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Protein

ATP-dependent helicase fft2

Gene

fft2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi575 – 5828ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent helicase fft2 (EC:3.6.4.12)
Alternative name(s):
Fun thirty-related protein 2
Gene namesi
Name:fft2
ORF Names:SPCC1235.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1235.05c.
PomBaseiSPCC1235.05c. fft2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12841284ATP-dependent helicase fft2PRO_0000310748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei323 – 3231Phosphoserine1 Publication
Modified residuei383 – 3831Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74842.

PTM databases

iPTMnetiO74842.

Interactioni

Protein-protein interaction databases

BioGridi275618. 30 interactions.
MINTiMINT-4681163.

Structurei

3D structure databases

ProteinModelPortaliO74842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini562 – 730169Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini928 – 1079152Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi681 – 6844DEGH box

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO74842.
KOiK14439.
OrthoDBiEOG092C0RAA.
PhylomeDBiO74842.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPYNSNYLS DNGKRKFSDE NPQSEVYGSS QTGLPSSYGN PQSYGTPPVQ
60 70 80 90 100
QSSAMYGVNN SMGGGMYNTS ENTQFMNTDY SQTSSYASTP MSNAYSRDAP
110 120 130 140 150
AAINNNFGYS YVGQSSQPVP SYNPLPSYNT ASLPNAGIPA AMPGMPSGYP
160 170 180 190 200
GTVPIPQGGY NAHYSSPYNN GYPIGAVNPT SAIPAQPPAQ PVNNVLPSYV
210 220 230 240 250
RSNSRSSARS TARSAPRSTQ RSRSSSANPV TTPPVNNTLL TPPAPPVELP
260 270 280 290 300
PVTTTSPNAI IRSVQWIRSF VPQAPIHQVI NTLAQTKWDE TAALSILSQK
310 320 330 340 350
YLSCDLGIPI QEHKRFKQSP VASNMPTYGS SNRTVQSQKR SIRDKYIQMP
360 370 380 390 400
NDSTQASLMP SYTRKTSNAS KKLTTEEDEF YDSEEEPEAI VHRDTSALER
410 420 430 440 450
TVLNFINSST AKELSDTASC PLSHSKLLLE HRPFQTLAEA CIIKHPDDVP
460 470 480 490 500
SKPGRRGRRR EKNPMGQKIV NACMETMEGY YAIDNLIAKC EFLGNRISKG
510 520 530 540 550
MASWGIKLEM SNGELNIVDM ESVPTEAADN SDFPKFVTEQ PKTLASDVQL
560 570 580 590 600
KSYQLVGVNW LHLLYQQKLS GILADEMGLG KTCQVVAFFA LLLEQGHHGP
610 620 630 640 650
HLVVVPSSTL ENWLRELARF CPSLRVEPYY GSQQERANIR EAIEENEIKY
660 670 680 690 700
DILVTTYQLA TNNKEDRSFL KHQNFDVCVY DEGHYLKNRM SERYKHLMNL
710 720 730 740 750
NANFRLLLTG TPLQNNLKEL VSLLAFILPN MFDSDMDDLD VIFKAKPTAD
760 770 780 790 800
ADIEQALLSK QRISRAKTMM TPFVLRRRKN QVLNDLPKKT QIIEHCKLSE
810 820 830 840 850
NQLEIYNRYA ALQKNQQLRR DDKRNKRSKN DEESDGKSLS AGHVLMQLRK
860 870 880 890 900
AANHALLFRK FYDDEKLKQM AKDIMQEEQY KNANEQYIYE DMEVMSDFEL
910 920 930 940 950
HRLCRSFPTL QSYTLKDDPW MDSGKIRVLK ELLPKMKEEG SRILLFSQFT
960 970 980 990 1000
QMLDILEQVL DTLKISYVRL DGSTQVEVRQ DIIDQFHKEE DVTVFLLSTK
1010 1020 1030 1040 1050
AGGFGINLAC ANVVILYDCS YNPFDDLQAE DRAHRVGQVR EVTVIRLITD
1060 1070 1080 1090 1100
NTIEEYIQKL ANTKLALDMS LSSDGKDREE IGERLVQDML DEENNGNNTK
1110 1120 1130 1140 1150
PEITGNESDG EFKVSSSNNS KQTDAEETNT GVPLEGSQPN SVEKTDLADG
1160 1170 1180 1190 1200
DEKANIKTEM KSETVEGDNK ELRETMKGEN VQTDSNAAVP SSKSSTEEPN
1210 1220 1230 1240 1250
ESVLSGHLDL DTEASPVVST IEKTTKGDVS VTEEQQSANI DGQLEKPEIE
1260 1270 1280
ESKKPDVLNQ VSLSIEEEKP KNKESEVDNN AAKD
Length:1,284
Mass (Da):143,667
Last modified:November 1, 1998 - v1
Checksum:i018E16C67B4C3759
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21109.1.
PIRiT40879.
RefSeqiNP_587731.1. NM_001022726.2.

Genome annotation databases

EnsemblFungiiSPCC1235.05c.1; SPCC1235.05c.1:pep; SPCC1235.05c.
GeneIDi2539045.
KEGGispo:SPCC1235.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21109.1.
PIRiT40879.
RefSeqiNP_587731.1. NM_001022726.2.

3D structure databases

ProteinModelPortaliO74842.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275618. 30 interactions.
MINTiMINT-4681163.

PTM databases

iPTMnetiO74842.

Proteomic databases

MaxQBiO74842.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1235.05c.1; SPCC1235.05c.1:pep; SPCC1235.05c.
GeneIDi2539045.
KEGGispo:SPCC1235.05c.

Organism-specific databases

EuPathDBiFungiDB:SPCC1235.05c.
PomBaseiSPCC1235.05c. fft2.

Phylogenomic databases

InParanoidiO74842.
KOiK14439.
OrthoDBiEOG092C0RAA.
PhylomeDBiO74842.

Miscellaneous databases

PROiO74842.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFFT2_SCHPO
AccessioniPrimary (citable) accession number: O74842
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.