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Protein

Transcription initiation factor IIA subunit 2

Gene

toa2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with tbp mediates transcriptional activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIA subunit 2
Alternative name(s):
General transcription factor IIA subunit 2
Transcription initiation factor IIA small chain
Gene namesi
Name:toa2
ORF Names:SPCC553.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC553.11c.
PomBaseiSPCC553.11c. toa2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • transcription factor TFIIA complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001940521 – 109Transcription initiation factor IIA subunit 2Add BLAST109

Proteomic databases

MaxQBiO74948.
PRIDEiO74948.

Interactioni

Subunit structurei

TFIIA is a heterodimer composed of the large toa1 and the small toa2 subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi275439. 1 interactor.
MINTiMINT-4682019.

Family & Domainsi

Sequence similaritiesi

Belongs to the TFIIA subunit 2 family.Curated

Phylogenomic databases

HOGENOMiHOG000167251.
InParanoidiO74948.
KOiK03123.
OMAiASAYYEF.
OrthoDBiEOG092C5KFB.

Family and domain databases

CDDicd10014. TFIIA_gamma_C. 1 hit.
cd10145. TFIIA_gamma_N. 1 hit.
Gene3Di1.10.287.190. 1 hit.
2.30.18.10. 1 hit.
InterProiIPR009083. TFIIA_a-hlx.
IPR009088. TFIIA_b-brl.
IPR003194. TFIIA_gsu.
IPR015871. TFIIA_gsu_C.
IPR015872. TFIIA_gsu_N.
[Graphical view]
PANTHERiPTHR10966. PTHR10966. 1 hit.
PfamiPF02751. TFIIA_gamma_C. 1 hit.
PF02268. TFIIA_gamma_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009415. Hum_TFIIA_gamma. 1 hit.
ProDomiPD009224. TFIIA_gsu_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47396. SSF47396. 1 hit.
SSF50784. SSF50784. 1 hit.

Sequencei

Sequence statusi: Complete.

O74948-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQYYELYRR SSIGISLTDA LDDLISQGKI SPQLAMKVLF NFDKSMTEAL
60 70 80 90 100
AEKVRSRLTF KGHLDTYRFC DEVWTFIIKN PSFRFDNETV TSNKIRIVAC

ATRDSSANR
Length:109
Mass (Da):12,584
Last modified:July 11, 2012 - v2
Checksum:iE17AC86529F36A37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19263.2.
PIRiT41393.
RefSeqiNP_587763.2. NM_001022756.2.

Genome annotation databases

EnsemblFungiiSPCC553.11c.1; SPCC553.11c.1:pep; SPCC553.11c.
GeneIDi2538859.
KEGGispo:SPCC553.11c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19263.2.
PIRiT41393.
RefSeqiNP_587763.2. NM_001022756.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275439. 1 interactor.
MINTiMINT-4682019.

Proteomic databases

MaxQBiO74948.
PRIDEiO74948.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC553.11c.1; SPCC553.11c.1:pep; SPCC553.11c.
GeneIDi2538859.
KEGGispo:SPCC553.11c.

Organism-specific databases

EuPathDBiFungiDB:SPCC553.11c.
PomBaseiSPCC553.11c. toa2.

Phylogenomic databases

HOGENOMiHOG000167251.
InParanoidiO74948.
KOiK03123.
OMAiASAYYEF.
OrthoDBiEOG092C5KFB.

Enzyme and pathway databases

ReactomeiR-SPO-674695. RNA Polymerase II Pre-transcription Events.
R-SPO-73776. RNA Polymerase II Promoter Escape.
R-SPO-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-SPO-75953. RNA Polymerase II Transcription Initiation.
R-SPO-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

PROiO74948.

Family and domain databases

CDDicd10014. TFIIA_gamma_C. 1 hit.
cd10145. TFIIA_gamma_N. 1 hit.
Gene3Di1.10.287.190. 1 hit.
2.30.18.10. 1 hit.
InterProiIPR009083. TFIIA_a-hlx.
IPR009088. TFIIA_b-brl.
IPR003194. TFIIA_gsu.
IPR015871. TFIIA_gsu_C.
IPR015872. TFIIA_gsu_N.
[Graphical view]
PANTHERiPTHR10966. PTHR10966. 1 hit.
PfamiPF02751. TFIIA_gamma_C. 1 hit.
PF02268. TFIIA_gamma_N. 1 hit.
[Graphical view]
PIRSFiPIRSF009415. Hum_TFIIA_gamma. 1 hit.
ProDomiPD009224. TFIIA_gsu_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF47396. SSF47396. 1 hit.
SSF50784. SSF50784. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiT2AG_SCHPO
AccessioniPrimary (citable) accession number: O74948
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: July 11, 2012
Last modified: November 30, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.