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Protein

Set3 complex subunit hif2

Gene

hif2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the set3 histone deacetylase complex which is involved in chromatin remodeling and transcription regulation, such as repression of the sporulation gene program.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Set3 complex subunit hif2
Gene namesi
Name:hif2
ORF Names:SPCC1235.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1235.09
PomBaseiSPCC1235.09 hif2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003038991 – 564Set3 complex subunit hif2Add BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei137Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74845
PaxDbiO74845
PRIDEiO74845

PTM databases

iPTMnetiO74845

Interactioni

Subunit structurei

Component of the set3 histone deacetylase complex.1 Publication

Protein-protein interaction databases

BioGridi275286, 103 interactors
STRINGi4896.SPCC1235.09.1

Structurei

3D structure databases

ProteinModelPortaliO74845
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 34LisHPROSITE-ProRule annotationAdd BLAST33
Repeati262 – 302WD 1Add BLAST41
Repeati303 – 342WD 2Add BLAST40
Repeati344 – 382WD 3Add BLAST39
Repeati386 – 425WD 4Add BLAST40
Repeati430 – 470WD 5Add BLAST41
Repeati473 – 512WD 6Add BLAST40

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

InParanoidiO74845
KOiK04508
OMAiENGAHEI
OrthoDBiEOG092C2LQW
PhylomeDBiO74845

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08513 LisH, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00667 LisH, 1 hit
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O74845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTNQVNYII WRYLKECGYS HTKFAFERET GIQNLDKQWG STCQVGALVE
60 70 80 90 100
ILQKGLQYVE LEKHYVDNHS SNEEASKTSI DGESLVNENP CKLPFYLTVP
110 120 130 140 150
HICETTLTKA DSTNGFCEHN NSNDHQLKIL QDKGSGSPSS PVMPFKDKIE
160 170 180 190 200
KRDIDITMAD ESNVEKDPAR PIAVYNSSPV TEITEIKQVT FTGGEDIKSD
210 220 230 240 250
FFKVIPTKHP VTCADWRPLL QENYHVYEFS IGMTNATLAS VSICEEQNDF
260 270 280 290 300
KAKTDYCLQS SFDNQDITGV AWNNSGSFLA YAFFSGVIEI YDSHGSQILS
310 320 330 340 350
FHNNKGPVLS LKWSGTDTYL AAGSADGTIT LFDQLKQTQY SIDTLASSVL
360 370 380 390 400
DIEWISFDEF VTSDVEGSLR VYKVDGKAPV STVSHAHDNS IVALRYNLRI
410 420 430 440 450
SLLLTASSDT TVKLWSRGDA GAFECLHVFS FSSPVNCIDW NLREGTPILA
460 470 480 490 500
VASNSIVSMY NAISLQQLAV FMRHTAPVSA LSFSHNGRYL ATGDTSGGVC
510 520 530 540 550
IWSCKTAKLF KELGSDNSEL IAVTNVLPEE QVNFLRWSFD DKDLLIGKQK
560
KEIICCCDFL HDSL
Length:564
Mass (Da):62,758
Last modified:November 1, 1998 - v1
Checksum:i11C836D2C295B389
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA21113.1
PIRiT40883
RefSeqiNP_587735.1, NM_001022730.2

Genome annotation databases

EnsemblFungiiSPCC1235.09.1; SPCC1235.09.1:pep; SPCC1235.09
GeneIDi2538701
KEGGispo:SPCC1235.09

Entry informationi

Entry nameiHIF2_SCHPO
AccessioniPrimary (citable) accession number: O74845
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health