Reviewed, UniProtKB/Swiss-Prot O74934 (ACOX1_YARLI)

Names and origin

Protein names

Recommended name:
    Acyl-coenzyme A oxidase 1
      Short name=Acyl-CoA oxidase 1
    EC=1.3.3.6

Gene names

Name:	POX1
Synonyms:	ACO1
Ordered Locus Names:	YALI0E32835g

Organism

Yarrowia lipolytica (Candida lipolytica) [Complete proteome]

Taxonomic identifier

4952 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	689 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.
Cofactor	FAD By similarity.
Pathway	Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Subunit structure	Heteropentamer composed of five different subunits. Ref.3
Subcellular location	Peroxisome. Ref.3
Sequence similarities	Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid beta-oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro acyl-CoA oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 689	689	Acyl-coenzyme A oxidase 1		PRO_0000204701
Sites
	Active site	444	1	Proton acceptor By similarity
	Binding site	149	1	FAD By similarity
	Binding site	188	1	FAD; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	O74934-1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 843D99D6DCEB4150	FASTA	689	77,282
	10 20 30 40 50 60 MTTNTFTDPP VEMAKERGKT QFTVRDVTNF LNGGEEETQI VEKIMSSIER DPVLSVTADY 70 80 90 100 110 120 DCNLQQARKQ TMERVAALSP YLVTDTEKLS LWRAQLHGMV DMSTRTRLSI HNNLFIGSIR 130 140 150 160 170 180 GSGTPEQFKY WVKKGAVAVK QFYGCFAMTE LGHGSNLKGL ETTATYDQDS DQFIINTPHI 190 200 210 220 230 240 GATKWWIGGA AHTSTHCVCF AKLIVHGKDY GTRNFVVPLR NVHDHSLKVG VSIGDIGKKM 250 260 270 280 290 300 GRDGVDNGWI QFTNVRIPRQ NMLMRYAKVS DTGVVTKPAL DQLTYGALIR GRVSMIADSF 310 320 330 340 350 360 HVSKRFLTIA LRYACVRRQF GTSGDTKETK IIDYPYHQRR LLPLLAYCYA MKMGADEAQK 370 380 390 400 410 420 TWIETTDRIL ALNPNDPAQK NDLEKAVTDT KELFAASAGM KAFTTWGCAK IIDECRQACG 430 440 450 460 470 480 GHGYSGYNGF GQGYADWVVQ CTWEGDNNVL CLSMGRGLVQ SALQILAGKH VGASIQYVGD 490 500 510 520 530 540 KSKISQNGQG TPREQLLSPE FLVEAFRTAS RNNILRTTDK YQELVKTLNP DQAFEELSQQ 550 560 570 580 590 600 RFQCARIHTR QHLISSFYAR IATAKDDIKP HLLKLANLFA LWSIEEDTGI FLRENILTPG 610 620 630 640 650 660 DIDLINSLVD ELCVAVRDQV IGLTDAFGLS DFFINAPIGS YDGNVYEKYF AKVNQQNPAT 670 680 NPRPPYYEST LKPFLFREEE DDEICDLDE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Le Clainche A., Nicaud J.-M. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 20460 / W29 / CBS 7504 / IFP29.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.
[3]	"Acyl-CoA oxidase is imported as a heteropentameric, cofactor-containing complex into peroxisomes of Yarrowia lipolytica." Titorenko V.I., Nicaud J.-M., Wang H., Chan H., Rachubinski R.A. J. Cell Biol. 156:481-494(2002) [PubMed: 11815635] [Abstract] Cited for: SUBUNIT, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ001299 Genomic DNA. Translation: CAA04659.1. CR382131 Genomic DNA. Translation: CAG80307.1. Different initiation.
RefSeq	XP_504703.1.
3D structure databases
HSSP	HSSP built from PDB template 1IS2 based on UniProtKB P07872.
ModBase	Search...
Genome annotation databases
GeneID	2912003.
GenomeReviews	Gene locus YALI0E32835g in contig CR382131_GR.
KEGG	yli:YALI0E32835g.
Phylogenomic databases
HOGENOM	O74934.
Enzyme and pathway databases
BRENDA	1.3.3.6. 3602.
Family and domain databases
InterPro	IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_M. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHER	PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACOX1_YARLI

Accession

Primary (citable) accession number: O74934
Secondary accession number(s): Q6C3Q9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	November 1, 1998
Last modified:	September 22, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)