Reviewed,
UniProtKB/Swiss-Prot O74991 (POF3_SCHPO)
Last modified
June 16, 2009.
Version 73.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: F-box/TPR repeat protein pof3 | ||||
| Gene names |
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| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4896 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 577 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Has a role in substrate recognition in the Skp1-Cullin-1/Cdc53-F-box (SCF) ubiquitin ligase complex. Required for the maintenance of telomere length and transcriptional silencing at the telomere. Also required for chromosome segregation. Ref.1 |
| Subunit structure | A part of the E3 ubiquitin ligase Skp1-Cullin-1-F-box (SCF) complex. Interacts with cul1, mcl1 and skp1. Ref.1 Ref.3 Ref.4 |
| Subcellular location | |
| Sequence similarities | Contains 1 F-box domain. Contains 3 TPR repeats. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation Ubl conjugation pathway |
| Cellular component | Chromosomal protein Mitochondrion Nucleus |
| Domain | Repeat TPR repeat |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW telomere maintenance Ref.1Inferred from mutant phenotype. Source: GeneDB_SPombe transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | chromosome Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Ref.5Inferred from direct assay. Source: GeneDB_SPombe nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | protein binding Ref.1 Ref.3 Ref.4 Inferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| cul1 | O13790 | 1 | EBI-1153554,EBI-1154807 | |
| mcl1 | Q9C107 | 1 | EBI-1153554,EBI-1203666 | |
| SKP1 | P52286 | 1 | EBI-1153554,EBI-4090 | From a different organism. |
| skp1 | Q9Y709 | 2 | EBI-1153554,EBI-1172248 |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Fission yeast F-box protein Pof3 is required for genome integrity and telomere function." Katayama S., Kitamura K., Lehmann A., Nikaido O., Toda T. Mol. Biol. Cell 13:211-224(2002) [PubMed: 11809834] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBUNIT, SUBCELLULAR LOCATION. Strain: ATCC 38366 / 972. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [3] | "Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint." Lehmann A., Katayama S., Harrison C., Dhut S., Kitamura K., McDonald N., Toda T. Genes Cells 9:367-382(2004) [PubMed: 15147268] [Abstract] Cited for: INTERACTION WITH SKP1. |
| [4] | "Fission yeast Mcl1 interacts with SCF(Pof3) and is required for centromere formation." Mamnun Y.M., Katayama S., Toda T. Biochem. Biophys. Res. Commun. 350:125-130(2006) [PubMed: 16997270] [Abstract] Cited for: INTERACTION WITH MCL1. |
| [5] | "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed: 16823372] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
Cross-references
Sequence databases | |
|---|---|
| AB032411 Genomic DNA. Translation: BAA84529.1. CU329672 Genomic DNA. Translation: CAA19347.1. | |
| PIR | T41727. |
| RefSeq | NP_588152.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O74991. 4 interactions. |
Genome annotation databases | |
| GeneID | 2539527. |
| KEGG | spo:SPCC338.16. |
| NMPDR | fig|4896.1.peg.490. |
Organism-specific databases | |
| GeneDB_Spombe | SPCC338.16. |
Phylogenomic databases | |
| OMA | O74991. RIDIINC. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-000092-MON. |
Gene expression databases | |
| ArrayExpress | O74991. |
Family and domain databases | |
| InterPro | IPR001810. F-box. IPR011990. TPR-like_helical. IPR013026. TPR_region. [Graphical view] |
| Gene3D | G3DSA:1.25.40.10. TPR-like_helical. 1 hit. |
| Pfam | PF00646. F-box. 1 hit. [Graphical view] |
| SMART | SM00256. FBOX. 1 hit. [Graphical view] |
| PROSITE | PS50181. FBOX. 1 hit. PS50005. TPR. False negative. PS50293. TPR_REGION. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | POF3_SCHPO | ||||||||
| Accession | Primary (citable) accession number: O74991 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


