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Protein

Ubiquitin-conjugating enzyme spm2

Gene

spm2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a role in the DNA error-free postreplication repair (PRR) pathway. Lacks catalytic activity by itself. The ubc13/spm2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'.1 Publication

GO - Molecular functioni

GO - Biological processi

  • postreplication repair Source: PomBase
  • protein K63-linked ubiquitination Source: PomBase

Keywordsi

Molecular functionLigase
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-8866654. E3 ubiquitin ligases ubiquitinate target proteins.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme spm2
Alternative name(s):
Ubiquitin-conjugating enzyme variant MMS2 homolog
Short name:
UEV MMS2
Gene namesi
Name:spm2
ORF Names:SPCC338.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC338.05c.
PomBaseiSPCC338.05c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825991 – 139Ubiquitin-conjugating enzyme spm2Add BLAST139

Proteomic databases

MaxQBiO74983.
PaxDbiO74983.
PRIDEiO74983.

Interactioni

Subunit structurei

Heterodimer with ubc13.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi275304. 8 interactors.
STRINGi4896.SPCC338.05c.1.

Structurei

3D structure databases

ProteinModelPortaliO74983.
SMRiO74983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000036561.
InParanoidiO74983.
KOiK10704.
OMAiGHTVHEN.
OrthoDBiEOG092C4YVR.
PhylomeDBiO74983.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O74983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPRNFKL LEELEKGEKG LGESSCSYGL TNADDITLSD WNATILGPAH
60 70 80 90 100
SVHENRIYSL KIHCDANYPD APPIVTFVSR INLPGVDGET GKVNPHKIDC
110 120 130
LRHWKREYSM ETVLLDLKKE MASSSNRKLP QPPEGSTFF
Length:139
Mass (Da):15,555
Last modified:November 1, 1998 - v1
Checksum:iBB247264D23F9BB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF470233 mRNA. Translation: AAL79845.1.
CU329672 Genomic DNA. Translation: CAA19336.1.
PIRiT41737.
RefSeqiNP_588162.1. NM_001023151.2.

Genome annotation databases

EnsemblFungiiSPCC338.05c.1; SPCC338.05c.1:pep; SPCC338.05c.
GeneIDi2538720.
KEGGispo:SPCC338.05c.

Similar proteinsi

Entry informationi

Entry nameiMMS2_SCHPO
AccessioniPrimary (citable) accession number: O74983
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1998
Last modified: February 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome