O74927 (MTHR2_SCHPO) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 89.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Methylenetetrahydrofolate reductase 2 EC=1.5.1.20 | ||||||
| Gene names |
| ||||||
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome] | ||||||
| Taxonomic identifier | 284812 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › ![]() |
Protein attributes
| Sequence length | 641 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Catalytic activity | 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. |
| Cofactor | FAD By similarity. |
| Pathway | |
| Sequence similarities | Belongs to the methylenetetrahydrofolate reductase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | FAD Flavoprotein NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | methionine biosynthetic process Inferred from direct assay PubMed 12112238. Source: PomBase tetrahydrofolate interconversionInferred from electronic annotation. Source: UniProtKB-UniPathway |
| Cellular_component | cytoplasm Inferred from sequence orthology. Source: PomBase |
| Molecular_function | methylenetetrahydrofolate reductase (NADPH) activity Inferred from direct assay PubMed 12112238. Source: PomBase |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 641 | 641 | Methylenetetrahydrofolate reductase 2 | PRO_0000190254 | |||||
Experimental info | |||||||||
| Sequence conflict | 202 | 1 | E → D in BAA13780. Ref.3 | ||||||
| Sequence conflict | 281 | 1 | G → A in BAA13780. Ref.3 | ||||||
| Sequence conflict | 455 | 1 | A → V in BAA13780. Ref.3 | ||||||
| Sequence conflict | 537 – 641 | 105 | QVTYY…LEIDF → HVRSNFSSSISDSTCFQRLV SKPLFLRIRATDRSKFSVQK in BAA13780. Ref.3 | ||||||
| Sequence conflict | 614 | 1 | I → L in CAA09738. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Naula N. Thesis (1998), University of Bern, Switzerland Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 38364 / 968. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843. |
| [3] | "Identification of open reading frames in Schizosaccharomyces pombe cDNAs." Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H. DNA Res. 4:363-369(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 11-641. Strain: PR745. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AJ011686 Genomic DNA. Translation: CAA09738.1. CU329670 Genomic DNA. Translation: CAB52273.1. D89118 mRNA. Translation: BAA13780.1. |
| PIR | T38659. |
| RefSeq | NP_593430.1. NM_001018863.2. |
3D structure databases | |
| ProteinModelPortal | O74927. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 4896.SPAC343.10-1. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | SPAC343.10.1; SPAC343.10.1:pep; SPAC343.10. |
| GeneID | 2543105. |
| KEGG | spo:SPAC343.10. |
Organism-specific databases | |
| PomBase | SPAC343.10. |
Phylogenomic databases | |
| eggNOG | COG0685. |
| HOGENOM | HOG000246234. |
| KO | K00297. |
| OMA | YGEIDGY. |
| OrthoDB | EOG444PTG. |
Enzyme and pathway databases | |
| UniPathway | UPA00193. |
Family and domain databases | |
| InterPro | IPR004621. Fadh2_euk. IPR003171. Mehydrof_redctse. [Graphical view] |
| Pfam | PF02219. MTHFR. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00677. fadh2_euk. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 20804132. |
Entry information
| Entry name | MTHR2_SCHPO | ||||||||
| Accession | Primary (citable) accession number: O74927 Secondary accession number(s): P78770, Q9UT80 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
