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Protein

Transcription initiation factor IIA subunit 2

Gene

toa2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with tbp mediates transcriptional activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-SPO-674695 RNA Polymerase II Pre-transcription Events
R-SPO-73776 RNA Polymerase II Promoter Escape
R-SPO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SPO-75953 RNA Polymerase II Transcription Initiation
R-SPO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SPO-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIA subunit 2
Alternative name(s):
General transcription factor IIA subunit 2
Transcription initiation factor IIA small chain
Gene namesi
Name:toa2
ORF Names:SPCC553.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:SPCC553.11c
PomBaseiSPCC553.11c toa2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001940521 – 109Transcription initiation factor IIA subunit 2Add BLAST109

Proteomic databases

MaxQBiO74948
PaxDbiO74948
PRIDEiO74948

Interactioni

Subunit structurei

TFIIA is a heterodimer composed of the large toa1 and the small toa2 subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi275439, 2 interactors
STRINGi4896.SPCC553.11c.1

Structurei

3D structure databases

SMRiO74948
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFIIA subunit 2 family.Curated

Phylogenomic databases

HOGENOMiHOG000167251
InParanoidiO74948
KOiK03123
OMAiFKMESNE
OrthoDBiEOG092C5KFB

Family and domain databases

CDDicd10014 TFIIA_gamma_C, 1 hit
cd10145 TFIIA_gamma_N, 1 hit
Gene3Di1.10.287.190, 1 hit
2.30.18.10, 1 hit
InterProiView protein in InterPro
IPR009083 TFIIA_a-hlx
IPR009088 TFIIA_b-brl
IPR003194 TFIIA_gsu
IPR015871 TFIIA_gsu_C
IPR015872 TFIIA_gsu_N
PANTHERiPTHR10966 PTHR10966, 1 hit
PfamiView protein in Pfam
PF02751 TFIIA_gamma_C, 1 hit
PF02268 TFIIA_gamma_N, 1 hit
PIRSFiPIRSF009415 Hum_TFIIA_gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009224 TFIIA_gsu_N, 1 hit
SUPFAMiSSF50784 SSF50784, 1 hit

Sequencei

Sequence statusi: Complete.

O74948-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQYYELYRR SSIGISLTDA LDDLISQGKI SPQLAMKVLF NFDKSMTEAL
60 70 80 90 100
AEKVRSRLTF KGHLDTYRFC DEVWTFIIKN PSFRFDNETV TSNKIRIVAC

ATRDSSANR
Length:109
Mass (Da):12,584
Last modified:July 11, 2012 - v2
Checksum:iE17AC86529F36A37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA19263.2
PIRiT41393
RefSeqiNP_587763.2, NM_001022756.2

Genome annotation databases

EnsemblFungiiSPCC553.11c.1; SPCC553.11c.1:pep; SPCC553.11c
GeneIDi2538859
KEGGispo:SPCC553.11c

Similar proteinsi

Entry informationi

Entry nameiT2AG_SCHPO
AccessioniPrimary (citable) accession number: O74948
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: July 11, 2012
Last modified: May 23, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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