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Protein

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit trm82

Gene

trm82

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the formation of N7-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

GO - Biological processi

Keywordsi

Biological processtRNA processing

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit trm82UniRule annotation
Alternative name(s):
Transfer RNA methyltransferase 82UniRule annotation
Gene namesi
Name:trm82
ORF Names:SPCC18.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC18.13
PomBaseiSPCC18.13 trm82

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512941 – 421tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit trm82Add BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei413Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74863
PaxDbiO74863
PRIDEiO74863

PTM databases

iPTMnetiO74863

Interactioni

Subunit structurei

Forms a heterodimer with the catalytic subunit trm8.UniRule annotation

Protein-protein interaction databases

BioGridi275816, 76 interactors
STRINGi4896.SPCC18.13.1

Structurei

3D structure databases

ProteinModelPortaliO74863
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati60 – 99WD 1Add BLAST40
Repeati176 – 222WD 2Add BLAST47
Repeati224 – 264WD 3Add BLAST41

Sequence similaritiesi

Belongs to the WD repeat TRM82 family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiO74863
KOiK15443
OrthoDBiEOG092C34WZ
PhylomeDBiO74863

Family and domain databases

Gene3Di2.130.10.10, 2 hits
HAMAPiMF_03056 TRM82, 1 hit
InterProiView protein in InterPro
IPR028884 Trm82
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR16288 PTHR16288, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 2 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

O74863-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQRVFKHP CQFLTWNSKH NYIVCCSGPY LLGFSCSTGE KIFEHCYRDN
60 70 80 90 100
INEKHREAAA YGEAIRQVAF SKDYSRMATV SEDKCLRLWD STQPDKIELL
110 120 130 140 150
YQKNIPKRCA DLCFAGSNEI VFGDKFGDVY CVDENWFTTS EVTEEKKSNV
160 170 180 190 200
VEGKQEPVNN DTLKDSKLQK LEPIMGHVSI LTQLIVAQNP QNSKEEIIIT
210 220 230 240 250
SDKDEHIRIS RFPNAFVIEG FCLGHEDFVS RMSLYDNRTL ISGGGDNHVF
260 270 280 290 300
VWDLENFKCL DAFDLRSAFS TYLSLNQPMV VSVILPIFKR QLVAFACEGM
310 320 330 340 350
AGLIFAKVTP EKRLLFHSAL KLSGPVLDAV LLDTDTDQIL ISLDSSFTFG
360 370 380 390 400
ACFECVKFDE GNAAVLTKPD VIKRIESDGL ISTEKPFCPL AQIHTLRKNH
410 420
SKFIRSVETG TSSPSVESKD N
Length:421
Mass (Da):47,498
Last modified:November 1, 1998 - v1
Checksum:i7B78AF95ABD7FDBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA21427.1
PIRiT41156
RefSeqiNP_588392.1, NM_001023383.2

Genome annotation databases

EnsemblFungiiSPCC18.13.1; SPCC18.13.1:pep; SPCC18.13
GeneIDi2539246
KEGGispo:SPCC18.13

Similar proteinsi

Entry informationi

Entry nameiTRM82_SCHPO
AccessioniPrimary (citable) accession number: O74863
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health