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Protein

Peptidyl-prolyl cis-trans isomerase 9

Gene

cyp9

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase 9 (EC:5.2.1.8)
Short name:
PPIase cyp9
Alternative name(s):
Cyclophilin 9
Rotamase cyp9
Gene namesi
Name:cyp9
ORF Names:SPCC553.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC553.04.
PomBaseiSPCC553.04. cyp9.

Subcellular locationi

GO - Cellular componenti

  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610Peptidyl-prolyl cis-trans isomerase 9PRO_0000358863Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74942.

PTM databases

iPTMnetiO74942.

Interactioni

Protein-protein interaction databases

MINTiMINT-4681958.

Structurei

3D structure databases

ProteinModelPortaliO74942.
SMRiO74942. Positions 455-607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati45 – 8339WD 1Add
BLAST
Repeati88 – 12740WD 2Add
BLAST
Repeati177 – 21640WD 3Add
BLAST
Domaini453 – 607155PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation
Contains 3 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000213214.
InParanoidiO74942.
KOiK12736.
OMAiVVLHTTK.
OrthoDBiEOG77HDQ6.
PhylomeDBiO74942.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF50978. SSF50978. 2 hits.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDGASPVDR DVSPVGLPKK RIKQNHDQVF LHNLPDAPRY TKSYMHNAEI
60 70 80 90 100
YKCFPTKSNY ILSVSYDGYV KFWHKTPNGV EYIKEFHAHN AMLLSAELSQ
110 120 130 140 150
DERLFITGAD DKSLKVFDVE SIDLVNIIDL EFLPKAICCF NSPSLKTSLI
160 170 180 190 200
AVSSAESPLI FFFESGGDGE VLYTVKKHTA PVHCLRYLST LDCFLSIDIG
210 220 230 240 250
GMVEYWSPEE PFQKPDTAEL FNMKSQTDLY IFKKQKSVPT SLEVSHFENF
260 270 280 290 300
WSTISYPDCK VRVFDTKSGR AILELDENPS NAAKKVEALF EKEDTESSYY
310 320 330 340 350
MSHVELGRRI AIERDIEKHG LTVGTTAIFD ESEKYLLYGS IVGIKVVSID
360 370 380 390 400
NGTVVRIYGK DEAVRFTRLS LYQQAPKKSN LPSLDVIASN NPLVEESFQK
410 420 430 440 450
DPTLFATAWK KQRFYLFSNM STKFTLSDRD VYNEQVLPVT NNEGRQENGN
460 470 480 490 500
ILLGKAAIIH TTQGDISIKL YPEEAPKAVQ NFTTHAENGY YDNTIFHRII
510 520 530 540 550
KNFMIQGGDP LGDGTGGESI WKKDFEDEIS PNLKHDRPFT VSMANSGPNT
560 570 580 590 600
NGSQFFITTD LTPWLDGKHT IFARAYAGLD VVHRIEQGET DKYDRPLEPT
610
KIINISIVYT
Length:610
Mass (Da):69,048
Last modified:November 1, 1998 - v1
Checksum:i28D06D189C76DF3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19257.1.
PIRiT41399.
RefSeqiNP_587769.1. NM_001022762.2.

Genome annotation databases

EnsemblFungiiSPCC553.04.1; SPCC553.04.1:pep; SPCC553.04.
GeneIDi2539557.
KEGGispo:SPCC553.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA19257.1.
PIRiT41399.
RefSeqiNP_587769.1. NM_001022762.2.

3D structure databases

ProteinModelPortaliO74942.
SMRiO74942. Positions 455-607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4681958.

PTM databases

iPTMnetiO74942.

Proteomic databases

MaxQBiO74942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC553.04.1; SPCC553.04.1:pep; SPCC553.04.
GeneIDi2539557.
KEGGispo:SPCC553.04.

Organism-specific databases

EuPathDBiFungiDB:SPCC553.04.
PomBaseiSPCC553.04. cyp9.

Phylogenomic databases

HOGENOMiHOG000213214.
InParanoidiO74942.
KOiK12736.
OMAiVVLHTTK.
OrthoDBiEOG77HDQ6.
PhylomeDBiO74942.

Miscellaneous databases

NextBioi20800717.
PROiO74942.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF50978. SSF50978. 2 hits.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCYP9_SCHPO
AccessioniPrimary (citable) accession number: O74942
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.