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Protein

UDP-N-acetylglucosamine pyrophosphorylase

Gene

UAP1

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.

Pathwayi: UDP-N-acetyl-alpha-D-glucosamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-N-acetylglucosamine pyrophosphorylase (UAP1)
This subpathway is part of the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate, the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231UTPBy similarity
Binding sitei199 – 1991UTPBy similarity
Binding sitei226 – 2261UTP; via amide nitrogenBy similarity
Binding sitei227 – 2271SubstrateBy similarity
Binding sitei257 – 2571UTPBy similarity
Binding sitei389 – 3891UTPBy similarity
Binding sitei421 – 4211SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.7.7.23. 1096.
UniPathwayiUPA00113; UER00533.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine pyrophosphorylase (EC:2.7.7.23)
Gene namesi
Name:UAP1
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486UDP-N-acetylglucosamine pyrophosphorylasePRO_0000185771Add
BLAST

Structurei

Secondary structure

1
486
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1510Combined sources
Helixi19 – 224Combined sources
Helixi25 – 273Combined sources
Helixi30 – 4112Combined sources
Beta strandi43 – 453Combined sources
Helixi46 – 5914Combined sources
Helixi74 – 763Combined sources
Beta strandi77 – 793Combined sources
Turni80 – 823Combined sources
Helixi85 – 10016Combined sources
Beta strandi104 – 11310Combined sources
Helixi115 – 1173Combined sources
Beta strandi120 – 1223Combined sources
Helixi123 – 1253Combined sources
Helixi136 – 15520Combined sources
Beta strandi164 – 1696Combined sources
Helixi171 – 1733Combined sources
Helixi174 – 18310Combined sources
Helixi185 – 1884Combined sources
Helixi191 – 1933Combined sources
Beta strandi194 – 1985Combined sources
Beta strandi201 – 2033Combined sources
Beta strandi209 – 2124Combined sources
Beta strandi214 – 2163Combined sources
Beta strandi222 – 2243Combined sources
Helixi227 – 2293Combined sources
Helixi230 – 2367Combined sources
Helixi239 – 2468Combined sources
Beta strandi250 – 2556Combined sources
Helixi266 – 27510Combined sources
Beta strandi278 – 2858Combined sources
Beta strandi295 – 2995Combined sources
Turni300 – 3034Combined sources
Beta strandi304 – 3085Combined sources
Helixi310 – 3123Combined sources
Helixi315 – 3195Combined sources
Beta strandi325 – 3317Combined sources
Beta strandi333 – 34210Combined sources
Helixi343 – 35311Combined sources
Turni357 – 3593Combined sources
Beta strandi363 – 3675Combined sources
Turni374 – 3763Combined sources
Beta strandi387 – 3915Combined sources
Helixi394 – 4007Combined sources
Helixi403 – 4053Combined sources
Beta strandi406 – 4116Combined sources
Helixi413 – 4164Combined sources
Beta strandi426 – 4305Combined sources
Helixi431 – 44818Combined sources
Helixi454 – 4563Combined sources
Turni463 – 4653Combined sources
Beta strandi467 – 4693Combined sources
Helixi473 – 4753Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YQCX-ray1.90A1-486[»]
2YQHX-ray2.30A/B1-486[»]
2YQJX-ray2.31A/B1-486[»]
2YQSX-ray2.30A1-486[»]
ProteinModelPortaliO74933.
SMRiO74933. Positions 3-486.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO74933.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni109 – 1124UTP bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi109 – 1124Substrate bindingBy similarity
Motifi309 – 3102Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

O74933-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVKSQQQII DSFKQANQDQ LFQYYDSLTI DQQQEFIDQL STIEEPAKLI
60 70 80 90 100
STVEQAIQFS QTNSTSRNFT QLPNEQTAST LDLSKDILQN WTELGLKAIG
110 120 130 140 150
NGEVAVLLMA GGQGTRLGSS APKGCFNIEL PSQKSLFQIQ AEKILKIEQL
160 170 180 190 200
AQQYLKSTKK PIINWYIMTS GPTRNATESF FIENNYFGLN SHQVIFFNQG
210 220 230 240 250
TLPCFNLQGN KILLESKNSI CQSPDGNGGL YKALKDNGIL DDLNSKGIKH
260 270 280 290 300
IHMYCVDNCL VKVADPIFIG FAIAKKFDLA TKVVRKRDAN ESVGLIVLDQ
310 320 330 340 350
DNQKPCVIEY SEISQELANK KDPQDSSKLF LRAANIVNHY YSVEFLNKMI
360 370 380 390 400
PKWISSQKYL PFHIAKKKIP SLNLENGEFY KPTEPNGIKL EQFIFDVFPS
410 420 430 440 450
VELNKFGCLE VDRLDEFSPL KNADGAKNDT PTTCRNHYLE RSSKWVIQNG
460 470 480
GVIDNQGLVE VDSKTSYGGE GLEFVNGKHF KNGDII
Length:486
Mass (Da):54,644
Last modified:November 1, 1998 - v1
Checksum:i6C488939A16870F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011003 Genomic DNA. Translation: BAA32334.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011003 Genomic DNA. Translation: BAA32334.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YQCX-ray1.90A1-486[»]
2YQHX-ray2.30A/B1-486[»]
2YQJX-ray2.31A/B1-486[»]
2YQSX-ray2.30A1-486[»]
ProteinModelPortaliO74933.
SMRiO74933. Positions 3-486.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00113; UER00533.
BRENDAi2.7.7.23. 1096.

Miscellaneous databases

EvolutionaryTraceiO74933.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUAP1_CANAX
AccessioniPrimary (citable) accession number: O74933
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.