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O74969 (GHT2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
High-affinity glucose transporter ght2
Alternative name(s):
Hexose transporter 2
Gene names
Name:ght2
ORF Names:SPBC4B4.08
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length531 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

High-affinity glucose transporter.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Ontologies

Keywords
   Biological processSugar transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentGolgi apparatus

Inferred from direct assay. Source: GeneDB_Spombe

integral to plasma membrane

Traceable author statement. Source: GeneDB_Spombe

   Molecular functionhexose transmembrane transporter activity

Traceable author statement. Source: GeneDB_Spombe

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 531531High-affinity glucose transporter ght2
PRO_0000050410

Regions

Topological domain5 – 139Cytoplasmic Potential
Transmembrane14 – 3421Helical; Name=1; Potential
Topological domain35 – 6228Extracellular Potential
Transmembrane63 – 8321Helical; Name=2; Potential
Topological domain84 – 918Cytoplasmic Potential
Transmembrane92 – 11221Helical; Name=3; Potential
Topological domain113 – 1164Extracellular Potential
Transmembrane117 – 13721Helical; Name=4; Potential
Topological domain138 – 14811Cytoplasmic Potential
Transmembrane149 – 16921Helical; Name=5; Potential
Topological domain170 – 18314Extracellular Potential
Transmembrane184 – 20421Helical; Name=6; Potential
Topological domain205 – 27066Cytoplasmic Potential
Transmembrane271 – 28919Helical; Name=7; Potential
Topological domain290 – 30516Extracellular Potential
Transmembrane306 – 32621Helical; Name=8; Potential
Topological domain327 – 3326Cytoplasmic Potential
Transmembrane333 – 35321Helical; Name=9; Potential
Topological domain354 – 36714Extracellular Potential
Transmembrane368 – 38821Helical; Name=10; Potential
Topological domain389 – 40820Cytoplasmic Potential
Transmembrane409 – 42921Helical; Name=11; Potential
Topological domain430 – 4367Extracellular Potential
Transmembrane437 – 45721Helical; Name=12; Potential
Topological domain458 – 53174Cytoplasmic Potential

Amino acid modifications

Modified residue5071Phosphoserine Ref.3
Modified residue5151Phosphoserine Ref.3
Modified residue5191Phosphoserine Ref.3
Modified residue5201Phosphoserine Ref.3
Modified residue5231Phosphotyrosine Ref.3
Glycosylation3611N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1 – 1212Missing in AAB70519. Ref.1
Sequence conflict291G → R in AAB70519. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O74969 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 6446BAAAC7FF698E

FASTA53158,846
        10         20         30         40         50         60 
MGFKRGKNFT LVMLIFVSMA GWMFGADTGS IGGVTSMRDF RERYADRYDP ITDQYSLSSA 

        70         80         90        100        110        120 
RQGLLTGMVN VGSLFGCIIS SPIADRFGKR LSIIGFCAVY IIGIIVQVTA VPSWVQIMVA 

       130        140        150        160        170        180 
KIWTGIGIGA LSVLAPGYQS ETAPPSIRGT VVVTYQLFVT GGIFIAACIN MGTHKLHKTA 

       190        200        210        220        230        240 
QWRVSIGINL LWGIITMIGI LFLPESPRYL IQVGKDEEAV RVLSESAELF PDSEEVQNEY 

       250        260        270        280        290        300 
HRLKSSIDEE FAGGPCSWAS IFGKDIRYRT FLGMFVMSLQ QLTGNNYFFY YGFSVMQGAG 

       310        320        330        340        350        360 
INSPYLSAMI LDAVNFGCTF GGMYVLERFG RRNPLIIGGI WQSICFFIYS AVGSRALYHK 

       370        380        390        400        410        420 
NGTSNTRAGA VMIVMACLFI FGFAQTWAPA AYVIVGESYP VRYRSKCAAV ATASNWLWNF 

       430        440        450        460        470        480 
LISFFTPFIQ ASIGFKYGYV FASCNLTGAI VIFLFAKETK GLTLEEINEL YMSVIKPWES 

       490        500        510        520        530 
GNFKLNYSEQ KKVEKEKSRK GGARGESVEY VERASNTDSS PQYSSHEEDY A

« Hide

References

« Hide 'large scale' references
[1]"Multiple hexose transporters of Schizosaccharomyces pombe."
Heiland S., Radovanovic N., Hoefer M., Winderickx J., Lichtenberg H.
J. Bacteriol. 182:2153-2162(2000) [PubMed: 10735857] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed: 18257517] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-507; SER-515; SER-519; SER-520 AND TYR-523, MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF017180 mRNA. Translation: AAB70519.1.
CU329671 Genomic DNA. Translation: CAA19288.1.
PIRT40480.
T43533.
RefSeqNP_596425.1. NM_001022344.1.

3D structure databases

ProteinModelPortalO74969.
ModBaseSearch...

Protein-protein interaction databases

STRINGO74969.

Protein family/group databases

TCDB2.A.1.1.21. major facilitator superfamily (MFS).

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPBC4B4.08.1; SPBC4B4.08.1:pep; SPBC4B4.08.
GeneID2539977.
GenomeReviewsGene locus ght2 in contig CU329671_GR.
KEGGspo:SPBC4B4.08.
NMPDRfig|4896.1.peg.2291.

Organism-specific databases

GeneDB_SpombeSPBC4B4.08.

Phylogenomic databases

eggNOGfuNOG06406.
GeneTreeEFGT00070000008710.
HOGENOMHBG744444.
OMASSHEEDY.
OrthoDBEOG43246F.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-004430-MONOMER.

Gene expression databases

ArrayExpressO74969.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
KOK08139.
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGHT2_SCHPO
AccessionPrimary (citable) accession number: O74969
Secondary accession number(s): O13346
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: December 14, 2011
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents