Reviewed, UniProtKB/Swiss-Prot O74935 (ACOX2_YARLI)

Names and origin

Protein names

Recommended name:
    Acyl-coenzyme A oxidase 2
      Short name=Acyl-CoA oxidase 2
    EC=1.3.3.6

Gene names

Name:	POX2
Synonyms:	ACO2
Ordered Locus Names:	YALI0F10857g

Organism

Yarrowia lipolytica (Candida lipolytica) [Complete proteome]

Taxonomic identifier

4952 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	700 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Oxidizes strain chain acyl-CoAs with a chain length of 10 to 14 carbons. Also active toward the 2S isomers of acyl-CoA-esters containing a 2-methyl group.
Catalytic activity	Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.
Cofactor	FAD.
Pathway	Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Subunit structure	Heteropentamer composed of five different subunits. Ref.3
Subcellular location	Peroxisome. Ref.3
Sequence similarities	Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid beta-oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro acyl-CoA oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 700	700	Acyl-coenzyme A oxidase 2		PRO_0000204702

Sequences

	Sequence		Length	Mass (Da)
	O74935-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 434C97B8A7D71E3E	FASTA	700	78,691
	10 20 30 40 50 60 MNPNNTGTIE INGKEYNTFT EPPVAMAQER AKTSFPVREM TYFLDGGEKN TLKNEQIMEE 70 80 90 100 110 120 IERDPLFNND NYYDLNKEQI RELTMERVAK LSLFVRDQPE DDIKKRFALI GIADMGTYTR 130 140 150 160 170 180 LGVHYGLFFG AVRGTGTAEQ FGHWISKGAG DLRKFYGCFS MTELGHGSNL AGLETTAIYD 190 200 210 220 230 240 EETDEFIINT PHIAATKWWI GGAAHTATHT VVFARLIVKG KDYGVKTFVV QLRNINDHSL 250 260 270 280 290 300 KVGISIGDIG KKMGRDGIDN GWIQFTNVRI PRQNLLMKYT KVDREGNVTQ PPLAQLTYGS 310 320 330 340 350 360 LITGRVSMAS DSHQVGKRFI TIALRYACIR RQFSTTPGQP ETKIIDYPYH QRRLLPLLAY 370 380 390 400 410 420 VYALKMTADE VGALFSRTML KMDDLKPDDK AGLNEVVSDV KELFSVSAGL KAFSTWACAD 430 440 450 460 470 480 VIDKTRQACG GHGYSGYNGF GQAYADWVVQ CTWEGDNNIL TLSAGRALIQ SAVALRKGEP 490 500 510 520 530 540 VGNAVSYLKR YKDLANAKLN GRSLTDPKVL VEAWEVAAGN IINRATDQYE KLIGEGLNAD 550 560 570 580 590 600 QAFEVLSQQR FQAAKVHTRR HLIAAFFSRI DTEAGEAIKQ PLLNLALLFA LWSIEEDSGL 610 620 630 640 650 660 FLREGFLEPK DIDTVTELVN KYCTTVREEV IGYTDAFNLS DYFINAPIGC YDGDAYRHYF 670 680 690 700 QKVNEQNPAR DPRPPYYAST LKPFLFREEE DDDICELDEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The acyl-CoA oxidases from the yeast Yarrowia lipolytica: characterization of Aox2p." Luo Y.S., Nicaud J.-M., Van Veldhoven P.P., Chardot T. Arch. Biochem. Biophys. 407:32-38(2002) [PubMed: 12392712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.
[3]	"Acyl-CoA oxidase is imported as a heteropentameric, cofactor-containing complex into peroxisomes of Yarrowia lipolytica." Titorenko V.I., Nicaud J.-M., Wang H., Chan H., Rachubinski R.A. J. Cell Biol. 156:481-494(2002) [PubMed: 11815635] [Abstract] Cited for: SUBUNIT, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ001300 Genomic DNA. Translation: CAA04660.1. CR382132 Genomic DNA. Translation: CAG78071.1.
RefSeq	XP_505264.1.
3D structure databases
HSSP	HSSP built from PDB template 1IS2 based on UniProtKB P07872.
ModBase	Search...
Genome annotation databases
GeneID	2907872.
KEGG	yli:YALI0F10857g.
Phylogenomic databases
HOGENOM	O74935.
OMA	O74935. ANASERT.
Enzyme and pathway databases
BRENDA	1.3.3.6. 3602.
Family and domain databases
InterPro	IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_M. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHER	PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACOX2_YARLI

Accession

Primary (citable) accession number: O74935
Secondary accession number(s): Q6C248

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)