O74966 (RUXG_SCHPO) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 86.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Small nuclear ribonucleoprotein G Short name=snRNP-G Alternative name(s): Sm protein G Short name=Sm-G Short name=SmG | ||||
| Gene names |
| ||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome] | ||||
| Taxonomic identifier | 284812 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›  |
Protein attributes
| Sequence length | 77 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site By similarity. |
| Subunit structure | Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2. Ref.2 |
| Subcellular location | |
| Sequence similarities | Belongs to the snRNP Sm proteins family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | mRNA processing mRNA splicing |
| Cellular component | Cytoplasm Nucleus Spliceosome |
| Ligand | RNA-binding |
| Molecular function | Ribonucleoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | mRNA 5'-splice site recognition Inferred by curator. Source: PomBase |
| Cellular_component | U1 snRNP Inferred from direct assay PubMed 17264129. Source: PomBase U4/U6 x U5 tri-snRNP complexInferred from sequence or structural similarity. Source: PomBase cytosolInferred from direct assay Ref.3. Source: PomBase spliceosomal complexInferred by curator. Source: PomBase |
| Molecular_function | RNA binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 77 | 77 | Small nuclear ribonucleoprotein G | PRO_0000125551 | |||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.  Nurse P.Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843. |
| [2] | "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs." Ohi M.D., Link A.J., Ren L., Jennings J.L., McDonald W.H., Gould K.L. Mol. Cell. Biol. 22:2011-2024(2002) [PubMed] [Europe PMC] [Abstract] Cited for: MASS SPECTROMETRY, IDENTIFICATION IN THE CWF COMPLEX. |
| [3] | "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe." Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M. Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CU329671 Genomic DNA. Translation: CAA19285.1. |
| PIR | T40477. |
| RefSeq | NP_596422.1. NM_001022341.2. |
3D structure databases | |
| ProteinModelPortal | O74966. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O74966. 7 interactions. |
| STRING | 4896.SPBC4B4.05-1. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | SPBC4B4.05.1; SPBC4B4.05.1:pep; SPBC4B4.05. |
| GeneID | 2540855. |
| KEGG | spo:SPBC4B4.05. |
Organism-specific databases | |
| PomBase | SPBC4B4.05. |
Phylogenomic databases | |
| eggNOG | COG1958. |
| HOGENOM | HOG000223546. |
| KO | K11099. |
| OMA | DLFLNVV. |
| OrthoDB | EOG4XWK7N. |
Family and domain databases | |
| InterPro | IPR010920. LSM_dom. IPR001163. Ribonucl_LSM. IPR006649. Ribonucl_LSM_euk/arc. [Graphical view] |
| Pfam | PF01423. LSM. 1 hit. [Graphical view] |
| SMART | SM00651. Sm. 1 hit. [Graphical view] |
| SUPFAM | SSF50182. Sm_like_riboprot. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 20801971. |
Entry information
| Entry name | RUXG_SCHPO | ||||||||
| Accession | Primary (citable) accession number: O74966 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |