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O74935

- ACOX2_YARLI

UniProt

O74935 - ACOX2_YARLI

Protein

Acyl-coenzyme A oxidase 2

Gene

POX2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Oxidizes strain chain acyl-CoAs with a chain length of 10 to 14 carbons. Also active toward the 2S isomers of acyl-CoA-esters containing a 2-methyl group.

    Catalytic activityi

    Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

    Cofactori

    FAD.

    Pathwayi

    GO - Molecular functioni

    1. acyl-CoA dehydrogenase activity Source: InterPro
    2. acyl-CoA oxidase activity Source: UniProtKB-EC
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. fatty acid beta-oxidation using acyl-CoA oxidase Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00661.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-coenzyme A oxidase 2 (EC:1.3.3.6)
    Short name:
    Acyl-CoA oxidase 2
    Gene namesi
    Name:POX2
    Synonyms:ACO2
    Ordered Locus Names:YALI0F10857g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome F

    Subcellular locationi

    Peroxisome 1 Publication

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 700700Acyl-coenzyme A oxidase 2PRO_0000204702Add
    BLAST

    Interactioni

    Subunit structurei

    Heteropentamer composed of five different subunits.1 Publication

    Protein-protein interaction databases

    STRINGi4952.O74935.

    Structurei

    3D structure databases

    ProteinModelPortaliO74935.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acyl-CoA oxidase family.Curated

    Phylogenomic databases

    eggNOGiCOG1960.
    HOGENOMiHOG000181256.
    KOiK00232.
    OMAiIPCITIT.
    OrthoDBiEOG7P02SG.

    Family and domain databases

    Gene3Di1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProiIPR029320. Acyl-CoA_ox_N.
    IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR012258. Acyl-CoA_oxidase.
    IPR002655. Acyl-CoA_oxidase_C.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view]
    PfamiPF01756. ACOX. 1 hit.
    PF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF14749. Acyl-CoA_ox_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
    SUPFAMiSSF47203. SSF47203. 2 hits.
    SSF56645. SSF56645. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O74935-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPNNTGTIE INGKEYNTFT EPPVAMAQER AKTSFPVREM TYFLDGGEKN    50
    TLKNEQIMEE IERDPLFNND NYYDLNKEQI RELTMERVAK LSLFVRDQPE 100
    DDIKKRFALI GIADMGTYTR LGVHYGLFFG AVRGTGTAEQ FGHWISKGAG 150
    DLRKFYGCFS MTELGHGSNL AGLETTAIYD EETDEFIINT PHIAATKWWI 200
    GGAAHTATHT VVFARLIVKG KDYGVKTFVV QLRNINDHSL KVGISIGDIG 250
    KKMGRDGIDN GWIQFTNVRI PRQNLLMKYT KVDREGNVTQ PPLAQLTYGS 300
    LITGRVSMAS DSHQVGKRFI TIALRYACIR RQFSTTPGQP ETKIIDYPYH 350
    QRRLLPLLAY VYALKMTADE VGALFSRTML KMDDLKPDDK AGLNEVVSDV 400
    KELFSVSAGL KAFSTWACAD VIDKTRQACG GHGYSGYNGF GQAYADWVVQ 450
    CTWEGDNNIL TLSAGRALIQ SAVALRKGEP VGNAVSYLKR YKDLANAKLN 500
    GRSLTDPKVL VEAWEVAAGN IINRATDQYE KLIGEGLNAD QAFEVLSQQR 550
    FQAAKVHTRR HLIAAFFSRI DTEAGEAIKQ PLLNLALLFA LWSIEEDSGL 600
    FLREGFLEPK DIDTVTELVN KYCTTVREEV IGYTDAFNLS DYFINAPIGC 650
    YDGDAYRHYF QKVNEQNPAR DPRPPYYAST LKPFLFREEE DDDICELDEE 700
    Length:700
    Mass (Da):78,691
    Last modified:November 1, 1998 - v1
    Checksum:i434C97B8A7D71E3E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001300 Genomic DNA. Translation: CAA04660.1.
    CR382132 Genomic DNA. Translation: CAG78071.1.
    RefSeqiXP_505264.1. XM_505264.1.

    Genome annotation databases

    EnsemblFungiiCAG78071; CAG78071; YALI0_F10857g.
    GeneIDi2907872.
    KEGGiyli:YALI0F10857g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ001300 Genomic DNA. Translation: CAA04660.1 .
    CR382132 Genomic DNA. Translation: CAG78071.1 .
    RefSeqi XP_505264.1. XM_505264.1.

    3D structure databases

    ProteinModelPortali O74935.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.O74935.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG78071 ; CAG78071 ; YALI0_F10857g .
    GeneIDi 2907872.
    KEGGi yli:YALI0F10857g.

    Phylogenomic databases

    eggNOGi COG1960.
    HOGENOMi HOG000181256.
    KOi K00232.
    OMAi IPCITIT.
    OrthoDBi EOG7P02SG.

    Enzyme and pathway databases

    UniPathwayi UPA00661 .

    Family and domain databases

    Gene3Di 1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProi IPR029320. Acyl-CoA_ox_N.
    IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR012258. Acyl-CoA_oxidase.
    IPR002655. Acyl-CoA_oxidase_C.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view ]
    Pfami PF01756. ACOX. 1 hit.
    PF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF14749. Acyl-CoA_ox_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000168. Acyl-CoA_oxidase. 1 hit.
    SUPFAMi SSF47203. SSF47203. 2 hits.
    SSF56645. SSF56645. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The acyl-CoA oxidases from the yeast Yarrowia lipolytica: characterization of Aox2p."
      Luo Y.S., Nicaud J.-M., Van Veldhoven P.P., Chardot T.
      Arch. Biochem. Biophys. 407:32-38(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
      Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.
    2. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CLIB 122 / E 150.
    3. "Acyl-CoA oxidase is imported as a heteropentameric, cofactor-containing complex into peroxisomes of Yarrowia lipolytica."
      Titorenko V.I., Nicaud J.-M., Wang H., Chan H., Rachubinski R.A.
      J. Cell Biol. 156:481-494(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiACOX2_YARLI
    AccessioniPrimary (citable) accession number: O74935
    Secondary accession number(s): Q6C248
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3