O74870 (MUG73_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Meiotically up-regulated gene 73 protein

Gene names

Name:	mug73
ORF Names:	SPCC31H12.02c

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]

Taxonomic identifier

284812 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has a role in meiosis. Ref.2
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the archaeal/bacterial/fungal opsin family.

Ontologies

Keywords
Biological process	Meiosis
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	meiosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from sequence model. Source: PomBase
Molecular_function	ion channel activity Inferred from sequence model. Source: PomBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Meiotically up-regulated gene 73 protein		PRO_0000278563
Regions
	Transmembrane	28 – 48	21	Helical; Potential
	Transmembrane	59 – 79	21	Helical; Potential
	Transmembrane	103 – 123	21	Helical; Potential
	Transmembrane	125 – 145	21	Helical; Potential
	Transmembrane	154 – 174	21	Helical; Potential
	Transmembrane	190 – 210	21	Helical; Potential
	Transmembrane	224 – 244	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O74870 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 5C18E637628DF080	FASTA	306	34,664
	10 20 30 40 50 60 MNAKLSSSGM VLKELPEVAL QKISSNYYWA VFAVFLLCAI VFPLVSIFSL PQKQTYHRFF 70 80 90 100 110 120 SILSLVSCLA YFTMACNYGL KNVFSSASFF REVSVRMVYY VRYIQWLINF PLIIVMLHWT 130 140 150 160 170 180 VGVSILEIAY VVCYVLFAIV CLLAAALTSS PYKWAYYGFS FVGYFIALAH SVVLHKKYAS 190 200 210 220 230 240 RLETSARLGF LWSIVYLHVI WFLYYACWIL SEGLNVISPI GEAIFYSILD LFEFGFFGAA 250 260 270 280 290 300 FSWMLDLVGI ENFKSPQSIP LGACSPADDK FSMCPDMEAQ NQADDLAVET RIQISNLPSS PTKNNC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 972 / ATCC 24843.
[2]	"A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events." Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L., Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P., Smith G.R., Moreno S. Curr. Biol. 15:2056-2062(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN MEIOSIS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CU329672 Genomic DNA. Translation: CAA21219.1.
PIR	T41290.
RefSeq	NP_587895.1. NM_001022887.2.
3D structure databases
ProteinModelPortal	O74870.
ModBase	Search...
Protein-protein interaction databases
STRING	4896.SPCC31H12.02c-1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	SPCC31H12.02c.1; SPCC31H12.02c.1:pep; SPCC31H12.02c.
GeneID	2538730.
KEGG	spo:SPCC31H12.02c.
Organism-specific databases
PomBase	SPCC31H12.02c.
Phylogenomic databases
eggNOG	COG5524.
OMA	SDWLWAV.
OrthoDB	EOG4HX897.
Family and domain databases
InterPro	IPR001425. Rhodopsin_arc/bac/fun. [Graphical view]
Pfam	PF01036. Bac_rhodopsin. 1 hit. [Graphical view]
PRINTS	PR00251. BACTRLOPSIN.
SMART	SM01021. Bac_rhodopsin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20799915.

Entry information

Entry name

MUG73_SCHPO

Accession

Primary (citable) accession number: O74870

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program