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O74859 (APTX_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aprataxin-like protein

EC=3.-.-.-
Alternative name(s):
Hit family protein 3
Gene names
Name:hnt3
ORF Names:SPCC18.09c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined By similarity.

Subcellular location

Nucleus. Cytoplasm Ref.2.

Sequence similarities

Contains 1 HIT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232Aprataxin-like protein
PRO_0000314650

Regions

Domain38 – 160123HIT

Secondary structure

.......................................... 232
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
O74859 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 7B448C953ED13CFB

FASTA23226,922
        10         20         30         40         50         60 
MSVHKTNDAF KVLMNSAKEP IVEDIPKKYR KQSFRDNLKV YIESPESYKN VIYYDDDVVL 

        70         80         90        100        110        120 
VRDMFPKSKM HLLLMTRDPH LTHVHPLEIM MKHRSLVEKL VSYVQGDLSG LIFDEARNCL 

       130        140        150        160        170        180 
SQQLTNEALC NYIKVGFHAG PSMNNLHLHI MTLDHVSPSL KNSAHYISFT SPFFVKIDTP 

       190        200        210        220        230 
TSNLPTRGTL TSLFQEDLKC WRCGETFGRH FTKLKAHLQE EYDDWLDKSV SM 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329672 Genomic DNA. Translation: CAA21423.1.
PIRT41152.
RefSeqNP_588388.1. NM_001023379.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3SP4X-ray1.80A/B33-232[»]
3SPDX-ray1.91A/B/C/D33-232[»]
3SPLX-ray2.10A/B/C/D33-232[»]
3SZQX-ray2.35A31-232[»]
ProteinModelPortalO74859.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275769. 3 interactions.
MINTMINT-4681359.
STRING4896.SPCC18.09c-1.

Proteomic databases

MaxQBO74859.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC18.09c.1; SPCC18.09c.1:pep; SPCC18.09c.
GeneID2539198.
KEGGspo:SPCC18.09c.

Organism-specific databases

PomBaseSPCC18.09c.

Phylogenomic databases

eggNOGNOG278510.
HOGENOMHOG000167639.
KOK10863.
OMAFTGEELY.
OrthoDBEOG7C8GT4.
PhylomeDBO74859.

Family and domain databases

Gene3D3.30.428.10. 1 hit.
InterProIPR026963. Aprataxin.
IPR001310. Histidine_triad_HIT.
IPR011146. HIT-like.
[Graphical view]
PANTHERPTHR12486. PTHR12486. 1 hit.
PTHR12486:SF4. PTHR12486:SF4. 1 hit.
PfamPF01230. HIT. 1 hit.
[Graphical view]
SUPFAMSSF54197. SSF54197. 1 hit.
ProtoNetSearch...

Other

NextBio20800369.

Entry information

Entry nameAPTX_SCHPO
AccessionPrimary (citable) accession number: O74859
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references