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Reviewed, UniProtKB/Swiss-Prot O74878 (ALG11_SCHPO)

Last modified December 15, 2009. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Alpha-1,2-mannosyltransferase alg11
    EC=2.4.1.-
Alternative name(s):
    Asparagine-linked glycosylation protein 11
    Galactomannan deficiency protein 3
Gene names
Name: alg11
Synonyms: gmd3
ORF Names: SPCC330.08
OrganismSchizosaccharomyces pombe (Fission yeast) [Complete proteome]
Taxonomic identifier4896 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length471 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Ref.1

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase 1 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
   DomainSignal-anchor
Transmembrane
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processprotein amino acid N-linked glycosylation Ref.1

Traceable author statement. Source: GeneDB_SPombe

   Cellular componentalpha-1,6-mannosyltransferase complex

Inferred by curator. Source: GeneDB_SPombe

endoplasmic reticulum

Inferred from direct assay. Source: GeneDB_SPombe

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionalpha-1,2-mannosyltransferase activity

Inferred from genetic interaction. Source: GeneDB_SPombe

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 471471Alpha-1,2-mannosyltransferase alg11
PRO_0000080278

Regions

Transmembrane1 – 2525Signal-anchor for type II membrane protein Potential
Topological domain26 – 471446Lumenal Potential

Amino acid modifications

Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation2361N-linked (GlcNAc...) Potential
Glycosylation2621N-linked (GlcNAc...) Potential
Glycosylation3901N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O74878-1 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 80D30A980D789366

FASTA47153,278
        10         20         30         40         50         60 
MITTLAIALF IAVVAIHSHI RRKICKEIGI RLIKKIAPVK ASLYKQVGVE PKLARTVGFF 

        70         80         90        100        110        120 
HPYCNAGGGG ERVLWTAVKS VQTEFPNVIS VVYTGDNVSK AEILRRVKNT FEIDLDSSKI 

       130        140        150        160        170        180 
VFVYLKLRFL VSATTWHRFT LLGQSLGSMI LGFEAIYRFA PDIFIDTMGY AFTFCVVKSF 

       190        200        210        220        230        240 
QNIPVGAYVH YPTISTDMLK SLKQVSLLAK VKMAYWRWFA QLYSDAGSHA DYVMTNSSWT 

       250        260        270        280        290        300 
RNHIASLWGK DIQLSVVFPP CNTSELEKID INRKREPTLL YLAQYRPEKN HENVLRSFAL 

       310        320        330        340        350        360 
YFEQHPDSPA KLLLVGSVRG EEDMCFVNHL KTLATELNLQ SKVKFVVDAP WPKVVEYLGT 

       370        380        390        400        410        420 
CSIGVNYMWN EHFGIGVVEY MAAGLIPVVN NSGGPKFDIV IPWIGKPTGF HASTISEYAE 

       430        440        450        460        470 
AYHKALTLSP QEQLEMRINA RSACARFGEH VFMRDFGNVF AKLLREDYSR T 

« Hide

References

« Hide 'large scale' references
[1]"Schizosaccharomyces pombe gmd3(+)/alg11(+) is a functional homologue of Saccharomyces cerevisiae ALG11 which is involved in N-linked oligosaccharide synthesis."
Umeda K., Yoko-o T., Nakayama K., Suzuki T.-O., Jigami Y.
Yeast 16:1261-1271(2000) [PubMed: 11015724] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 38366 / 972.

Cross-references

Sequence databases

CU329672 Genomic DNA. Translation: CAA20913.1.
PIRT41318.
RefSeqNP_587708.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGO74878.

Protein family/group databases

CAZyGT4. Glycosyltransferase Family 4.

Genome annotation databases

GeneID2539054.
GenomeReviewsGene locus alg11 in contig CU329672_GR.
KEGGspo:SPCC330.08.
NMPDRfig|4896.1.peg.46.

Organism-specific databases

GeneDB_SpombeSPCC330.08.

Phylogenomic databases

HOGENOMHBG525304.
OMAGCYVHYP.
OrthoDBEOG9PG7HC.

Gene expression databases

ArrayExpressO74878.

Family and domain databases

InterProIPR001296. Glyco_trans_1.
[Graphical view]
PfamPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALG11_SCHPO
AccessionPrimary (citable) accession number: O74878
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: November 1, 1998
Last modified: December 15, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents