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Protein

Probable tRNA-splicing endonuclease subunit sen54

Gene

sen54

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. May be required to embody the molecular ruler of the complex (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA-splicing endonuclease subunit sen54
Alternative name(s):
tRNA-intron endonuclease sen54
Gene namesi
Name:sen54
ORF Names:SPCC613.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC613.09.
PomBaseiSPCC613.09. sen54.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Probable tRNA-splicing endonuclease subunit sen54PRO_0000194033Add
BLAST

Proteomic databases

MaxQBiO74908.

Interactioni

Subunit structurei

tRNA splicing endonuclease is a heterotetramer composed of sen2, sen15, sen34 and sen54. Interacts directly with sen2 (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-4681764.

Structurei

3D structure databases

ProteinModelPortaliO74908.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEN54 family.Curated

Phylogenomic databases

HOGENOMiHOG000216526.
InParanoidiO74908.
KOiK15326.
OMAiRIHRGDA.
OrthoDBiEOG092C3DBL.
PhylomeDBiO74908.

Family and domain databases

InterProiIPR024337. tRNA_splic_suSen54.
IPR024336. tRNA_splic_suSen54_N.
[Graphical view]
PANTHERiPTHR21027. PTHR21027. 1 hit.
PfamiPF12928. tRNA_int_end_N2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74908-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAQDEDNPF TNLETTVDVT EEIQDWRFLS NVEKDQGTYT IPKRGQKDFE
60 70 80 90 100
PDGTNKQHSA LDLSRKAMFD ALSVERLISA KHAIIATWNA QNGMSCVEKA
110 120 130 140 150
HGPLFKTMGT ADSQNRMWLL PEETLYLVER GSMECWSEEG LPMSLQAVYS
160 170 180 190 200
ASIPLCGSLE NYLVYAHLRR CGFSVIRSNL VPVKEDEYRC DSKIMNFKDL
210 220 230 240 250
LFLGLGKASQ ILQTFNFRKL AFPFSKRRRQ SILLHDTFYT YEEVYHDLQI
260 270 280 290 300
VRGYVPIACN LITSSDSLFQ ITFHAYKPSA SFKKSALSEP DFRICVVSSQ
310 320 330 340 350
DTLLPTIFEI DALFSSTPLR QNMPQHMFQR LKEGYRNIII AIVDYGVISY
360 370 380
IRLSDVCFEE KVYTDFSKKG SKRKRVSKKF QQLV
Length:384
Mass (Da):44,151
Last modified:November 1, 1998 - v1
Checksum:i69AA96FD3AF30636
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21061.1.
PIRiT41475.
RefSeqiNP_587697.1. NM_001022692.2.

Genome annotation databases

EnsemblFungiiSPCC613.09.1; SPCC613.09.1:pep; SPCC613.09.
GeneIDi2538979.
KEGGispo:SPCC613.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21061.1.
PIRiT41475.
RefSeqiNP_587697.1. NM_001022692.2.

3D structure databases

ProteinModelPortaliO74908.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4681764.

Proteomic databases

MaxQBiO74908.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC613.09.1; SPCC613.09.1:pep; SPCC613.09.
GeneIDi2538979.
KEGGispo:SPCC613.09.

Organism-specific databases

EuPathDBiFungiDB:SPCC613.09.
PomBaseiSPCC613.09. sen54.

Phylogenomic databases

HOGENOMiHOG000216526.
InParanoidiO74908.
KOiK15326.
OMAiRIHRGDA.
OrthoDBiEOG092C3DBL.
PhylomeDBiO74908.

Miscellaneous databases

PROiO74908.

Family and domain databases

InterProiIPR024337. tRNA_splic_suSen54.
IPR024336. tRNA_splic_suSen54_N.
[Graphical view]
PANTHERiPTHR21027. PTHR21027. 1 hit.
PfamiPF12928. tRNA_int_end_N2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEN54_SCHPO
AccessioniPrimary (citable) accession number: O74908
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.