UniProtKB - O74894 (PRS6B_SCHPO)
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Protein
26S proteasome regulatory subunit 6B homolog
Gene
rpt3
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 175 – 182 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATPase activity Source: PomBase
- ATP binding Source: UniProtKB-KW
- proteasome-activating ATPase activity Source: GO_Central
- TBP-class protein binding Source: GO_Central
GO - Biological processi
- CENP-A containing chromatin organization Source: PomBase
- positive regulation of mitotic metaphase/anaphase transition Source: PomBase
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: GO_Central
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: PomBase
- ubiquitin-dependent ERAD pathway Source: GO_Central
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SPO-1236978. Cross-presentation of soluble exogenous antigens (endosomes). R-SPO-174113. SCF-beta-TrCP mediated degradation of Emi1. R-SPO-5689603. UCH proteinases. R-SPO-5689880. Ub-specific processing proteases. R-SPO-68949. Orc1 removal from chromatin. R-SPO-69017. CDK-mediated phosphorylation and removal of Cdc6. R-SPO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A. R-SPO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis. R-SPO-983168. Antigen processing: Ubiquitination & Proteasome degradation. |
Names & Taxonomyi
Protein namesi | Recommended name: 26S proteasome regulatory subunit 6B homolog |
Gene namesi | Name:rpt3 ORF Names:SPCC576.10c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:SPCC576.10c. |
PomBasei | SPCC576.10c. rpt3. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084696 | 1 – 389 | 26S proteasome regulatory subunit 6B homologAdd BLAST | 389 |
Proteomic databases
MaxQBi | O74894. |
PaxDbi | O74894. |
PRIDEi | O74894. |
PTM databases
iPTMneti | O74894. |
Interactioni
GO - Molecular functioni
- TBP-class protein binding Source: GO_Central
Protein-protein interaction databases
BioGridi | 276101. 13 interactors. |
STRINGi | 4896.SPCC576.10c.1. |
Structurei
3D structure databases
ProteinModelPortali | O74894. |
SMRi | O74894. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the AAA ATPase family.Curated
Phylogenomic databases
HOGENOMi | HOG000225143. |
InParanoidi | O74894. |
KOi | K03063. |
OMAi | LIIRNDP. |
OrthoDBi | EOG092C19WS. |
PhylomeDBi | O74894. |
Family and domain databases
InterProi | View protein in InterPro IPR005937. 26S_Psome_P45-like. IPR003593. AAA+_ATPase. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. IPR027417. P-loop_NTPase. IPR035256. PSMC4. |
PANTHERi | PTHR23073:SF8. PTHR23073:SF8. 1 hit. |
Pfami | View protein in Pfam PF00004. AAA. 1 hit. |
SMARTi | View protein in SMART SM00382. AAA. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
TIGRFAMsi | TIGR01242. 26Sp45. 1 hit. |
PROSITEi | View protein in PROSITE PS00674. AAA. 1 hit. |
i Sequence
Sequence statusi: Complete.
O74894-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSTEEIDLY NRWKALERQL EMLDLQEGFI KEDCKSLKRE LIRAQEEVKR
60 70 80 90 100
IQSVPLVIGQ FLEAIDQNTA IVGSTTGSNY VVRILSTLDR ELLKPSASVA
110 120 130 140 150
LQRHSNALVD ILPPEADSSI SMLRPDERPD VSYADVGGLD VQKQEVREAV
160 170 180 190 200
ELPLTQGDLY RQIGIDPPRG VLLYGPPGTG KTMLVKAVAN STAANFIRVV
210 220 230 240 250
GSEFVQKYLG EGPRMVRDVF RMARENAPAI IFIDEIDAIA TKRFDAQTGA
260 270 280 290 300
DREVQRILIE LLTQMDGFDQ GANVKVIMAT NRADTLDPAL LRPGRLDRKI
310 320 330 340 350
EFPSYRDRRQ RRLVFQTITA KMLLSPEVDL DTFIMRPDAS SGAQIAAIMQ
360 370 380
DAGLLAVRKS RGVILQSDIE EAYARAVKPT DMEQFAFYK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329672 Genomic DNA. Translation: CAA21189.1. |
PIRi | T41420. |
RefSeqi | NP_588437.1. NM_001023428.2. |
Genome annotation databases
EnsemblFungii | SPCC576.10c.1; SPCC576.10c.1:pep; SPCC576.10c. |
GeneIDi | 2539539. |
KEGGi | spo:SPCC576.10c. |
Similar proteinsi
Entry informationi
Entry namei | PRS6B_SCHPO | |
Accessioni | O74894Primary (citable) accession number: O74894 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2002 |
Last sequence update: | November 1, 1998 | |
Last modified: | February 28, 2018 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |