UniProtKB - O74922 (AMY1_SCHPO)
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Protein
Alpha-amylase 1
Gene
aah1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Catalytic activityi
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.
Cofactori
Ca2+By similarityNote: Binds 2 calcium ions per subunit. Calcium is inhibitory at high concentrations.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 105 | SubstrateBy similarity | 1 | |
Metal bindingi | 143 | Calcium 1By similarity | 1 | |
Metal bindingi | 185 | Calcium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 198 | Calcium 1By similarity | 1 | |
Binding sitei | 227 | SubstrateBy similarity | 1 | |
Active sitei | 229 | NucleophileBy similarity | 1 | |
Metal bindingi | 229 | Calcium 2By similarity | 1 | |
Active sitei | 253 | Proton donorBy similarity | 1 | |
Metal bindingi | 253 | Calcium 2By similarity | 1 | |
Binding sitei | 322 | SubstrateBy similarity | 1 | |
Sitei | 322 | Transition state stabilizerBy similarity | 1 | |
Binding sitei | 370 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- alpha-amylase activity Source: UniProtKB-EC
- alpha-amylase activity (releasing maltohexaose) Source: UniProtKB-EC
- calcium ion binding Source: InterPro
GO - Biological processi
- carbohydrate catabolic process Source: InterPro
- fungal-type cell wall biogenesis Source: PomBase
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Biological process | Carbohydrate metabolism |
Ligand | Calcium, Metal-binding |
Protein family/group databases
CAZyi | GH13 Glycoside Hydrolase Family 13 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-amylase 1 (EC:3.2.1.1)Alternative name(s): 1,4-alpha-D-glucan glucanohydrolase |
Gene namesi | Name:aah1 ORF Names:SPCC757.12 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPCC757.12 |
PomBasei | SPCC757.12 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000374015 | 23 – 603 | Alpha-amylase 1Add BLAST | 581 | |
PropeptideiPRO_0000374016 | 604 – 625 | Removed in mature formSequence analysisAdd BLAST | 22 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 51 ↔ 59 | By similarity | ||
Glycosylationi | 153 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 163 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 172 ↔ 187 | By similarity | ||
Glycosylationi | 180 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 241 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 260 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 263 ↔ 306 | By similarity | ||
Glycosylationi | 286 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 331 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 440 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 461 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 603 | GPI-anchor amidated serineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
MaxQBi | O74922 |
PaxDbi | O74922 |
PRIDEi | O74922 |
Interactioni
Protein-protein interaction databases
BioGridi | 2754069 interactors. |
STRINGi | 4896.SPCC757.12.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 232 – 233 | Substrate bindingBy similarity | 2 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 502 – 604 | Ser-richAdd BLAST | 103 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 13 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
HOGENOMi | HOG000165530 |
InParanoidi | O74922 |
KOi | K01176 |
OMAi | HTTWIKS |
OrthoDBi | EOG092C1HLH |
PhylomeDBi | O74922 |
Family and domain databases
Gene3Di | 2.60.40.11801 hit |
InterProi | View protein in InterPro IPR013777 A-amylase-like IPR015340 A_amylase_DUF1966_C IPR006047 Glyco_hydro_13_cat_dom IPR013780 Glyco_hydro_b IPR017853 Glycoside_hydrolase_SF |
Pfami | View protein in Pfam PF00128 Alpha-amylase, 1 hit PF09260 DUF1966, 1 hit |
PIRSFi | PIRSF001024 Alph-amyl_fung, 1 hit |
SMARTi | View protein in SMART SM00642 Aamy, 1 hit |
SUPFAMi | SSF51445 SSF51445, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O74922-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGFSKIALFS LFALFGLPTS LAKSSEEWRD RIIYQVITDR FAVDSDNTPD
60 70 80 90 100
CSFDDSSYCG GTWSGIRSKL DYIQGMGFNA IWISPVEKNL EGSYGSDGEA
110 120 130 140 150
YHGYWNTDFT QLNEHFGSED DLIDLITDMH NRDMWIMFDA LANSMAIPGP
160 170 180 190 200
TDNISYSNLV PFNDSSYFHP YCWIDYGSNN NTDIEDCWTG DDNVILADLD
210 220 230 240 250
IESTNVADYL HEHIHDMVER YQIDGIRIDA VKQMNPEFFP NYTSAAGVFA
260 270 280 290 300
IGEMFSYDPN VSCSVRNYLD SITSYPIRQG IEFAFNYTGA AFEYLQEIDT
310 320 330 340 350
QFQQACEGQD MSVIGNFLEN HDLPRYTSIT NDTSQDIGAI VFLLLHTGIP
360 370 380 390 400
IIYYGEEQRL PGGSDTPENR AALWNYGYDT DANYYQTIRT AIALRKQAIS
410 420 430 440 450
DSDSWTTDSH SYLDYDLRHA VVRKGDVLGV YTNYESSSDN VTYDVSSNFD
460 470 480 490 500
DGTVLREVLS NTTTTVGSSG ALHVTVVSGL PQVYYPEASL TSFGNFLGTA
510 520 530 540 550
TSYSSASASY PSTSMSASLS SVHTSSATSS SKSSSSSSSR SGSSSSSSSR
560 570 580 590 600
SGSTSSSGSS HTITSTSQSV HTSGSSTSTS SVAVTSTAYS SSSSSSSSSS
610 620
IESSANAVRV SILGVAAFIA IVLFI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329672 Genomic DNA Translation: CAA21237.1 |
PIRi | T41603 |
RefSeqi | NP_587687.1, NM_001022682.2 |
Genome annotation databases
EnsemblFungii | SPCC757.12.1; SPCC757.12.1:pep; SPCC757.12 |
GeneIDi | 2538825 |
KEGGi | spo:SPCC757.12 |
Similar proteinsi
Entry informationi
Entry namei | AMY1_SCHPO | |
Accessioni | O74922Primary (citable) accession number: O74922 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 28, 2018 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |