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Protein

Small nuclear ribonucleoprotein G

Gene

smg1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-SPO-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein G
Short name:
snRNP-G
Alternative name(s):
Sm protein G
Short name:
Sm-G
Short name:
SmG
Gene namesi
Name:smg1
ORF Names:SPBC4B4.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4B4.05.
PomBaseiSPBC4B4.05. smg1.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: GO_Central
  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • P granule Source: GO_Central
  • precatalytic spliceosome Source: GO_Central
  • SMN-Sm protein complex Source: GO_Central
  • spliceosomal complex Source: PomBase
  • spliceosomal tri-snRNP complex Source: GO_Central
  • U12-type spliceosomal complex Source: GO_Central
  • U1 snRNP Source: PomBase
  • U2 snRNP Source: PomBase
  • U2-type prespliceosome Source: PomBase
  • U4/U6 x U5 tri-snRNP complex Source: PomBase
  • U4 snRNP Source: GO_Central
  • U5 snRNP Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7777Small nuclear ribonucleoprotein GPRO_0000125551Add
BLAST

Proteomic databases

MaxQBiO74966.

Interactioni

Subunit structurei

Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2.1 Publication

Protein-protein interaction databases

BioGridi277372. 18 interactions.
IntActiO74966. 7 interactions.
MINTiMINT-4682124.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JB9electron microscopy3.60J/o1-77[»]
ProteinModelPortaliO74966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

HOGENOMiHOG000223546.
InParanoidiO74966.
KOiK11099.
OMAiQIKMNAN.
OrthoDBiEOG092C5VL3.
PhylomeDBiO74966.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

O74966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKAGAPDLK KYLDRQVFVQ LNGSRKVYGV LRGYDIFLNI VLEDSIEEKV
60 70
DGEKVKIGSV AIRGNSVIMI ETLDKMT
Length:77
Mass (Da):8,604
Last modified:November 1, 1998 - v1
Checksum:i6468E36CFEA8139A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19285.1.
PIRiT40477.
RefSeqiNP_596422.1. NM_001022341.2.

Genome annotation databases

EnsemblFungiiSPBC4B4.05.1; SPBC4B4.05.1:pep; SPBC4B4.05.
GeneIDi2540855.
KEGGispo:SPBC4B4.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19285.1.
PIRiT40477.
RefSeqiNP_596422.1. NM_001022341.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JB9electron microscopy3.60J/o1-77[»]
ProteinModelPortaliO74966.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277372. 18 interactions.
IntActiO74966. 7 interactions.
MINTiMINT-4682124.

Proteomic databases

MaxQBiO74966.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC4B4.05.1; SPBC4B4.05.1:pep; SPBC4B4.05.
GeneIDi2540855.
KEGGispo:SPBC4B4.05.

Organism-specific databases

EuPathDBiFungiDB:SPBC4B4.05.
PomBaseiSPBC4B4.05. smg1.

Phylogenomic databases

HOGENOMiHOG000223546.
InParanoidiO74966.
KOiK11099.
OMAiQIKMNAN.
OrthoDBiEOG092C5VL3.
PhylomeDBiO74966.

Enzyme and pathway databases

ReactomeiR-SPO-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

PROiO74966.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRUXG_SCHPO
AccessioniPrimary (citable) accession number: O74966
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.