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Protein

High-affinity glucose transporter ght2

Gene

ght2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity glucose transporter.

GO - Molecular functioni

  • fructose:proton symporter activity Source: PomBase
  • high-affinity hydrogen:glucose symporter activity Source: PomBase

GO - Biological processi

  • fructose import across plasma membrane Source: PomBase
  • glucose import across plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Protein family/group databases

TCDBi2.A.1.1.21. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity glucose transporter ght2
Alternative name(s):
Hexose transporter 2
Gene namesi
Name:ght2
ORF Names:SPBC4B4.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4B4.08.
PomBaseiSPBC4B4.08. ght2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini5 – 13CytoplasmicSequence analysis9
Transmembranei14 – 34Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini35 – 62ExtracellularSequence analysisAdd BLAST28
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini84 – 91CytoplasmicSequence analysis8
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 116ExtracellularSequence analysis4
Transmembranei117 – 137Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini138 – 148CytoplasmicSequence analysisAdd BLAST11
Transmembranei149 – 169Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini170 – 183ExtracellularSequence analysisAdd BLAST14
Transmembranei184 – 204Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini205 – 270CytoplasmicSequence analysisAdd BLAST66
Transmembranei271 – 289Helical; Name=7Sequence analysisAdd BLAST19
Topological domaini290 – 305ExtracellularSequence analysisAdd BLAST16
Transmembranei306 – 326Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini327 – 332CytoplasmicSequence analysis6
Transmembranei333 – 353Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini354 – 367ExtracellularSequence analysisAdd BLAST14
Transmembranei368 – 388Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini389 – 408CytoplasmicSequence analysisAdd BLAST20
Transmembranei409 – 429Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini430 – 436ExtracellularSequence analysis7
Transmembranei437 – 457Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini458 – 531CytoplasmicSequence analysisAdd BLAST74

GO - Cellular componenti

  • Golgi apparatus Source: PomBase
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504101 – 531High-affinity glucose transporter ght2Add BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi361N-linked (GlcNAc...)Sequence analysis1
Modified residuei507Phosphoserine1 Publication1
Modified residuei515Phosphoserine1 Publication1
Modified residuei519Phosphoserine1 Publication1
Modified residuei520Phosphoserine1 Publication1
Modified residuei523Phosphotyrosine1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO74969.
PRIDEiO74969.

PTM databases

iPTMnetiO74969.

Interactioni

Protein-protein interaction databases

BioGridi276521. 1 interactor.
MINTiMINT-4682153.

Structurei

3D structure databases

ProteinModelPortaliO74969.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202870.
InParanoidiO74969.
KOiK08139.
OrthoDBiEOG092C1Q5W.
PhylomeDBiO74969.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFKRGKNFT LVMLIFVSMA GWMFGADTGS IGGVTSMRDF RERYADRYDP
60 70 80 90 100
ITDQYSLSSA RQGLLTGMVN VGSLFGCIIS SPIADRFGKR LSIIGFCAVY
110 120 130 140 150
IIGIIVQVTA VPSWVQIMVA KIWTGIGIGA LSVLAPGYQS ETAPPSIRGT
160 170 180 190 200
VVVTYQLFVT GGIFIAACIN MGTHKLHKTA QWRVSIGINL LWGIITMIGI
210 220 230 240 250
LFLPESPRYL IQVGKDEEAV RVLSESAELF PDSEEVQNEY HRLKSSIDEE
260 270 280 290 300
FAGGPCSWAS IFGKDIRYRT FLGMFVMSLQ QLTGNNYFFY YGFSVMQGAG
310 320 330 340 350
INSPYLSAMI LDAVNFGCTF GGMYVLERFG RRNPLIIGGI WQSICFFIYS
360 370 380 390 400
AVGSRALYHK NGTSNTRAGA VMIVMACLFI FGFAQTWAPA AYVIVGESYP
410 420 430 440 450
VRYRSKCAAV ATASNWLWNF LISFFTPFIQ ASIGFKYGYV FASCNLTGAI
460 470 480 490 500
VIFLFAKETK GLTLEEINEL YMSVIKPWES GNFKLNYSEQ KKVEKEKSRK
510 520 530
GGARGESVEY VERASNTDSS PQYSSHEEDY A
Length:531
Mass (Da):58,846
Last modified:November 1, 1998 - v1
Checksum:i6446BAAAC7FF698E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 12Missing in AAB70519 (PubMed:10735857).CuratedAdd BLAST12
Sequence conflicti29G → R in AAB70519 (PubMed:10735857).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017180 mRNA. Translation: AAB70519.1.
CU329671 Genomic DNA. Translation: CAA19288.1.
PIRiT40480.
T43533.
RefSeqiNP_596425.1. NM_001022344.2.

Genome annotation databases

EnsemblFungiiSPBC4B4.08.1; SPBC4B4.08.1:pep; SPBC4B4.08.
GeneIDi2539977.
KEGGispo:SPBC4B4.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017180 mRNA. Translation: AAB70519.1.
CU329671 Genomic DNA. Translation: CAA19288.1.
PIRiT40480.
T43533.
RefSeqiNP_596425.1. NM_001022344.2.

3D structure databases

ProteinModelPortaliO74969.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276521. 1 interactor.
MINTiMINT-4682153.

Protein family/group databases

TCDBi2.A.1.1.21. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiO74969.

Proteomic databases

MaxQBiO74969.
PRIDEiO74969.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC4B4.08.1; SPBC4B4.08.1:pep; SPBC4B4.08.
GeneIDi2539977.
KEGGispo:SPBC4B4.08.

Organism-specific databases

EuPathDBiFungiDB:SPBC4B4.08.
PomBaseiSPBC4B4.08. ght2.

Phylogenomic databases

HOGENOMiHOG000202870.
InParanoidiO74969.
KOiK08139.
OrthoDBiEOG092C1Q5W.
PhylomeDBiO74969.

Miscellaneous databases

PROiO74969.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGHT2_SCHPO
AccessioniPrimary (citable) accession number: O74969
Secondary accession number(s): O13346
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.