Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine--tRNA ligase, mitochondrial

Gene

msy1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).By similarity

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33TyrosineBy similarity1
Binding sitei37ATPBy similarity1
Binding sitei77TyrosineBy similarity1
Binding sitei184TyrosineBy similarity1
Binding sitei188TyrosineBy similarity1
Binding sitei191TyrosineBy similarity1
Binding sitei210TyrosineBy similarity1
Binding sitei248ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligase, mitochondrial (EC:6.1.1.1By similarity)
Alternative name(s):
Tyrosyl-tRNA synthetase
Short name:
TyrRS
Gene namesi
Name:msy1By similarity
ORF Names:SPCC576.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC576.06c
PomBaseiSPCC576.06c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000314632? – 445Tyrosine--tRNA ligase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysisBy similarity

Proteomic databases

MaxQBiO74890
PaxDbiO74890
PRIDEiO74890

PTM databases

iPTMnetiO74890

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi4896.SPCC576.06c.1

Structurei

3D structure databases

ProteinModelPortaliO74890
SMRiO74890
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini384 – 445S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST62

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 47"HIGH" regionSequence analysis10
Motifi245 – 249"KMSKS" regionSequence analysis5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.Sequence analysis

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000242790
InParanoidiO74890
KOiK01866
OMAiHRIEGQD
OrthoDBiEOG092C2LDP
PhylomeDBiO74890

Family and domain databases

CDDicd00805 TyrRS_core, 1 hit
Gene3Di3.10.290.10, 1 hit
3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002942 S4_RNA-bd
IPR036986 S4_RNA-bd_sf
IPR002307 Tyr-tRNA-ligase
IPR024088 Tyr-tRNA-ligase_bac-type
PANTHERiPTHR11766 PTHR11766, 1 hit
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01040 TRNASYNTHTYR
TIGRFAMsiTIGR00234 tyrS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLLACLKQ LQARSLIHNT TLLQPSCNVN SVYLGADPTA ASLHVGNLVA
60 70 80 90 100
LMPLVHFFLN GFPVFTVIGD ATAQLGDPSG RSTSRKQMAE TTRTANSNSI
110 120 130 140 150
HNQLKDLSSS ILSYAQDCNY PFSQMPSSSQ WSIVRNSSWY ENLKLLKFLS
160 170 180 190 200
SVGPHVRVSQ MLARDSVTTR LQSPSGLSFA ELTYQLLQAY DYSYLYENHS
210 220 230 240 250
VNLQIGGSDQ WGNITAGTDL VRRTHPNANV YALTTPLLTS SSGQKLGKSA
260 270 280 290 300
GNAIWLDPKL TDSYSLYQYF ISAPDDLACK CLDMLTLLPL EQLEQIKAEH
310 320 330 340 350
EKDPSQRIVH KYLASNVVRM VHGKKALELA QIQTKLLHGA HQAPFGFYSE
360 370 380 390 400
APQQGDSFPS LPEIRALFKD CKFYRTIDSS IKDQPFSRLL RTLQIYTSRK
410 420 430 440
EATEHILSGA VSLGHKPILD SNYKFPDNSL FVLRAGKRTF VLDSL
Length:445
Mass (Da):49,498
Last modified:November 1, 1998 - v1
Checksum:iE47BD594369C7EE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA21185.1
PIRiT41416
RefSeqiNP_588433.1, NM_001023424.2

Genome annotation databases

EnsemblFungiiSPCC576.06c.1; SPCC576.06c.1:pep; SPCC576.06c
GeneIDi2539529
KEGGispo:SPCC576.06c

Similar proteinsi

Entry informationi

Entry nameiSYYM_SCHPO
AccessioniPrimary (citable) accession number: O74890
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health