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O74866

- RIFK_SCHPO

UniProt

O74866 - RIFK_SCHPO

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Protein
Riboflavin kinase
Gene
fmn1, SPCC18.16c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.

Catalytic activityi

ATP + riboflavin = ADP + FMN.

Cofactori

Binds 1 zinc ion per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Zinc
Active sitei96 – 961Nucleophile Inferred

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. riboflavin kinase activity Source: PomBase
  3. zinc ion binding Source: PomBase

GO - Biological processi

  1. FMN biosynthetic process Source: PomBase
  2. riboflavin biosynthetic process Source: InterPro
  3. riboflavin metabolic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Flavoprotein, FMN, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00276; UER00406.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin kinase (EC:2.7.1.26)
Alternative name(s):
ATP:riboflavin 5'-phosphotransferase
Flavin mononucleotide kinase 1
Flavokinase
Gene namesi
Name:fmn1
ORF Names:SPCC18.16c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC18.16c.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. mitochondrial inner membrane Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 163163Riboflavin kinase
PRO_0000194151Add
BLAST

Proteomic databases

MaxQBiO74866.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

MINTiMINT-4681425.
STRINGi4896.SPCC18.16c-1.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 318
Beta strandi34 – 363
Helixi38 – 414
Beta strandi46 – 483
Helixi50 – 523
Turni53 – 597
Beta strandi62 – 7110
Beta strandi74 – 8411
Beta strandi93 – 997
Beta strandi111 – 12111
Helixi129 – 14719
Helixi150 – 1534
Helixi154 – 1574
Helixi159 – 1613

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1N05X-ray2.10A1-163[»]
1N06X-ray2.00A/B1-163[»]
1N07X-ray2.45A/B1-163[»]
1N08X-ray1.60A/B1-163[»]
ProteinModelPortaliO74866.
SMRiO74866. Positions 8-162.

Miscellaneous databases

EvolutionaryTraceiO74866.

Family & Domainsi

Sequence similaritiesi

Belongs to the flavokinase family.

Phylogenomic databases

eggNOGiCOG0196.
HOGENOMiHOG000260803.
KOiK00861.
OMAiSLPYFCR.
OrthoDBiEOG7K3V05.
PhylomeDBiO74866.

Family and domain databases

Gene3Di2.40.30.30. 1 hit.
InterProiIPR023468. Riboflavin_kinase.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023465. Riboflavin_kinase_domain.
[Graphical view]
PANTHERiPTHR22749. PTHR22749. 1 hit.
PfamiPF01687. Flavokinase. 1 hit.
[Graphical view]
SMARTiSM00904. Flavokinase. 1 hit.
[Graphical view]
SUPFAMiSSF82114. SSF82114. 1 hit.

Sequencei

Sequence statusi: Complete.

O74866-1 [UniParc]FASTAAdd to Basket

« Hide

MTVNLEEKRP EIVGPEKVQS PYPIRFEGKV VHGFGRGSKE LGIPTANISE    50
DAIQELLRYR DSGVYFGYAM VQKRVFPMVM SVGWNPYYKN KLRSAEVHLI 100
ERQGEDFYEE IMRVIVLGYI RPELNYAGLD KLIEDIHTDI RVALNSMDRP 150
SYSSYKKDPF FKV 163
Length:163
Mass (Da):18,913
Last modified:November 1, 1998 - v1
Checksum:iADFD49D12FD7472F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA21430.1.
PIRiT41159.
RefSeqiNP_588395.1. NM_001023386.2.

Genome annotation databases

EnsemblFungiiSPCC18.16c.1; SPCC18.16c.1:pep; SPCC18.16c.
GeneIDi2539192.
KEGGispo:SPCC18.16c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA21430.1 .
PIRi T41159.
RefSeqi NP_588395.1. NM_001023386.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1N05 X-ray 2.10 A 1-163 [» ]
1N06 X-ray 2.00 A/B 1-163 [» ]
1N07 X-ray 2.45 A/B 1-163 [» ]
1N08 X-ray 1.60 A/B 1-163 [» ]
ProteinModelPortali O74866.
SMRi O74866. Positions 8-162.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4681425.
STRINGi 4896.SPCC18.16c-1.

Proteomic databases

MaxQBi O74866.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC18.16c.1 ; SPCC18.16c.1:pep ; SPCC18.16c .
GeneIDi 2539192.
KEGGi spo:SPCC18.16c.

Organism-specific databases

PomBasei SPCC18.16c.

Phylogenomic databases

eggNOGi COG0196.
HOGENOMi HOG000260803.
KOi K00861.
OMAi SLPYFCR.
OrthoDBi EOG7K3V05.
PhylomeDBi O74866.

Enzyme and pathway databases

UniPathwayi UPA00276 ; UER00406 .

Miscellaneous databases

EvolutionaryTracei O74866.
NextBioi 20800363.
PROi O74866.

Family and domain databases

Gene3Di 2.40.30.30. 1 hit.
InterProi IPR023468. Riboflavin_kinase.
IPR015865. Riboflavin_kinase_bac/euk.
IPR023465. Riboflavin_kinase_domain.
[Graphical view ]
PANTHERi PTHR22749. PTHR22749. 1 hit.
Pfami PF01687. Flavokinase. 1 hit.
[Graphical view ]
SMARTi SM00904. Flavokinase. 1 hit.
[Graphical view ]
SUPFAMi SSF82114. SSF82114. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Crystal structure of Schizosaccharomyces pombe riboflavin kinase reveals a novel ATP and riboflavin-binding fold."
    Bauer S., Kemter K., Bacher A., Huber R., Fischer M., Steinbacher S.
    J. Mol. Biol. 326:1463-1473(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).

Entry informationi

Entry nameiRIFK_SCHPO
AccessioniPrimary (citable) accession number: O74866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 1, 1998
Last modified: May 14, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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