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Protein

High-affinity glucose transporter ght2

Gene

ght2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity glucose transporter.

GO - Molecular functioni

  • fructose:proton symporter activity Source: PomBase
  • high-affinity hydrogen:glucose symporter activity Source: PomBase

GO - Biological processi

  • fructose import across plasma membrane Source: PomBase
  • glucose import across plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Protein family/group databases

TCDBi2.A.1.1.21. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity glucose transporter ght2
Alternative name(s):
Hexose transporter 2
Gene namesi
Name:ght2
ORF Names:SPBC4B4.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4B4.08.
PomBaseiSPBC4B4.08. ght2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini5 – 139CytoplasmicSequence analysis
Transmembranei14 – 3421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini35 – 6228ExtracellularSequence analysisAdd
BLAST
Transmembranei63 – 8321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini84 – 918CytoplasmicSequence analysis
Transmembranei92 – 11221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini113 – 1164ExtracellularSequence analysis
Transmembranei117 – 13721Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini138 – 14811CytoplasmicSequence analysisAdd
BLAST
Transmembranei149 – 16921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini170 – 18314ExtracellularSequence analysisAdd
BLAST
Transmembranei184 – 20421Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini205 – 27066CytoplasmicSequence analysisAdd
BLAST
Transmembranei271 – 28919Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini290 – 30516ExtracellularSequence analysisAdd
BLAST
Transmembranei306 – 32621Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini327 – 3326CytoplasmicSequence analysis
Transmembranei333 – 35321Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini354 – 36714ExtracellularSequence analysisAdd
BLAST
Transmembranei368 – 38821Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini389 – 40820CytoplasmicSequence analysisAdd
BLAST
Transmembranei409 – 42921Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini430 – 4367ExtracellularSequence analysis
Transmembranei437 – 45721Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini458 – 53174CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi apparatus Source: PomBase
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531High-affinity glucose transporter ght2PRO_0000050410Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence analysis
Modified residuei507 – 5071Phosphoserine1 Publication
Modified residuei515 – 5151Phosphoserine1 Publication
Modified residuei519 – 5191Phosphoserine1 Publication
Modified residuei520 – 5201Phosphoserine1 Publication
Modified residuei523 – 5231Phosphotyrosine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO74969.

PTM databases

iPTMnetiO74969.

Interactioni

Protein-protein interaction databases

BioGridi276521. 1 interaction.
MINTiMINT-4682153.

Structurei

3D structure databases

ProteinModelPortaliO74969.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202870.
InParanoidiO74969.
KOiK08139.
OrthoDBiEOG092C1Q5W.
PhylomeDBiO74969.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFKRGKNFT LVMLIFVSMA GWMFGADTGS IGGVTSMRDF RERYADRYDP
60 70 80 90 100
ITDQYSLSSA RQGLLTGMVN VGSLFGCIIS SPIADRFGKR LSIIGFCAVY
110 120 130 140 150
IIGIIVQVTA VPSWVQIMVA KIWTGIGIGA LSVLAPGYQS ETAPPSIRGT
160 170 180 190 200
VVVTYQLFVT GGIFIAACIN MGTHKLHKTA QWRVSIGINL LWGIITMIGI
210 220 230 240 250
LFLPESPRYL IQVGKDEEAV RVLSESAELF PDSEEVQNEY HRLKSSIDEE
260 270 280 290 300
FAGGPCSWAS IFGKDIRYRT FLGMFVMSLQ QLTGNNYFFY YGFSVMQGAG
310 320 330 340 350
INSPYLSAMI LDAVNFGCTF GGMYVLERFG RRNPLIIGGI WQSICFFIYS
360 370 380 390 400
AVGSRALYHK NGTSNTRAGA VMIVMACLFI FGFAQTWAPA AYVIVGESYP
410 420 430 440 450
VRYRSKCAAV ATASNWLWNF LISFFTPFIQ ASIGFKYGYV FASCNLTGAI
460 470 480 490 500
VIFLFAKETK GLTLEEINEL YMSVIKPWES GNFKLNYSEQ KKVEKEKSRK
510 520 530
GGARGESVEY VERASNTDSS PQYSSHEEDY A
Length:531
Mass (Da):58,846
Last modified:November 1, 1998 - v1
Checksum:i6446BAAAC7FF698E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 1212Missing in AAB70519 (PubMed:10735857).CuratedAdd
BLAST
Sequence conflicti29 – 291G → R in AAB70519 (PubMed:10735857).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017180 mRNA. Translation: AAB70519.1.
CU329671 Genomic DNA. Translation: CAA19288.1.
PIRiT40480.
T43533.
RefSeqiNP_596425.1. NM_001022344.2.

Genome annotation databases

EnsemblFungiiSPBC4B4.08.1; SPBC4B4.08.1:pep; SPBC4B4.08.
GeneIDi2539977.
KEGGispo:SPBC4B4.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017180 mRNA. Translation: AAB70519.1.
CU329671 Genomic DNA. Translation: CAA19288.1.
PIRiT40480.
T43533.
RefSeqiNP_596425.1. NM_001022344.2.

3D structure databases

ProteinModelPortaliO74969.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276521. 1 interaction.
MINTiMINT-4682153.

Protein family/group databases

TCDBi2.A.1.1.21. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiO74969.

Proteomic databases

MaxQBiO74969.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC4B4.08.1; SPBC4B4.08.1:pep; SPBC4B4.08.
GeneIDi2539977.
KEGGispo:SPBC4B4.08.

Organism-specific databases

EuPathDBiFungiDB:SPBC4B4.08.
PomBaseiSPBC4B4.08. ght2.

Phylogenomic databases

HOGENOMiHOG000202870.
InParanoidiO74969.
KOiK08139.
OrthoDBiEOG092C1Q5W.
PhylomeDBiO74969.

Miscellaneous databases

PROiO74969.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGHT2_SCHPO
AccessioniPrimary (citable) accession number: O74969
Secondary accession number(s): O13346
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.