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O74849 (GHT6_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
High-affinity fructose transporter ght6
Alternative name(s):
Hexose transporter 6
Meiotic expression up-regulated protein 12
Gene names
Name:ght6
Synonyms:meu12
ORF Names:SPCC1235.13
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length535 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

High-affinity fructose transporter.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Ontologies

Keywords
   Biological processMeiosis
Sugar transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processmeiosis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcell division site

Inferred from direct assay. Source: GeneDB_Spombe

cell tip

Inferred from direct assay. Source: GeneDB_Spombe

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from sequence or structural similarity. Source: GeneDB_Spombe

   Molecular functionhexose transmembrane transporter activity

Non-traceable author statement. Source: GeneDB_Spombe

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 535535High-affinity fructose transporter ght6
PRO_0000050414

Regions

Topological domain1 – 99Cytoplasmic Potential
Transmembrane10 – 3021Helical; Name=1; Potential
Topological domain31 – 5828Extracellular Potential
Transmembrane59 – 7921Helical; Name=2; Potential
Topological domain80 – 878Cytoplasmic Potential
Transmembrane88 – 10821Helical; Name=3; Potential
Topological domain109 – 1124Extracellular Potential
Transmembrane113 – 13321Helical; Name=4; Potential
Topological domain134 – 14411Cytoplasmic Potential
Transmembrane145 – 16521Helical; Name=5; Potential
Topological domain166 – 18116Extracellular Potential
Transmembrane182 – 20221Helical; Name=6; Potential
Topological domain203 – 26866Cytoplasmic Potential
Transmembrane269 – 28719Helical; Name=7; Potential
Topological domain288 – 30316Extracellular Potential
Transmembrane304 – 32421Helical; Name=8; Potential
Topological domain325 – 3306Cytoplasmic Potential
Transmembrane331 – 35121Helical; Name=9; Potential
Topological domain352 – 36514Extracellular Potential
Transmembrane366 – 38621Helical; Name=10; Potential
Topological domain387 – 40620Cytoplasmic Potential
Transmembrane407 – 42721Helical; Name=11; Potential
Topological domain428 – 4347Extracellular Potential
Transmembrane435 – 45521Helical; Name=12; Potential
Topological domain456 – 53580Cytoplasmic Potential

Amino acid modifications

Glycosylation3591N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O74849 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: FECBDB9A4E51E844

FASTA53559,404
        10         20         30         40         50         60 
MAKILTIVML VFVSMAGWMF GADTGSIGGI TNMRDFQSRY ADRYDPVTDT YSYSSARQGL 

        70         80         90        100        110        120 
LVGMVNTGTT VGCLLSSPLG DRFGKRKCIM GWTLVYITGV IVQLTTIPSW VQMMVAKIWT 

       130        140        150        160        170        180 
GLGIGALSVI APGYQSESSP PHIRGAIVTT YQLFITLGIF IAACINMGTH KYTTHPEAQW 

       190        200        210        220        230        240 
RVPIGINLLW GILMFFGMLF LPESPRYLAV KGRNEECMKI LTRNAGLPAD HPIMQKEYNA 

       250        260        270        280        290        300 
IQADVEAELA GGPCSWPQIF SNEIRYRTLL GMGVMAFQQL TGNNYFFYYG TQVFRGTGLN 

       310        320        330        340        350        360 
SPFLAALILD AVNFGCTFGA IFVLEYFGRR GPLIVGGVWQ SICFFIYASV GDRALTRPNG 

       370        380        390        400        410        420 
TSNHRAGAVM IVFSCLFIFS FAQTWAPAAY VIVGESYPIR YRSKCAAVAT ASNWFWNFMI 

       430        440        450        460        470        480 
SFFTPFISNS IGFKYGYVFA ACNLCAAIII FLFAKETKGL TLEEINQLYL SNIKPWNTGA 

       490        500        510        520        530 
YQRDREDIKQ SDSEKERGPT SKLHEYVEHA PNSYASTHST ESENYPQQVT NPVGL

« Hide

References

« Hide 'large scale' references
[1]"Multiple hexose transporters of Schizosaccharomyces pombe."
Heiland S., Radovanovic N., Hoefer M., Winderickx J., Lichtenberg H.
J. Bacteriol. 182:2153-2162(2000) [PubMed: 10735857] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
Strain: 972 / ATCC 24843.
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed: 11859360] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Comprehensive isolation of meiosis-specific genes identifies novel proteins and unusual non-coding transcripts in Schizosaccharomyces pombe."
Watanabe T., Miyashita K., Saito T.T., Yoneki T., Kakihara Y., Nabeshima K., Kishi Y.A., Shimoda C., Nojima H.
Nucleic Acids Res. 29:2327-2337(2001) [PubMed: 11376151] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 478-535.
Strain: CD16-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF098076 Genomic DNA. Translation: AAC64976.1.
CU329672 Genomic DNA. Translation: CAA21117.1.
AB054532 mRNA. Translation: BAB60886.1.
PIRT40887.
RefSeqNP_587739.1. NM_001022734.1.

3D structure databases

ProteinModelPortalO74849.
ModBaseSearch...

Protein-protein interaction databases

STRINGO74849.

Protein family/group databases

TCDB2.A.1.1.22. major facilitator superfamily (MFS).

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC1235.13.1; SPCC1235.13.1:pep; SPCC1235.13.
GeneID2538845.
GenomeReviewsGene locus ght6 in contig CU329672_GR.
KEGGspo:SPCC1235.13.
NMPDRfig|4896.1.peg.77.

Organism-specific databases

GeneDB_SpombeSPCC1235.13.

Phylogenomic databases

eggNOGfuNOG06406.
GeneTreeEFGT00070000008710.
HOGENOMHBG744444.
OrthoDBEOG43246F.

Enzyme and pathway databases

BioCycSPOM-XXX-01:SPOM-XXX-01-002102-MONOMER.

Gene expression databases

ArrayExpressO74849.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
KOK08139.
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSPR00171. SUGRTRNSPORT.
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR00879. SP. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGHT6_SCHPO
AccessionPrimary (citable) accession number: O74849
Secondary accession number(s): Q96TK9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: December 14, 2011
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents