Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O74878 (ALG11_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

EC=2.4.1.131
Alternative name(s):
Alpha-1,2-mannosyltransferase alg11
Asparagine-linked glycosylation protein 11
Galactomannan deficiency protein 3
Glycolipid 2-alpha-mannosyltransferase
Gene names
Name:alg11
Synonyms:gmd3
ORF Names:SPCC330.08
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Ref.1

Catalytic activity

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
PRO_0000080278

Regions

Transmembrane1 – 2525Helical; Signal-anchor for type II membrane protein; Potential
Topological domain26 – 471446Lumenal Potential

Amino acid modifications

Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation2361N-linked (GlcNAc...) Potential
Glycosylation2621N-linked (GlcNAc...) Potential
Glycosylation3901N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O74878 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 80D30A980D789366

FASTA47153,278
        10         20         30         40         50         60 
MITTLAIALF IAVVAIHSHI RRKICKEIGI RLIKKIAPVK ASLYKQVGVE PKLARTVGFF 

        70         80         90        100        110        120 
HPYCNAGGGG ERVLWTAVKS VQTEFPNVIS VVYTGDNVSK AEILRRVKNT FEIDLDSSKI 

       130        140        150        160        170        180 
VFVYLKLRFL VSATTWHRFT LLGQSLGSMI LGFEAIYRFA PDIFIDTMGY AFTFCVVKSF 

       190        200        210        220        230        240 
QNIPVGAYVH YPTISTDMLK SLKQVSLLAK VKMAYWRWFA QLYSDAGSHA DYVMTNSSWT 

       250        260        270        280        290        300 
RNHIASLWGK DIQLSVVFPP CNTSELEKID INRKREPTLL YLAQYRPEKN HENVLRSFAL 

       310        320        330        340        350        360 
YFEQHPDSPA KLLLVGSVRG EEDMCFVNHL KTLATELNLQ SKVKFVVDAP WPKVVEYLGT 

       370        380        390        400        410        420 
CSIGVNYMWN EHFGIGVVEY MAAGLIPVVN NSGGPKFDIV IPWIGKPTGF HASTISEYAE 

       430        440        450        460        470 
AYHKALTLSP QEQLEMRINA RSACARFGEH VFMRDFGNVF AKLLREDYSR T 

« Hide

References

« Hide 'large scale' references
[1]"Schizosaccharomyces pombe gmd3(+)/alg11(+) is a functional homologue of Saccharomyces cerevisiae ALG11 which is involved in N-linked oligosaccharide synthesis."
Umeda K., Yoko-o T., Nakayama K., Suzuki T.-O., Jigami Y.
Yeast 16:1261-1271(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329672 Genomic DNA. Translation: CAA20913.1.
PIRT41318.
RefSeqNP_587708.1. NM_001022703.2.

3D structure databases

ProteinModelPortalO74878.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275627. 3 interactions.
MINTMINT-4681498.
STRING4896.SPCC330.08-1.

Protein family/group databases

CAZyGT4. Glycosyltransferase Family 4.

Proteomic databases

MaxQBO74878.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC330.08.1; SPCC330.08.1:pep; SPCC330.08.
GeneID2539054.
KEGGspo:SPCC330.08.

Organism-specific databases

PomBaseSPCC330.08.

Phylogenomic databases

eggNOGCOG0438.
HOGENOMHOG000209670.
KOK03844.
OMAGTVILAH.
OrthoDBEOG7673KQ.
PhylomeDBO74878.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

InterProIPR001296. Glyco_trans_1.
[Graphical view]
PfamPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800228.
PROO74878.

Entry information

Entry nameALG11_SCHPO
AccessionPrimary (citable) accession number: O74878
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways