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O74859

- APTX_SCHPO

UniProt

O74859 - APTX_SCHPO

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Protein

Aprataxin-like protein

Gene

hnt3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (By similarity).By similarity

GO - Molecular functioni

  1. DNA 5'-adenosine monophosphate hydrolase activity Source: PomBase
  2. mismatched DNA binding Source: PomBase
  3. single-strand break-containing DNA binding Source: PomBase
  4. single-stranded DNA binding Source: PomBase
  5. zinc ion binding Source: PomBase

GO - Biological processi

  1. DNA catabolic process, exonucleolytic Source: GOC
  2. DNA repair Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aprataxin-like protein (EC:3.-.-.-)
Alternative name(s):
Hit family protein 3
Gene namesi
Name:hnt3
ORF Names:SPCC18.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC18.09c.

Subcellular locationi

Nucleus 1 Publication. Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232Aprataxin-like proteinPRO_0000314650Add
BLAST

Proteomic databases

MaxQBiO74859.

Interactioni

Protein-protein interaction databases

BioGridi275769. 3 interactions.
MINTiMINT-4681359.
STRINGi4896.SPCC18.09c-1.

Structurei

Secondary structure

1
232
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi34 – 385
Helixi39 – 435
Helixi45 – 473
Beta strandi51 – 544
Beta strandi56 – 627
Beta strandi67 – 7610
Turni79 – 835
Helixi86 – 927
Helixi94 – 10512
Turni106 – 1083
Helixi109 – 11911
Helixi126 – 1305
Beta strandi133 – 1408
Beta strandi142 – 1454
Beta strandi148 – 1536
Helixi163 – 1708
Beta strandi174 – 1763
Helixi181 – 1833
Helixi187 – 1959
Turni201 – 2033
Beta strandi206 – 2083
Helixi211 – 22919

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SP4X-ray1.80A/B33-232[»]
3SPDX-ray1.91A/B/C/D33-232[»]
3SPLX-ray2.10A/B/C/D33-232[»]
3SZQX-ray2.35A31-232[»]
ProteinModelPortaliO74859.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 160123HITAdd
BLAST

Sequence similaritiesi

Contains 1 HIT domain.Curated

Phylogenomic databases

eggNOGiNOG278510.
HOGENOMiHOG000167639.
InParanoidiO74859.
KOiK10863.
OMAiFTGEELY.
OrthoDBiEOG7C8GT4.
PhylomeDBiO74859.

Family and domain databases

Gene3Di3.30.428.10. 1 hit.
InterProiIPR026963. Aprataxin.
IPR001310. Histidine_triad_HIT.
IPR011146. HIT-like.
[Graphical view]
PANTHERiPTHR12486. PTHR12486. 1 hit.
PTHR12486:SF4. PTHR12486:SF4. 1 hit.
PfamiPF01230. HIT. 1 hit.
[Graphical view]
SUPFAMiSSF54197. SSF54197. 1 hit.

Sequencei

Sequence statusi: Complete.

O74859 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVHKTNDAF KVLMNSAKEP IVEDIPKKYR KQSFRDNLKV YIESPESYKN
60 70 80 90 100
VIYYDDDVVL VRDMFPKSKM HLLLMTRDPH LTHVHPLEIM MKHRSLVEKL
110 120 130 140 150
VSYVQGDLSG LIFDEARNCL SQQLTNEALC NYIKVGFHAG PSMNNLHLHI
160 170 180 190 200
MTLDHVSPSL KNSAHYISFT SPFFVKIDTP TSNLPTRGTL TSLFQEDLKC
210 220 230
WRCGETFGRH FTKLKAHLQE EYDDWLDKSV SM
Length:232
Mass (Da):26,922
Last modified:November 1, 1998 - v1
Checksum:i7B448C953ED13CFB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA21423.1.
PIRiT41152.
RefSeqiNP_588388.1. NM_001023379.2.

Genome annotation databases

EnsemblFungiiSPCC18.09c.1; SPCC18.09c.1:pep; SPCC18.09c.
GeneIDi2539198.
KEGGispo:SPCC18.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAA21423.1 .
PIRi T41152.
RefSeqi NP_588388.1. NM_001023379.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3SP4 X-ray 1.80 A/B 33-232 [» ]
3SPD X-ray 1.91 A/B/C/D 33-232 [» ]
3SPL X-ray 2.10 A/B/C/D 33-232 [» ]
3SZQ X-ray 2.35 A 31-232 [» ]
ProteinModelPortali O74859.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275769. 3 interactions.
MINTi MINT-4681359.
STRINGi 4896.SPCC18.09c-1.

Proteomic databases

MaxQBi O74859.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC18.09c.1 ; SPCC18.09c.1:pep ; SPCC18.09c .
GeneIDi 2539198.
KEGGi spo:SPCC18.09c.

Organism-specific databases

PomBasei SPCC18.09c.

Phylogenomic databases

eggNOGi NOG278510.
HOGENOMi HOG000167639.
InParanoidi O74859.
KOi K10863.
OMAi FTGEELY.
OrthoDBi EOG7C8GT4.
PhylomeDBi O74859.

Miscellaneous databases

NextBioi 20800369.

Family and domain databases

Gene3Di 3.30.428.10. 1 hit.
InterProi IPR026963. Aprataxin.
IPR001310. Histidine_triad_HIT.
IPR011146. HIT-like.
[Graphical view ]
PANTHERi PTHR12486. PTHR12486. 1 hit.
PTHR12486:SF4. PTHR12486:SF4. 1 hit.
Pfami PF01230. HIT. 1 hit.
[Graphical view ]
SUPFAMi SSF54197. SSF54197. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAPTX_SCHPO
AccessioniPrimary (citable) accession number: O74859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3