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Protein

BTB/POZ domain-containing protein 1

Gene

btb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 1
Gene namesi
Name:btb1
ORF Names:SPCC330.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC330.11.
PomBaseiSPCC330.11. btb1.

Subcellular locationi

GO - Cellular componenti

  • ubiquitin ligase complex Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13471347BTB/POZ domain-containing protein 1PRO_0000278357Add
BLAST

Proteomic databases

MaxQBiO74881.

Interactioni

Subunit structurei

Interacts with cul3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
cul3Q097603EBI-3647943,EBI-3647930

Protein-protein interaction databases

BioGridi275298. 28 interactions.
IntActiO74881. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO74881.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati51 – 8131ANK 1Add
BLAST
Repeati86 – 11530ANK 2Add
BLAST
Repeati148 – 19851RCC1 1Add
BLAST
Repeati215 – 26450RCC1 2Add
BLAST
Repeati265 – 32258RCC1 3Add
BLAST
Repeati324 – 37249RCC1 4Add
BLAST
Domaini619 – 69880BTB 1PROSITE-ProRule annotationAdd
BLAST
Domaini758 – 82972BTB 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.PROSITE-ProRule annotation
Contains 2 BTB (POZ) domains.PROSITE-ProRule annotation
Contains 4 RCC1 repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

InParanoidiO74881.
OMAiSNEVFAW.
OrthoDBiEOG092C03TY.
PhylomeDBiO74881.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.130.10.30. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ_dom.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00651. BTB. 2 hits.
PF00415. RCC1. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00225. BTB. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50985. SSF50985. 1 hit.
SSF54695. SSF54695. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50097. BTB. 2 hits.
PS50012. RCC1_3. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLLFAYYL CNDIRSFQNL LKQDDSKVKE PRKGFSEKSG QKLRINQKDR
60 70 80 90 100
YGRTVLHIAV SENKNSFVRS LLQHKGIDVF VQDEESGYTA LHRAIYVGNL
110 120 130 140 150
EAASLLLSKD PSFRSLRIKD KEGLSPFQFL SRVLSSTIHP VLDLPIIGNE
160 170 180 190 200
LYGFGTNVNN TLGIANGKEP SSPERVFLLK NQTESPTSGQ LFSRDKILDV
210 220 230 240 250
QASKFHSVVL TDEPSQNVYV CGIGAGGRIG FNTDVQYNFI PIPGIIHKVI
260 270 280 290 300
QISVSHTHSL ALTKFGSIYS WGKNGSGELG LSNDELKKDD PIQITPRRIS
310 320 330 340 350
AFKDYQIIGM AAGKSYSVAW TDTDIYSWGL NNGQLGISDH ISVVSTPRRV
360 370 380 390 400
AGLLSPVIHA VCTTRATICL LQNNSIIAFC NYNQVKLPFN VDFGSSLKVT
410 420 430 440 450
KHPLSLTRFN VRKLLASENK LAVLTELGEV YEFDMKLLLD RDSTSSKNST
460 470 480 490 500
RTSFKFTPLW IFESSDLAAL DIAWTADNSL ILCTRNGTCW KRELRSKKRE
510 520 530 540 550
KSSSSPYSRG PYKYNRIENL QMVVGVRASA SGSFFAIRND YLPPPIYKPS
560 570 580 590 600
NMLIDLLRSL LPYDHLLHVR QPRLIPPEDE DGVPIFDEDR AASSNEMQLL
610 620 630 640 650
FEGSIPILTS YENYKQSFSD VTIYCGTSMF HSHKFILCAR SSFLRKLLLQ
660 670 680 690 700
KKKSSVSNII YIEEITQSHS TIRVEDIPPL AVAILLHYLY TDTLLSPWHL
710 720 730 740 750
DSRFSPLKEN LSKLANLLEL PHLAEVLPFS VSRQPLLSLT NDILQLYNNF
760 770 780 790 800
YVLCEETMDT VIKLKDGELK AHGLFLSLRS EYFSSYFQFV SMESNSFDIP
810 820 830 840 850
ITVNLSHLTV EHMSIVLRHV YSDLKVELFD DLKESDFHNW LETMFEILSI
860 870 880 890 900
ADELLFLELK SIAQQSLLRF LNLKTLPTLM DLSLSYHAEE LYSRCIDYAC
910 920 930 940 950
HNIEFFLEAN RISEWDGFHL KKVAQRLTEL LSDQRVHLPS SKIANRLLIR
960 970 980 990 1000
DPVLMEKRNY ELKVLREYLF SQESSQLWDD SPYRSIFEDR RCSTSAVILE
1010 1020 1030 1040 1050
SGIVPSSNQS DSLNKEDAEE KSPKPNVVNV TSITKTAGAS VEIQNNIESA
1060 1070 1080 1090 1100
SSGGDKTQLN GPGADQPVTA TITFDKTSPW RNRENLSHNN NTTRASLREL
1110 1120 1130 1140 1150
LEQEKADAST TTVLSDSRFM KAPTKKSQRE KKKELSKQVP ISKTNVGHID
1160 1170 1180 1190 1200
IELGKSNHSN PWSVATHQRG SFSSSTGVKK SFNGILREAA REEGSSQVIY
1210 1220 1230 1240 1250
QESKKRISNG SPTSWNLLTK PSPRSASLPK NSQPLSISEI MTEQKEEIES
1260 1270 1280 1290 1300
QKRRSSFRKT IEEIQQEEEF QKWWEEESLR VQKELGILKT ERDTSTNRKQ
1310 1320 1330 1340
GQASKQPQRR HRKEKDSKVS ESTAEFKSLP IDIPRTTHKK GKARAVK
Length:1,347
Mass (Da):152,586
Last modified:November 1, 1998 - v1
Checksum:iA5A3C9FF2E682C3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20916.1.
PIRiT41321.
RefSeqiNP_587711.1. NM_001022706.1.

Genome annotation databases

EnsemblFungiiSPCC330.11.1; SPCC330.11.1:pep; SPCC330.11.
GeneIDi2538714.
KEGGispo:SPCC330.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA20916.1.
PIRiT41321.
RefSeqiNP_587711.1. NM_001022706.1.

3D structure databases

ProteinModelPortaliO74881.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275298. 28 interactions.
IntActiO74881. 2 interactions.

Proteomic databases

MaxQBiO74881.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC330.11.1; SPCC330.11.1:pep; SPCC330.11.
GeneIDi2538714.
KEGGispo:SPCC330.11.

Organism-specific databases

EuPathDBiFungiDB:SPCC330.11.
PomBaseiSPCC330.11. btb1.

Phylogenomic databases

InParanoidiO74881.
OMAiSNEVFAW.
OrthoDBiEOG092C03TY.
PhylomeDBiO74881.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiO74881.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.130.10.30. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ_dom.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00651. BTB. 2 hits.
PF00415. RCC1. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 2 hits.
SM00225. BTB. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF50985. SSF50985. 1 hit.
SSF54695. SSF54695. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
PS50097. BTB. 2 hits.
PS50012. RCC1_3. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBTB1_SCHPO
AccessioniPrimary (citable) accession number: O74881
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.