Reviewed, UniProtKB/Swiss-Prot O75004 (CDC24_SCHPO)

Names and origin

Protein names

Recommended name:
    Cell division control protein 24

Gene names

Name:	cdc24
ORF Names:	SPAC8F11.07c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has a role in the progression of DNA replication and in the maintenance of genomic integrity. Acts during S phase, after intiation, where it is essential for completion. Ref.1 Ref.2
Subunit structure	Interacts with pcn1 and rfc1. Ref.2
Subcellular location	Nucleus Potential.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Nucleus
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication, removal of RNA primer Inferred from genetic interaction. Source: GeneDB_SPombe cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell division site Inferred from direct assay. Source: GeneDB_SPombe cytosol Inferred from direct assay. Source: GeneDB_SPombe nuclear replication fork Inferred by curator. Source: GeneDB_SPombe
Molecular function	protein binding Ref.2 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
pcn1	Q03392	1	EBI-1559355,EBI-768724
rfc1	O60182	1	EBI-1559355,EBI-1208914

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 501	501	Cell division control protein 24		PRO_0000089445

Sequences

	Sequence		Length	Mass (Da)
	O75004-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 66E84CCB46244863	FASTA	501	58,043
	10 20 30 40 50 60 MDFPGLIKKI KEDLENRLVE KSKQPAFTDY WLINKTISLL KEYPSGFSYP ILINEIELAC 70 80 90 100 110 120 SERNKLDNVF SSLEWLTKSD AVIYLEDQFH FHCYDYYYTP IPSLKLKDSE ENTCEMILHS 130 140 150 160 170 180 SFYLLFHEPF NILKGSTLRF SQSRIHQKWY LRKQIRFLPT TSFVPVLQYA ASKSFVKSMV 190 200 210 220 230 240 ESTEHEFFQI RDITISKSDQ GVKRITVELG RIISLDKKGA FLIDNNTNFI HFSGTYHDFP 250 260 270 280 290 300 KLLDKQQYLL IPFWSTVWEG STNWQDGMIG ILVILSENDF EEKKCDSWQV GRLAAVNSNF 310 320 330 340 350 360 LVLDNNGQRV KILYSNSQKH YFKDTYIGDL LCISPINHSS DNLSDYSCVS DTTTEILSNL 370 380 390 400 410 420 ENPLSSNFLR NDLCKFSNLF SGVSGHLKIQ PLTLVITGFV ANLTRQSDLN TSLVLPEVNP 430 440 450 460 470 480 LTAKMEVIDC LRNSFWAALR PNCVSYFASM ISGFKELFQK EMEFPIYLDL KSYKLGFHWC 490 500 DIYVDSEHNC HIQKINSLPC E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Fission yeast cdc24(+) encodes a novel replication factor required for chromosome integrity." Gould K.L., Burns C.G., Feoktistova A., Hu C.-P., Pasion S.G., Forsburg S.L. Genetics 149:1221-1233(1998) [PubMed: 9649516] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Strain: ATCC 38366 / 972.
[2]	"Fission yeast cdc24 is a replication factor C- and proliferating cell nuclear antigen-interacting factor essential for S-phase completion." Tanaka H., Tanaka K., Murakami H., Okayama H. Mol. Cell. Biol. 19:1038-1048(1999) [PubMed: 9891039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH PNC1 AND RFC1.
[3]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF085329 Genomic DNA. Translation: AAC34684.1. AB015436 mRNA. Translation: BAA28896.1. CU329670 Genomic DNA. Translation: CAB52168.1.
PIR	T43375.
RefSeq	NP_593956.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O75004. 2 interactions.
STRING	O75004.
Genome annotation databases
GeneID	2543407.
GenomeReviews	Gene locus cdc24 in contig CU329670_GR.
KEGG	spo:SPAC8F11.07c.
NMPDR	fig|4896.1.peg.3926.
Organism-specific databases
GeneDB_Spombe	SPAC8F11.07c.
Gene expression databases
ArrayExpress	O75004.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CDC24_SCHPO

Accession

Primary (citable) accession number: O75004

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2003
Last sequence update:	November 1, 1998
Last modified:	November 24, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)