Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chromatin structure-remodeling complex subunit rsc1

Gene

rsc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin structure-remodeling complex subunit rsc1
Alternative name(s):
RSC complex subunit rsc1
Remodel the structure of chromatin complex subunit 1
Gene namesi
Name:rsc1
ORF Names:SPBC4B4.03
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC4B4.03.
PomBaseiSPBC4B4.03. rsc1.

Subcellular locationi

GO - Cellular componenti

  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
  • RSC complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 803803Chromatin structure-remodeling complex subunit rsc1PRO_0000211210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei168 – 1681Phosphoserine1 Publication
Modified residuei331 – 3311Phosphoserine1 Publication
Modified residuei334 – 3341Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74964.

PTM databases

iPTMnetiO74964.

Interactioni

Subunit structurei

Component of the RSC complex composed of at least arp9, arp42, rsc1, rsc4, rsc7, rsc9, rsc58, sfh1, snf21, ssr1, ssr2, ssr3 and ssr4. The complex interacts with histone and histone variant components of centromeric chromatin (By similarity).By similarity

Protein-protein interaction databases

BioGridi277271. 105 interactions.
DIPiDIP-48389N.
MINTiMINT-4682104.

Structurei

3D structure databases

ProteinModelPortaliO74964.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 10171Bromo 1PROSITE-ProRule annotationAdd
BLAST
Domaini229 – 29971Bromo 2PROSITE-ProRule annotationAdd
BLAST
Domaini351 – 469119BAHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RSC1 family.Curated
Contains 1 BAH domain.PROSITE-ProRule annotation
Contains 2 bromo domains.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

InParanoidiO74964.
KOiK11756.
OrthoDBiEOG71RXT3.
PhylomeDBiO74964.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
InterProiIPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00439. BAH. 1 hit.
SM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
PROSITEiPS51038. BAH. 1 hit.
PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74964-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSKIRPSAD DKKLQRVLYF FLERVRAAKD VSGQLLSPLI DNASVDTASV
60 70 80 90 100
SPSSNGRPTT LKSIQSKIDE FQYHDFSEFV SDLAYLFINV KALYEGTQTY
110 120 130 140 150
SFVQALEEFC IQQLRTFQQQ GYIPVITWPN TDSPSATTSS PISRNPEYSV
160 170 180 190 200
SPPNGSKFVK NEDEAYDSDL YVEEEDSDVK GRSMVGRDGR YKSEDLKRRK
210 220 230 240 250
LQPSSKPLSS LEARAKVIMR QVRRYRDGSG RQLFAPFERL PDPRMFPEYY
260 270 280 290 300
QAIEQPMALE VIQKKLSKHR YETIEQFVDD FNLMFDNAKS FNDPSSQVYR
310 320 330 340 350
DADFLKNYLA DVLRLEAGKL DSEFFNYETD SRASPQLPKN DIQPAVSIDG
360 370 380 390 400
TLLNVGDWVL IRNPADSSKP IVSQIYRIWK SDDDINYVTV CWYLRPEQTV
410 420 430 440 450
HRADAVFYEN EVFKTSLYRD HPVSEIVGRC FVMYITRYIR GRPKGIRSTP
460 470 480 490 500
VFVCESRYND DTKQFSKIKS WKACMPQEVS GSEYEMILFD RPITLTKVAS
510 520 530 540 550
PLLHLLASKS QGLPSPATTD SNTHMLPSQG SLLPPSSISE TKSFSTKAST
560 570 580 590 600
PLSTDDIATP LSSAPNPPSV MPTYARKTSS HSERSSHSSY HNSSHVPTAA
610 620 630 640 650
FNSPIMRTST KSTSPIPARP FYAQSGSLQS LNTTQHSHQI SGGHSGRMNV
660 670 680 690 700
PYAKLSYTSH NGRHGGSNGN ISGAKTPMTN YTINSMPSLP VFPPAFIVPG
710 720 730 740 750
THQKLDESSP VPGIDDVTVI NTETAKMLDK DEHQNVLWYT VPPLDPIPLE
760 770 780 790 800
NRNGSLTHSV EYVLYKKSKG SQVITEKARS NELSREAKFE NLVASLSDAL

IPP
Length:803
Mass (Da):90,132
Last modified:November 1, 1998 - v1
Checksum:i2C2706CB022510F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19283.1.
PIRiT40475.
RefSeqiNP_596420.1. NM_001022339.2.

Genome annotation databases

EnsemblFungiiSPBC4B4.03.1; SPBC4B4.03.1:pep; SPBC4B4.03.
GeneIDi2540749.
KEGGispo:SPBC4B4.03.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA19283.1.
PIRiT40475.
RefSeqiNP_596420.1. NM_001022339.2.

3D structure databases

ProteinModelPortaliO74964.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277271. 105 interactions.
DIPiDIP-48389N.
MINTiMINT-4682104.

PTM databases

iPTMnetiO74964.

Proteomic databases

MaxQBiO74964.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC4B4.03.1; SPBC4B4.03.1:pep; SPBC4B4.03.
GeneIDi2540749.
KEGGispo:SPBC4B4.03.

Organism-specific databases

EuPathDBiFungiDB:SPBC4B4.03.
PomBaseiSPBC4B4.03. rsc1.

Phylogenomic databases

InParanoidiO74964.
KOiK11756.
OrthoDBiEOG71RXT3.
PhylomeDBiO74964.

Miscellaneous databases

NextBioi20801870.
PROiO74964.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
InterProiIPR001025. BAH_dom.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
[Graphical view]
PfamiPF01426. BAH. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00439. BAH. 1 hit.
SM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
PROSITEiPS51038. BAH. 1 hit.
PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168; SER-331 AND SER-334, IDENTIFICATION BY MASS SPECTROMETRY.
  4. "Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast."
    Monahan B.J., Villen J., Marguerat S., Baehler J., Gygi S.P., Winston F.
    Nat. Struct. Mol. Biol. 15:873-880(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RSC COMPLEX, FUNCTION OF THE RSC COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiRSC1_SCHPO
AccessioniPrimary (citable) accession number: O74964
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: November 1, 1998
Last modified: February 17, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.