O74932 (TPS1_YARLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
EC=2.4.1.15

Alternative name(s):
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase

Gene names

Name:	TPS1
Ordered Locus Names:	YALI0E14685g

Organism

Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]

Taxonomic identifier

284591 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia › Yarrowia lipolytica

Protein attributes

Sequence length	469 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.
Sequence similarities	Belongs to the glycosyltransferase 20 family.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	trehalose biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 469	469	Alpha,alpha-trehalose-phosphate synthase [UDP-forming]		PRO_0000122501

Sequences

	Sequence		Length	Mass (Da)
	O74932 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: BCA5A82B98B0F23E	FASTA	469	53,259
	10 20 30 40 50 60 MPNVLVISNR LPVTISREED GTYKYTMSSG GLVTALSGLK QSTTFQWFGW PGLEIPEKDK 70 80 90 100 110 120 PRLINDLETM FSCVPVFMDD DLADLHYNGF SNSILWPLFH YHPGEMNFDQ VAWEAYTQAN 130 140 150 160 170 180 RLFAKKVASI VKPGDIVWVH DYHLMLLPEM LREECENNSA LDGLKIGFFL HTPFPSSEIY 190 200 210 220 230 240 RILPVRKEVL TGVLSCNLIG FHTYDYARHF LSSVSRILDL ETMPNGTYYK GRHVVVGAFP 250 260 270 280 290 300 IGIDVNKFLE GCKRPAVQER IAQLQDKFKG IKVVVGVDRL DYIKGVPQKL HAFEVFLSEH 310 320 330 340 350 360 PEWIGKVVLV QVAVPSRGLV EEYQNLRAVV NELVGRINGM FGTVEFTPIH FMHRSVDFNE 370 380 390 400 410 420 LIALYSISDV CFVSSTRDGM NLVSYEYVAC QTEKHGSLIL SEFTGAAQSL NGALIVNPWN 430 440 450 460 TEDMAEALYD SLTFSPEKKA ENHRKLFKYV SKYTSQHWGE AFVSELKRC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the TPS1 gene from Yarrowia lipolytica." Petit T., Flores C.L., Gancedo C. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: PO1a.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ011032 mRNA. Translation: CAA09463.1. CR382131 Genomic DNA. Translation: CAG79544.1.
RefSeq	XP_503951.1. XM_503951.1.
3D structure databases
ProteinModelPortal	O74932.
ModBase	Search...
Protein-protein interaction databases
STRING	4952.O74932.
Protein family/group databases
CAZy	GT20. Glycosyltransferase Family 20.
Proteomic databases
PRIDE	O74932.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2912305.
KEGG	yli:YALI0E14685g.
Phylogenomic databases
eggNOG	COG0380.
HOGENOM	HOG000191477.
KO	K00697.
OMA	EYGRKEM.
OrthoDB	EOG4KPXK7.
Family and domain databases
InterPro	IPR001830. Glyco_trans_20. IPR012766. Trehalose_OtsA. [Graphical view]
Pfam	PF00982. Glyco_transf_20. 1 hit. [Graphical view]
TIGRFAMs	TIGR02400. trehalose_OtsA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TPS1_YARLI

Accession

Primary (citable) accession number: O74932

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program