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Protein

5-demethoxyubiquinone hydroxylase, mitochondrial

Gene

coq7

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 2 iron ions per subunit.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Iron 1UniRule annotation1
Metal bindingi86Iron 1UniRule annotation1
Metal bindingi86Iron 2UniRule annotation1
Metal bindingi89Iron 1UniRule annotation1
Metal bindingi138Iron 2UniRule annotation1
Metal bindingi176Iron 1UniRule annotation1
Metal bindingi176Iron 2UniRule annotation1
Metal bindingi179Iron 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • ubiquinone biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
5-demethoxyubiquinone hydroxylase, mitochondrialUniRule annotation (EC:1.14.13.-UniRule annotation)
Short name:
DMQ hydroxylaseUniRule annotation
Alternative name(s):
Ubiquinone biosynthesis monooxygenase COQ7UniRule annotation
Gene namesi
Name:coq7UniRule annotation
ORF Names:SPBC337.15c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC337.15c.
PomBaseiSPBC337.15c. coq7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionSequence analysisAdd BLAST27
ChainiPRO_000031589728 – 2165-demethoxyubiquinone hydroxylase, mitochondrialAdd BLAST189

Proteomic databases

MaxQBiO74826.
PRIDEiO74826.

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation

Protein-protein interaction databases

BioGridi277539. 1 interactor.
MINTiMINT-4681033.

Family & Domainsi

Sequence similaritiesi

Belongs to the COQ7 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000184972.
InParanoidiO74826.
KOiK06134.
OMAiEYGAVCI.
OrthoDBiEOG092C4BLJ.
PhylomeDBiO74826.

Family and domain databases

CDDicd01042. DMQH. 1 hit.
HAMAPiMF_01658. COQ7. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR011566. Ubq_synth_Coq7.
[Graphical view]
PANTHERiPTHR11237. PTHR11237. 1 hit.
PfamiPF03232. COQ7. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O74826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSRRQLIPI ATKSVSPFLR SSITCRRISM GRKELSEKDS NILDSVIRVD
60 70 80 90 100
QAGELGANQI YKGQHFILQF TDPKVAPTIQ HMWDQEKYHL ATFDNYVLKN
110 120 130 140 150
RVRPTFLRPF WDIAGFALGA GTALLGTKAA MACTEAVETV IGGHYNDQLR
160 170 180 190 200
ETAHLENKAP EFKEIRSHLA EFRDDELEHL NTAVEGWNAK EAPAHALLTN
210
AIQMGCKAAI WMCKRF
Length:216
Mass (Da):24,397
Last modified:November 1, 1998 - v1
Checksum:i1493BD6358E9EBD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21285.1.
PIRiT40268.
RefSeqiNP_595416.1. NM_001021323.2.

Genome annotation databases

EnsemblFungiiSPBC337.15c.1; SPBC337.15c.1:pep; SPBC337.15c.
GeneIDi2541024.
KEGGispo:SPBC337.15c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA21285.1.
PIRiT40268.
RefSeqiNP_595416.1. NM_001021323.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277539. 1 interactor.
MINTiMINT-4681033.

Proteomic databases

MaxQBiO74826.
PRIDEiO74826.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC337.15c.1; SPBC337.15c.1:pep; SPBC337.15c.
GeneIDi2541024.
KEGGispo:SPBC337.15c.

Organism-specific databases

EuPathDBiFungiDB:SPBC337.15c.
PomBaseiSPBC337.15c. coq7.

Phylogenomic databases

HOGENOMiHOG000184972.
InParanoidiO74826.
KOiK06134.
OMAiEYGAVCI.
OrthoDBiEOG092C4BLJ.
PhylomeDBiO74826.

Enzyme and pathway databases

UniPathwayiUPA00232.

Miscellaneous databases

PROiO74826.

Family and domain databases

CDDicd01042. DMQH. 1 hit.
HAMAPiMF_01658. COQ7. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR011566. Ubq_synth_Coq7.
[Graphical view]
PANTHERiPTHR11237. PTHR11237. 1 hit.
PfamiPF03232. COQ7. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOQ7_SCHPO
AccessioniPrimary (citable) accession number: O74826
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.