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Protein

BTB/POZ domain-containing protein 1

Gene

btb1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • protein modification by small protein conjugation or removal Source: PomBase
  • protein ubiquitination Source: UniProtKB-UniPathway

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 1
Gene namesi
Name:btb1
ORF Names:SPCC330.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC330.11
PomBaseiSPCC330.11 btb1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002783571 – 1347BTB/POZ domain-containing protein 1Add BLAST1347

Proteomic databases

MaxQBiO74881
PaxDbiO74881
PRIDEiO74881

PTM databases

iPTMnetiO74881

Interactioni

Subunit structurei

Interacts with cul3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
cul3Q097603EBI-3647943,EBI-3647930

Protein-protein interaction databases

BioGridi275298, 28 interactors
IntActiO74881, 2 interactors
STRINGi4896.SPCC330.11.1

Structurei

3D structure databases

ProteinModelPortaliO74881
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 81ANK 1Add BLAST31
Repeati86 – 115ANK 2Add BLAST30
Repeati148 – 198RCC1 1Add BLAST51
Repeati215 – 264RCC1 2Add BLAST50
Repeati265 – 322RCC1 3Add BLAST58
Repeati324 – 372RCC1 4Add BLAST49
Domaini619 – 698BTB 1PROSITE-ProRule annotationAdd BLAST80
Domaini758 – 829BTB 2PROSITE-ProRule annotationAdd BLAST72

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

InParanoidiO74881
OMAiCQRCPFF
OrthoDBiEOG092C03TY
PhylomeDBiO74881

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.130.10.30, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR000210 BTB/POZ_dom
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF00651 BTB, 2 hits
PF00415 RCC1, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SM00225 BTB, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF50985 SSF50985, 1 hit
SSF54695 SSF54695, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50097 BTB, 2 hits
PS50012 RCC1_3, 4 hits

Sequencei

Sequence statusi: Complete.

O74881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLLFAYYL CNDIRSFQNL LKQDDSKVKE PRKGFSEKSG QKLRINQKDR
60 70 80 90 100
YGRTVLHIAV SENKNSFVRS LLQHKGIDVF VQDEESGYTA LHRAIYVGNL
110 120 130 140 150
EAASLLLSKD PSFRSLRIKD KEGLSPFQFL SRVLSSTIHP VLDLPIIGNE
160 170 180 190 200
LYGFGTNVNN TLGIANGKEP SSPERVFLLK NQTESPTSGQ LFSRDKILDV
210 220 230 240 250
QASKFHSVVL TDEPSQNVYV CGIGAGGRIG FNTDVQYNFI PIPGIIHKVI
260 270 280 290 300
QISVSHTHSL ALTKFGSIYS WGKNGSGELG LSNDELKKDD PIQITPRRIS
310 320 330 340 350
AFKDYQIIGM AAGKSYSVAW TDTDIYSWGL NNGQLGISDH ISVVSTPRRV
360 370 380 390 400
AGLLSPVIHA VCTTRATICL LQNNSIIAFC NYNQVKLPFN VDFGSSLKVT
410 420 430 440 450
KHPLSLTRFN VRKLLASENK LAVLTELGEV YEFDMKLLLD RDSTSSKNST
460 470 480 490 500
RTSFKFTPLW IFESSDLAAL DIAWTADNSL ILCTRNGTCW KRELRSKKRE
510 520 530 540 550
KSSSSPYSRG PYKYNRIENL QMVVGVRASA SGSFFAIRND YLPPPIYKPS
560 570 580 590 600
NMLIDLLRSL LPYDHLLHVR QPRLIPPEDE DGVPIFDEDR AASSNEMQLL
610 620 630 640 650
FEGSIPILTS YENYKQSFSD VTIYCGTSMF HSHKFILCAR SSFLRKLLLQ
660 670 680 690 700
KKKSSVSNII YIEEITQSHS TIRVEDIPPL AVAILLHYLY TDTLLSPWHL
710 720 730 740 750
DSRFSPLKEN LSKLANLLEL PHLAEVLPFS VSRQPLLSLT NDILQLYNNF
760 770 780 790 800
YVLCEETMDT VIKLKDGELK AHGLFLSLRS EYFSSYFQFV SMESNSFDIP
810 820 830 840 850
ITVNLSHLTV EHMSIVLRHV YSDLKVELFD DLKESDFHNW LETMFEILSI
860 870 880 890 900
ADELLFLELK SIAQQSLLRF LNLKTLPTLM DLSLSYHAEE LYSRCIDYAC
910 920 930 940 950
HNIEFFLEAN RISEWDGFHL KKVAQRLTEL LSDQRVHLPS SKIANRLLIR
960 970 980 990 1000
DPVLMEKRNY ELKVLREYLF SQESSQLWDD SPYRSIFEDR RCSTSAVILE
1010 1020 1030 1040 1050
SGIVPSSNQS DSLNKEDAEE KSPKPNVVNV TSITKTAGAS VEIQNNIESA
1060 1070 1080 1090 1100
SSGGDKTQLN GPGADQPVTA TITFDKTSPW RNRENLSHNN NTTRASLREL
1110 1120 1130 1140 1150
LEQEKADAST TTVLSDSRFM KAPTKKSQRE KKKELSKQVP ISKTNVGHID
1160 1170 1180 1190 1200
IELGKSNHSN PWSVATHQRG SFSSSTGVKK SFNGILREAA REEGSSQVIY
1210 1220 1230 1240 1250
QESKKRISNG SPTSWNLLTK PSPRSASLPK NSQPLSISEI MTEQKEEIES
1260 1270 1280 1290 1300
QKRRSSFRKT IEEIQQEEEF QKWWEEESLR VQKELGILKT ERDTSTNRKQ
1310 1320 1330 1340
GQASKQPQRR HRKEKDSKVS ESTAEFKSLP IDIPRTTHKK GKARAVK
Length:1,347
Mass (Da):152,586
Last modified:November 1, 1998 - v1
Checksum:iA5A3C9FF2E682C3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA20916.1
PIRiT41321
RefSeqiNP_587711.1, NM_001022706.1

Genome annotation databases

EnsemblFungiiSPCC330.11.1; SPCC330.11.1:pep; SPCC330.11
GeneIDi2538714
KEGGispo:SPCC330.11

Similar proteinsi

Entry informationi

Entry nameiBTB1_SCHPO
AccessioniPrimary (citable) accession number: O74881
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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