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Protein

High-affinity fructose transporter ght6

Gene

ght6

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity fructose transporter.

GO - Molecular functioni

  • carbohydrate:proton symporter activity Source: GO_Central
  • fructose transmembrane transporter activity Source: PomBase
  • glucose transmembrane transporter activity Source: PomBase

GO - Biological processi

  • fructose import across plasma membrane Source: PomBase
  • glucose import across plasma membrane Source: PomBase
  • meiotic cell cycle Source: UniProtKB-KW

Keywordsi

Biological processMeiosis, Sugar transport, Transport

Protein family/group databases

TCDBi2.A.1.1.22 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
High-affinity fructose transporter ght6
Alternative name(s):
Hexose transporter 6
Meiotic expression up-regulated protein 12
Gene namesi
Name:ght6
Synonyms:meu12
ORF Names:SPCC1235.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1235.13
PomBaseiSPCC1235.13 ght6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 58ExtracellularSequence analysisAdd BLAST28
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 87CytoplasmicSequence analysis8
Transmembranei88 – 108Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini109 – 112ExtracellularSequence analysis4
Transmembranei113 – 133Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini134 – 144CytoplasmicSequence analysisAdd BLAST11
Transmembranei145 – 165Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini166 – 181ExtracellularSequence analysisAdd BLAST16
Transmembranei182 – 202Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini203 – 268CytoplasmicSequence analysisAdd BLAST66
Transmembranei269 – 287Helical; Name=7Sequence analysisAdd BLAST19
Topological domaini288 – 303ExtracellularSequence analysisAdd BLAST16
Transmembranei304 – 324Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini325 – 330CytoplasmicSequence analysis6
Transmembranei331 – 351Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini352 – 365ExtracellularSequence analysisAdd BLAST14
Transmembranei366 – 386Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini387 – 406CytoplasmicSequence analysisAdd BLAST20
Transmembranei407 – 427Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini428 – 434ExtracellularSequence analysis7
Transmembranei435 – 455Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini456 – 535CytoplasmicSequence analysisAdd BLAST80

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504141 – 535High-affinity fructose transporter ght6Add BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO74849
PRIDEiO74849

Interactioni

Protein-protein interaction databases

BioGridi275426, 11 interactors
STRINGi4896.SPCC1235.13.1

Structurei

3D structure databases

ProteinModelPortaliO74849
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000202870
InParanoidiO74849
KOiK08139
OMAiMGASIGW
OrthoDBiEOG092C1Q5W
PhylomeDBiO74849

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

Sequencei

Sequence statusi: Complete.

O74849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKILTIVML VFVSMAGWMF GADTGSIGGI TNMRDFQSRY ADRYDPVTDT
60 70 80 90 100
YSYSSARQGL LVGMVNTGTT VGCLLSSPLG DRFGKRKCIM GWTLVYITGV
110 120 130 140 150
IVQLTTIPSW VQMMVAKIWT GLGIGALSVI APGYQSESSP PHIRGAIVTT
160 170 180 190 200
YQLFITLGIF IAACINMGTH KYTTHPEAQW RVPIGINLLW GILMFFGMLF
210 220 230 240 250
LPESPRYLAV KGRNEECMKI LTRNAGLPAD HPIMQKEYNA IQADVEAELA
260 270 280 290 300
GGPCSWPQIF SNEIRYRTLL GMGVMAFQQL TGNNYFFYYG TQVFRGTGLN
310 320 330 340 350
SPFLAALILD AVNFGCTFGA IFVLEYFGRR GPLIVGGVWQ SICFFIYASV
360 370 380 390 400
GDRALTRPNG TSNHRAGAVM IVFSCLFIFS FAQTWAPAAY VIVGESYPIR
410 420 430 440 450
YRSKCAAVAT ASNWFWNFMI SFFTPFISNS IGFKYGYVFA ACNLCAAIII
460 470 480 490 500
FLFAKETKGL TLEEINQLYL SNIKPWNTGA YQRDREDIKQ SDSEKERGPT
510 520 530
SKLHEYVEHA PNSYASTHST ESENYPQQVT NPVGL
Length:535
Mass (Da):59,404
Last modified:November 1, 1998 - v1
Checksum:iFECBDB9A4E51E844
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098076 Genomic DNA Translation: AAC64976.1
CU329672 Genomic DNA Translation: CAA21117.1
AB054532 mRNA Translation: BAB60886.1
PIRiT40887
RefSeqiNP_587739.1, NM_001022734.2

Genome annotation databases

EnsemblFungiiSPCC1235.13.1; SPCC1235.13.1:pep; SPCC1235.13
GeneIDi2538845
KEGGispo:SPCC1235.13

Similar proteinsi

Entry informationi

Entry nameiGHT6_SCHPO
AccessioniPrimary (citable) accession number: O74849
Secondary accession number(s): Q96TK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health