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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Gene

TPS1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. ascospore formation Source: EnsemblFungi
  2. cellular response to oxidative stress Source: EnsemblFungi
  3. trehalose biosynthesis in response to heat stress Source: EnsemblFungi
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:TPS1
Ordered Locus Names:YALI0E14685g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300 Componenti: Chromosome E

Subcellular locationi

GO - Cellular componenti

  1. alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) Source: EnsemblFungi
  2. cytosol Source: EnsemblFungi
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Alpha,alpha-trehalose-phosphate synthase [UDP-forming]PRO_0000122501Add
BLAST

Proteomic databases

PRIDEiO74932.

Interactioni

Protein-protein interaction databases

STRINGi4952.O74932.

Structurei

3D structure databases

ProteinModelPortaliO74932.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 20 family.Curated

Phylogenomic databases

eggNOGiCOG0380.
HOGENOMiHOG000191477.
InParanoidiO74932.
KOiK00697.
OMAiIEFMPIH.
OrthoDBiEOG76QFS6.

Family and domain databases

InterProiIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.

Sequencei

Sequence statusi: Complete.

O74932-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNVLVISNR LPVTISREED GTYKYTMSSG GLVTALSGLK QSTTFQWFGW
60 70 80 90 100
PGLEIPEKDK PRLINDLETM FSCVPVFMDD DLADLHYNGF SNSILWPLFH
110 120 130 140 150
YHPGEMNFDQ VAWEAYTQAN RLFAKKVASI VKPGDIVWVH DYHLMLLPEM
160 170 180 190 200
LREECENNSA LDGLKIGFFL HTPFPSSEIY RILPVRKEVL TGVLSCNLIG
210 220 230 240 250
FHTYDYARHF LSSVSRILDL ETMPNGTYYK GRHVVVGAFP IGIDVNKFLE
260 270 280 290 300
GCKRPAVQER IAQLQDKFKG IKVVVGVDRL DYIKGVPQKL HAFEVFLSEH
310 320 330 340 350
PEWIGKVVLV QVAVPSRGLV EEYQNLRAVV NELVGRINGM FGTVEFTPIH
360 370 380 390 400
FMHRSVDFNE LIALYSISDV CFVSSTRDGM NLVSYEYVAC QTEKHGSLIL
410 420 430 440 450
SEFTGAAQSL NGALIVNPWN TEDMAEALYD SLTFSPEKKA ENHRKLFKYV
460
SKYTSQHWGE AFVSELKRC
Length:469
Mass (Da):53,259
Last modified:October 31, 1998 - v1
Checksum:iBCA5A82B98B0F23E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011032 mRNA. Translation: CAA09463.1.
CR382131 Genomic DNA. Translation: CAG79544.1.
RefSeqiXP_503951.1. XM_503951.1.

Genome annotation databases

EnsemblFungiiCAG79544; CAG79544; YALI0_E14685g.
GeneIDi2912305.
KEGGiyli:YALI0E14685g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011032 mRNA. Translation: CAA09463.1.
CR382131 Genomic DNA. Translation: CAG79544.1.
RefSeqiXP_503951.1. XM_503951.1.

3D structure databases

ProteinModelPortaliO74932.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4952.O74932.

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Proteomic databases

PRIDEiO74932.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG79544; CAG79544; YALI0_E14685g.
GeneIDi2912305.
KEGGiyli:YALI0E14685g.

Phylogenomic databases

eggNOGiCOG0380.
HOGENOMiHOG000191477.
InParanoidiO74932.
KOiK00697.
OMAiIEFMPIH.
OrthoDBiEOG76QFS6.

Family and domain databases

InterProiIPR001830. Glyco_trans_20.
IPR012766. Trehalose_OtsA.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02400. trehalose_OtsA. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the TPS1 gene from Yarrowia lipolytica."
    Petit T., Flores C.L., Gancedo C.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: PO1a.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIB 122 / E 150.

Entry informationi

Entry nameiTPS1_YARLI
AccessioniPrimary (citable) accession number: O74932
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 5, 2002
Last sequence update: October 31, 1998
Last modified: March 31, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.