMEFG TGAVKITPAH DPNDYEVGKR
410 420 430 440 450
HNLEFINIFT DDGLLNENCG EFAGMKRFTA RVKVVERLKE LGLFVGTKEN
460 470 480 490 500
PMVIPLCGKT SDIIEPVMKP QWWVNQKEMA AAAAEVVKSG EIEIAPDMSR
510 520 530 540 550
REFIRWMENI QDWCISRQLW WGHRIPAYFV NLADEPSQDR SEGRYWVTGR
560 570 580 590 600
TLEQAEEKAK AAFPGKSFTL EQDEDVLDTW FSSGLWPFST LGWPKDTSDY
610 620 630 640 650
ENFYPTTLME TGWDILFFWI ARMVMLGLKL TGKIPFKRVF CHALVRDAQG
660 670 680 690 700
RKMSKSLGNV VDPIDVIEGI SLQALHDKLL VGNLDSREVE KAKKGQRLSY
710 720 730 740 750
PKGIPQCGTD ALRFTLCSLT TGGRDLNLDI LRVEGYRKFC NKLYNATKFA
760 770 780 790 800
LGRLGSNFVP NKTADLTGNE SLVEKWIFHR LNIAAAAMNK NMEEMNFLQA
810 820 830 840 850
TSAVHQFWLY ELCDVYIENS KYLLSDGTEV QQESAKQTLY TVLDNALRLM
860 870 880 890 900
HPFMPYVTEE MWQRLPRRPG DKTQTIVKAA FPVERVDYSN EIAAKYYESI
910 920 930 940 950
ITVVHSTRSM MAENGIKSDA VVYIHPDEEH SKLITSESAS IQSLIKKCKT
960 970 980
LSIVDNTFDS DKCVKNEVLE GSTIFLERNN
Length:980
Mass (Da):111,317
Last modified:November 1, 1998 - v1
Checksum:iBB91FAF976030C3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21312.1.
PIRiT39630.
RefSeqiNP_595435.1. NM_001021343.2.

Genome annotation databases

EnsemblFungiiSPBC1709.02c.1; SPBC1709.02c.1:pep; SPBC1709.02c.
GeneIDi2540197.
KEGGispo:SPBC1709.02c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21312.1.
PIRiT39630.
RefSeqiNP_595435.1. NM_001021343.2.

3D structure databases

ProteinModelPortaliO75005.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276730. 1 interaction.
MINTiMINT-4682403.

Proteomic databases

MaxQBiO75005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1709.02c.1; SPBC1709.02c.1:pep; SPBC1709.02c.
GeneIDi2540197.
KEGGispo:SPBC1709.02c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1709.02c.
PomBaseiSPBC1709.02c.

Phylogenomic databases

HOGENOMiHOG000020094.
InParanoidiO75005.
KOiK01873.
OMAiHEENIIY.
OrthoDBiEOG092C0H3K.
PhylomeDBiO75005.

Enzyme and pathway databases

BRENDAi6.1.1.9. 5613.

Miscellaneous databases

PROiO75005.

Family and domain databases

CDDicd07962. Anticodon_Ia_Val. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_02004. Val_tRNA_synth_type1. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR033705. Anticodon_Ia_Val.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
IPR002303. Valyl-tRNA_ligase.
[Graphical view]
PANTHERiPTHR11946:SF5. PTHR11946:SF5. 2 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00986. TRNASYNTHVAL.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00422. valS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYV_SCHPO
AccessioniPrimary (citable) accession number: O75005
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.