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Protein

High-affinity glucose transporter ght2

Gene

ght2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity glucose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: PomBase
  • glucose transmembrane transporter activity Source: PomBase

GO - Biological processi

  • fructose import across plasma membrane Source: PomBase
  • glucose import across plasma membrane Source: PomBase

Keywordsi

Biological processSugar transport, Transport

Protein family/group databases

TCDBi2.A.1.1.21 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity glucose transporter ght2
Alternative name(s):
Hexose transporter 2
Gene namesi
Name:ght2
ORF Names:SPBC4B4.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4B4.08
PomBaseiSPBC4B4.08 ght2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini5 – 13CytoplasmicSequence analysis9
Transmembranei14 – 34Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini35 – 62ExtracellularSequence analysisAdd BLAST28
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini84 – 91CytoplasmicSequence analysis8
Transmembranei92 – 112Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini113 – 116ExtracellularSequence analysis4
Transmembranei117 – 137Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini138 – 148CytoplasmicSequence analysisAdd BLAST11
Transmembranei149 – 169Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini170 – 183ExtracellularSequence analysisAdd BLAST14
Transmembranei184 – 204Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini205 – 270CytoplasmicSequence analysisAdd BLAST66
Transmembranei271 – 289Helical; Name=7Sequence analysisAdd BLAST19
Topological domaini290 – 305ExtracellularSequence analysisAdd BLAST16
Transmembranei306 – 326Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini327 – 332CytoplasmicSequence analysis6
Transmembranei333 – 353Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini354 – 367ExtracellularSequence analysisAdd BLAST14
Transmembranei368 – 388Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini389 – 408CytoplasmicSequence analysisAdd BLAST20
Transmembranei409 – 429Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini430 – 436ExtracellularSequence analysis7
Transmembranei437 – 457Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini458 – 531CytoplasmicSequence analysisAdd BLAST74

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504101 – 531High-affinity glucose transporter ght2Add BLAST531

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi361N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei507Phosphoserine1 Publication1
Modified residuei515Phosphoserine1 Publication1
Modified residuei519Phosphoserine1 Publication1
Modified residuei520Phosphoserine1 Publication1
Modified residuei523Phosphotyrosine1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO74969
PaxDbiO74969
PRIDEiO74969

PTM databases

iPTMnetiO74969

Interactioni

Protein-protein interaction databases

BioGridi276521, 1 interactor
STRINGi4896.SPBC4B4.08.1

Structurei

3D structure databases

ProteinModelPortaliO74969
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202870
InParanoidiO74969
KOiK08139
OMAiVPWVMIG
OrthoDBiEOG092C1Q5W
PhylomeDBiO74969

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

Sequencei

Sequence statusi: Complete.

O74969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFKRGKNFT LVMLIFVSMA GWMFGADTGS IGGVTSMRDF RERYADRYDP
60 70 80 90 100
ITDQYSLSSA RQGLLTGMVN VGSLFGCIIS SPIADRFGKR LSIIGFCAVY
110 120 130 140 150
IIGIIVQVTA VPSWVQIMVA KIWTGIGIGA LSVLAPGYQS ETAPPSIRGT
160 170 180 190 200
VVVTYQLFVT GGIFIAACIN MGTHKLHKTA QWRVSIGINL LWGIITMIGI
210 220 230 240 250
LFLPESPRYL IQVGKDEEAV RVLSESAELF PDSEEVQNEY HRLKSSIDEE
260 270 280 290 300
FAGGPCSWAS IFGKDIRYRT FLGMFVMSLQ QLTGNNYFFY YGFSVMQGAG
310 320 330 340 350
INSPYLSAMI LDAVNFGCTF GGMYVLERFG RRNPLIIGGI WQSICFFIYS
360 370 380 390 400
AVGSRALYHK NGTSNTRAGA VMIVMACLFI FGFAQTWAPA AYVIVGESYP
410 420 430 440 450
VRYRSKCAAV ATASNWLWNF LISFFTPFIQ ASIGFKYGYV FASCNLTGAI
460 470 480 490 500
VIFLFAKETK GLTLEEINEL YMSVIKPWES GNFKLNYSEQ KKVEKEKSRK
510 520 530
GGARGESVEY VERASNTDSS PQYSSHEEDY A
Length:531
Mass (Da):58,846
Last modified:November 1, 1998 - v1
Checksum:i6446BAAAC7FF698E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 12Missing in AAB70519 (PubMed:10735857).CuratedAdd BLAST12
Sequence conflicti29G → R in AAB70519 (PubMed:10735857).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017180 mRNA Translation: AAB70519.1
CU329671 Genomic DNA Translation: CAA19288.1
PIRiT40480
T43533
RefSeqiNP_596425.1, NM_001022344.2

Genome annotation databases

EnsemblFungiiSPBC4B4.08.1; SPBC4B4.08.1:pep; SPBC4B4.08
GeneIDi2539977
KEGGispo:SPBC4B4.08

Similar proteinsi

Entry informationi

Entry nameiGHT2_SCHPO
AccessioniPrimary (citable) accession number: O74969
Secondary accession number(s): O13346
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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