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Protein

Acyl-coenzyme A oxidase 2

Gene

POX2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Oxidizes strain chain acyl-CoAs with a chain length of 10 to 14 carbons. Also active toward the 2S isomers of acyl-CoA-esters containing a 2-methyl group.

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

Pathwayi: peroxisomal fatty acid beta-oxidation

This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandFAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.3.3.6 1122
UniPathwayiUPA00661

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A oxidase 2 (EC:1.3.3.6)
Short name:
Acyl-CoA oxidase 2
Gene namesi
Name:POX2
Synonyms:ACO2
Ordered Locus Names:YALI0F10857g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome F

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047021 – 700Acyl-coenzyme A oxidase 2Add BLAST700

Proteomic databases

PRIDEiO74935

Interactioni

Subunit structurei

Heteropentamer composed of five different subunits.1 Publication

Protein-protein interaction databases

STRINGi4952.XP_505264.1

Structurei

3D structure databases

ProteinModelPortaliO74935
SMRiO74935
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

HOGENOMiHOG000181256
InParanoidiO74935
KOiK00232
OMAiQKACVIA
OrthoDBiEOG092C0VH7

Family and domain databases

Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR029320 Acyl-CoA_ox_N
IPR006091 Acyl-CoA_Oxase/DH_cen-dom
IPR012258 Acyl-CoA_oxidase
IPR002655 Acyl-CoA_oxidase_C
IPR036250 AcylCo_DH-like_C
IPR009075 AcylCo_DH/oxidase_C
IPR037069 AcylCoA_DH/ox_N_sf
IPR009100 AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF01756 ACOX, 1 hit
PF00441 Acyl-CoA_dh_1, 1 hit
PF02770 Acyl-CoA_dh_M, 1 hit
PF14749 Acyl-CoA_ox_N, 1 hit
PIRSFiPIRSF000168 Acyl-CoA_oxidase, 1 hit
SUPFAMiSSF47203 SSF47203, 2 hits
SSF56645 SSF56645, 1 hit

Sequencei

Sequence statusi: Complete.

O74935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPNNTGTIE INGKEYNTFT EPPVAMAQER AKTSFPVREM TYFLDGGEKN
60 70 80 90 100
TLKNEQIMEE IERDPLFNND NYYDLNKEQI RELTMERVAK LSLFVRDQPE
110 120 130 140 150
DDIKKRFALI GIADMGTYTR LGVHYGLFFG AVRGTGTAEQ FGHWISKGAG
160 170 180 190 200
DLRKFYGCFS MTELGHGSNL AGLETTAIYD EETDEFIINT PHIAATKWWI
210 220 230 240 250
GGAAHTATHT VVFARLIVKG KDYGVKTFVV QLRNINDHSL KVGISIGDIG
260 270 280 290 300
KKMGRDGIDN GWIQFTNVRI PRQNLLMKYT KVDREGNVTQ PPLAQLTYGS
310 320 330 340 350
LITGRVSMAS DSHQVGKRFI TIALRYACIR RQFSTTPGQP ETKIIDYPYH
360 370 380 390 400
QRRLLPLLAY VYALKMTADE VGALFSRTML KMDDLKPDDK AGLNEVVSDV
410 420 430 440 450
KELFSVSAGL KAFSTWACAD VIDKTRQACG GHGYSGYNGF GQAYADWVVQ
460 470 480 490 500
CTWEGDNNIL TLSAGRALIQ SAVALRKGEP VGNAVSYLKR YKDLANAKLN
510 520 530 540 550
GRSLTDPKVL VEAWEVAAGN IINRATDQYE KLIGEGLNAD QAFEVLSQQR
560 570 580 590 600
FQAAKVHTRR HLIAAFFSRI DTEAGEAIKQ PLLNLALLFA LWSIEEDSGL
610 620 630 640 650
FLREGFLEPK DIDTVTELVN KYCTTVREEV IGYTDAFNLS DYFINAPIGC
660 670 680 690 700
YDGDAYRHYF QKVNEQNPAR DPRPPYYAST LKPFLFREEE DDDICELDEE
Length:700
Mass (Da):78,691
Last modified:November 1, 1998 - v1
Checksum:i434C97B8A7D71E3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ001300 Genomic DNA Translation: CAA04660.1
CR382132 Genomic DNA Translation: CAG78071.1
RefSeqiXP_505264.1, XM_505264.1

Genome annotation databases

EnsemblFungiiCAG78071; CAG78071; YALI0_F10857g
GeneIDi2907872
KEGGiyli:YALI0F10857g

Similar proteinsi

Entry informationi

Entry nameiACOX2_YARLI
AccessioniPrimary (citable) accession number: O74935
Secondary accession number(s): Q6C248
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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