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O74935

- ACOX2_YARLI

UniProt

O74935 - ACOX2_YARLI

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Protein

Acyl-coenzyme A oxidase 2

Gene

POX2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Oxidizes strain chain acyl-CoAs with a chain length of 10 to 14 carbons. Also active toward the 2S isomers of acyl-CoA-esters containing a 2-methyl group.

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

FAD.

Pathwayi

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. acyl-CoA oxidase activity Source: UniProtKB-EC
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. fatty acid beta-oxidation using acyl-CoA oxidase Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00661.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A oxidase 2 (EC:1.3.3.6)
Short name:
Acyl-CoA oxidase 2
Gene namesi
Name:POX2
Synonyms:ACO2
Ordered Locus Names:YALI0F10857g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome F

Subcellular locationi

Peroxisome 1 Publication

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 700700Acyl-coenzyme A oxidase 2PRO_0000204702Add
BLAST

Interactioni

Subunit structurei

Heteropentamer composed of five different subunits.1 Publication

Protein-protein interaction databases

STRINGi4952.O74935.

Structurei

3D structure databases

ProteinModelPortaliO74935.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiCOG1960.
HOGENOMiHOG000181256.
InParanoidiO74935.
KOiK00232.
OMAiIPCITIT.
OrthoDBiEOG7P02SG.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

O74935 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPNNTGTIE INGKEYNTFT EPPVAMAQER AKTSFPVREM TYFLDGGEKN
60 70 80 90 100
TLKNEQIMEE IERDPLFNND NYYDLNKEQI RELTMERVAK LSLFVRDQPE
110 120 130 140 150
DDIKKRFALI GIADMGTYTR LGVHYGLFFG AVRGTGTAEQ FGHWISKGAG
160 170 180 190 200
DLRKFYGCFS MTELGHGSNL AGLETTAIYD EETDEFIINT PHIAATKWWI
210 220 230 240 250
GGAAHTATHT VVFARLIVKG KDYGVKTFVV QLRNINDHSL KVGISIGDIG
260 270 280 290 300
KKMGRDGIDN GWIQFTNVRI PRQNLLMKYT KVDREGNVTQ PPLAQLTYGS
310 320 330 340 350
LITGRVSMAS DSHQVGKRFI TIALRYACIR RQFSTTPGQP ETKIIDYPYH
360 370 380 390 400
QRRLLPLLAY VYALKMTADE VGALFSRTML KMDDLKPDDK AGLNEVVSDV
410 420 430 440 450
KELFSVSAGL KAFSTWACAD VIDKTRQACG GHGYSGYNGF GQAYADWVVQ
460 470 480 490 500
CTWEGDNNIL TLSAGRALIQ SAVALRKGEP VGNAVSYLKR YKDLANAKLN
510 520 530 540 550
GRSLTDPKVL VEAWEVAAGN IINRATDQYE KLIGEGLNAD QAFEVLSQQR
560 570 580 590 600
FQAAKVHTRR HLIAAFFSRI DTEAGEAIKQ PLLNLALLFA LWSIEEDSGL
610 620 630 640 650
FLREGFLEPK DIDTVTELVN KYCTTVREEV IGYTDAFNLS DYFINAPIGC
660 670 680 690 700
YDGDAYRHYF QKVNEQNPAR DPRPPYYAST LKPFLFREEE DDDICELDEE
Length:700
Mass (Da):78,691
Last modified:November 1, 1998 - v1
Checksum:i434C97B8A7D71E3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001300 Genomic DNA. Translation: CAA04660.1.
CR382132 Genomic DNA. Translation: CAG78071.1.
RefSeqiXP_505264.1. XM_505264.1.

Genome annotation databases

EnsemblFungiiCAG78071; CAG78071; YALI0_F10857g.
GeneIDi2907872.
KEGGiyli:YALI0F10857g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ001300 Genomic DNA. Translation: CAA04660.1 .
CR382132 Genomic DNA. Translation: CAG78071.1 .
RefSeqi XP_505264.1. XM_505264.1.

3D structure databases

ProteinModelPortali O74935.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.O74935.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG78071 ; CAG78071 ; YALI0_F10857g .
GeneIDi 2907872.
KEGGi yli:YALI0F10857g.

Phylogenomic databases

eggNOGi COG1960.
HOGENOMi HOG000181256.
InParanoidi O74935.
KOi K00232.
OMAi IPCITIT.
OrthoDBi EOG7P02SG.

Enzyme and pathway databases

UniPathwayi UPA00661 .

Family and domain databases

Gene3Di 1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProi IPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMi SSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The acyl-CoA oxidases from the yeast Yarrowia lipolytica: characterization of Aox2p."
    Luo Y.S., Nicaud J.-M., Van Veldhoven P.P., Chardot T.
    Arch. Biochem. Biophys. 407:32-38(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIB 122 / E 150.
  3. "Acyl-CoA oxidase is imported as a heteropentameric, cofactor-containing complex into peroxisomes of Yarrowia lipolytica."
    Titorenko V.I., Nicaud J.-M., Wang H., Chan H., Rachubinski R.A.
    J. Cell Biol. 156:481-494(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiACOX2_YARLI
AccessioniPrimary (citable) accession number: O74935
Secondary accession number(s): Q6C248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3