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Protein

Probable FAD synthase

Gene

SPCC1235.04c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Adenylates FMN to FAD.By similarity

Catalytic activityi

ATP + FMN = diphosphate + FAD.

Pathway: FAD biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes FAD from FMN.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable FAD synthase (SPCC1235.04c)
This subpathway is part of the pathway FAD biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes FAD from FMN, the pathway FAD biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_318965. Vitamin B2 (riboflavin) metabolism.
UniPathwayiUPA00277; UER00407.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable FAD synthase (EC:2.7.7.2)
Alternative name(s):
FAD pyrophosphorylase
FMN adenylyltransferase
Flavin adenine dinucleotide synthase
Gene namesi
ORF Names:SPCC1235.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC1235.04c.
PomBaseiSPCC1235.04c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Probable FAD synthasePRO_0000100690Add
BLAST

Proteomic databases

MaxQBiO74841.

Interactioni

Protein-protein interaction databases

MINTiMINT-4681153.
STRINGi4896.SPCC1235.04c.1.

Structurei

3D structure databases

ProteinModelPortaliO74841.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAPS reductase family. FAD1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0175.
HOGENOMiHOG000216561.
InParanoidiO74841.
KOiK00953.
OMAiFLRIHPI.
OrthoDBiEOG7DJSXH.
PhylomeDBiO74841.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01507. PAPS_reduct. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O74841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDELERVYQS IKNIFTHSAP SEKLVGLQNR LSISLRFIEY AFETYQPERL
60 70 80 90 100
AMSFNGGKDC LVLFLLCIYY LKEKYKEQAQ AKLSNIPFVF VRPRDEFPEM
110 120 130 140 150
DDFVNECQSK YRLNIIKISL PMKEAFCKFL KEHKHIQAIL IGIRRLDPHG
160 170 180 190 200
LHRIAFEVTD KGWPKFMRIQ PILDWSYTEI WDLLLETNTK YCSLYDRGYT
210 220 230 240 250
SLGGVSDTSP NPALKNPDGT YSPAYLLSDG SLERAGRNNT VPFSRTNSRF
260
LYDSGASSYA SSEVS
Length:265
Mass (Da):30,608
Last modified:November 1, 1998 - v1
Checksum:iBC6C662E6F43A6F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21108.1.
PIRiT40878.
RefSeqiNP_587730.1. NM_001022725.2.

Genome annotation databases

EnsemblFungiiSPCC1235.04c.1; SPCC1235.04c.1:pep; SPCC1235.04c.
GeneIDi2539270.
KEGGispo:SPCC1235.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA. Translation: CAA21108.1.
PIRiT40878.
RefSeqiNP_587730.1. NM_001022725.2.

3D structure databases

ProteinModelPortaliO74841.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4681153.
STRINGi4896.SPCC1235.04c.1.

Proteomic databases

MaxQBiO74841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC1235.04c.1; SPCC1235.04c.1:pep; SPCC1235.04c.
GeneIDi2539270.
KEGGispo:SPCC1235.04c.

Organism-specific databases

EuPathDBiFungiDB:SPCC1235.04c.
PomBaseiSPCC1235.04c.

Phylogenomic databases

eggNOGiCOG0175.
HOGENOMiHOG000216561.
InParanoidiO74841.
KOiK00953.
OMAiFLRIHPI.
OrthoDBiEOG7DJSXH.
PhylomeDBiO74841.

Enzyme and pathway databases

UniPathwayiUPA00277; UER00407.
ReactomeiREACT_318965. Vitamin B2 (riboflavin) metabolism.

Miscellaneous databases

NextBioi20800440.
PROiO74841.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01507. PAPS_reduct. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiFAD1_SCHPO
AccessioniPrimary (citable) accession number: O74841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: June 24, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.