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Protein

Probable coatomer subunit zeta

Gene

ret3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).By similarity
The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-6807878. COPI-mediated anterograde transport.
R-SPO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable coatomer subunit zeta
Alternative name(s):
Zeta-coat protein
Short name:
Zeta-COP
Gene namesi
Name:ret3
ORF Names:SPCC576.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC576.07.
PomBaseiSPCC576.07. ret3.

Subcellular locationi

GO - Cellular componenti

  • COPI vesicle coat Source: PomBase
  • cytosol Source: PomBase
  • Golgi membrane Source: UniProtKB-SubCell
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938291 – 190Probable coatomer subunit zetaAdd BLAST190

Proteomic databases

MaxQBiO74891.
PRIDEiO74891.

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Protein-protein interaction databases

MINTiMINT-4681608.

Structurei

3D structure databases

ProteinModelPortaliO74891.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000214428.
InParanoidiO74891.
KOiK20472.
OMAiPGQIAYK.
OrthoDBiEOG092C4SI2.
PhylomeDBiO74891.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR011012. Longin-like_dom.
[Graphical view]
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.

Sequencei

Sequence statusi: Complete.

O74891-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLTLYAVNA FLILDSSGKR IFTKYYAPPH LKEGEGGVFN SVKEEKTFEK
60 70 80 90 100
GLFEKTWKTQ NDILTYDGKL VVMLTVMDVI FYIVGGMEEN EVMLYECLRS
110 120 130 140 150
IRDALELLFK YVPDKRTLLE NYDQLVIVVD ETIDDGVILE TEPALIAARV
160 170 180 190
TKGPVSEAQA IVSDFKEMGF MNSFQKAREK ITERILKGTF
Length:190
Mass (Da):21,686
Last modified:November 1, 1998 - v1
Checksum:iF0CCBFA254DF430F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21186.1.
PIRiT41417.
RefSeqiNP_588434.1. NM_001023425.2.

Genome annotation databases

EnsemblFungiiSPCC576.07.1; SPCC576.07.1:pep; SPCC576.07.
GeneIDi2539522.
KEGGispo:SPCC576.07.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21186.1.
PIRiT41417.
RefSeqiNP_588434.1. NM_001023425.2.

3D structure databases

ProteinModelPortaliO74891.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4681608.

Proteomic databases

MaxQBiO74891.
PRIDEiO74891.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC576.07.1; SPCC576.07.1:pep; SPCC576.07.
GeneIDi2539522.
KEGGispo:SPCC576.07.

Organism-specific databases

EuPathDBiFungiDB:SPCC576.07.
PomBaseiSPCC576.07. ret3.

Phylogenomic databases

HOGENOMiHOG000214428.
InParanoidiO74891.
KOiK20472.
OMAiPGQIAYK.
OrthoDBiEOG092C4SI2.
PhylomeDBiO74891.

Enzyme and pathway databases

ReactomeiR-SPO-6807878. COPI-mediated anterograde transport.
R-SPO-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiO74891.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR011012. Longin-like_dom.
[Graphical view]
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOPZ_SCHPO
AccessioniPrimary (citable) accession number: O74891
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.