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Protein

UDP-N-acetylglucosamine pyrophosphorylase

Gene

UAP1

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.

Pathwayi: UDP-N-acetyl-alpha-D-glucosamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. UDP-N-acetylglucosamine pyrophosphorylase (UAP1)
This subpathway is part of the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate, the pathway UDP-N-acetyl-alpha-D-glucosamine biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123UTPBy similarity1
Binding sitei199UTPBy similarity1
Binding sitei226UTP; via amide nitrogenBy similarity1
Binding sitei227SubstrateBy similarity1
Binding sitei257UTPBy similarity1
Binding sitei389UTPBy similarity1
Binding sitei421SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.7.7.23. 1096.
UniPathwayiUPA00113; UER00533.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine pyrophosphorylase (EC:2.7.7.23)
Gene namesi
Name:UAP1
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857711 – 486UDP-N-acetylglucosamine pyrophosphorylaseAdd BLAST486

Structurei

Secondary structure

1486
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 15Combined sources10
Helixi19 – 22Combined sources4
Helixi25 – 27Combined sources3
Helixi30 – 41Combined sources12
Beta strandi43 – 45Combined sources3
Helixi46 – 59Combined sources14
Helixi74 – 76Combined sources3
Beta strandi77 – 79Combined sources3
Turni80 – 82Combined sources3
Helixi85 – 100Combined sources16
Beta strandi104 – 113Combined sources10
Helixi115 – 117Combined sources3
Beta strandi120 – 122Combined sources3
Helixi123 – 125Combined sources3
Helixi136 – 155Combined sources20
Beta strandi164 – 169Combined sources6
Helixi171 – 173Combined sources3
Helixi174 – 183Combined sources10
Helixi185 – 188Combined sources4
Helixi191 – 193Combined sources3
Beta strandi194 – 198Combined sources5
Beta strandi201 – 203Combined sources3
Beta strandi209 – 212Combined sources4
Beta strandi214 – 216Combined sources3
Beta strandi222 – 224Combined sources3
Helixi227 – 229Combined sources3
Helixi230 – 236Combined sources7
Helixi239 – 246Combined sources8
Beta strandi250 – 255Combined sources6
Helixi266 – 275Combined sources10
Beta strandi278 – 285Combined sources8
Beta strandi295 – 299Combined sources5
Turni300 – 303Combined sources4
Beta strandi304 – 308Combined sources5
Helixi310 – 312Combined sources3
Helixi315 – 319Combined sources5
Beta strandi325 – 331Combined sources7
Beta strandi333 – 342Combined sources10
Helixi343 – 353Combined sources11
Turni357 – 359Combined sources3
Beta strandi363 – 367Combined sources5
Turni374 – 376Combined sources3
Beta strandi387 – 391Combined sources5
Helixi394 – 400Combined sources7
Helixi403 – 405Combined sources3
Beta strandi406 – 411Combined sources6
Helixi413 – 416Combined sources4
Beta strandi426 – 430Combined sources5
Helixi431 – 448Combined sources18
Helixi454 – 456Combined sources3
Turni463 – 465Combined sources3
Beta strandi467 – 469Combined sources3
Helixi473 – 475Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YQCX-ray1.90A1-486[»]
2YQHX-ray2.30A/B1-486[»]
2YQJX-ray2.31A/B1-486[»]
2YQSX-ray2.30A1-486[»]
ProteinModelPortaliO74933.
SMRiO74933.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO74933.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112UTP bindingBy similarity4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi109 – 112Substrate bindingBy similarity4
Motifi309 – 310Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

O74933-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVKSQQQII DSFKQANQDQ LFQYYDSLTI DQQQEFIDQL STIEEPAKLI
60 70 80 90 100
STVEQAIQFS QTNSTSRNFT QLPNEQTAST LDLSKDILQN WTELGLKAIG
110 120 130 140 150
NGEVAVLLMA GGQGTRLGSS APKGCFNIEL PSQKSLFQIQ AEKILKIEQL
160 170 180 190 200
AQQYLKSTKK PIINWYIMTS GPTRNATESF FIENNYFGLN SHQVIFFNQG
210 220 230 240 250
TLPCFNLQGN KILLESKNSI CQSPDGNGGL YKALKDNGIL DDLNSKGIKH
260 270 280 290 300
IHMYCVDNCL VKVADPIFIG FAIAKKFDLA TKVVRKRDAN ESVGLIVLDQ
310 320 330 340 350
DNQKPCVIEY SEISQELANK KDPQDSSKLF LRAANIVNHY YSVEFLNKMI
360 370 380 390 400
PKWISSQKYL PFHIAKKKIP SLNLENGEFY KPTEPNGIKL EQFIFDVFPS
410 420 430 440 450
VELNKFGCLE VDRLDEFSPL KNADGAKNDT PTTCRNHYLE RSSKWVIQNG
460 470 480
GVIDNQGLVE VDSKTSYGGE GLEFVNGKHF KNGDII
Length:486
Mass (Da):54,644
Last modified:November 1, 1998 - v1
Checksum:i6C488939A16870F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011003 Genomic DNA. Translation: BAA32334.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011003 Genomic DNA. Translation: BAA32334.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YQCX-ray1.90A1-486[»]
2YQHX-ray2.30A/B1-486[»]
2YQJX-ray2.31A/B1-486[»]
2YQSX-ray2.30A1-486[»]
ProteinModelPortaliO74933.
SMRiO74933.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00113; UER00533.
BRENDAi2.7.7.23. 1096.

Miscellaneous databases

EvolutionaryTraceiO74933.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUAP1_CANAX
AccessioniPrimary (citable) accession number: O74933
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.