rpt3

Functionⁱ

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	175 – 182	ATPSequence analysis		8

GO - Molecular functionⁱ

ATPase activity Source: PomBase
ATP binding Source: UniProtKB-KW
proteasome-activating ATPase activity Source: GO_Central
TBP-class protein binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

CENP-A containing chromatin organization
Source: PomBase
Inferred from mutant phenotypeⁱ
- 24710126
positive regulation of mitotic metaphase/anaphase transition Source: PomBase
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: GO_Central
proteasome-mediated ubiquitin-dependent protein catabolic process Source: PomBase
ubiquitin-dependent ERAD pathway Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	ATP-binding, Nucleotide-binding

Ligand

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes). R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1. R-SPO-5689603. UCH proteinases. R-SPO-5689880. Ub-specific processing proteases. R-SPO-68949. Orc1 removal from chromatin. R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6. R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A. R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis. R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Reactomeⁱ

R-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-5689603. UCH proteinases.
R-SPO-5689880. Ub-specific processing proteases.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 26S proteasome regulatory subunit 6B homolog
Gene namesⁱ	Name:rpt3 ORF Names:SPCC576.10c
Organismⁱ	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifierⁱ	284812 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe
Proteomesⁱ	UP000002485 Componentⁱ: Chromosome III

Organism-specific databases

EuPathDBⁱ	FungiDB:SPCC576.10c.
PomBaseⁱ	SPCC576.10c. rpt3.

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus, Proteasome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000084696	1 – 389	26S proteasome regulatory subunit 6B homologAdd BLAST		389

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O74894.
PaxDbⁱ	O74894.
PRIDEⁱ	O74894.

PTM databases

iPTMnetⁱ	O74894.

iPTMnetⁱ

O74894.

Interactionⁱ

GO - Molecular functionⁱ

TBP-class protein binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	276101. 13 interactors.
STRINGⁱ	4896.SPCC576.10c.1.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O74894.
SMRⁱ	O74894.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

HOGENOMⁱ	HOG000225143.
InParanoidⁱ	O74894.
KEGG Orthology (KO) More...KOⁱ	K03063.
OMAⁱ	LIIRNDP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C19WS.
PhylomeDBⁱ	O74894.

Family and domain databases

InterProⁱ	View protein in InterPro IPR005937. 26S_Psome_P45-like. IPR003593. AAA+_ATPase. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. IPR027417. P-loop_NTPase. IPR035256. PSMC4.
PANTHERⁱ	PTHR23073:SF8. PTHR23073:SF8. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00004. AAA. 1 hit.
SMARTⁱ	View protein in SMART SM00382. AAA. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR01242. 26Sp45. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00674. AAA. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

O74894-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNSTEEIDLY NRWKALERQL EMLDLQEGFI KEDCKSLKRE LIRAQEEVKR 
        60         70         80         90        100
IQSVPLVIGQ FLEAIDQNTA IVGSTTGSNY VVRILSTLDR ELLKPSASVA 
       110        120        130        140        150
LQRHSNALVD ILPPEADSSI SMLRPDERPD VSYADVGGLD VQKQEVREAV 
       160        170        180        190        200
ELPLTQGDLY RQIGIDPPRG VLLYGPPGTG KTMLVKAVAN STAANFIRVV 
       210        220        230        240        250
GSEFVQKYLG EGPRMVRDVF RMARENAPAI IFIDEIDAIA TKRFDAQTGA 
       260        270        280        290        300
DREVQRILIE LLTQMDGFDQ GANVKVIMAT NRADTLDPAL LRPGRLDRKI 
       310        320        330        340        350
EFPSYRDRRQ RRLVFQTITA KMLLSPEVDL DTFIMRPDAS SGAQIAAIMQ 
       360        370        380 
DAGLLAVRKS RGVILQSDIE EAYARAVKPT DMEQFAFYK

Length:389

Mass (Da):43,553

Last modified:November 1, 1998 - v1

Checksum:ⁱ24504B23D40F322A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CU329672 Genomic DNA. Translation: CAA21189.1.
PIRⁱ	T41420.
NCBI Reference Sequences More...RefSeqⁱ	NP_588437.1. NM_001023428.2.

