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Protein

ATP-dependent helicase fft2

Gene

fft2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi575 – 582ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent helicase fft2 (EC:3.6.4.12)
Alternative name(s):
Fun thirty-related protein 2
Gene namesi
Name:fft2
ORF Names:SPCC1235.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1235.05c
PomBaseiSPCC1235.05c fft2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003107481 – 1284ATP-dependent helicase fft2Add BLAST1284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei323Phosphoserine1 Publication1
Modified residuei383Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO74842
PaxDbiO74842
PRIDEiO74842

PTM databases

iPTMnetiO74842

Interactioni

Protein-protein interaction databases

BioGridi275618, 30 interactors
STRINGi4896.SPCC1235.05c.1

Structurei

3D structure databases

ProteinModelPortaliO74842
SMRiO74842
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini562 – 730Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST169
Domaini928 – 1079Helicase C-terminalPROSITE-ProRule annotationAdd BLAST152

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi681 – 684DEGH box4

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Phylogenomic databases

InParanoidiO74842
KOiK14439
OrthoDBiEOG092C0RAA
PhylomeDBiO74842

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

O74842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPYNSNYLS DNGKRKFSDE NPQSEVYGSS QTGLPSSYGN PQSYGTPPVQ
60 70 80 90 100
QSSAMYGVNN SMGGGMYNTS ENTQFMNTDY SQTSSYASTP MSNAYSRDAP
110 120 130 140 150
AAINNNFGYS YVGQSSQPVP SYNPLPSYNT ASLPNAGIPA AMPGMPSGYP
160 170 180 190 200
GTVPIPQGGY NAHYSSPYNN GYPIGAVNPT SAIPAQPPAQ PVNNVLPSYV
210 220 230 240 250
RSNSRSSARS TARSAPRSTQ RSRSSSANPV TTPPVNNTLL TPPAPPVELP
260 270 280 290 300
PVTTTSPNAI IRSVQWIRSF VPQAPIHQVI NTLAQTKWDE TAALSILSQK
310 320 330 340 350
YLSCDLGIPI QEHKRFKQSP VASNMPTYGS SNRTVQSQKR SIRDKYIQMP
360 370 380 390 400
NDSTQASLMP SYTRKTSNAS KKLTTEEDEF YDSEEEPEAI VHRDTSALER
410 420 430 440 450
TVLNFINSST AKELSDTASC PLSHSKLLLE HRPFQTLAEA CIIKHPDDVP
460 470 480 490 500
SKPGRRGRRR EKNPMGQKIV NACMETMEGY YAIDNLIAKC EFLGNRISKG
510 520 530 540 550
MASWGIKLEM SNGELNIVDM ESVPTEAADN SDFPKFVTEQ PKTLASDVQL
560 570 580 590 600
KSYQLVGVNW LHLLYQQKLS GILADEMGLG KTCQVVAFFA LLLEQGHHGP
610 620 630 640 650
HLVVVPSSTL ENWLRELARF CPSLRVEPYY GSQQERANIR EAIEENEIKY
660 670 680 690 700
DILVTTYQLA TNNKEDRSFL KHQNFDVCVY DEGHYLKNRM SERYKHLMNL
710 720 730 740 750
NANFRLLLTG TPLQNNLKEL VSLLAFILPN MFDSDMDDLD VIFKAKPTAD
760 770 780 790 800
ADIEQALLSK QRISRAKTMM TPFVLRRRKN QVLNDLPKKT QIIEHCKLSE
810 820 830 840 850
NQLEIYNRYA ALQKNQQLRR DDKRNKRSKN DEESDGKSLS AGHVLMQLRK
860 870 880 890 900
AANHALLFRK FYDDEKLKQM AKDIMQEEQY KNANEQYIYE DMEVMSDFEL
910 920 930 940 950
HRLCRSFPTL QSYTLKDDPW MDSGKIRVLK ELLPKMKEEG SRILLFSQFT
960 970 980 990 1000
QMLDILEQVL DTLKISYVRL DGSTQVEVRQ DIIDQFHKEE DVTVFLLSTK
1010 1020 1030 1040 1050
AGGFGINLAC ANVVILYDCS YNPFDDLQAE DRAHRVGQVR EVTVIRLITD
1060 1070 1080 1090 1100
NTIEEYIQKL ANTKLALDMS LSSDGKDREE IGERLVQDML DEENNGNNTK
1110 1120 1130 1140 1150
PEITGNESDG EFKVSSSNNS KQTDAEETNT GVPLEGSQPN SVEKTDLADG
1160 1170 1180 1190 1200
DEKANIKTEM KSETVEGDNK ELRETMKGEN VQTDSNAAVP SSKSSTEEPN
1210 1220 1230 1240 1250
ESVLSGHLDL DTEASPVVST IEKTTKGDVS VTEEQQSANI DGQLEKPEIE
1260 1270 1280
ESKKPDVLNQ VSLSIEEEKP KNKESEVDNN AAKD
Length:1,284
Mass (Da):143,667
Last modified:November 1, 1998 - v1
Checksum:i018E16C67B4C3759
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAA21109.1
PIRiT40879
RefSeqiNP_587731.1, NM_001022726.2

Genome annotation databases

EnsemblFungiiSPCC1235.05c.1; SPCC1235.05c.1:pep; SPCC1235.05c
GeneIDi2539045
KEGGispo:SPCC1235.05c

Similar proteinsi

Entry informationi

Entry nameiFFT2_SCHPO
AccessioniPrimary (citable) accession number: O74842
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 1, 1998
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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