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O74859

- APTX_SCHPO

UniProt

O74859 - APTX_SCHPO

Protein

Aprataxin-like protein

Gene

hnt3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined By similarity.By similarity

    GO - Molecular functioni

    1. DNA 5'-adenosine monophosphate hydrolase activity Source: PomBase
    2. mismatched DNA binding Source: PomBase
    3. single-strand break-containing DNA binding Source: PomBase
    4. single-stranded DNA binding Source: PomBase
    5. zinc ion binding Source: PomBase

    GO - Biological processi

    1. DNA catabolic process, exonucleolytic Source: GOC
    2. DNA repair Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aprataxin-like protein (EC:3.-.-.-)
    Alternative name(s):
    Hit family protein 3
    Gene namesi
    Name:hnt3
    ORF Names:SPCC18.09c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC18.09c.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 232232Aprataxin-like proteinPRO_0000314650Add
    BLAST

    Proteomic databases

    MaxQBiO74859.

    Interactioni

    Protein-protein interaction databases

    BioGridi275769. 3 interactions.
    MINTiMINT-4681359.
    STRINGi4896.SPCC18.09c-1.

    Structurei

    Secondary structure

    1
    232
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi34 – 385
    Helixi39 – 435
    Helixi45 – 473
    Beta strandi51 – 544
    Beta strandi56 – 627
    Beta strandi67 – 7610
    Turni79 – 835
    Helixi86 – 927
    Helixi94 – 10512
    Turni106 – 1083
    Helixi109 – 11911
    Helixi126 – 1305
    Beta strandi133 – 1408
    Beta strandi142 – 1454
    Beta strandi148 – 1536
    Helixi163 – 1708
    Beta strandi174 – 1763
    Helixi181 – 1833
    Helixi187 – 1959
    Turni201 – 2033
    Beta strandi206 – 2083
    Helixi211 – 22919

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3SP4X-ray1.80A/B33-232[»]
    3SPDX-ray1.91A/B/C/D33-232[»]
    3SPLX-ray2.10A/B/C/D33-232[»]
    3SZQX-ray2.35A31-232[»]
    ProteinModelPortaliO74859.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 160123HITAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HIT domain.Curated

    Phylogenomic databases

    eggNOGiNOG278510.
    HOGENOMiHOG000167639.
    KOiK10863.
    OMAiFTGEELY.
    OrthoDBiEOG7C8GT4.
    PhylomeDBiO74859.

    Family and domain databases

    Gene3Di3.30.428.10. 1 hit.
    InterProiIPR026963. Aprataxin.
    IPR001310. Histidine_triad_HIT.
    IPR011146. HIT-like.
    [Graphical view]
    PANTHERiPTHR12486. PTHR12486. 1 hit.
    PTHR12486:SF4. PTHR12486:SF4. 1 hit.
    PfamiPF01230. HIT. 1 hit.
    [Graphical view]
    SUPFAMiSSF54197. SSF54197. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O74859-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVHKTNDAF KVLMNSAKEP IVEDIPKKYR KQSFRDNLKV YIESPESYKN    50
    VIYYDDDVVL VRDMFPKSKM HLLLMTRDPH LTHVHPLEIM MKHRSLVEKL 100
    VSYVQGDLSG LIFDEARNCL SQQLTNEALC NYIKVGFHAG PSMNNLHLHI 150
    MTLDHVSPSL KNSAHYISFT SPFFVKIDTP TSNLPTRGTL TSLFQEDLKC 200
    WRCGETFGRH FTKLKAHLQE EYDDWLDKSV SM 232
    Length:232
    Mass (Da):26,922
    Last modified:November 1, 1998 - v1
    Checksum:i7B448C953ED13CFB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA21423.1.
    PIRiT41152.
    RefSeqiNP_588388.1. NM_001023379.2.

    Genome annotation databases

    EnsemblFungiiSPCC18.09c.1; SPCC18.09c.1:pep; SPCC18.09c.
    GeneIDi2539198.
    KEGGispo:SPCC18.09c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAA21423.1 .
    PIRi T41152.
    RefSeqi NP_588388.1. NM_001023379.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3SP4 X-ray 1.80 A/B 33-232 [» ]
    3SPD X-ray 1.91 A/B/C/D 33-232 [» ]
    3SPL X-ray 2.10 A/B/C/D 33-232 [» ]
    3SZQ X-ray 2.35 A 31-232 [» ]
    ProteinModelPortali O74859.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275769. 3 interactions.
    MINTi MINT-4681359.
    STRINGi 4896.SPCC18.09c-1.

    Proteomic databases

    MaxQBi O74859.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC18.09c.1 ; SPCC18.09c.1:pep ; SPCC18.09c .
    GeneIDi 2539198.
    KEGGi spo:SPCC18.09c.

    Organism-specific databases

    PomBasei SPCC18.09c.

    Phylogenomic databases

    eggNOGi NOG278510.
    HOGENOMi HOG000167639.
    KOi K10863.
    OMAi FTGEELY.
    OrthoDBi EOG7C8GT4.
    PhylomeDBi O74859.

    Miscellaneous databases

    NextBioi 20800369.

    Family and domain databases

    Gene3Di 3.30.428.10. 1 hit.
    InterProi IPR026963. Aprataxin.
    IPR001310. Histidine_triad_HIT.
    IPR011146. HIT-like.
    [Graphical view ]
    PANTHERi PTHR12486. PTHR12486. 1 hit.
    PTHR12486:SF4. PTHR12486:SF4. 1 hit.
    Pfami PF01230. HIT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54197. SSF54197. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAPTX_SCHPO
    AccessioniPrimary (citable) accession number: O74859
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3