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O74918

- RRP45_SCHPO

UniProt

O74918 - RRP45_SCHPO

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Protein
Exosome complex component rrp45
Gene
rrp45, SPCC757.08
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. ski6 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation By similarity.

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: PomBase
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: PomBase
  2. ncRNA catabolic process Source: PomBase
  3. nonfunctional rRNA decay Source: PomBase
  4. nuclear polyadenylation-dependent mRNA catabolic process Source: PomBase
  5. nuclear polyadenylation-dependent rRNA catabolic process Source: PomBase
  6. nuclear polyadenylation-dependent tRNA catabolic process Source: PomBase
  7. nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay Source: PomBase
  8. nuclear-transcribed mRNA catabolic process, non-stop decay Source: PomBase
Complete GO annotation...

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome complex component rrp45
Alternative name(s):
Ribosomal RNA-processing protein 45
Gene namesi
Name:rrp45
ORF Names:SPCC757.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC757.08.

Subcellular locationi

Cytoplasm. Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. cytoplasmic exosome (RNase complex) Source: PomBase
  2. cytosol Source: PomBase
  3. exosome (RNase complex) Source: PomBase
  4. nuclear exosome (RNase complex) Source: PomBase
  5. nucleolus Source: UniProtKB-SubCell
  6. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Exosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Exosome complex component rrp45
PRO_0000139973Add
BLAST

Proteomic databases

MaxQBiO74918.

Interactioni

Subunit structurei

Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which associates with catalytic subunits dis3 and rrp6 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits and peripheral S1 domain-containing components csl4, rrp4 and rrp40 located on the top of the ring structure By similarity.

Protein-protein interaction databases

BioGridi275678. 3 interactions.
MINTiMINT-4681826.
STRINGi4896.SPCC757.08-1.

Structurei

3D structure databases

ProteinModelPortaliO74918.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase PH family.

Phylogenomic databases

eggNOGiCOG2123.
HOGENOMiHOG000229504.
KOiK03678.
OMAiCWSVRVD.
OrthoDBiEOG79CZ8V.
PhylomeDBiO74918.

Family and domain databases

Gene3Di3.30.230.70. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 2 hits.
SSF55666. SSF55666. 1 hit.

Sequencei

Sequence statusi: Complete.

O74918-1 [UniParc]FASTAAdd to Basket

« Hide

MSRHLETSLN NKEFVLNSLE KGLRLDGRQL SDFRSLEIQF GKEYGQVDVS    50
FGHTRVMARI TTEITKPYTD RPFDGIFSIT TELTPLAYSA FEAGRVSDQE 100
IVISRLIEKA VRRSNALDTE SLCIISGQKC WHVRASVHFI NHDGNLVDAA 150
CIAVIAALCH FRRPELTVVG EEVTVHPVEE RVPVPLSILH MPICVTFSFF 200
NNGELAIVDA TLEEEDLCNG SMTITLNKNR EVCQIYKAGG IIIDPSKIIS 250
CAKTAFDIAV SVCSVIQQAL DEDLRKKETQ YLGGSAENER S 291
Length:291
Mass (Da):32,378
Last modified:November 1, 1998 - v1
Checksum:iDA0E97C737EC3EAC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA21233.1.
PIRiT41599.
RefSeqiNP_587683.1. NM_001022678.2.

Genome annotation databases

EnsemblFungiiSPCC757.08.1; SPCC757.08.1:pep; SPCC757.08.
GeneIDi2539106.
KEGGispo:SPCC757.08.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA21233.1 .
PIRi T41599.
RefSeqi NP_587683.1. NM_001022678.2.

3D structure databases

ProteinModelPortali O74918.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275678. 3 interactions.
MINTi MINT-4681826.
STRINGi 4896.SPCC757.08-1.

Proteomic databases

MaxQBi O74918.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC757.08.1 ; SPCC757.08.1:pep ; SPCC757.08 .
GeneIDi 2539106.
KEGGi spo:SPCC757.08.

Organism-specific databases

PomBasei SPCC757.08.

Phylogenomic databases

eggNOGi COG2123.
HOGENOMi HOG000229504.
KOi K03678.
OMAi CWSVRVD.
OrthoDBi EOG79CZ8V.
PhylomeDBi O74918.

Miscellaneous databases

NextBioi 20800278.
PROi O74918.

Family and domain databases

Gene3Di 3.30.230.70. 1 hit.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view ]
Pfami PF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 2 hits.
SSF55666. SSF55666. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRRP45_SCHPO
AccessioniPrimary (citable) accession number: O74918
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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