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Protein

High-affinity fructose transporter ght6

Gene

ght6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity fructose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: PomBase
  • glucose transmembrane transporter activity Source: PomBase

GO - Biological processi

  • fructose import across plasma membrane Source: PomBase
  • glucose import across plasma membrane Source: PomBase
  • meiotic cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Meiosis, Sugar transport, Transport

Protein family/group databases

TCDBi2.A.1.1.22. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity fructose transporter ght6
Alternative name(s):
Hexose transporter 6
Meiotic expression up-regulated protein 12
Gene namesi
Name:ght6
Synonyms:meu12
ORF Names:SPCC1235.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1235.13.
PomBaseiSPCC1235.13. ght6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence analysis
Transmembranei10 – 3021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini31 – 5828ExtracellularSequence analysisAdd
BLAST
Transmembranei59 – 7921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 878CytoplasmicSequence analysis
Transmembranei88 – 10821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini109 – 1124ExtracellularSequence analysis
Transmembranei113 – 13321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini134 – 14411CytoplasmicSequence analysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini166 – 18116ExtracellularSequence analysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini203 – 26866CytoplasmicSequence analysisAdd
BLAST
Transmembranei269 – 28719Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini288 – 30316ExtracellularSequence analysisAdd
BLAST
Transmembranei304 – 32421Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini325 – 3306CytoplasmicSequence analysis
Transmembranei331 – 35121Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini352 – 36514ExtracellularSequence analysisAdd
BLAST
Transmembranei366 – 38621Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini387 – 40620CytoplasmicSequence analysisAdd
BLAST
Transmembranei407 – 42721Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini428 – 4347ExtracellularSequence analysis
Transmembranei435 – 45521Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini456 – 53580CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell division site Source: PomBase
  • cell tip Source: PomBase
  • integral component of plasma membrane Source: PomBase
  • plasma membrane Source: PomBase
  • vacuole Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 535535High-affinity fructose transporter ght6PRO_0000050414Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi359 – 3591N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

BioGridi275426. 11 interactions.
MINTiMINT-4681235.

Structurei

3D structure databases

ProteinModelPortaliO74849.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202870.
InParanoidiO74849.
KOiK08139.
OrthoDBiEOG73JM4H.
PhylomeDBiO74849.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKILTIVML VFVSMAGWMF GADTGSIGGI TNMRDFQSRY ADRYDPVTDT
60 70 80 90 100
YSYSSARQGL LVGMVNTGTT VGCLLSSPLG DRFGKRKCIM GWTLVYITGV
110 120 130 140 150
IVQLTTIPSW VQMMVAKIWT GLGIGALSVI APGYQSESSP PHIRGAIVTT
160 170 180 190 200
YQLFITLGIF IAACINMGTH KYTTHPEAQW RVPIGINLLW GILMFFGMLF
210 220 230 240 250
LPESPRYLAV KGRNEECMKI LTRNAGLPAD HPIMQKEYNA IQADVEAELA
260 270 280 290 300
GGPCSWPQIF SNEIRYRTLL GMGVMAFQQL TGNNYFFYYG TQVFRGTGLN
310 320 330 340 350
SPFLAALILD AVNFGCTFGA IFVLEYFGRR GPLIVGGVWQ SICFFIYASV
360 370 380 390 400
GDRALTRPNG TSNHRAGAVM IVFSCLFIFS FAQTWAPAAY VIVGESYPIR
410 420 430 440 450
YRSKCAAVAT ASNWFWNFMI SFFTPFISNS IGFKYGYVFA ACNLCAAIII
460 470 480 490 500
FLFAKETKGL TLEEINQLYL SNIKPWNTGA YQRDREDIKQ SDSEKERGPT
510 520 530
SKLHEYVEHA PNSYASTHST ESENYPQQVT NPVGL
Length:535
Mass (Da):59,404
Last modified:November 1, 1998 - v1
Checksum:iFECBDB9A4E51E844
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098076 Genomic DNA. Translation: AAC64976.1.
CU329672 Genomic DNA. Translation: CAA21117.1.
AB054532 mRNA. Translation: BAB60886.1.
PIRiT40887.
RefSeqiNP_587739.1. NM_001022734.2.

Genome annotation databases

EnsemblFungiiSPCC1235.13.1; SPCC1235.13.1:pep; SPCC1235.13.
GeneIDi2538845.
KEGGispo:SPCC1235.13.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098076 Genomic DNA. Translation: AAC64976.1.
CU329672 Genomic DNA. Translation: CAA21117.1.
AB054532 mRNA. Translation: BAB60886.1.
PIRiT40887.
RefSeqiNP_587739.1. NM_001022734.2.

3D structure databases

ProteinModelPortaliO74849.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275426. 11 interactions.
MINTiMINT-4681235.

Protein family/group databases

TCDBi2.A.1.1.22. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1235.13.1; SPCC1235.13.1:pep; SPCC1235.13.
GeneIDi2538845.
KEGGispo:SPCC1235.13.

Organism-specific databases

EuPathDBiFungiDB:SPCC1235.13.
PomBaseiSPCC1235.13. ght6.

Phylogenomic databases

HOGENOMiHOG000202870.
InParanoidiO74849.
KOiK08139.
OrthoDBiEOG73JM4H.
PhylomeDBiO74849.

Miscellaneous databases

PROiO74849.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: 972 / ATCC 24843.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Comprehensive isolation of meiosis-specific genes identifies novel proteins and unusual non-coding transcripts in Schizosaccharomyces pombe."
    Watanabe T., Miyashita K., Saito T.T., Yoneki T., Kakihara Y., Nabeshima K., Kishi Y.A., Shimoda C., Nojima H.
    Nucleic Acids Res. 29:2327-2337(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 478-535.
    Strain: CD16-1.

Entry informationi

Entry nameiGHT6_SCHPO
AccessioniPrimary (citable) accession number: O74849
Secondary accession number(s): Q96TK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.