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O74928

- PUR9_SCHPO

UniProt

O74928 - PUR9_SCHPO

Protein

Bifunctional purine biosynthesis protein ade10

Gene

ade10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: PomBase
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: PomBase

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: PomBase
    2. IMP biosynthetic process Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    ReactomeiREACT_207552. Purine ribonucleoside monophosphate biosynthesis.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein ade10
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
    Alternative name(s):
    5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
    AICAR transformylase
    IMP cyclohydrolase (EC:3.5.4.10)
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
    Gene namesi
    Name:ade10
    ORF Names:SPCPB16A4.03c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCPB16A4.03c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 585585Bifunctional purine biosynthesis protein ade10PRO_0000192158Add
    BLAST

    Proteomic databases

    MaxQBiO74928.
    PaxDbiO74928.
    PRIDEiO74928.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi276129. 12 interactions.
    MINTiMINT-4681916.
    STRINGi4896.SPCPB16A4.03c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO74928.
    SMRiO74928. Positions 3-585.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.By similarity

    Sequence similaritiesi

    Belongs to the PurH family.Curated

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230372.
    KOiK00602.
    OMAiAGDKANC.
    OrthoDBiEOG7HXD0J.
    PhylomeDBiO74928.

    Family and domain databases

    Gene3Di1.10.287.440. 1 hit.
    3.40.140.20. 3 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR024050. AICAR_Tfase_insert_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O74928-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYALLSVYDK TGLLELAKAL TSKGVKLLGS GGTAKMIRES GMEVADVSSI    50
    TNAPEILGGR VKTLHPAVHG GILARDIPSD EKDLVEQSIE KIDIVVCNLY 100
    PFRETIAKPN VTIPEAVEEI DIGGVTLLRA AAKNHARVTI LSDPADYATF 150
    TDKFLSDKLT QDDRNTYALK AFASTASYDA AITDYFRKQY AAGVDQLTLR 200
    YGANPHQSPA QAFMEQGPLP FKVLCGSPGY INLMDALNSW PLVKELRENI 250
    GIPAAASFKH VSPAGAAVGL PLSDVEKKVY FVSDITEFTP LACAYARARG 300
    ADRMSSFGDF IALSDTVDVC TARIISREVS DGVIAPGYEP EALELLKKKK 350
    GGKYCVLQMD PKYVPAEIET RQVYGISLQQ HRNHAKIDFS LFEKVVSKNK 400
    DLPKSALIDL VIATTALKYT QSNSVCYAKN GMVVGLGAGQ QSRIHCNRLA 450
    GDKADNWWLR HHPKVLGMQF KKSAKRPEKS NAIDLYVLDA VPAEGSEREQ 500
    WESAFETIPE PLTKKEREEF LATCKDVVCA SDAFFPFPDN IYRLAQSGVK 550
    YVAAPGGSVM DQAVRDTANE FNMVFSEIPL RLFHH 585
    Length:585
    Mass (Da):64,123
    Last modified:November 1, 1998 - v1
    Checksum:i103031D3F957529F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti404 – 4041K → Q in BAA13904. (PubMed:9501991)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16419 Genomic DNA. Translation: CAA76207.1.
    CU329672 Genomic DNA. Translation: CAC39322.1.
    D89243 mRNA. Translation: BAA13904.1.
    PIRiT43150.
    RefSeqiNP_588027.1. NM_001023018.2.

    Genome annotation databases

    EnsemblFungiiSPCPB16A4.03c.1; SPCPB16A4.03c.1:pep; SPCPB16A4.03c.
    GeneIDi2539569.
    KEGGispo:SPCPB16A4.03c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16419 Genomic DNA. Translation: CAA76207.1 .
    CU329672 Genomic DNA. Translation: CAC39322.1 .
    D89243 mRNA. Translation: BAA13904.1 .
    PIRi T43150.
    RefSeqi NP_588027.1. NM_001023018.2.

    3D structure databases

    ProteinModelPortali O74928.
    SMRi O74928. Positions 3-585.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 276129. 12 interactions.
    MINTi MINT-4681916.
    STRINGi 4896.SPCPB16A4.03c-1.

    Proteomic databases

    MaxQBi O74928.
    PaxDbi O74928.
    PRIDEi O74928.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCPB16A4.03c.1 ; SPCPB16A4.03c.1:pep ; SPCPB16A4.03c .
    GeneIDi 2539569.
    KEGGi spo:SPCPB16A4.03c.

    Organism-specific databases

    PomBasei SPCPB16A4.03c.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230372.
    KOi K00602.
    OMAi AGDKANC.
    OrthoDBi EOG7HXD0J.
    PhylomeDBi O74928.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    Reactomei REACT_207552. Purine ribonucleoside monophosphate biosynthesis.

    Miscellaneous databases

    NextBioi 20800728.
    PROi O74928.

    Family and domain databases

    Gene3Di 1.10.287.440. 1 hit.
    3.40.140.20. 3 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR024050. AICAR_Tfase_insert_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequence analysis of the Schizosaccharomyces pombe ade10+ gene."
      Liedtke C., Schmidt H.
      Yeast 14:1307-1310(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    3. "Identification of open reading frames in Schizosaccharomyces pombe cDNAs."
      Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H.
      DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 166-585.
      Strain: PR745.

    Entry informationi

    Entry nameiPUR9_SCHPO
    AccessioniPrimary (citable) accession number: O74928
    Secondary accession number(s): P78892
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3