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O74918

- RRP45_SCHPO

UniProt

O74918 - RRP45_SCHPO

Protein

Exosome complex component rrp45

Gene

rrp45

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. ski6 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation By similarity.By similarity

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: PomBase
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: PomBase
    2. ncRNA catabolic process Source: PomBase
    3. nonfunctional rRNA decay Source: PomBase
    4. nuclear polyadenylation-dependent mRNA catabolic process Source: PomBase
    5. nuclear polyadenylation-dependent rRNA catabolic process Source: PomBase
    6. nuclear polyadenylation-dependent tRNA catabolic process Source: PomBase
    7. nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay Source: PomBase
    8. nuclear-transcribed mRNA catabolic process, non-stop decay Source: PomBase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exosome complex component rrp45
    Alternative name(s):
    Ribosomal RNA-processing protein 45
    Gene namesi
    Name:rrp45
    ORF Names:SPCC757.08
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC757.08.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. cytoplasmic exosome (RNase complex) Source: PomBase
    2. cytosol Source: PomBase
    3. exosome (RNase complex) Source: PomBase
    4. nuclear exosome (RNase complex) Source: PomBase
    5. nucleolus Source: UniProtKB-SubCell
    6. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Exosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Exosome complex component rrp45PRO_0000139973Add
    BLAST

    Proteomic databases

    MaxQBiO74918.

    Interactioni

    Subunit structurei

    Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which associates with catalytic subunits dis3 and rrp6 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits and peripheral S1 domain-containing components csl4, rrp4 and rrp40 located on the top of the ring structure By similarity.By similarity

    Protein-protein interaction databases

    BioGridi275678. 3 interactions.
    MINTiMINT-4681826.
    STRINGi4896.SPCC757.08-1.

    Structurei

    3D structure databases

    ProteinModelPortaliO74918.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNase PH family.Curated

    Phylogenomic databases

    eggNOGiCOG2123.
    HOGENOMiHOG000229504.
    KOiK03678.
    OMAiCWSVRVD.
    OrthoDBiEOG79CZ8V.
    PhylomeDBiO74918.

    Family and domain databases

    Gene3Di3.30.230.70. 1 hit.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR027408. PNPase/RNase_PH_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view]
    PfamiPF01138. RNase_PH. 1 hit.
    PF03725. RNase_PH_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 2 hits.
    SSF55666. SSF55666. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O74918-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRHLETSLN NKEFVLNSLE KGLRLDGRQL SDFRSLEIQF GKEYGQVDVS    50
    FGHTRVMARI TTEITKPYTD RPFDGIFSIT TELTPLAYSA FEAGRVSDQE 100
    IVISRLIEKA VRRSNALDTE SLCIISGQKC WHVRASVHFI NHDGNLVDAA 150
    CIAVIAALCH FRRPELTVVG EEVTVHPVEE RVPVPLSILH MPICVTFSFF 200
    NNGELAIVDA TLEEEDLCNG SMTITLNKNR EVCQIYKAGG IIIDPSKIIS 250
    CAKTAFDIAV SVCSVIQQAL DEDLRKKETQ YLGGSAENER S 291
    Length:291
    Mass (Da):32,378
    Last modified:November 1, 1998 - v1
    Checksum:iDA0E97C737EC3EAC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA21233.1.
    PIRiT41599.
    RefSeqiNP_587683.1. NM_001022678.2.

    Genome annotation databases

    EnsemblFungiiSPCC757.08.1; SPCC757.08.1:pep; SPCC757.08.
    GeneIDi2539106.
    KEGGispo:SPCC757.08.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA21233.1 .
    PIRi T41599.
    RefSeqi NP_587683.1. NM_001022678.2.

    3D structure databases

    ProteinModelPortali O74918.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275678. 3 interactions.
    MINTi MINT-4681826.
    STRINGi 4896.SPCC757.08-1.

    Proteomic databases

    MaxQBi O74918.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC757.08.1 ; SPCC757.08.1:pep ; SPCC757.08 .
    GeneIDi 2539106.
    KEGGi spo:SPCC757.08.

    Organism-specific databases

    PomBasei SPCC757.08.

    Phylogenomic databases

    eggNOGi COG2123.
    HOGENOMi HOG000229504.
    KOi K03678.
    OMAi CWSVRVD.
    OrthoDBi EOG79CZ8V.
    PhylomeDBi O74918.

    Miscellaneous databases

    NextBioi 20800278.
    PROi O74918.

    Family and domain databases

    Gene3Di 3.30.230.70. 1 hit.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR027408. PNPase/RNase_PH_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view ]
    Pfami PF01138. RNase_PH. 1 hit.
    PF03725. RNase_PH_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 2 hits.
    SSF55666. SSF55666. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRRP45_SCHPO
    AccessioniPrimary (citable) accession number: O74918
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3