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Protein

Set3 complex subunit hif2

Gene

hif2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the set3 histone deacetylase complex which is involved in chromatin remodeling and transcription regulation, such as repression of the sporulation gene program.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Set3 complex subunit hif2
Gene namesi
Name:hif2
ORF Names:SPCC1235.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1235.09.
PomBaseiSPCC1235.09. hif2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase
  • Rpd3L-Expanded complex Source: PomBase
  • Set3 complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003038991 – 564Set3 complex subunit hif2Add BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei137Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74845.
PRIDEiO74845.

PTM databases

iPTMnetiO74845.

Interactioni

Subunit structurei

Component of the set3 histone deacetylase complex.1 Publication

Protein-protein interaction databases

BioGridi275286. 103 interactors.
MINTiMINT-4681192.

Structurei

3D structure databases

ProteinModelPortaliO74845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 34LisHPROSITE-ProRule annotationAdd BLAST33
Repeati262 – 302WD 1Add BLAST41
Repeati303 – 342WD 2Add BLAST40
Repeati344 – 382WD 3Add BLAST39
Repeati386 – 425WD 4Add BLAST40
Repeati430 – 470WD 5Add BLAST41
Repeati473 – 512WD 6Add BLAST40

Sequence similaritiesi

Contains 1 LisH domain.PROSITE-ProRule annotation
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiO74845.
KOiK04508.
OMAiAHEREEP.
OrthoDBiEOG092C2LQW.
PhylomeDBiO74845.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTNQVNYII WRYLKECGYS HTKFAFERET GIQNLDKQWG STCQVGALVE
60 70 80 90 100
ILQKGLQYVE LEKHYVDNHS SNEEASKTSI DGESLVNENP CKLPFYLTVP
110 120 130 140 150
HICETTLTKA DSTNGFCEHN NSNDHQLKIL QDKGSGSPSS PVMPFKDKIE
160 170 180 190 200
KRDIDITMAD ESNVEKDPAR PIAVYNSSPV TEITEIKQVT FTGGEDIKSD
210 220 230 240 250
FFKVIPTKHP VTCADWRPLL QENYHVYEFS IGMTNATLAS VSICEEQNDF
260 270 280 290 300
KAKTDYCLQS SFDNQDITGV AWNNSGSFLA YAFFSGVIEI YDSHGSQILS
310 320 330 340 350
FHNNKGPVLS LKWSGTDTYL AAGSADGTIT LFDQLKQTQY SIDTLASSVL
360 370 380 390 400
DIEWISFDEF VTSDVEGSLR VYKVDGKAPV STVSHAHDNS IVALRYNLRI
410 420 430 440 450
SLLLTASSDT TVKLWSRGDA GAFECLHVFS FSSPVNCIDW NLREGTPILA
460 470 480 490 500
VASNSIVSMY NAISLQQLAV FMRHTAPVSA LSFSHNGRYL ATGDTSGGVC
510 520 530 540 550
IWSCKTAKLF KELGSDNSEL IAVTNVLPEE QVNFLRWSFD DKDLLIGKQK
560
KEIICCCDFL HDSL
Length:564
Mass (Da):62,758
Last modified:November 1, 1998 - v1
Checksum:i11C836D2C295B389
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21113.1.
PIRiT40883.
RefSeqiNP_587735.1. NM_001022730.2.

Genome annotation databases

EnsemblFungiiSPCC1235.09.1; SPCC1235.09.1:pep; SPCC1235.09.
GeneIDi2538701.
KEGGispo:SPCC1235.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21113.1.
PIRiT40883.
RefSeqiNP_587735.1. NM_001022730.2.

3D structure databases

ProteinModelPortaliO74845.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275286. 103 interactors.
MINTiMINT-4681192.

PTM databases

iPTMnetiO74845.

Proteomic databases

MaxQBiO74845.
PRIDEiO74845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1235.09.1; SPCC1235.09.1:pep; SPCC1235.09.
GeneIDi2538701.
KEGGispo:SPCC1235.09.

Organism-specific databases

EuPathDBiFungiDB:SPCC1235.09.
PomBaseiSPCC1235.09. hif2.

Phylogenomic databases

InParanoidiO74845.
KOiK04508.
OMAiAHEREEP.
OrthoDBiEOG092C2LQW.
PhylomeDBiO74845.

Miscellaneous databases

PROiO74845.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR006594. LisH.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50896. LISH. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIF2_SCHPO
AccessioniPrimary (citable) accession number: O74845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.