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Protein

26S proteasome regulatory subunit 6B homolog

Gene

rpt3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi175 – 182ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-SPO-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-SPO-5689603. UCH proteinases.
R-SPO-5689880. Ub-specific processing proteases.
R-SPO-68949. Orc1 removal from chromatin.
R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome regulatory subunit 6B homolog
Gene namesi
Name:rpt3
ORF Names:SPCC576.10c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC576.10c.
PomBaseiSPCC576.10c. rpt3.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • cytosolic proteasome complex Source: GO_Central
  • nuclear chromatin Source: PomBase
  • nuclear periphery Source: PomBase
  • nuclear proteasome complex Source: GO_Central
  • proteasome regulatory particle, base subcomplex Source: PomBase

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000846961 – 38926S proteasome regulatory subunit 6B homologAdd BLAST389

Proteomic databases

MaxQBiO74894.
PRIDEiO74894.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi276101. 13 interactors.
MINTiMINT-4681643.
STRINGi4896.SPCC576.10c.1.

Structurei

3D structure databases

ProteinModelPortaliO74894.
SMRiO74894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

HOGENOMiHOG000225143.
InParanoidiO74894.
KOiK03063.
OMAiLIIRNDP.
OrthoDBiEOG092C19WS.
PhylomeDBiO74894.

Family and domain databases

InterProiView protein in InterPro
IPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
IPR035256. PSMC4.
PANTHERiPTHR23073:SF50. PTHR23073:SF50. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01242. 26Sp45. 1 hit.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

O74894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTEEIDLY NRWKALERQL EMLDLQEGFI KEDCKSLKRE LIRAQEEVKR
60 70 80 90 100
IQSVPLVIGQ FLEAIDQNTA IVGSTTGSNY VVRILSTLDR ELLKPSASVA
110 120 130 140 150
LQRHSNALVD ILPPEADSSI SMLRPDERPD VSYADVGGLD VQKQEVREAV
160 170 180 190 200
ELPLTQGDLY RQIGIDPPRG VLLYGPPGTG KTMLVKAVAN STAANFIRVV
210 220 230 240 250
GSEFVQKYLG EGPRMVRDVF RMARENAPAI IFIDEIDAIA TKRFDAQTGA
260 270 280 290 300
DREVQRILIE LLTQMDGFDQ GANVKVIMAT NRADTLDPAL LRPGRLDRKI
310 320 330 340 350
EFPSYRDRRQ RRLVFQTITA KMLLSPEVDL DTFIMRPDAS SGAQIAAIMQ
360 370 380
DAGLLAVRKS RGVILQSDIE EAYARAVKPT DMEQFAFYK
Length:389
Mass (Da):43,553
Last modified:November 1, 1998 - v1
Checksum:i24504B23D40F322A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21189.1.
PIRiT41420.
RefSeqiNP_588437.1. NM_001023428.2.

Genome annotation databases

EnsemblFungiiSPCC576.10c.1; SPCC576.10c.1:pep; SPCC576.10c.
GeneIDi2539539.
KEGGispo:SPCC576.10c.

Similar proteinsi

Entry informationi

Entry nameiPRS6B_SCHPO
AccessioniPrimary (citable) accession number: O74894
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 1, 1998
Last modified: August 30, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families