Genome annotation databases

EnsemblFungiⁱ	SPCC576.10c.1; SPCC576.10c.1:pep; SPCC576.10c.
GeneIDⁱ	2539539.
KEGGⁱ	spo:SPCC576.10c.

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O74894	S9Q1P5 B6K6X7 S9VZL2	Schizosaccharomyces octosporus (strain yFS286) (Fission yeast) (Octosporomyces octosporus) Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast) Schizosaccharomyces cryophilus (strain OY26 / ATCC MYA-4695 / CBS 11777 / NBRC 106824 / NRRL Y48691) (Fission yeast)	389	UniRef90_O74894	Cluster: 26S proteasome regulatory subunit 6B homolog	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
O74894	B6K6X7 S9VZL2 S9Q1P5 T0L2W3 I7AP72 I6TLE8 E0S8B7 M1KMM2 Q8SQI9 E0S9F0 +93	Schizosaccharomyces japonicus (strain yFS275 / FY16936) (Fission yeast) Schizosaccharomyces cryophilus (strain OY26 / ATCC MYA-4695 / CBS 11777 / NBRC 106824 / NRRL Y48691) (Fission yeast) Schizosaccharomyces octosporus (strain yFS286) (Fission yeast) (Octosporomyces octosporus) Nosema apis BRL 01 Encephalitozoon romaleae (strain SJ-2008) (Microsporidian parasite) Encephalitozoon hellem (strain ATCC 50504) (Microsporidian parasite) Encephalitozoon intestinalis (strain ATCC 50506) (Microsporidian parasite) (Septata intestinalis) Encephalitozoon cuniculi (Microsporidian parasite) Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) Pseudocohnilembus persalinus (Ciliate) And more	389	UniRef50_O74894	Cluster: 26S proteasome regulatory subunit 6B homolog	104

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CU329672 Genomic DNA. Translation: CAA21189.1.
PIRⁱ	T41420.
NCBI Reference Sequences More...RefSeqⁱ	NP_588437.1. NM_001023428.2.

3D structure databases

ProteinModelPortalⁱ	O74894.
SMRⁱ	O74894.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	276101. 13 interactors.
STRINGⁱ	4896.SPCC576.10c.1.

PTM databases

iPTMnetⁱ	O74894.

iPTMnetⁱ

O74894.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O74894.
PaxDbⁱ	O74894.
PRIDEⁱ	O74894.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	SPCC576.10c.1; SPCC576.10c.1:pep; SPCC576.10c.
GeneIDⁱ	2539539.
KEGGⁱ	spo:SPCC576.10c.

Organism-specific databases

EuPathDBⁱ	FungiDB:SPCC576.10c.
PomBaseⁱ	SPCC576.10c. rpt3.

Phylogenomic databases

HOGENOMⁱ	HOG000225143.
InParanoidⁱ	O74894.
KEGG Orthology (KO) More...KOⁱ	K03063.
OMAⁱ	LIIRNDP.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C19WS.
PhylomeDBⁱ	O74894.

Enzyme and pathway databases

Reactomeⁱ	R-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes). R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1. R-SPO-5689603. UCH proteinases. R-SPO-5689880. Ub-specific processing proteases. R-SPO-68949. Orc1 removal from chromatin. R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6. R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A. R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis. R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Reactomeⁱ

R-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-5689603. UCH proteinases.
R-SPO-5689880. Ub-specific processing proteases.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O74894.

PROⁱ

PR:O74894.

Family and domain databases

InterProⁱ	View protein in InterPro IPR005937. 26S_Psome_P45-like. IPR003593. AAA+_ATPase. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. IPR027417. P-loop_NTPase. IPR035256. PSMC4.
PANTHERⁱ	PTHR23073:SF8. PTHR23073:SF8. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00004. AAA. 1 hit.
SMARTⁱ	View protein in SMART SM00382. AAA. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
TIGRFAMsⁱ	TIGR01242. 26Sp45. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00674. AAA. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRS6B_SCHPO
Accessionⁱ	O74894Primary (citable) accession number: O74894
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
	Last sequence update:	November 1, 1998
	Last modified:	February 28, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O74894 (PRS6B_SCHPO)

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26S proteasome regulatory subunit 6B homolog

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