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Protein

5-demethoxyubiquinone hydroxylase, mitochondrial

Gene

coq7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 2 iron ions per subunit.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Iron 1UniRule annotation1
Metal bindingi86Iron 1UniRule annotation1
Metal bindingi86Iron 2UniRule annotation1
Metal bindingi89Iron 1UniRule annotation1
Metal bindingi138Iron 2UniRule annotation1
Metal bindingi176Iron 1UniRule annotation1
Metal bindingi176Iron 2UniRule annotation1
Metal bindingi179Iron 2UniRule annotation1

GO - Molecular functioni

  • 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity Source: PomBase
  • metal ion binding Source: UniProtKB-KW
  • monooxygenase activity Source: UniProtKB-KW

GO - Biological processi

  • ubiquinone biosynthetic process Source: PomBase

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processUbiquinone biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
5-demethoxyubiquinone hydroxylase, mitochondrialUniRule annotation (EC:1.14.13.-UniRule annotation)
Short name:
DMQ hydroxylaseUniRule annotation
Alternative name(s):
Ubiquinone biosynthesis monooxygenase COQ7UniRule annotation
Gene namesi
Name:coq7UniRule annotation
ORF Names:SPBC337.15c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC337.15c.
PomBaseiSPBC337.15c. coq7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionUniRule annotationAdd BLAST27
ChainiPRO_000031589728 – 2165-demethoxyubiquinone hydroxylase, mitochondrialAdd BLAST189

Proteomic databases

MaxQBiO74826.
PRIDEiO74826.

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation

Protein-protein interaction databases

BioGridi277539. 1 interactor.
MINTiMINT-4681033.
STRINGi4896.SPBC337.15c.1.

Structurei

3D structure databases

SMRiO74826.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COQ7 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000184972.
InParanoidiO74826.
KOiK06134.
OMAiNPLWYGG.
OrthoDBiEOG092C4BLJ.
PhylomeDBiO74826.

Family and domain databases

CDDicd01042. DMQH. 1 hit.
Gene3Di1.20.1260.10. 1 hit.
HAMAPiMF_01658. COQ7. 1 hit.
InterProiView protein in InterPro
IPR012347. Ferritin-like.
IPR009078. Ferritin-like_SF.
IPR011566. Ubq_synth_Coq7.
PANTHERiPTHR11237. PTHR11237. 1 hit.
PfamiView protein in Pfam
PF03232. COQ7. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRRQLIPI ATKSVSPFLR SSITCRRISM GRKELSEKDS NILDSVIRVD
60 70 80 90 100
QAGELGANQI YKGQHFILQF TDPKVAPTIQ HMWDQEKYHL ATFDNYVLKN
110 120 130 140 150
RVRPTFLRPF WDIAGFALGA GTALLGTKAA MACTEAVETV IGGHYNDQLR
160 170 180 190 200
ETAHLENKAP EFKEIRSHLA EFRDDELEHL NTAVEGWNAK EAPAHALLTN
210
AIQMGCKAAI WMCKRF
Length:216
Mass (Da):24,397
Last modified:November 1, 1998 - v1
Checksum:i1493BD6358E9EBD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21285.1.
PIRiT40268.
RefSeqiNP_595416.1. NM_001021323.2.

Genome annotation databases

EnsemblFungiiSPBC337.15c.1; SPBC337.15c.1:pep; SPBC337.15c.
GeneIDi2541024.
KEGGispo:SPBC337.15c.

Similar proteinsi

Entry informationi

Entry nameiCOQ7_SCHPO
AccessioniPrimary (citable) accession number: O74826
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1998
Last modified: November 22, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families